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The map label for this gene is ilvD [H]

Identifier: 150397921

GI number: 150397921

Start: 2835974

End: 2837812

Strand: Direct

Name: ilvD [H]

Synonym: Smed_2723

Alternate gene names: 150397921

Gene position: 2835974-2837812 (Clockwise)

Preceding gene: 150397920

Following gene: 150397923

Centisome position: 74.99

GC content: 64.17

Gene sequence:

>1839_bases
ATGCCTGCCTATCGCTCCCGCACCACCACCCACGGCCGCAACATGGCCGGCGCCCGCGGCCTCTGGCGCGCGACGGGCAT
GAAGGACAGCGACTTCGGCAAACCCATTATTGCGGTGGTGAACTCCTTTACGCAGTTCGTACCGGGCCACGTCCATCTCA
AGGACCTTGGCCAGCTCGTCGCGCGGGAAATCGAGGCGGCGGGCGGCGTCGCCAAGGAATTCAACACGATTGCCGTCGAC
GACGGCATCGCCATGGGCCATGACGGCATGCTCTATTCGCTGCCCTCGCGCGAGATCATCGCCGACAGCGTCGAATATAT
GGTCAACGCCCATTGCGCCGACGCCATGGTCTGCATCTCCAATTGCGACAAGATCACCCCCGGCATGCTGATGGCGGCAC
TGCGCCTCAATATTCCGGCCGTCTTCGTTTCCGGCGGCCCCATGGAGGCCGGCAAGGTGGTTCTGCACGGAAAGACGCAT
GCGCTCGACCTCGTCGACGCGATGGTCGCGGCCGCCGACGACAAGGTGTCCGACGAGGACGTCCAGATCATCGAGCGCTC
CGCCTGCCCGACCTGCGGCTCCTGCTCCGGTATGTTCACAGCCAACTCGATGAACTGTCTGACCGAAGCTCTCGGCCTGT
CGCTGCCCGGCAATGGCTCGACGCTTGCGACCCATGCCGACCGCAAGCGTCTGTTCGTCGAAGCCGGTCACCTCATCGTC
GACATTGCCCGCCGCTATTACGAGCAGGAGGACGAGCGCGTTCTGCCGCGCTCGATCGCCAGCAAACAGGCCTTCGAAAA
TGCCATGGCGCTCGACATCGCCATGGGCGGCTCGACCAACACGGTGCTCCACATCCTTGCCGCGGCTTACGAAGGCGAGA
TCGACTTCACCATGGACGACATCGACCGGCTGTCGCGCAAGGTGCCGTGCTTGTCAAAAGTCGCGCCGGCAAAAGCCGAC
GTGCATATGGAAGACGTGCACCGGGCCGGCGGCATCATGTCGATCCTCGGCGAACTGGACAAAGGCGGCCTGATCAACCG
CGACTGCCCGACGGTACATGCCGAAACACTCGGCGACGCCATCGACCGCTGGGACATCACCCGCACGTCGAGCGAAACGG
TCCGAAACTTCTTCCGCGCCGCTCCTGGCGGCATTCCGACGCAGACCGCCTTCAGCCAGGCGGCCCGCTGGGACGAACTC
GATACCGATCGCCAGAACGGCGTCATCCGTTCGGTGGAACATCCCTTCTCCAAGGATGGCGGCCTTGCGGTGCTCAAGGG
CAACATCGCGCTTGACGGCTGCATCGTGAAAACCGCGGGCGTCGACGAGAGTATCCTGAAATTCTCCGGTCCGGCACGAG
TCTTCGAAAGCCAGGACTCGGCCGTGAAGGGGATCCTCGCCAATGAGGTCAAGGCCGGCGACGTCGTCGTCATCCGCTAT
GAAGGACCGAAGGGCGGGCCGGGCATGCAGGAAATGCTCTATCCGACGAGCTACCTGAAGTCGAAGGGTCTCGGCAAGGC
CTGCGCATTGATCACCGACGGCCGCTTCTCCGGCGGTACGTCCGGTCTTTCGATCGGCCATGTCTCGCCCGAGGCGGCGA
ATGGCGGAACGATCGGGCTCGTGCGCGAAGGTGACATGATCGACATCGACATTCCGAACCGCACCATCGTTCTCCGGGTC
GACGAGGCCGAACTTGCCGCTCGCCGCAAGGAGCAGGATGCCAAGGGCTGGAAGCCGGTCGAGCAGCGCAAGCGCCGGGT
GACGACCGCGCTGAAGGCCTATGCGGCTTTCGCGACCTCCGCCGACCGCGGCGCCGTGAGAGATCTGGGCGACCGCTAA

Upstream 100 bases:

>100_bases
AAGATGACGTGCGCGCAATTTTGCGCTACTACCCCCTGCAATGGCGCTCTGTGATCGCCATATTCCGCCTCGTCACATTC
GTCCGTGAAGGAACACGTTC

Downstream 100 bases:

