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The map label for this gene is tesB [H]

Identifier: 150398243

GI number: 150398243

Start: 3197678

End: 3198562

Strand: Direct

Name: tesB [H]

Synonym: Smed_3049

Alternate gene names: 150398243

Gene position: 3197678-3198562 (Clockwise)

Preceding gene: 150398241

Following gene: 150398244

Centisome position: 84.55

GC content: 63.95

Gene sequence:

>885_bases
ATGTCGCGCCTCACCGAGACTGCCACGCCAATGGACGCGCTGCTTGCGATACTCGACCTCGAAAAGCTCGAAGAGAACCT
CTTCAGGGGCTTAAGCCCGCAGGTCGGCTGGCAGCGGGTCTTCGGCGGCCAGGTGATCGGCCAGGCGCTGGTCGCCGCCC
AGCGCACGGTCGAAGGAGGCCGTTACGTCCATTCACTGCACGCCTATTTCATGCGGCCGGGCGATCCGTCGGTCCCTATC
GTCTACGAAGTTGACCGGATCCGCGACGGCTCGAGCTTCGCCACGCGGCGCGTGGCGGCGATCCAGCACGGCAAGGCCAT
CTTCGCCATGTCGGCCTCCTTCCAATACGACGAGGATGGATTCGAACACCAGTTCGACATGCCGGACGTGCCTATGCCGG
AGACGCTGCCGGGCGAGCAGGAACTCAAGGAGAAGTTCCTCGTCCACGCGCCGGAGGCGATCCGCCGTTATTGGGAGCGG
CCGCGGCCGATCGAAATCCGCCCCGTCTCGCTCGAGCATTATTTCTCACGAGCCAAGGCATCGCCGAAGCAGGACGTCTG
GGTGAAAGCGGTCGGCGCGGTGCCTGACGAGCGCCATCTGCAGGCCGCCGTCCTTGCCTATCTTTCCGACATGACGCTTC
TCGACACATCGCTTTACGCGCACGGCACGTCGGTGTTCGACCGCAGCCTCCAGGTCGCGAGCCTCGACCACGCAATGTGG
TTCCACCGGCCCTCGAAGATGGACGATTGGCTGCTCTACACCCAGGACAGCCCGAGTGCGCACGGCGCGCGCGGCATGAC
CCGTGGCAGCCTTTTCGATCGCTCCGGCGTTCTGATTGCCTCTGTGGCGCAGGAAGGATTGATCCGCAAAAAGGCAACTG
CATAA

Upstream 100 bases:

>100_bases
TCAATACATCGATCATCCGCCTCGTCTCCCGCACTTGAGCATCATCTCGTGCCTATATAGATCAATGCCATCGCCGTTCC
TACCATAGGAGACCGCCAAG

Downstream 100 bases:

>100_bases
AATTAGTTCAATTTTTCGATTCTGCCCGAATAATAATCATTCCACGTGGCTTTTTTTTAGCTCCCTCGGGCAGATGCCGC
TCCAATCAAATTTTTTCCAT

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSRLTETATPMDALLAILDLEKLEENLFRGLSPQVGWQRVFGGQVIGQALVAAQRTVEGGRYVHSLHAYFMRPGDPSVPI
VYEVDRIRDGSSFATRRVAAIQHGKAIFAMSASFQYDEDGFEHQFDMPDVPMPETLPGEQELKEKFLVHAPEAIRRYWER
PRPIEIRPVSLEHYFSRAKASPKQDVWVKAVGAVPDERHLQAAVLAYLSDMTLLDTSLYAHGTSVFDRSLQVASLDHAMW
FHRPSKMDDWLLYTQDSPSAHGARGMTRGSLFDRSGVLIASVAQEGLIRKKATA

Sequences:

>Translated_294_residues
MSRLTETATPMDALLAILDLEKLEENLFRGLSPQVGWQRVFGGQVIGQALVAAQRTVEGGRYVHSLHAYFMRPGDPSVPI
VYEVDRIRDGSSFATRRVAAIQHGKAIFAMSASFQYDEDGFEHQFDMPDVPMPETLPGEQELKEKFLVHAPEAIRRYWER
PRPIEIRPVSLEHYFSRAKASPKQDVWVKAVGAVPDERHLQAAVLAYLSDMTLLDTSLYAHGTSVFDRSLQVASLDHAMW
FHRPSKMDDWLLYTQDSPSAHGARGMTRGSLFDRSGVLIASVAQEGLIRKKATA
>Mature_293_residues
SRLTETATPMDALLAILDLEKLEENLFRGLSPQVGWQRVFGGQVIGQALVAAQRTVEGGRYVHSLHAYFMRPGDPSVPIV
YEVDRIRDGSSFATRRVAAIQHGKAIFAMSASFQYDEDGFEHQFDMPDVPMPETLPGEQELKEKFLVHAPEAIRRYWERP
RPIEIRPVSLEHYFSRAKASPKQDVWVKAVGAVPDERHLQAAVLAYLSDMTLLDTSLYAHGTSVFDRSLQVASLDHAMWF
HRPSKMDDWLLYTQDSPSAHGARGMTRGSLFDRSGVLIASVAQEGLIRKKATA

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=284, Percent_Identity=43.6619718309859, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI1786657, Length=270, Percent_Identity=47.4074074074074, Blast_Score=275, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71988741, Length=294, Percent_Identity=36.734693877551, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17558508, Length=299, Percent_Identity=38.4615384615385, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI115532456, Length=299, Percent_Identity=36.1204013377926, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17531885, Length=271, Percent_Identity=38.0073800738007, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17531889, Length=299, Percent_Identity=36.1204013377926, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI212645202, Length=265, Percent_Identity=36.9811320754717, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71982224, Length=298, Percent_Identity=32.2147651006711, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322480, Length=337, Percent_Identity=27.0029673590504, Blast_Score=105, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32993; Mature: 32862

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLTETATPMDALLAILDLEKLEENLFRGLSPQVGWQRVFGGQVIGQALVAAQRTVEGG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
RYVHSLHAYFMRPGDPSVPIVYEVDRIRDGSSFATRRVAAIQHGKAIFAMSASFQYDEDG
HHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCC
FEHQFDMPDVPMPETLPGEQELKEKFLVHAPEAIRRYWERPRPIEIRPVSLEHYFSRAKA
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECHHHHHHHHHCC
SPKQDVWVKAVGAVPDERHLQAAVLAYLSDMTLLDTSLYAHGTSVFDRSLQVASLDHAMW
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHH
FHRPSKMDDWLLYTQDSPSAHGARGMTRGSLFDRSGVLIASVAQEGLIRKKATA
HCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCC
>Mature Secondary Structure 
SRLTETATPMDALLAILDLEKLEENLFRGLSPQVGWQRVFGGQVIGQALVAAQRTVEGG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
RYVHSLHAYFMRPGDPSVPIVYEVDRIRDGSSFATRRVAAIQHGKAIFAMSASFQYDEDG
HHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCC
FEHQFDMPDVPMPETLPGEQELKEKFLVHAPEAIRRYWERPRPIEIRPVSLEHYFSRAKA
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECHHHHHHHHHCC
SPKQDVWVKAVGAVPDERHLQAAVLAYLSDMTLLDTSLYAHGTSVFDRSLQVASLDHAMW
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHH
FHRPSKMDDWLLYTQDSPSAHGARGMTRGSLFDRSGVLIASVAQEGLIRKKATA
HCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]