Click here to switch to the map view.

The map label for this gene is clpP [H]

Identifier: 150398272

GI number: 150398272

Start: 3226503

End: 3227120

Strand: Reverse

Name: clpP [H]

Synonym: Smed_3078

Alternate gene names: 150398272

Gene position: 3227120-3226503 (Counterclockwise)

Preceding gene: 150398273

Following gene: 150398267

Centisome position: 85.33

GC content: 56.47

Gene sequence:

>618_bases
ATGCGTGAAGCAATGCAACTCGTCCCCATGGTCGTTGAACAATCCAGCCGAGGCGAGCGCTCCTTTGACATCTATTCCCG
CCTGCTGCGTGAGAGAATCATTTTTCTGAACGGCGAGGTGAACGATGCCGTATCCGCTCTGGTTTGCGCACAATTGCTGT
TTCTGGAGGCTGAAAGCCCCACGAAACCGATCCAGCTCTACATCAATTCGCCTGGCGGTGTCGTTACAAGCGGCTTCGCC
ATGTATGACACGATGCGATATATCCGAGCGCCGGTTCATACGCTTTGCATGGGGACCGCCCGTTCGATGGGGTCATTCCT
GCTGATGGCAGGCGAGGCGGGCGGGCGTGCCGCCCTGCCAAATACCAGCATACTTGTCCATCAGCCTTCAGGCGGCTTCC
AGGGGCAGGCATCCGATATGCTTATCCATGCCGAGGAAATCAGGCGAACCAAACACCGAATGACGCGGCTTTATGCCGAG
CATTGCGGGCGAACCTATGAAGAATTCGAGCGTGCGATGGATCGCGATCGTTTCATGACGGCGGAAGAAGCTCTGGAGTG
GGGTTTGATCGACTGTATCCTCACCGAACGAGTGGCCGGTGCTGAACGTGACGGATAA

Upstream 100 bases:

>100_bases
AGGATGAGCGTCTGGGCCCGCCGGCTGCGAACAGCAATCAGCCTTGGCTGATGCGCGCCGCCTGACGTCTCGATCTACAA
AAATAAACAGGAGTTCGCCT

Downstream 100 bases:

>100_bases
AGTTCTCGCGCTGCGCTGCAGGCTGCATCTCAACCCCTGTAAAGCGTGTCCGGATAGACACCCGCTGCGGGCGTCGTTGT
CGTGCCCTCGCCGAGCGGAC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MREAMQLVPMVVEQSSRGERSFDIYSRLLRERIIFLNGEVNDAVSALVCAQLLFLEAESPTKPIQLYINSPGGVVTSGFA
MYDTMRYIRAPVHTLCMGTARSMGSFLLMAGEAGGRAALPNTSILVHQPSGGFQGQASDMLIHAEEIRRTKHRMTRLYAE
HCGRTYEEFERAMDRDRFMTAEEALEWGLIDCILTERVAGAERDG

Sequences:

>Translated_205_residues
MREAMQLVPMVVEQSSRGERSFDIYSRLLRERIIFLNGEVNDAVSALVCAQLLFLEAESPTKPIQLYINSPGGVVTSGFA
MYDTMRYIRAPVHTLCMGTARSMGSFLLMAGEAGGRAALPNTSILVHQPSGGFQGQASDMLIHAEEIRRTKHRMTRLYAE
HCGRTYEEFERAMDRDRFMTAEEALEWGLIDCILTERVAGAERDG
>Mature_205_residues
MREAMQLVPMVVEQSSRGERSFDIYSRLLRERIIFLNGEVNDAVSALVCAQLLFLEAESPTKPIQLYINSPGGVVTSGFA
MYDTMRYIRAPVHTLCMGTARSMGSFLLMAGEAGGRAALPNTSILVHQPSGGFQGQASDMLIHAEEIRRTKHRMTRLYAE
HCGRTYEEFERAMDRDRFMTAEEALEWGLIDCILTERVAGAERDG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=193, Percent_Identity=55.440414507772, Blast_Score=234, Evalue=6e-62,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=60.6217616580311, Blast_Score=256, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=55.7894736842105, Blast_Score=229, Evalue=6e-61,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=58.9473684210526, Blast_Score=243, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22942; Mature: 22942

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAMQLVPMVVEQSSRGERSFDIYSRLLRERIIFLNGEVNDAVSALVCAQLLFLEAESP
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCC
TKPIQLYINSPGGVVTSGFAMYDTMRYIRAPVHTLCMGTARSMGSFLLMAGEAGGRAALP
CCCEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
NTSILVHQPSGGFQGQASDMLIHAEEIRRTKHRMTRLYAEHCGRTYEEFERAMDRDRFMT
CCEEEEECCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AEEALEWGLIDCILTERVAGAERDG
HHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MREAMQLVPMVVEQSSRGERSFDIYSRLLRERIIFLNGEVNDAVSALVCAQLLFLEAESP
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCC
TKPIQLYINSPGGVVTSGFAMYDTMRYIRAPVHTLCMGTARSMGSFLLMAGEAGGRAALP
CCCEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
NTSILVHQPSGGFQGQASDMLIHAEEIRRTKHRMTRLYAEHCGRTYEEFERAMDRDRFMT
CCEEEEECCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AEEALEWGLIDCILTERVAGAERDG
HHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]