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The map label for this gene is cytR [H]

Identifier: 150397962

GI number: 150397962

Start: 2884444

End: 2885466

Strand: Reverse

Name: cytR [H]

Synonym: Smed_2764

Alternate gene names: 150397962

Gene position: 2885466-2884444 (Counterclockwise)

Preceding gene: 150397963

Following gene: 150397961

Centisome position: 76.3

GC content: 62.66

Gene sequence:

>1023_bases
GTGGCGCAAAAGGTCAAGCTTTCTACAATCGCGGAAACACTCGGCCTTTCGACGGCGACGGTATCCCTGGCATTGCGCGA
CAGTCCGCTGGTGGCCGCGGTTACCCGCGACAAGATAAAGGAACAGGCACGCGCACTCGGCTATATCTACAATCGCCGTG
CCGCCAGCCTCAGGACGTCGCGCTCGGGCATCATCGGCGTCGTCGTTCACGACATCATGAACCCTTTCTACGGTGAGATC
CTGAAGGCGATCGAAGCGGAACTCGATCGCGACAAGCAGACCTTTATTCTGTCCAATCATTACGATTCCGTCGAGAAGCA
GCGCGATTTCATCGAGACGCTGCTGCAGCTCGGCGGCGACGGCGTCATCATGTCGCCCGCTATCGGCACGCCGCCGCAGG
ATATTCAGCTTGCCGAGGACAATAACATGCCGGCGATCCTGATCGCCCGCTCGATAGAAGGGCTTGACGTGCCGATCTTC
CGCGGCGACGACGCCTATGGCATCGCGCTTGCCACCAACCACCTCATCGGGTTGGGCCACCGCTGCATCGCGATGGTCGG
CGGAACCGATCAGACTTCCACCGGACGGGACCGCTATCAGGGCTATGTCAATGCGCTTCGCAAGGCGAATATCGACGTCG
ATCCGGACTTGCGCATCCCCGGGCCACGCTCCAAGCAGGGCGGTTTCGAGGCCGCCGTGCATCTCCTCTCTCTGCCGCAA
AAGCCGACGGCGGTCGTCTGCTGGAACGATCTGGTCGCCATCGGCATGATGAACGGCATTGCCCGAGCCGGTCTCGTTCC
GGGCGTCGACATCTCGGTCACCGGCTATGACGATCTCGAGGAGGCGTCGATCGCGACGCCGGCGCTGACGACCGTCTGGA
ACGGCCAGGCAGAGGTGGGCCGCAGCGCGGCGCGCGCGCTCCTCGACAAGCTTTCCGGCAGCCACGAACCGGACGGCATA
CATCTGATCAAGCCGGAAATGCGCATCCGCCAGTCGACCGGACCGCTGCGCGTAACCGCTTGA

Upstream 100 bases:

>100_bases
GCGGATTGAGCGTCGGACCGACTTGCCGATTGCAGCGGGAATTTAAACAGTTTAAAGAGATTTAAAACGGTGACGGCAGC
GGCTGCAATCGGGGGGCATG

Downstream 100 bases:

>100_bases
TCGTTTCCTCCGAGTCTGAACAGGATGCGTGCGTGATCGTTCGCATTCCCGCTACGCCTGGAAAGGAAACCCGATGAGCC
GTCCTAGAATTCTTGTGCCT

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAQKVKLSTIAETLGLSTATVSLALRDSPLVAAVTRDKIKEQARALGYIYNRRAASLRTSRSGIIGVVVHDIMNPFYGEI
LKAIEAELDRDKQTFILSNHYDSVEKQRDFIETLLQLGGDGVIMSPAIGTPPQDIQLAEDNNMPAILIARSIEGLDVPIF
RGDDAYGIALATNHLIGLGHRCIAMVGGTDQTSTGRDRYQGYVNALRKANIDVDPDLRIPGPRSKQGGFEAAVHLLSLPQ
KPTAVVCWNDLVAIGMMNGIARAGLVPGVDISVTGYDDLEEASIATPALTTVWNGQAEVGRSAARALLDKLSGSHEPDGI
HLIKPEMRIRQSTGPLRVTA

Sequences:

>Translated_340_residues
MAQKVKLSTIAETLGLSTATVSLALRDSPLVAAVTRDKIKEQARALGYIYNRRAASLRTSRSGIIGVVVHDIMNPFYGEI
LKAIEAELDRDKQTFILSNHYDSVEKQRDFIETLLQLGGDGVIMSPAIGTPPQDIQLAEDNNMPAILIARSIEGLDVPIF
RGDDAYGIALATNHLIGLGHRCIAMVGGTDQTSTGRDRYQGYVNALRKANIDVDPDLRIPGPRSKQGGFEAAVHLLSLPQ
KPTAVVCWNDLVAIGMMNGIARAGLVPGVDISVTGYDDLEEASIATPALTTVWNGQAEVGRSAARALLDKLSGSHEPDGI
HLIKPEMRIRQSTGPLRVTA
>Mature_339_residues
AQKVKLSTIAETLGLSTATVSLALRDSPLVAAVTRDKIKEQARALGYIYNRRAASLRTSRSGIIGVVVHDIMNPFYGEIL
KAIEAELDRDKQTFILSNHYDSVEKQRDFIETLLQLGGDGVIMSPAIGTPPQDIQLAEDNNMPAILIARSIEGLDVPIFR
GDDAYGIALATNHLIGLGHRCIAMVGGTDQTSTGRDRYQGYVNALRKANIDVDPDLRIPGPRSKQGGFEAAVHLLSLPQK
PTAVVCWNDLVAIGMMNGIARAGLVPGVDISVTGYDDLEEASIATPALTTVWNGQAEVGRSAARALLDKLSGSHEPDGIH
LIKPEMRIRQSTGPLRVTA

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=332, Percent_Identity=31.6265060240964, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1787948, Length=335, Percent_Identity=29.2537313432836, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1790194, Length=306, Percent_Identity=28.4313725490196, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787906, Length=290, Percent_Identity=30.6896551724138, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789202, Length=284, Percent_Identity=31.6901408450704, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788474, Length=334, Percent_Identity=29.940119760479, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786540, Length=331, Percent_Identity=30.5135951661631, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789068, Length=285, Percent_Identity=26.3157894736842, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI48994940, Length=310, Percent_Identity=26.4516129032258, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1790715, Length=317, Percent_Identity=26.4984227129338, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787580, Length=320, Percent_Identity=25.9375, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790689, Length=341, Percent_Identity=24.0469208211144, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36549; Mature: 36418

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQKVKLSTIAETLGLSTATVSLALRDSPLVAAVTRDKIKEQARALGYIYNRRAASLRTS
CCCCCHHHHHHHHHCCCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RSGIIGVVVHDIMNPFYGEILKAIEAELDRDKQTFILSNHYDSVEKQRDFIETLLQLGGD
CCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCC
GVIMSPAIGTPPQDIQLAEDNNMPAILIARSIEGLDVPIFRGDDAYGIALATNHLIGLGH
CEEECCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCEEEECCCCEEEEEEHHHHHHCCC
RCIAMVGGTDQTSTGRDRYQGYVNALRKANIDVDPDLRIPGPRSKQGGFEAAVHLLSLPQ
EEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
KPTAVVCWNDLVAIGMMNGIARAGLVPGVDISVTGYDDLEEASIATPALTTVWNGQAEVG
CCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCHHEEECCHHHHH
RSAARALLDKLSGSHEPDGIHLIKPEMRIRQSTGPLRVTA
HHHHHHHHHHHCCCCCCCCEEEECCHHHHHCCCCCEEEEC
>Mature Secondary Structure 
AQKVKLSTIAETLGLSTATVSLALRDSPLVAAVTRDKIKEQARALGYIYNRRAASLRTS
CCCCHHHHHHHHHCCCEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RSGIIGVVVHDIMNPFYGEILKAIEAELDRDKQTFILSNHYDSVEKQRDFIETLLQLGGD
CCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCC
GVIMSPAIGTPPQDIQLAEDNNMPAILIARSIEGLDVPIFRGDDAYGIALATNHLIGLGH
CEEECCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCEEEECCCCEEEEEEHHHHHHCCC
RCIAMVGGTDQTSTGRDRYQGYVNALRKANIDVDPDLRIPGPRSKQGGFEAAVHLLSLPQ
EEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
KPTAVVCWNDLVAIGMMNGIARAGLVPGVDISVTGYDDLEEASIATPALTTVWNGQAEVG
CCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCHHEEECCHHHHH
RSAARALLDKLSGSHEPDGIHLIKPEMRIRQSTGPLRVTA
HHHHHHHHHHHCCCCCCCCEEEECCHHHHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]