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The map label for this gene is mro [H]

Identifier: 150398226

GI number: 150398226

Start: 3179518

End: 3180534

Strand: Direct

Name: mro [H]

Synonym: Smed_3031

Alternate gene names: 150398226

Gene position: 3179518-3180534 (Clockwise)

Preceding gene: 150398225

Following gene: 150398237

Centisome position: 84.07

GC content: 61.95

Gene sequence:

>1017_bases
ATGACGACCGACATGGAAATCTTCGGCCATCTGGCCTCAGGCGAGCCCGTCCACCGGGTGACCCTCAAGGGCGGCGGTCT
GACGGCGTCGGTAATCACCTGGGGCTCGGTCATCCAGGATCTGCGGCTCGACGGACATGCGCCGCCGCTGGTGCTCGGCT
TCGAGGATTTCCCAAGCTATCCAGCCCATTCCTCCTATTTCGGCGCCACGCCCGGCCGCAACGCCAACCGCATCGGCGAC
GGCCGTTTCTCGCTCGACGGCAGGGCCTATCAGCTCGAACGCAACGAGAAGGGCGTCACGCATCTACATGGGGGCAGTGA
CAATATCGCCAGGCGCAACTGGACGATCGTCGGACGGGACGAAGACAGTGTGACGCTCAAAATCACCGATCCGGACGGCC
GTGCCGGCTATCCCGGCAATTGCACGATCACCTGCACATATCGGCTGAAGCCCGGCGGTACGCTCAACGTCGTCTACGAA
ACCGAGACCGACGCGCCGACGCTCGCCAATGTCTGCCAGCACAGCTATTTCAACCTCGATGGCGGATCGGACGCGTTCGG
CCACGATATCATGATCGCGGCGGACCACTTCCTGCCTACCGACGAGCGGCAGATTCCAACGGGAGAGATCCGCCCCGTCG
ACGGCACCGCCTTCGACCTGCGCGAAATGACCTCGCTCAAGCGACAACTGGACGGCGACAGGATAGGCTACGATCACAAT
TTCTGCCTCTCCCCGGAACGGATGCAGAAGCGATCCGTCGCGCTGGTACGCAGCATCAATTCGGGCGTGTCGCTGGAAGT
TCTGACGACGGAGTCCGGCGTCCAGCTCTATACCGGAGAAAAACTCGACGTAGCCGTTCCCGGCCTCGAAGGCCGCCGCT
ACGGCGCCTTTGCAGGCTTCTGTCTCGAAACACAGATCTGGCCCGATGCGGTCAATCACGAAGGTTTTCCTAACGCAATT
CTGCGGCCGGGCGAAACGCTTCGGCAGGAGACGGACTACGTCTTCACCAGGAATTGA

Upstream 100 bases:

>100_bases
GGAGCCGGAGCGTATTGAAGCGGAAAAGTATGACTTTATAGTTGCCGCACCGCCGGAAATGCCGCAGGTTGGCGCCCGAT
TGCGGAAATGGGGAGACAAA

Downstream 100 bases:

>100_bases
GGGCTGAGTAAGGGCAGGGACGAGCGCGCGCCCTGCCGCCAACTTTCGTTTTTGGCCGCTGACGAGGCCCGCATACGAGC
TTCGGGGTTGACAAGCATCG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MTTDMEIFGHLASGEPVHRVTLKGGGLTASVITWGSVIQDLRLDGHAPPLVLGFEDFPSYPAHSSYFGATPGRNANRIGD
GRFSLDGRAYQLERNEKGVTHLHGGSDNIARRNWTIVGRDEDSVTLKITDPDGRAGYPGNCTITCTYRLKPGGTLNVVYE
TETDAPTLANVCQHSYFNLDGGSDAFGHDIMIAADHFLPTDERQIPTGEIRPVDGTAFDLREMTSLKRQLDGDRIGYDHN
FCLSPERMQKRSVALVRSINSGVSLEVLTTESGVQLYTGEKLDVAVPGLEGRRYGAFAGFCLETQIWPDAVNHEGFPNAI
LRPGETLRQETDYVFTRN

Sequences:

>Translated_338_residues
MTTDMEIFGHLASGEPVHRVTLKGGGLTASVITWGSVIQDLRLDGHAPPLVLGFEDFPSYPAHSSYFGATPGRNANRIGD
GRFSLDGRAYQLERNEKGVTHLHGGSDNIARRNWTIVGRDEDSVTLKITDPDGRAGYPGNCTITCTYRLKPGGTLNVVYE
TETDAPTLANVCQHSYFNLDGGSDAFGHDIMIAADHFLPTDERQIPTGEIRPVDGTAFDLREMTSLKRQLDGDRIGYDHN
FCLSPERMQKRSVALVRSINSGVSLEVLTTESGVQLYTGEKLDVAVPGLEGRRYGAFAGFCLETQIWPDAVNHEGFPNAI
LRPGETLRQETDYVFTRN
>Mature_337_residues
TTDMEIFGHLASGEPVHRVTLKGGGLTASVITWGSVIQDLRLDGHAPPLVLGFEDFPSYPAHSSYFGATPGRNANRIGDG
RFSLDGRAYQLERNEKGVTHLHGGSDNIARRNWTIVGRDEDSVTLKITDPDGRAGYPGNCTITCTYRLKPGGTLNVVYET
ETDAPTLANVCQHSYFNLDGGSDAFGHDIMIAADHFLPTDERQIPTGEIRPVDGTAFDLREMTSLKRQLDGDRIGYDHNF
CLSPERMQKRSVALVRSINSGVSLEVLTTESGVQLYTGEKLDVAVPGLEGRRYGAFAGFCLETQIWPDAVNHEGFPNAIL
RPGETLRQETDYVFTRN

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=337, Percent_Identity=42.433234421365, Blast_Score=231, Evalue=1e-60,
Organism=Escherichia coli, GI1786971, Length=334, Percent_Identity=33.5329341317365, Blast_Score=188, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17557428, Length=319, Percent_Identity=30.4075235109718, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI115533334, Length=319, Percent_Identity=30.4075235109718, Blast_Score=149, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319493, Length=330, Percent_Identity=29.6969696969697, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6322004, Length=333, Percent_Identity=30.6306306306306, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324399, Length=334, Percent_Identity=26.6467065868263, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24659048, Length=343, Percent_Identity=39.067055393586, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24668278, Length=355, Percent_Identity=36.6197183098592, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24583720, Length=341, Percent_Identity=35.4838709677419, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24668282, Length=330, Percent_Identity=35.1515151515151, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24641876, Length=330, Percent_Identity=29.0909090909091, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37106; Mature: 36975

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDMEIFGHLASGEPVHRVTLKGGGLTASVITWGSVIQDLRLDGHAPPLVLGFEDFPSY
CCCCHHHHEEECCCCCEEEEEEECCCEEEEEHHHHHHHHHHHCCCCCCCEEEEHHHCCCC
PAHSSYFGATPGRNANRIGDGRFSLDGRAYQLERNEKGVTHLHGGSDNIARRNWTIVGRD
CCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCEEEECCCCCCEECCCEEEECC
EDSVTLKITDPDGRAGYPGNCTITCTYRLKPGGTLNVVYETETDAPTLANVCQHSYFNLD
CCEEEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHCEEECC
GGSDAFGHDIMIAADHFLPTDERQIPTGEIRPVDGTAFDLREMTSLKRQLDGDRIGYDHN
CCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCC
FCLSPERMQKRSVALVRSINSGVSLEVLTTESGVQLYTGEKLDVAVPGLEGRRYGAFAGF
EECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCEEEEECCCCCCCCCCCEEEE
CLETQIWPDAVNHEGFPNAILRPGETLRQETDYVFTRN
EEECCCCCCCCCCCCCCCHHCCCCHHHHHCCCEEEECC
>Mature Secondary Structure 
TTDMEIFGHLASGEPVHRVTLKGGGLTASVITWGSVIQDLRLDGHAPPLVLGFEDFPSY
CCCHHHHEEECCCCCEEEEEEECCCEEEEEHHHHHHHHHHHCCCCCCCEEEEHHHCCCC
PAHSSYFGATPGRNANRIGDGRFSLDGRAYQLERNEKGVTHLHGGSDNIARRNWTIVGRD
CCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCEEEECCCCCCEECCCEEEECC
EDSVTLKITDPDGRAGYPGNCTITCTYRLKPGGTLNVVYETETDAPTLANVCQHSYFNLD
CCEEEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHCEEECC
GGSDAFGHDIMIAADHFLPTDERQIPTGEIRPVDGTAFDLREMTSLKRQLDGDRIGYDHN
CCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCC
FCLSPERMQKRSVALVRSINSGVSLEVLTTESGVQLYTGEKLDVAVPGLEGRRYGAFAGF
EECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCEEEEECCCCCCCCCCCEEEE
CLETQIWPDAVNHEGFPNAILRPGETLRQETDYVFTRN
EEECCCCCCCCCCCCCCCHHCCCCHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]