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The map label for this gene is trxA [C]

Identifier: 150398433

GI number: 150398433

Start: 3416463

End: 3416786

Strand: Reverse

Name: trxA [C]

Synonym: Smed_3241

Alternate gene names: 150398433

Gene position: 3416786-3416463 (Counterclockwise)

Preceding gene: 150398434

Following gene: 150398424

Centisome position: 90.35

GC content: 56.79

Gene sequence:

>324_bases
ATGGCTACTGTGAAAGTCGATACTTCCAATTTCCAGAAAGAAGTTCTGAACTCGGCCGAACCGGTCGTCGTCGACTTCTG
GGCAGAATGGTGCGGGCCGTGCAAGATGATTGCACCCAGCCTCGAAGAAATCTCCACCGAGCTTGCCGGCAAGGTCAAGG
TCGTCAAGCTCAACATCGACGAAAACCCCGAGCTCGCGGCGCAGTATGGCGTACGCTCGATTCCGACGCTTGCCATGTTC
AAGGGCGGCGAAGTCGCCGACATCAAGGTCGGAGCCGCACCTAAGACGGCACTCAGCTCCTGGATTTCGAACGCGGTAGC
TTAA

Upstream 100 bases:

>100_bases
AGCGCTCGCGACAAAGTGAGATACCCGATATTGAAAATCCAGTGGCGATGCCTCACATGAGACACAACATCTGGACACTG
CCATTCCGAAGGAGCACCCG

Downstream 100 bases:

>100_bases
ACCCGCCGGAACCTGAACGCAGGCGTACGAAGCCCGGCTTGGCCGGGCTTTTTCTTTCGGGCAGGCGCACATGATAAGAC
CAGGGCGCGCTCATCCGCAT

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MATVKVDTSNFQKEVLNSAEPVVVDFWAEWCGPCKMIAPSLEEISTELAGKVKVVKLNIDENPELAAQYGVRSIPTLAMF
KGGEVADIKVGAAPKTALSSWISNAVA

Sequences:

>Translated_107_residues
MATVKVDTSNFQKEVLNSAEPVVVDFWAEWCGPCKMIAPSLEEISTELAGKVKVVKLNIDENPELAAQYGVRSIPTLAMF
KGGEVADIKVGAAPKTALSSWISNAVA
>Mature_106_residues
ATVKVDTSNFQKEVLNSAEPVVVDFWAEWCGPCKMIAPSLEEISTELAGKVKVVKLNIDENPELAAQYGVRSIPTLAMFK
GGEVADIKVGAAPKTALSSWISNAVA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=101, Percent_Identity=40.5940594059406, Blast_Score=92, Evalue=6e-20,
Organism=Homo sapiens, GI5031973, Length=77, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI20070125, Length=92, Percent_Identity=35.8695652173913, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI21361657, Length=90, Percent_Identity=38.8888888888889, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=51.9230769230769, Blast_Score=118, Evalue=1e-28,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=45.1612903225806, Blast_Score=104, Evalue=2e-24,
Organism=Escherichia coli, GI87081747, Length=104, Percent_Identity=30.7692307692308, Blast_Score=66, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=39.7959183673469, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI115532380, Length=74, Percent_Identity=41.8918918918919, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115532378, Length=74, Percent_Identity=41.8918918918919, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17544108, Length=74, Percent_Identity=41.8918918918919, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17556044, Length=75, Percent_Identity=40, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=79, Percent_Identity=36.7088607594937, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=82, Percent_Identity=36.5853658536585, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=105, Percent_Identity=34.2857142857143, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=73, Percent_Identity=35.6164383561644, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=103, Percent_Identity=32.0388349514563, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=104, Percent_Identity=37.5, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=85, Percent_Identity=47.0588235294118, Blast_Score=70, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=92, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=43.298969072165, Blast_Score=96, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=45, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358065, Length=97, Percent_Identity=41.2371134020619, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17648013, Length=66, Percent_Identity=48.4848484848485, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583090, Length=66, Percent_Identity=48.4848484848485, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664269, Length=79, Percent_Identity=40.5063291139241, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921434, Length=79, Percent_Identity=39.2405063291139, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639068, Length=97, Percent_Identity=29.8969072164948, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17647799, Length=78, Percent_Identity=41.025641025641, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11422; Mature: 11291

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVKVDTSNFQKEVLNSAEPVVVDFWAEWCGPCKMIAPSLEEISTELAGKVKVVKLNID
CCEEEECCHHHHHHHHCCCCCEEEEEHHHHCCCHHHHCCCHHHHHHHHCCCEEEEEEECC
ENPELAAQYGVRSIPTLAMFKGGEVADIKVGAAPKTALSSWISNAVA
CCCHHHHHCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
ATVKVDTSNFQKEVLNSAEPVVVDFWAEWCGPCKMIAPSLEEISTELAGKVKVVKLNID
CEEEECCHHHHHHHHCCCCCEEEEEHHHHCCCHHHHCCCHHHHHHHHCCCEEEEEEECC
ENPELAAQYGVRSIPTLAMFKGGEVADIKVGAAPKTALSSWISNAVA
CCCHHHHHCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]