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The map label for this gene is betC [H]

Identifier: 150398338

GI number: 150398338

Start: 3296658

End: 3298127

Strand: Direct

Name: betC [H]

Synonym: Smed_3146

Alternate gene names: 150398338

Gene position: 3296658-3298127 (Clockwise)

Preceding gene: 150398337

Following gene: 150398339

Centisome position: 87.17

GC content: 60.48

Gene sequence:

>1470_bases
GTGAACAAGCCGAATGTCCTGTTCATATTCTCTGATCAGCACGCGCAGAAAGTAGCGGGCTGTTATGGCGATGATGTCGT
CCGAACGCCCAATATCGACCGGCTCGCGCAGGAAGGTGTGCGCTTCGACAATGCCTATTGCCCGTCACCGATCTGCACGC
CAAGCCGGATGTCGATGCTGACCGCCCGCTGGCCGCACAGGCAGGAATGCTGGACGAATGACGACATGCTTCGTTCGGAT
GTCCCGACATGGCTGCACCGGGCGGGAGAGGCCGGCTACCGCCCCGCGCTGATCGGCCGGATGCATTCGATAGGCCCGGA
CCAGCTTCACGGCTATGCCGAGCGTGGAATCGGGGATCATACGCCGAATTTCGCGGGGATCGCACGATTTCCCATGGGTG
TGCTTGAAGGCACCAACGAACCGGATTCCGTATCCCTGACGCAAAGTGGAGCGGGAATGGCGATCTACCAGCGGAAAGAT
CAGGACGTCGTGGATGCCGCTGCGGCCTGGCTTCGGGATAAGGGAGCGGCCAGAAACGCCGCCGGGCAGCAATTTTGCCT
GACGGTCGGGCTGATGACGCCGCATGCCCCCTATGTCGTCGATCGCGAGGCCTTCGACCATTATCACGGGCAAGTACCGC
CGCCCCGTCTGGATGTGCCGCAGGACGAGCATGACTGGCATCGGTGGTGGCGTCACGACCGCGGCATCGGCGAAGTGTCT
GATGCAGTCAGGGATCGCGCCCGTGCCGCCTATTGGGGGCTTGTGCAGCGCACCGATGAAATGATCGGGCAGGTTCTCGA
CGCGCTCAAGGAAATCGGCGCGATGGACGATACCCTGATCGTCTATGCGTCCGATCACGGCGACCATGTCGGAGAACGTG
GCCTGTGGTGGAAACATACATTCTTTGAAGAATCCGTGAAGTTTCCGCTGGTGATGCGGCTTCCCGGCGCCATTCCGGCG
GGCGAAAGCCGGGATCAGGTCGTCAATCTGGTCGATCTCAGCCAGACGATGATCGAGGTCATGGGGGCTCAGCCTTTGCC
CTATGCGGATGGCAAAAGTTTCTGGGCCGTTGCCTGTGATCGCGAAGCGCCATGGGAGAACGAGACATTCAGCGAATACT
GTACGGATCCGGTACCATCATGGACCGGAGGACGGGCTGTGCAGCAGCGGATGATCCGGTCAGGTTCGTGGAAATTGTCC
GTCTATGACGGCGAGCCGCCGCTTTTGTTTGATCTGTCCACAGATCCGGATGAGCGTATCAATCGCGCCGAGGACCCGGA
TTGTGCGGAAATGTTTCAACGATTGTCGGCGCGCCTGGCCCATGACGGTTGGCGGCCCGAAACGGTTGCCGCCCGCATGC
GGGAACGACGAGCCGAGAAAGACATTCTCGCCGCTTGGGCGCGTGAGGTTCAGCCAGCGCAGACCCATGTCTGGGAATAC
ACCGCCGATATGAACAGACTCGATAACTAA

Upstream 100 bases:

>100_bases
ACGCGCTGCTGGCGACGGATGAAAACGCTGCGGTCGCCGCATTGAAGTCTCATCTCACCACATCATGGCGGCGCGCCCTT
GGACATGAGGATCTGTCATC

Downstream 100 bases:

>100_bases
CCGCCATTTTCATGTAATTCTGGGAGGAATAAACACATGAAACACCTAATTGCCGCCATCCTTGCCGCGACGCTTTCGAC
AGGCACCGCCTGGGCCGAGG

Product: sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MNKPNVLFIFSDQHAQKVAGCYGDDVVRTPNIDRLAQEGVRFDNAYCPSPICTPSRMSMLTARWPHRQECWTNDDMLRSD
VPTWLHRAGEAGYRPALIGRMHSIGPDQLHGYAERGIGDHTPNFAGIARFPMGVLEGTNEPDSVSLTQSGAGMAIYQRKD
QDVVDAAAAWLRDKGAARNAAGQQFCLTVGLMTPHAPYVVDREAFDHYHGQVPPPRLDVPQDEHDWHRWWRHDRGIGEVS
DAVRDRARAAYWGLVQRTDEMIGQVLDALKEIGAMDDTLIVYASDHGDHVGERGLWWKHTFFEESVKFPLVMRLPGAIPA
GESRDQVVNLVDLSQTMIEVMGAQPLPYADGKSFWAVACDREAPWENETFSEYCTDPVPSWTGGRAVQQRMIRSGSWKLS
VYDGEPPLLFDLSTDPDERINRAEDPDCAEMFQRLSARLAHDGWRPETVAARMRERRAEKDILAAWAREVQPAQTHVWEY
TADMNRLDN

Sequences:

>Translated_489_residues
MNKPNVLFIFSDQHAQKVAGCYGDDVVRTPNIDRLAQEGVRFDNAYCPSPICTPSRMSMLTARWPHRQECWTNDDMLRSD
VPTWLHRAGEAGYRPALIGRMHSIGPDQLHGYAERGIGDHTPNFAGIARFPMGVLEGTNEPDSVSLTQSGAGMAIYQRKD
QDVVDAAAAWLRDKGAARNAAGQQFCLTVGLMTPHAPYVVDREAFDHYHGQVPPPRLDVPQDEHDWHRWWRHDRGIGEVS
DAVRDRARAAYWGLVQRTDEMIGQVLDALKEIGAMDDTLIVYASDHGDHVGERGLWWKHTFFEESVKFPLVMRLPGAIPA
GESRDQVVNLVDLSQTMIEVMGAQPLPYADGKSFWAVACDREAPWENETFSEYCTDPVPSWTGGRAVQQRMIRSGSWKLS
VYDGEPPLLFDLSTDPDERINRAEDPDCAEMFQRLSARLAHDGWRPETVAARMRERRAEKDILAAWAREVQPAQTHVWEY
TADMNRLDN
>Mature_489_residues
MNKPNVLFIFSDQHAQKVAGCYGDDVVRTPNIDRLAQEGVRFDNAYCPSPICTPSRMSMLTARWPHRQECWTNDDMLRSD
VPTWLHRAGEAGYRPALIGRMHSIGPDQLHGYAERGIGDHTPNFAGIARFPMGVLEGTNEPDSVSLTQSGAGMAIYQRKD
QDVVDAAAAWLRDKGAARNAAGQQFCLTVGLMTPHAPYVVDREAFDHYHGQVPPPRLDVPQDEHDWHRWWRHDRGIGEVS
DAVRDRARAAYWGLVQRTDEMIGQVLDALKEIGAMDDTLIVYASDHGDHVGERGLWWKHTFFEESVKFPLVMRLPGAIPA
GESRDQVVNLVDLSQTMIEVMGAQPLPYADGKSFWAVACDREAPWENETFSEYCTDPVPSWTGGRAVQQRMIRSGSWKLS
VYDGEPPLLFDLSTDPDERINRAEDPDCAEMFQRLSARLAHDGWRPETVAARMRERRAEKDILAAWAREVQPAQTHVWEY
TADMNRLDN

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI39930577, Length=447, Percent_Identity=28.1879194630872, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI4504061, Length=477, Percent_Identity=22.2222222222222, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI146229331, Length=468, Percent_Identity=24.7863247863248, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI146229329, Length=468, Percent_Identity=24.7863247863248, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI6005990, Length=468, Percent_Identity=24.7863247863248, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI146229324, Length=468, Percent_Identity=24.7863247863248, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI109389362, Length=354, Percent_Identity=25.1412429378531, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI53831991, Length=112, Percent_Identity=35.7142857142857, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI157266309, Length=112, Percent_Identity=35.7142857142857, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI71852586, Length=151, Percent_Identity=33.7748344370861, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI71852584, Length=151, Percent_Identity=33.7748344370861, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI58743319, Length=151, Percent_Identity=33.7748344370861, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI31742482, Length=67, Percent_Identity=46.2686567164179, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790112, Length=452, Percent_Identity=25, Blast_Score=119, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24653364, Length=370, Percent_Identity=26.2162162162162, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19922168, Length=370, Percent_Identity=26.2162162162162, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24647401, Length=376, Percent_Identity=25, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 55261; Mature: 55261

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPNVLFIFSDQHAQKVAGCYGDDVVRTPNIDRLAQEGVRFDNAYCPSPICTPSRMSML
CCCCCEEEEECCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
TARWPHRQECWTNDDMLRSDVPTWLHRAGEAGYRPALIGRMHSIGPDQLHGYAERGIGDH
HHCCCCHHHCCCCCHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCC
TPNFAGIARFPMGVLEGTNEPDSVSLTQSGAGMAIYQRKDQDVVDAAAAWLRDKGAARNA
CCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCC
AGQQFCLTVGLMTPHAPYVVDREAFDHYHGQVPPPRLDVPQDEHDWHRWWRHDRGIGEVS
CCCEEEEEEECCCCCCCEEECHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHH
DAVRDRARAAYWGLVQRTDEMIGQVLDALKEIGAMDDTLIVYASDHGDHVGERGLWWKHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEHH
FFEESVKFPLVMRLPGAIPAGESRDQVVNLVDLSQTMIEVMGAQPLPYADGKSFWAVACD
HHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
REAPWENETFSEYCTDPVPSWTGGRAVQQRMIRSGSWKLSVYDGEPPLLFDLSTDPDERI
CCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEEECCCCHHHHH
NRAEDPDCAEMFQRLSARLAHDGWRPETVAARMRERRAEKDILAAWAREVQPAQTHVWEY
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TADMNRLDN
HHHHHHCCC
>Mature Secondary Structure
MNKPNVLFIFSDQHAQKVAGCYGDDVVRTPNIDRLAQEGVRFDNAYCPSPICTPSRMSML
CCCCCEEEEECCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
TARWPHRQECWTNDDMLRSDVPTWLHRAGEAGYRPALIGRMHSIGPDQLHGYAERGIGDH
HHCCCCHHHCCCCCHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCC
TPNFAGIARFPMGVLEGTNEPDSVSLTQSGAGMAIYQRKDQDVVDAAAAWLRDKGAARNA
CCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCC
AGQQFCLTVGLMTPHAPYVVDREAFDHYHGQVPPPRLDVPQDEHDWHRWWRHDRGIGEVS
CCCEEEEEEECCCCCCCEEECHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHH
DAVRDRARAAYWGLVQRTDEMIGQVLDALKEIGAMDDTLIVYASDHGDHVGERGLWWKHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEHH
FFEESVKFPLVMRLPGAIPAGESRDQVVNLVDLSQTMIEVMGAQPLPYADGKSFWAVACD
HHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
REAPWENETFSEYCTDPVPSWTGGRAVQQRMIRSGSWKLSVYDGEPPLLFDLSTDPDERI
CCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCEEEECCCCHHHHH
NRAEDPDCAEMFQRLSARLAHDGWRPETVAARMRERRAEKDILAAWAREVQPAQTHVWEY
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TADMNRLDN
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]