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The map label for this gene is adhA [H]

Identifier: 150398193

GI number: 150398193

Start: 3147005

End: 3148039

Strand: Reverse

Name: adhA [H]

Synonym: Smed_2996

Alternate gene names: 150398193

Gene position: 3148039-3147005 (Counterclockwise)

Preceding gene: 150398194

Following gene: 150398192

Centisome position: 83.24

GC content: 60.29

Gene sequence:

>1035_bases
ATGAAAATGGCACAGACGATGAAGGCGGCTGTCGTACGCCAGTTCCGCGCTCCGCTGACCATAGAGGAGATGGAAGTCCC
AACGCCTGGCGCCGGGCAGGTCCTCGTAAAATATGAAGCAACGGGCGTGTGCCATACCGATCTGCATGCGGCAAACGGCG
ATTGGCCCGTTAAGCCGGCTCCGCCCTTTATTCCAGGGCACGAGGGTGTTGGCTTCGTCTCGGCCGTGGGCGCCGGCGTG
AGGAGAGTGAAAGAAGGTGACAGGGTTGGGGTGCCATGGCTCCACACCGCTTGCCGTTACTGTACCTATTGCCGGACCGG
TTGGGAAACGCTGTGCTCTTCGCAATCGAACACCGGGTACTCGGTGAACGGCACCTTCGCGGAGTTCGGACTGGCAGATC
CCGAGTTCGCGGGAAAGATTCCTGATCGGTTGGAATTCGGAGCCGCCGCGCCCGTTCTCTGCGCGGGAGTGACCGTCTAC
AAGGGGCTGAAGGAAACGGAAGTCCGTCCCGGTGAATGGGTGGCCATCTCGGGCGTCGGCGGTCTCGGCCACATGGCGGT
GCAATATGCCAAGGCAATGGGAATGCACGTGGTGGCCGCCGACATATCCGAAGACAAGCTGGCGCTGGCCAAGCAACTTG
GCGCCGACATCGCAGTAAACGGCAAGTCGGACGATGCAGTCGAGCAGGTACAGAAGGCCACGAGCGGCGGCGTTCACGGA
GTGCTCGTGACCGCTGTCTCTCCCGCCGCCATGGAACAGGCCTTTGGTTTCCTGCGGTCGAAAGGCACGATGGTCTTGGT
CGGTCTTCCCCCCGGAATGATGTCCTTGCCGGTTTTCGAGACCGTCCTGAAACGCATAACCGTGCGTGGATCAATCGTGG
GTACCCGACAAGACCTCGAGGAATCGCTCGCTTTCGCGGCGGAAGGCAAGGTAAAGCCGTATTTCTCGTGGGAGAGCCTC
GAGAACATCAACGACATCTTCCATCGCATGGAAGCGGGCAAGATCGACGGTCGAATAGTGGTGCGATTACAGTAG

Upstream 100 bases:

>100_bases
GCATTTTCCAGATCCCTACACGCAATAGCGCCGCCGTTCACAAAACAACTTCTCGCCAACTTCTGAGAAATGTCTCTGAA
GCCGTATGGGATGGATGGGA

Downstream 100 bases:

>100_bases
CTTGCATCAACAGCAAGCCGGAGAGATTTCAGAATTCATTATGATCGGGAGGTGCAGATGACTTCGCTTGAAACGGCAGC
GATGAACGAGACGACATCAG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKMAQTMKAAVVRQFRAPLTIEEMEVPTPGAGQVLVKYEATGVCHTDLHAANGDWPVKPAPPFIPGHEGVGFVSAVGAGV
RRVKEGDRVGVPWLHTACRYCTYCRTGWETLCSSQSNTGYSVNGTFAEFGLADPEFAGKIPDRLEFGAAAPVLCAGVTVY
KGLKETEVRPGEWVAISGVGGLGHMAVQYAKAMGMHVVAADISEDKLALAKQLGADIAVNGKSDDAVEQVQKATSGGVHG
VLVTAVSPAAMEQAFGFLRSKGTMVLVGLPPGMMSLPVFETVLKRITVRGSIVGTRQDLEESLAFAAEGKVKPYFSWESL
ENINDIFHRMEAGKIDGRIVVRLQ

Sequences:

>Translated_344_residues
MKMAQTMKAAVVRQFRAPLTIEEMEVPTPGAGQVLVKYEATGVCHTDLHAANGDWPVKPAPPFIPGHEGVGFVSAVGAGV
RRVKEGDRVGVPWLHTACRYCTYCRTGWETLCSSQSNTGYSVNGTFAEFGLADPEFAGKIPDRLEFGAAAPVLCAGVTVY
KGLKETEVRPGEWVAISGVGGLGHMAVQYAKAMGMHVVAADISEDKLALAKQLGADIAVNGKSDDAVEQVQKATSGGVHG
VLVTAVSPAAMEQAFGFLRSKGTMVLVGLPPGMMSLPVFETVLKRITVRGSIVGTRQDLEESLAFAAEGKVKPYFSWESL
ENINDIFHRMEAGKIDGRIVVRLQ
>Mature_344_residues
MKMAQTMKAAVVRQFRAPLTIEEMEVPTPGAGQVLVKYEATGVCHTDLHAANGDWPVKPAPPFIPGHEGVGFVSAVGAGV
RRVKEGDRVGVPWLHTACRYCTYCRTGWETLCSSQSNTGYSVNGTFAEFGLADPEFAGKIPDRLEFGAAAPVLCAGVTVY
KGLKETEVRPGEWVAISGVGGLGHMAVQYAKAMGMHVVAADISEDKLALAKQLGADIAVNGKSDDAVEQVQKATSGGVHG
VLVTAVSPAAMEQAFGFLRSKGTMVLVGLPPGMMSLPVFETVLKRITVRGSIVGTRQDLEESLAFAAEGKVKPYFSWESL
ENINDIFHRMEAGKIDGRIVVRLQ

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=361, Percent_Identity=31.0249307479224, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI34577061, Length=361, Percent_Identity=31.0249307479224, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4501929, Length=361, Percent_Identity=30.7479224376731, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI71565152, Length=366, Percent_Identity=28.1420765027322, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI262073058, Length=291, Percent_Identity=30.5841924398625, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI71743840, Length=291, Percent_Identity=30.5841924398625, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=28.3018867924528, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI156627571, Length=286, Percent_Identity=26.9230769230769, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=26.7029972752044, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4501939, Length=367, Percent_Identity=26.7029972752044, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI194239674, Length=307, Percent_Identity=23.7785016286645, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI13236495, Length=307, Percent_Identity=23.7785016286645, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI194239676, Length=238, Percent_Identity=26.890756302521, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI28557745, Length=374, Percent_Identity=25.668449197861, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI87081918, Length=340, Percent_Identity=47.3529411764706, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1786518, Length=348, Percent_Identity=33.6206896551724, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788073, Length=297, Percent_Identity=31.3131313131313, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082125, Length=356, Percent_Identity=30.0561797752809, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790045, Length=289, Percent_Identity=32.5259515570934, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI87082401, Length=340, Percent_Identity=28.8235294117647, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI226510992, Length=310, Percent_Identity=29.6774193548387, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1787863, Length=259, Percent_Identity=30.5019305019305, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788075, Length=315, Percent_Identity=27.6190476190476, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1786552, Length=372, Percent_Identity=30.6451612903226, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790718, Length=289, Percent_Identity=26.9896193771626, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790485, Length=285, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788407, Length=270, Percent_Identity=31.4814814814815, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786825, Length=376, Percent_Identity=23.6702127659574, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=340, Percent_Identity=40.2941176470588, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71988145, Length=339, Percent_Identity=38.0530973451327, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17562582, Length=346, Percent_Identity=40.7514450867052, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17562876, Length=334, Percent_Identity=32.6347305389222, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562878, Length=351, Percent_Identity=30.7692307692308, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=239, Percent_Identity=33.4728033472803, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71997431, Length=241, Percent_Identity=33.195020746888, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17507255, Length=268, Percent_Identity=26.865671641791, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=206, Percent_Identity=30.5825242718447, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536829, Length=226, Percent_Identity=28.7610619469027, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=344, Percent_Identity=42.7325581395349, Blast_Score=272, Evalue=7e-74,
Organism=Saccharomyces cerevisiae, GI6324486, Length=344, Percent_Identity=42.1511627906977, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6323729, Length=342, Percent_Identity=41.2280701754386, Blast_Score=269, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6319621, Length=343, Percent_Identity=42.2740524781341, Blast_Score=267, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6319949, Length=328, Percent_Identity=31.7073170731707, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322619, Length=329, Percent_Identity=30.0911854103343, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=329, Percent_Identity=30.0911854103343, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=261, Percent_Identity=33.7164750957854, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323980, Length=323, Percent_Identity=29.1021671826625, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=334, Percent_Identity=24.5508982035928, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=223, Percent_Identity=27.8026905829596, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137530, Length=310, Percent_Identity=29.0322580645161, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737895, Length=241, Percent_Identity=31.9502074688797, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17737897, Length=310, Percent_Identity=28.7096774193548, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36647; Mature: 36647

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMAQTMKAAVVRQFRAPLTIEEMEVPTPGAGQVLVKYEATGVCHTDLHAANGDWPVKPA
CCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCCCCC
PPFIPGHEGVGFVSAVGAGVRRVKEGDRVGVPWLHTACRYCTYCRTGWETLCSSQSNTGY
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
SVNGTFAEFGLADPEFAGKIPDRLEFGAAAPVLCAGVTVYKGLKETEVRPGEWVAISGVG
EECCCHHHCCCCCHHHCCCCCCHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCEEEEECCC
GLGHMAVQYAKAMGMHVVAADISEDKLALAKQLGADIAVNGKSDDAVEQVQKATSGGVHG
CHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCE
VLVTAVSPAAMEQAFGFLRSKGTMVLVGLPPGMMSLPVFETVLKRITVRGSIVGTRQDLE
EEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEECCHHHHH
ESLAFAAEGKVKPYFSWESLENINDIFHRMEAGKIDGRIVVRLQ
HHHHHHHCCCCCCEECHHHHHHHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MKMAQTMKAAVVRQFRAPLTIEEMEVPTPGAGQVLVKYEATGVCHTDLHAANGDWPVKPA
CCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCCCCC
PPFIPGHEGVGFVSAVGAGVRRVKEGDRVGVPWLHTACRYCTYCRTGWETLCSSQSNTGY
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
SVNGTFAEFGLADPEFAGKIPDRLEFGAAAPVLCAGVTVYKGLKETEVRPGEWVAISGVG
EECCCHHHCCCCCHHHCCCCCCHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCEEEEECCC
GLGHMAVQYAKAMGMHVVAADISEDKLALAKQLGADIAVNGKSDDAVEQVQKATSGGVHG
CHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCE
VLVTAVSPAAMEQAFGFLRSKGTMVLVGLPPGMMSLPVFETVLKRITVRGSIVGTRQDLE
EEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEECCHHHHH
ESLAFAAEGKVKPYFSWESLENINDIFHRMEAGKIDGRIVVRLQ
HHHHHHHCCCCCCEECHHHHHHHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]