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The map label for this gene is fabB [H]

Identifier: 150398635

GI number: 150398635

Start: 3658073

End: 3659293

Strand: Reverse

Name: fabB [H]

Synonym: Smed_3449

Alternate gene names: 150398635

Gene position: 3659293-3658073 (Counterclockwise)

Preceding gene: 150398636

Following gene: 150398634

Centisome position: 96.76

GC content: 62.08

Gene sequence:

>1221_bases
ATGAGACGGGTTGTTGTAACGGGCCTCGGGATCGTTTCCTCGATCGGCAGCGATGCCGACGAAGTCACCGCGTCGCTCCG
CGATGCGCGTTCGGGCATCACGTTTTCTCCGGATTTTGCCGAGCACGGCTTTAAATGCCAGGTCTGGGGAGCGCCTGCGC
TCGACCCGACAGATCTGGTCGACCGGCGCGCCATGCGCTTCCTCTCTCAGGGCGGAGCCTGGAACCATGTGGCGATGAAG
CAGGCTATCGCGGATTCCGGATTGGAAGCCGGCGACATCACAAACGAACGCACCGGCATCATAATGGGATCGGGCGGCCC
TTCGACGCGCACGATCGTCGAAGCGGCGGACATTACCCGCAAGAACAACAGCCCCAAGCGCATCGGCCCCTTCGCCGTGC
CAAAGGCGATGTCGTCCACGGCCTCCGCGACCCTTGCGACCTGGTTCCAGATCCACGGCGTCAACTATTCCATCTCGTCG
GCCTGCTCGACCTCGGCACACTGCATCGGCAATGCCGCAGAAATGATCCAGTGGGGCAAACAGGACGTGATGTTCGCCGG
AGGTCACGAAGATCTCGACTGGACCATGTCAAATCTGTTCGACGCCATGGGCGCCATGTCTTCCAAGTATAACGATACGC
CGGCAATTGCTTCCCGTGCCTATGACGCGAACCGCGACGGCTTCGTCATCGCCGGCGGTGCCGGTGTCCTCGTCCTGGAG
GAACTGGAGCGTGCCAAGGCGCGCGGTGCGAAGATTTACGCCGAAATCGTCGGCTACGGCGCGACCTCGGACGGATACGA
CATGGTCGCCCCCTCCGGCGAAGGCGCCGCGCGCTGCATGCGCCAGGCGCTCGCCACGGTGAATGGCGATGTCGACTACA
TCAATACCCACGGCACCTCCACGCCGGTCGGCGATCAAAAGGAGATCGGCGCCATCCGCGAGGTCTTCGGTGAGAAGATG
CCGCATATCCAGTCCACGAAATCGCTGACCGGTCACTCACTCGGCGCGGCTGGTGTACAGGAATCGATCTACGGCCTCCT
GATGATGCAGGCCGGCTTCATCGGCGAAAGCGCTCACATCACCGAGCTCGACGCCGAATTCGAAGGCGTGCCGATCGTCC
GCAAGCGCATCGACAATGCCAGGATCGACACGGTTCTTTCGAACTCCTTCGGCTTCGGCGGCACCAACGCGACGCTCGTC
TTCCAGCGCTATAACGGATAA

Upstream 100 bases:

>100_bases
CTATAAGGCCACCGACCTCAGGGTCGGCCTCTTCCAGGAAAAGGCCGGCTGAACTGCGGGCGATCCCGCACGGTTCCAAT
CGAAGAAAAGGTCATCTGAC

Downstream 100 bases:

>100_bases
CACGATGAACGGATTGATGAACGGAAAGCGCGGCCTCATCATGGGCGTCGCCAACAACCATTCTATTGCCTGGGGGATCG
CCAAGACACTCGCCGCGCAG

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MRRVVVTGLGIVSSIGSDADEVTASLRDARSGITFSPDFAEHGFKCQVWGAPALDPTDLVDRRAMRFLSQGGAWNHVAMK
QAIADSGLEAGDITNERTGIIMGSGGPSTRTIVEAADITRKNNSPKRIGPFAVPKAMSSTASATLATWFQIHGVNYSISS
ACSTSAHCIGNAAEMIQWGKQDVMFAGGHEDLDWTMSNLFDAMGAMSSKYNDTPAIASRAYDANRDGFVIAGGAGVLVLE
ELERAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAARCMRQALATVNGDVDYINTHGTSTPVGDQKEIGAIREVFGEKM
PHIQSTKSLTGHSLGAAGVQESIYGLLMMQAGFIGESAHITELDAEFEGVPIVRKRIDNARIDTVLSNSFGFGGTNATLV
FQRYNG

Sequences:

>Translated_406_residues
MRRVVVTGLGIVSSIGSDADEVTASLRDARSGITFSPDFAEHGFKCQVWGAPALDPTDLVDRRAMRFLSQGGAWNHVAMK
QAIADSGLEAGDITNERTGIIMGSGGPSTRTIVEAADITRKNNSPKRIGPFAVPKAMSSTASATLATWFQIHGVNYSISS
ACSTSAHCIGNAAEMIQWGKQDVMFAGGHEDLDWTMSNLFDAMGAMSSKYNDTPAIASRAYDANRDGFVIAGGAGVLVLE
ELERAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAARCMRQALATVNGDVDYINTHGTSTPVGDQKEIGAIREVFGEKM
PHIQSTKSLTGHSLGAAGVQESIYGLLMMQAGFIGESAHITELDAEFEGVPIVRKRIDNARIDTVLSNSFGFGGTNATLV
FQRYNG
>Mature_406_residues
MRRVVVTGLGIVSSIGSDADEVTASLRDARSGITFSPDFAEHGFKCQVWGAPALDPTDLVDRRAMRFLSQGGAWNHVAMK
QAIADSGLEAGDITNERTGIIMGSGGPSTRTIVEAADITRKNNSPKRIGPFAVPKAMSSTASATLATWFQIHGVNYSISS
ACSTSAHCIGNAAEMIQWGKQDVMFAGGHEDLDWTMSNLFDAMGAMSSKYNDTPAIASRAYDANRDGFVIAGGAGVLVLE
ELERAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAARCMRQALATVNGDVDYINTHGTSTPVGDQKEIGAIREVFGEKM
PHIQSTKSLTGHSLGAAGVQESIYGLLMMQAGFIGESAHITELDAEFEGVPIVRKRIDNARIDTVLSNSFGFGGTNATLV
FQRYNG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=33.7320574162679, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI41872631, Length=336, Percent_Identity=25.297619047619, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI223972627, Length=138, Percent_Identity=39.1304347826087, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1788663, Length=404, Percent_Identity=61.8811881188119, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=37.046004842615, Blast_Score=238, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=32.289156626506, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=38.2239382239382, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI212642053, Length=338, Percent_Identity=26.0355029585799, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=279, Percent_Identity=25.4480286738351, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=31.3333333333333, Blast_Score=186, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=35.6294536817102, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI221330659, Length=337, Percent_Identity=27.5964391691395, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19920632, Length=337, Percent_Identity=27.5964391691395, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24581345, Length=344, Percent_Identity=25.8720930232558, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42964; Mature: 42964

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGIVSSIGSDADEVTASLRDARSGITFSPDFAEHGFKCQVWGAPALDPTDLV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHCCCEEEECCCCCCCHHHHH
DRRAMRFLSQGGAWNHVAMKQAIADSGLEAGDITNERTGIIMGSGGPSTRTIVEAADITR
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEEHHHHHC
KNNSPKRIGPFAVPKAMSSTASATLATWFQIHGVNYSISSACSTSAHCIGNAAEMIQWGK
CCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCEEHHHHCCCCHHHHCCHHHHHHCCC
QDVMFAGGHEDLDWTMSNLFDAMGAMSSKYNDTPAIASRAYDANRDGFVIAGGAGVLVLE
CCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEHHH
ELERAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAARCMRQALATVNGDVDYINTHGTS
HHHHHHHCCCEEEEEHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCC
TPVGDQKEIGAIREVFGEKMPHIQSTKSLTGHSLGAAGVQESIYGLLMMQAGFIGESAHI
CCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCE
TELDAEFEGVPIVRKRIDNARIDTVLSNSFGFGGTNATLVFQRYNG
EECCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRRVVVTGLGIVSSIGSDADEVTASLRDARSGITFSPDFAEHGFKCQVWGAPALDPTDLV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHCCCEEEECCCCCCCHHHHH
DRRAMRFLSQGGAWNHVAMKQAIADSGLEAGDITNERTGIIMGSGGPSTRTIVEAADITR
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEEHHHHHC
KNNSPKRIGPFAVPKAMSSTASATLATWFQIHGVNYSISSACSTSAHCIGNAAEMIQWGK
CCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCEEHHHHCCCCHHHHCCHHHHHHCCC
QDVMFAGGHEDLDWTMSNLFDAMGAMSSKYNDTPAIASRAYDANRDGFVIAGGAGVLVLE
CCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEHHH
ELERAKARGAKIYAEIVGYGATSDGYDMVAPSGEGAARCMRQALATVNGDVDYINTHGTS
HHHHHHHCCCEEEEEHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCC
TPVGDQKEIGAIREVFGEKMPHIQSTKSLTGHSLGAAGVQESIYGLLMMQAGFIGESAHI
CCCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCE
TELDAEFEGVPIVRKRIDNARIDTVLSNSFGFGGTNATLVFQRYNG
EECCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]