Click here to switch to the map view.

The map label for this gene is sucC

Identifier: 150398140

GI number: 150398140

Start: 3091283

End: 3092479

Strand: Reverse

Name: sucC

Synonym: Smed_2943

Alternate gene names: 150398140

Gene position: 3092479-3091283 (Counterclockwise)

Preceding gene: 150398141

Following gene: 150398139

Centisome position: 81.77

GC content: 61.15

Gene sequence:

>1197_bases
ATGAACATCCATGAATATCAGGCCAAGGCTCTCTTGAAGAGCTACGGCGCGCCGGTCGCGGAAGGCGTCGCGATCTTCTC
CGCCGACGAGGCCGCAGCGGCAGCCAAGAAGCTGCCGGGTCCGCTCTACGTCGTGAAGAGCCAGATCCATGCAGGCGGCC
GCGGCAAAGGCAAGTTCAAGGAACTCGGCGCCGATGCCAAGGGCGGCGTGCGCCTGGCCAAGTCGGCCGACGAGGTCGTC
GCCCATGCCAGGGAAATGCTCGGCAACACGCTGGTGACCAAGCAGACCGGCCCGTCCGGCAAACAGGTCAACCGCCTCTA
TATCGAGGACGGCGCCGACATAGACCGTGAGCTCTACCTTTCGATTCTCGTCGATCGCTCCGTCGGCCAGGTTGCCTTCG
TCGTTTCGACCGAAGGCGGCATGGACATCGAGGCGGTCGCCGAGCATACGCCGGAGAAGATCGTTACCGTCGCAATCGAC
CCGGATAAGGGCGTGACCGCAGACGATCTGAAGACGCTCACCGAGGCGCTCAAGCTCGACGGCGAAGCGCGCGCCGATGC
CGAGAAGCTCTTCCCCATCCTGTACAAGGCGTTTGTCGAAAAGGACATGAGCCTGCTCGAGGTCAATCCGCTGATCGTCA
TGACGAACGGCCGTATGCGCGTCCTTGACGCAAAGGTCTCCTTCGACGGCAACGCTCTCTTCCGCCATGAGGATGTGGTT
GCTCTGCGCGACACGACGGAAGAGGACGAGAAGGAAATCGAAGCGTCGAAGTACGACCTCGCCTATGTCGCCCTCGACGG
CAATATCGGCTGTATGGTCAACGGCGCCGGTCTCGCCATGGCGACGATGGACATCATCAAGCTCTACGGCGCCGAGCCCG
CGAACTTCCTCGATGTCGGCGGTGGTGCCTCGAAGGAAAAGGTAACGCAGGCCTTCAAGATCATTACGGCCGATCCGGCC
GTGAAGGGCATTCTGGTCAACATCTTCGGCGGAATCATGAAATGCGACGTCATCGCCGAGGGCGTCATTGCAGCGGTCAA
GGAAGTGGGCCTCAAGGTGCCGCTCGTCGTGCGGCTCGAAGGCACCAATGTCGAGCTCGGCAAGAAGATCATCAATGAAT
CGGGCCTCAACGTGATTTCCGCCGATGATCTGGACGATGCCGCCCAGAAGATCGTTGCAGCCGTCAAGGGAGCCTGA

Upstream 100 bases:

>100_bases
CAAGTCGGTGGCGGCCGTGGCCGGCCTTTGCGAAGCCTGCATCAACATCGCACCGAGCCTGAAGTAATCGCCAACCGGCC
CATCAGACAGGAAAGAACCC

Downstream 100 bases:

>100_bases
GGTTTCATGTCCATCCTGATCAACAAAGACACCAAGGTTCTCGTTCAGGGCCTGACCGGCAAGACCGGCACCTTTCACAC
CGAACAGGCGCTCGCCTATA

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNIHEYQAKALLKSYGAPVAEGVAIFSADEAAAAAKKLPGPLYVVKSQIHAGGRGKGKFKELGADAKGGVRLAKSADEVV
AHAREMLGNTLVTKQTGPSGKQVNRLYIEDGADIDRELYLSILVDRSVGQVAFVVSTEGGMDIEAVAEHTPEKIVTVAID
PDKGVTADDLKTLTEALKLDGEARADAEKLFPILYKAFVEKDMSLLEVNPLIVMTNGRMRVLDAKVSFDGNALFRHEDVV
ALRDTTEEDEKEIEASKYDLAYVALDGNIGCMVNGAGLAMATMDIIKLYGAEPANFLDVGGGASKEKVTQAFKIITADPA
VKGILVNIFGGIMKCDVIAEGVIAAVKEVGLKVPLVVRLEGTNVELGKKIINESGLNVISADDLDDAAQKIVAAVKGA

Sequences:

>Translated_398_residues
MNIHEYQAKALLKSYGAPVAEGVAIFSADEAAAAAKKLPGPLYVVKSQIHAGGRGKGKFKELGADAKGGVRLAKSADEVV
AHAREMLGNTLVTKQTGPSGKQVNRLYIEDGADIDRELYLSILVDRSVGQVAFVVSTEGGMDIEAVAEHTPEKIVTVAID
PDKGVTADDLKTLTEALKLDGEARADAEKLFPILYKAFVEKDMSLLEVNPLIVMTNGRMRVLDAKVSFDGNALFRHEDVV
ALRDTTEEDEKEIEASKYDLAYVALDGNIGCMVNGAGLAMATMDIIKLYGAEPANFLDVGGGASKEKVTQAFKIITADPA
VKGILVNIFGGIMKCDVIAEGVIAAVKEVGLKVPLVVRLEGTNVELGKKIINESGLNVISADDLDDAAQKIVAAVKGA
>Mature_398_residues
MNIHEYQAKALLKSYGAPVAEGVAIFSADEAAAAAKKLPGPLYVVKSQIHAGGRGKGKFKELGADAKGGVRLAKSADEVV
AHAREMLGNTLVTKQTGPSGKQVNRLYIEDGADIDRELYLSILVDRSVGQVAFVVSTEGGMDIEAVAEHTPEKIVTVAID
PDKGVTADDLKTLTEALKLDGEARADAEKLFPILYKAFVEKDMSLLEVNPLIVMTNGRMRVLDAKVSFDGNALFRHEDVV
ALRDTTEEDEKEIEASKYDLAYVALDGNIGCMVNGAGLAMATMDIIKLYGAEPANFLDVGGGASKEKVTQAFKIITADPA
VKGILVNIFGGIMKCDVIAEGVIAAVKEVGLKVPLVVRLEGTNVELGKKIINESGLNVISADDLDDAAQKIVAAVKGA

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI11321583, Length=392, Percent_Identity=44.6428571428571, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI157779135, Length=386, Percent_Identity=47.9274611398964, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI294862256, Length=365, Percent_Identity=47.3972602739726, Blast_Score=318, Evalue=6e-87,
Organism=Escherichia coli, GI1786948, Length=397, Percent_Identity=52.6448362720403, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17539378, Length=395, Percent_Identity=45.3164556962025, Blast_Score=349, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17567829, Length=391, Percent_Identity=45.0127877237852, Blast_Score=325, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6321683, Length=395, Percent_Identity=45.8227848101266, Blast_Score=351, Evalue=1e-97,
Organism=Drosophila melanogaster, GI21356231, Length=396, Percent_Identity=49.2424242424242, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI161078106, Length=388, Percent_Identity=46.3917525773196, Blast_Score=335, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24645208, Length=388, Percent_Identity=46.3917525773196, Blast_Score=335, Evalue=2e-92,
Organism=Drosophila melanogaster, GI281361397, Length=389, Percent_Identity=46.5295629820051, Blast_Score=335, Evalue=3e-92,
Organism=Drosophila melanogaster, GI281361395, Length=389, Percent_Identity=46.5295629820051, Blast_Score=335, Evalue=3e-92,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SUCC_SINMW (A6UDP2)

Other databases:

- EMBL:   CP000738
- RefSeq:   YP_001328607.1
- ProteinModelPortal:   A6UDP2
- SMR:   A6UDP2
- STRING:   A6UDP2
- GeneID:   5323820
- GenomeReviews:   CP000738_GR
- KEGG:   smd:Smed_2943
- eggNOG:   COG0045
- HOGENOM:   HBG315432
- OMA:   IFINILG
- ProtClustDB:   PRK00696
- BioCyc:   SMED366394:SMED_2943-MONOMER
- HAMAP:   MF_00558
- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.261
- PANTHER:   PTHR11815
- TIGRFAMs:   TIGR01016

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 42121; Mature: 42121

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS50975 ATP_GRASP; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIHEYQAKALLKSYGAPVAEGVAIFSADEAAAAAKKLPGPLYVVKSQIHAGGRGKGKFK
CCCHHHHHHHHHHHHCCCHHHCEEEEECCHHHHHHHHCCCCEEEEEHHHCCCCCCCCHHH
ELGADAKGGVRLAKSADEVVAHAREMLGNTLVTKQTGPSGKQVNRLYIEDGADIDRELYL
HCCCCCCCCEEECCCHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEEECCCCCCHHHEE
SILVDRSVGQVAFVVSTEGGMDIEAVAEHTPEKIVTVAIDPDKGVTADDLKTLTEALKLD
HEEEECCCCCEEEEEECCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCC
GEARADAEKLFPILYKAFVEKDMSLLEVNPLIVMTNGRMRVLDAKVSFDGNALFRHEDVV
CCCCCCHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCEEEEEEEEECCCCEEEEECCEE
ALRDTTEEDEKEIEASKYDLAYVALDGNIGCMVNGAGLAMATMDIIKLYGAEPANFLDVG
EECCCCCHHHHHHHHCCEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEECC
GGASKEKVTQAFKIITADPAVKGILVNIFGGIMKCDVIAEGVIAAVKEVGLKVPLVVRLE
CCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
GTNVELGKKIINESGLNVISADDLDDAAQKIVAAVKGA
CCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIHEYQAKALLKSYGAPVAEGVAIFSADEAAAAAKKLPGPLYVVKSQIHAGGRGKGKFK
CCCHHHHHHHHHHHHCCCHHHCEEEEECCHHHHHHHHCCCCEEEEEHHHCCCCCCCCHHH
ELGADAKGGVRLAKSADEVVAHAREMLGNTLVTKQTGPSGKQVNRLYIEDGADIDRELYL
HCCCCCCCCEEECCCHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEEECCCCCCHHHEE
SILVDRSVGQVAFVVSTEGGMDIEAVAEHTPEKIVTVAIDPDKGVTADDLKTLTEALKLD
HEEEECCCCCEEEEEECCCCCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCC
GEARADAEKLFPILYKAFVEKDMSLLEVNPLIVMTNGRMRVLDAKVSFDGNALFRHEDVV
CCCCCCHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCEEEEEEEEECCCCEEEEECCEE
ALRDTTEEDEKEIEASKYDLAYVALDGNIGCMVNGAGLAMATMDIIKLYGAEPANFLDVG
EECCCCCHHHHHHHHCCEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEECC
GGASKEKVTQAFKIITADPAVKGILVNIFGGIMKCDVIAEGVIAAVKEVGLKVPLVVRLE
CCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
GTNVELGKKIINESGLNVISADDLDDAAQKIVAAVKGA
CCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA