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The map label for this gene is bioA [C]

Identifier: 150398354

GI number: 150398354

Start: 3321941

End: 3323278

Strand: Direct

Name: bioA [C]

Synonym: Smed_3162

Alternate gene names: 150398354

Gene position: 3321941-3323278 (Clockwise)

Preceding gene: 150398352

Following gene: 150398368

Centisome position: 87.84

GC content: 65.47

Gene sequence:

>1338_bases
ATGAACGCCCACAACAAGCCCAACGCTCCGGTTCTCGACAGCTACTGGATGCCCTTCACCGCGAACCGCCAGTTCAAGGC
GGCACCCCGGCTGCTCGCCTCCGCGGAGGGCATGCACTACACCAGCGTCGACGGTCGGACGGTTCTCGATGGTACCGCCG
GTCTCTGGTGCGTTAATGCCGGTCACGGCCGCCGGCAAATCGCCGCCGCCGTCGAGCGCCAGCTTTCGACCATGGACTTC
GCGCCGTCCTTCCAGATGGGCCATCCGATCGCCTTCGACTTCGCCGAGCGGCTGGCAGAGATCGCGCCCGGCCCTGGGGG
CGCCAAGCTCGACCGGGTCTTTTTCACCGGCTCGGGCTCGGAATCCGTCGACACGGCGCTCAAAATCGCGATCGCCTACC
AGCGATCGATCGGCCAGGGCACCCGCACGCGGCTCATCGGCCGTGAGCGCGGCTATCATGGTGTCGGCTTCGGTGGCATT
TCCGTCGGCGGCATTGTCAACAACCGCCGCGTCTTCCCGCAACTCCCGGGCTCCGACCATCTGCGTCACACCCATGACCC
GGCGAAGAACGCTTTCGTCAAGGGACAGCCTGAGCATGGTGCCGAACTTGCCGACGATCTCGAAAGGCTCGTGGCGCTTC
ACGGCGCCGAGACGATCGCCGCCTGCATCGTCGAGCCCGTCGCCGGCTCGACCGGCGTGCTCATCCCGCCGAAGGGCTAT
CTCGAGCGTCTGCGCGCCATCTGCGACAAGCACGGAATCCTTCTGATTTTCGACGAGGTGATCACCGGCTTCGGCCGCCT
CGGCGCGGCCTTCGCGACAGATTATTTCGGCGTCACGCCCGATCTCGTCACCGCTGCCAAGGGGCTTACCAATGGTGCGA
TCCCGATGGGCGCGGTGTTTGCGAGCCGCAAGGTGCACGACGCGCTGATGCACGGGCCGGAAGGTCAGATCGAACTCTTC
CACGGCTACACCTATTCCGGTCATCCCGCCGCCTGCGCCGCGGGCATCGCCACGCTCGACATCTATCGTGACGAAGGCCT
GATGACCCGCGCCGCCGAAATCGAGGGCGACTGGCATGAGGCGATGCATTCGCTCAAGGGCCTGCCGCACGTCAACGACA
TCCGCACCATTGGCCTCATCGCCGGTATCGAGCTCAATTCGCGTGACGGCGCGCCCGGCGCCCGCGCCTATGACGCCTTC
GTCGATTGCTTCGAGCGCGGCCTGCTGATCCGCGTCACCGGCGACATCATCGCCTTCTCGCCGCCGCTGATCGCGGAGAA
GAAGCATTTCGGCGAGATCGTGTCGATGCTCGCCGATGCTCTGAAACGGGTGAAATAG

Upstream 100 bases:

>100_bases
AACGTCAATCATGTAAATACAATTACTTAGAGAACTCCAGAAAAGGACTTGTTCGGAAATTCAAATCATGGCGTCAATCA
GCCAGTGACAGGAGGATGCC

Downstream 100 bases:

>100_bases
CGAGCCAGTGCTGTCAGGCTGCCCTCCCACCAGTCCAGTGGGAGGGGCAACCCCCGCCCGACACGCCATCCTCTCTCGAG
GAAGCAAACTCAGCGGATCA

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MNAHNKPNAPVLDSYWMPFTANRQFKAAPRLLASAEGMHYTSVDGRTVLDGTAGLWCVNAGHGRRQIAAAVERQLSTMDF
APSFQMGHPIAFDFAERLAEIAPGPGGAKLDRVFFTGSGSESVDTALKIAIAYQRSIGQGTRTRLIGRERGYHGVGFGGI
SVGGIVNNRRVFPQLPGSDHLRHTHDPAKNAFVKGQPEHGAELADDLERLVALHGAETIAACIVEPVAGSTGVLIPPKGY
LERLRAICDKHGILLIFDEVITGFGRLGAAFATDYFGVTPDLVTAAKGLTNGAIPMGAVFASRKVHDALMHGPEGQIELF
HGYTYSGHPAACAAGIATLDIYRDEGLMTRAAEIEGDWHEAMHSLKGLPHVNDIRTIGLIAGIELNSRDGAPGARAYDAF
VDCFERGLLIRVTGDIIAFSPPLIAEKKHFGEIVSMLADALKRVK

Sequences:

>Translated_445_residues
MNAHNKPNAPVLDSYWMPFTANRQFKAAPRLLASAEGMHYTSVDGRTVLDGTAGLWCVNAGHGRRQIAAAVERQLSTMDF
APSFQMGHPIAFDFAERLAEIAPGPGGAKLDRVFFTGSGSESVDTALKIAIAYQRSIGQGTRTRLIGRERGYHGVGFGGI
SVGGIVNNRRVFPQLPGSDHLRHTHDPAKNAFVKGQPEHGAELADDLERLVALHGAETIAACIVEPVAGSTGVLIPPKGY
LERLRAICDKHGILLIFDEVITGFGRLGAAFATDYFGVTPDLVTAAKGLTNGAIPMGAVFASRKVHDALMHGPEGQIELF
HGYTYSGHPAACAAGIATLDIYRDEGLMTRAAEIEGDWHEAMHSLKGLPHVNDIRTIGLIAGIELNSRDGAPGARAYDAF
VDCFERGLLIRVTGDIIAFSPPLIAEKKHFGEIVSMLADALKRVK
>Mature_445_residues
MNAHNKPNAPVLDSYWMPFTANRQFKAAPRLLASAEGMHYTSVDGRTVLDGTAGLWCVNAGHGRRQIAAAVERQLSTMDF
APSFQMGHPIAFDFAERLAEIAPGPGGAKLDRVFFTGSGSESVDTALKIAIAYQRSIGQGTRTRLIGRERGYHGVGFGGI
SVGGIVNNRRVFPQLPGSDHLRHTHDPAKNAFVKGQPEHGAELADDLERLVALHGAETIAACIVEPVAGSTGVLIPPKGY
LERLRAICDKHGILLIFDEVITGFGRLGAAFATDYFGVTPDLVTAAKGLTNGAIPMGAVFASRKVHDALMHGPEGQIELF
HGYTYSGHPAACAAGIATLDIYRDEGLMTRAAEIEGDWHEAMHSLKGLPHVNDIRTIGLIAGIELNSRDGAPGARAYDAF
VDCFERGLLIRVTGDIIAFSPPLIAEKKHFGEIVSMLADALKRVK

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=427, Percent_Identity=26.463700234192, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI13994255, Length=472, Percent_Identity=26.0593220338983, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI284507298, Length=329, Percent_Identity=29.1793313069909, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI37574042, Length=439, Percent_Identity=25.9681093394077, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI226442705, Length=436, Percent_Identity=26.1467889908257, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=26.5664160401003, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI24119277, Length=428, Percent_Identity=24.7663551401869, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1786991, Length=431, Percent_Identity=30.8584686774942, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI145693181, Length=321, Percent_Identity=34.8909657320872, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1787560, Length=440, Percent_Identity=31.1363636363636, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1789016, Length=430, Percent_Identity=29.3023255813954, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789759, Length=435, Percent_Identity=27.3563218390805, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788044, Length=417, Percent_Identity=26.8585131894484, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1786349, Length=346, Percent_Identity=30.9248554913295, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=442, Percent_Identity=29.8642533936652, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI25144271, Length=433, Percent_Identity=29.0993071593533, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71992977, Length=443, Percent_Identity=27.9909706546275, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=237, Percent_Identity=36.2869198312236, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=230, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=438, Percent_Identity=26.7123287671233, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6324386, Length=436, Percent_Identity=25.9174311926606, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=414, Percent_Identity=26.8115942028986, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21357415, Length=418, Percent_Identity=27.0334928229665, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI161085790, Length=438, Percent_Identity=29.2237442922374, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28574759, Length=419, Percent_Identity=29.5942720763723, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21356575, Length=444, Percent_Identity=26.5765765765766, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 47643; Mature: 47643

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAHNKPNAPVLDSYWMPFTANRQFKAAPRLLASAEGMHYTSVDGRTVLDGTAGLWCVNA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEEECCCCCEEEEEC
GHGRRQIAAAVERQLSTMDFAPSFQMGHPIAFDFAERLAEIAPGPGGAKLDRVFFTGSGS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCC
ESVDTALKIAIAYQRSIGQGTRTRLIGRERGYHGVGFGGISVGGIVNNRRVFPQLPGSDH
CHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEECCEECCCEECCCCCCCCC
LRHTHDPAKNAFVKGQPEHGAELADDLERLVALHGAETIAACIVEPVAGSTGVLIPPKGY
CCCCCCHHHCCEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEECCHHH
LERLRAICDKHGILLIFDEVITGFGRLGAAFATDYFGVTPDLVTAAKGLTNGAIPMGAVF
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHH
ASRKVHDALMHGPEGQIELFHGYTYSGHPAACAAGIATLDIYRDEGLMTRAAEIEGDWHE
HHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHEEEEECCCCCEEHHHHCCCHHHH
AMHSLKGLPHVNDIRTIGLIAGIELNSRDGAPGARAYDAFVDCFERGLLIRVTGDIIAFS
HHHHHCCCCCCHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECCEEEEC
PPLIAEKKHFGEIVSMLADALKRVK
CCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNAHNKPNAPVLDSYWMPFTANRQFKAAPRLLASAEGMHYTSVDGRTVLDGTAGLWCVNA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEEECCCCCEEEEEC
GHGRRQIAAAVERQLSTMDFAPSFQMGHPIAFDFAERLAEIAPGPGGAKLDRVFFTGSGS
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCC
ESVDTALKIAIAYQRSIGQGTRTRLIGRERGYHGVGFGGISVGGIVNNRRVFPQLPGSDH
CHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEEECCEECCCEECCCCCCCCC
LRHTHDPAKNAFVKGQPEHGAELADDLERLVALHGAETIAACIVEPVAGSTGVLIPPKGY
CCCCCCHHHCCEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEECCHHH
LERLRAICDKHGILLIFDEVITGFGRLGAAFATDYFGVTPDLVTAAKGLTNGAIPMGAVF
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHH
ASRKVHDALMHGPEGQIELFHGYTYSGHPAACAAGIATLDIYRDEGLMTRAAEIEGDWHE
HHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHEEEEECCCCCEEHHHHCCCHHHH
AMHSLKGLPHVNDIRTIGLIAGIELNSRDGAPGARAYDAFVDCFERGLLIRVTGDIIAFS
HHHHHCCCCCCHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECCEEEEC
PPLIAEKKHFGEIVSMLADALKRVK
CCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]