>100_bases
GCAGCATCGCAGCTGTCGCAGAAGGCTCCCACACCGAGGGAGCCTTCTCGATTCTAAGCCGGCGAGATCACATGTGCCGC
GTCTCGGCCGGTGCGTTCCA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPAVFVSGGPMEAGKVVLHGKTH
ALDLVDAMVAAADDKVSDEDVQIIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
DIARRYYEQEDERVLPRSIASKQAFENAMALDIAMGGSTNTVLHILAAAYEGEIDFTMDDIDRLSRKVPCLSKVAPAKAD
VHMEDVHRAGGIMSILGELDKGGLINRDCPTVHAETLGDAIDRWDITRTSSETVRNFFRAAPGGIPTQTAFSQAARWDEL
DTDRQNGVIRSVEHPFSKDGGLAVLKGNIALDGCIVKTAGVDESILKFSGPARVFESQDSAVKGILANEVKAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAANGGTIGLVREGDMIDIDIPNRTIVLRV
DEAELAARRKEQDAKGWKPVEQRKRRVTTALKAYAAFATSADRGAVRDLGDR

Sequences:

>Translated_612_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPAVFVSGGPMEAGKVVLHGKTH
ALDLVDAMVAAADDKVSDEDVQIIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
DIARRYYEQEDERVLPRSIASKQAFENAMALDIAMGGSTNTVLHILAAAYEGEIDFTMDDIDRLSRKVPCLSKVAPAKAD
VHMEDVHRAGGIMSILGELDKGGLINRDCPTVHAETLGDAIDRWDITRTSSETVRNFFRAAPGGIPTQTAFSQAARWDEL
DTDRQNGVIRSVEHPFSKDGGLAVLKGNIALDGCIVKTAGVDESILKFSGPARVFESQDSAVKGILANEVKAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAANGGTIGLVREGDMIDIDIPNRTIVLRV
DEAELAARRKEQDAKGWKPVEQRKRRVTTALKAYAAFATSADRGAVRDLGDR
>Mature_611_residues
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPAVFVSGGPMEAGKVVLHGKTHA
LDLVDAMVAAADDKVSDEDVQIIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIVD
IARRYYEQEDERVLPRSIASKQAFENAMALDIAMGGSTNTVLHILAAAYEGEIDFTMDDIDRLSRKVPCLSKVAPAKADV
HMEDVHRAGGIMSILGELDKGGLINRDCPTVHAETLGDAIDRWDITRTSSETVRNFFRAAPGGIPTQTAFSQAARWDELD
TDRQNGVIRSVEHPFSKDGGLAVLKGNIALDGCIVKTAGVDESILKFSGPARVFESQDSAVKGILANEVKAGDVVVIRYE
GPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAANGGTIGLVREGDMIDIDIPNRTIVLRVD
EAELAARRKEQDAKGWKPVEQRKRRVTTALKAYAAFATSADRGAVRDLGDR

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=611, Percent_Identity=75.4500818330606, Blast_Score=951, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=539, Percent_Identity=30.7977736549165, Blast_Score=198, Evalue=1e-51,
Organism=Escherichia coli, GI1786464, Length=537, Percent_Identity=31.098696461825, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI2367371, Length=570, Percent_Identity=31.2280701754386, Blast_Score=183, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=610, Percent_Identity=36.0655737704918, Blast_Score=344, Evalue=3e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65412; Mature: 65281

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPAVFVSGGPMEAGKVVLHGKTHALDLVDAMVAAADDKVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCH
VQIIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHCHHHH
DIARRYYEQEDERVLPRSIASKQAFENAMALDIAMGGSTNTVLHILAAAYEGEIDFTMDD
HHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEHHH
IDRLSRKVPCLSKVAPAKADVHMEDVHRAGGIMSILGELDKGGLINRDCPTVHAETLGDA
HHHHHHCCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
IDRWDITRTSSETVRNFFRAAPGGIPTQTAFSQAARWDELDTDRQNGVIRSVEHPFSKDG
HHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHCCCEEECCCCCCCCC
GLAVLKGNIALDGCIVKTAGVDESILKFSGPARVFESQDSAVKGILANEVKAGDVVVIRY
CEEEEECCEEECCEEEEECCCCHHHHHCCCCHHHHCCCCHHHHHHHHCCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAANGGTIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VREGDMIDIDIPNRTIVLRVDEAELAARRKEQDAKGWKPVEQRKRRVTTALKAYAAFATS
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
ADRGAVRDLGDR
CCCCHHHHCCCC
>Mature Secondary Structure 
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPAVFVSGGPMEAGKVVLHGKTHALDLVDAMVAAADDKVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCH
VQIIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHCHHHH
DIARRYYEQEDERVLPRSIASKQAFENAMALDIAMGGSTNTVLHILAAAYEGEIDFTMDD
HHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEHHH
IDRLSRKVPCLSKVAPAKADVHMEDVHRAGGIMSILGELDKGGLINRDCPTVHAETLGDA
HHHHHHCCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
IDRWDITRTSSETVRNFFRAAPGGIPTQTAFSQAARWDELDTDRQNGVIRSVEHPFSKDG
HHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHCCCEEECCCCCCCCC
GLAVLKGNIALDGCIVKTAGVDESILKFSGPARVFESQDSAVKGILANEVKAGDVVVIRY
CEEEEECCEEECCEEEEECCCCHHHHHCCCCHHHHCCCCHHHHHHHHCCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAANGGTIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VREGDMIDIDIPNRTIVLRVDEAELAARRKEQDAKGWKPVEQRKRRVTTALKAYAAFATS
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
ADRGAVRDLGDR
CCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA