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The map label for this gene is gyaR [H]

Identifier: 150397961

GI number: 150397961

Start: 2883405

End: 2884370

Strand: Reverse

Name: gyaR [H]

Synonym: Smed_2763

Alternate gene names: 150397961

Gene position: 2884370-2883405 (Counterclockwise)

Preceding gene: 150397962

Following gene: 150397959

Centisome position: 76.27

GC content: 63.15

Gene sequence:

>966_bases
ATGAGCCGTCCTAGAATTCTTGTGCCTGGTAAGATCAATGCGAGGGTCCTCGAACGGCTGCCCGAGTTGTTCGAGACCGT
GCGCATCGAGCGCGCCGATGCGGCGCTCGTGACCGCCGACATGCGCGATATCTCCGGCATTGCCGTTTCGGGCAAGCTTC
CGGTGCCGCTGATGGATGCGTTCCCCAGCCTCGAGATCGTTGCGAATTTCGGCGTCGGCTATGATGGCGTCGATGTCTCG
CGCGCAGCAGCCCGCGGCATTGTCGTCACCAACACGCCTGATGTCCTGACGGAGGAAGTCGCAGATACGGCCATCGGCCT
CCTCCTCAATACGCTGCGCCTCCTGCCGCAAGCCGAGCAATGGCTGCGACAAGGCCGCTGGGAGCGCGACGGCGCCTTTC
CGCTATCGCCTCTTTCGCTGCGCGGGCGGAAAGTCGGGCTGTTCGGTCTCGGCCGGATCGGCCTTGCAATCGCACGGCGA
CTTGAAGCCTTCGGCGTGTCGATCGCCTATCACACGCGTACGCCCCGCGAAGGCCTTGCCTTCGCCTATTGTTCGAGCCT
CATTGGATTGGCCGAAGCCGTCGACACGCTCATCGTCATCGTGCCGGGCACGGCGAGCACATTGAGGGCGATCAATTCGG
ATGTACTCTCGGCGCTCGGGCCGAATGGTGTGCTGATCAATGTCGGCCGCGGCTCGACCGTCGACGAGGCGGCGCTCGTC
ACCGCGCTTCAGAACGGTACGATCGCGGGCGCCGGTCTCGACGTCTTCGAGAACGAGCCTCATGTTCCCGGAGCGCTGCT
TGAGCTTCCCAATGTTTCGCTGCTGCCGCATGTGGCATCGGCCTCGGTCGTCACGCGCAACGCCATGTCCGATCTCGTCG
TCGACAATCTGAAGGCATGGTTCTCGACCGGCGAGGCGTTGACGCCGGTCGTCGAGACGCCGTTTCGGCGTAAAGTGTCT
AATTAA

Upstream 100 bases:

>100_bases
ACCGGACCGCTGCGCGTAACCGCTTGATCGTTTCCTCCGAGTCTGAACAGGATGCGTGCGTGATCGTTCGCATTCCCGCT
ACGCCTGGAAAGGAAACCCG

Downstream 100 bases:

>100_bases
CGGGCCTTGCTCTCACGATAGGCGCGTGCGGCATCGCCGAAGGCCCTGAAGAGGGCGGCTGATGGGGCGTCGGTGCGTAC
CCAGTATTCGGGATGCCACT

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSRPRILVPGKINARVLERLPELFETVRIERADAALVTADMRDISGIAVSGKLPVPLMDAFPSLEIVANFGVGYDGVDVS
RAAARGIVVTNTPDVLTEEVADTAIGLLLNTLRLLPQAEQWLRQGRWERDGAFPLSPLSLRGRKVGLFGLGRIGLAIARR
LEAFGVSIAYHTRTPREGLAFAYCSSLIGLAEAVDTLIVIVPGTASTLRAINSDVLSALGPNGVLINVGRGSTVDEAALV
TALQNGTIAGAGLDVFENEPHVPGALLELPNVSLLPHVASASVVTRNAMSDLVVDNLKAWFSTGEALTPVVETPFRRKVS
N

Sequences:

>Translated_321_residues
MSRPRILVPGKINARVLERLPELFETVRIERADAALVTADMRDISGIAVSGKLPVPLMDAFPSLEIVANFGVGYDGVDVS
RAAARGIVVTNTPDVLTEEVADTAIGLLLNTLRLLPQAEQWLRQGRWERDGAFPLSPLSLRGRKVGLFGLGRIGLAIARR
LEAFGVSIAYHTRTPREGLAFAYCSSLIGLAEAVDTLIVIVPGTASTLRAINSDVLSALGPNGVLINVGRGSTVDEAALV
TALQNGTIAGAGLDVFENEPHVPGALLELPNVSLLPHVASASVVTRNAMSDLVVDNLKAWFSTGEALTPVVETPFRRKVS
N
>Mature_320_residues
SRPRILVPGKINARVLERLPELFETVRIERADAALVTADMRDISGIAVSGKLPVPLMDAFPSLEIVANFGVGYDGVDVSR
AAARGIVVTNTPDVLTEEVADTAIGLLLNTLRLLPQAEQWLRQGRWERDGAFPLSPLSLRGRKVGLFGLGRIGLAIARRL
EAFGVSIAYHTRTPREGLAFAYCSSLIGLAEAVDTLIVIVPGTASTLRAINSDVLSALGPNGVLINVGRGSTVDEAALVT
ALQNGTIAGAGLDVFENEPHVPGALLELPNVSLLPHVASASVVTRNAMSDLVVDNLKAWFSTGEALTPVVETPFRRKVSN

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=242, Percent_Identity=39.2561983471074, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI23308577, Length=283, Percent_Identity=31.4487632508834, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=33.0612244897959, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=33.0612244897959, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI61743967, Length=232, Percent_Identity=32.3275862068966, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4557497, Length=232, Percent_Identity=32.3275862068966, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI145580575, Length=237, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI87082289, Length=305, Percent_Identity=32.7868852459016, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1789279, Length=289, Percent_Identity=29.4117647058824, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1787645, Length=210, Percent_Identity=30, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87081824, Length=214, Percent_Identity=27.5700934579439, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=310, Percent_Identity=30.3225806451613, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI25147481, Length=260, Percent_Identity=27.6923076923077, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=280, Percent_Identity=36.7857142857143, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322116, Length=337, Percent_Identity=25.8160237388724, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=339, Percent_Identity=25.6637168141593, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6325144, Length=377, Percent_Identity=25.9946949602122, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=265, Percent_Identity=27.5471698113208, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571528, Length=295, Percent_Identity=36.271186440678, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24585516, Length=240, Percent_Identity=34.5833333333333, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45552429, Length=293, Percent_Identity=31.0580204778157, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24585514, Length=293, Percent_Identity=31.0580204778157, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574282, Length=293, Percent_Identity=31.0580204778157, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45551003, Length=293, Percent_Identity=31.0580204778157, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574284, Length=283, Percent_Identity=31.8021201413428, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574286, Length=298, Percent_Identity=32.2147651006711, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646446, Length=237, Percent_Identity=33.7552742616034, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646448, Length=237, Percent_Identity=33.7552742616034, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646452, Length=237, Percent_Identity=33.7552742616034, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24646450, Length=237, Percent_Identity=33.7552742616034, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI62472511, Length=253, Percent_Identity=31.6205533596838, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19921140, Length=272, Percent_Identity=29.4117647058824, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34051; Mature: 33920

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPRILVPGKINARVLERLPELFETVRIERADAALVTADMRDISGIAVSGKLPVPLMDA
CCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCEEEECCCCCHHHHH
FPSLEIVANFGVGYDGVDVSRAAARGIVVTNTPDVLTEEVADTAIGLLLNTLRLLPQAEQ
CCCEEEEEECCCCCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHH
WLRQGRWERDGAFPLSPLSLRGRKVGLFGLGRIGLAIARRLEAFGVSIAYHTRTPREGLA
HHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCEEEEEECCCCCHHHH
FAYCSSLIGLAEAVDTLIVIVPGTASTLRAINSDVLSALGPNGVLINVGRGSTVDEAALV
HHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHH
TALQNGTIAGAGLDVFENEPHVPGALLELPNVSLLPHVASASVVTRNAMSDLVVDNLKAW
HHHCCCEEEECCCHHCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FSTGEALTPVVETPFRRKVSN
HCCCCCCCHHHCCCHHHHCCC
>Mature Secondary Structure 
SRPRILVPGKINARVLERLPELFETVRIERADAALVTADMRDISGIAVSGKLPVPLMDA
CCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCEEEECCCCCHHHHH
FPSLEIVANFGVGYDGVDVSRAAARGIVVTNTPDVLTEEVADTAIGLLLNTLRLLPQAEQ
CCCEEEEEECCCCCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHHHH
WLRQGRWERDGAFPLSPLSLRGRKVGLFGLGRIGLAIARRLEAFGVSIAYHTRTPREGLA
HHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCEEEEEECCCCCHHHH
FAYCSSLIGLAEAVDTLIVIVPGTASTLRAINSDVLSALGPNGVLINVGRGSTVDEAALV
HHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHH
TALQNGTIAGAGLDVFENEPHVPGALLELPNVSLLPHVASASVVTRNAMSDLVVDNLKAW
HHHCCCEEEECCCHHCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FSTGEALTPVVETPFRRKVSN
HCCCCCCCHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA