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The map label for this gene is hisN [H]

Identifier: 150397915

GI number: 150397915

Start: 2831287

End: 2832153

Strand: Reverse

Name: hisN [H]

Synonym: Smed_2717

Alternate gene names: 150397915

Gene position: 2832153-2831287 (Counterclockwise)

Preceding gene: 150397916

Following gene: 150397913

Centisome position: 74.89

GC content: 62.86

Gene sequence:

>867_bases
TTGATCGGGAACTGTGGGCGTGAGCCCGGTCGTTGCCTTTCGCTGAATTTCGGCTATTCAGGTCGGAACTCCTCTCTCTC
AGAGAACGACATGCTGCCAGACCGCTCCTTTTTCGATCGCCTCGCCGATGCCGCCAAGGCCGAAACCATGCCGCGCTTTC
GCGTCGGCACGAGTGTCCTGAACAAGCTCGAAGGCGGCTTCGACCCGGTTACGGAAGCCGACAGATCGGCTGAGGCATCG
ATTCGCGCGCTGATCGAGAGCAGCTTTCCGGACCATGGCATCCTCGGCGAGGAGCACGGCAATATCGGCCTCGATCGGGA
GCTTGTCTGGGTCATCGACCCGATTGACGGGACCCGCGCTTTCATCTCGGGCCTGCCCGTTTGGGGCACGCTGATCGGCC
TCTACCGCAACGGCAAGGCCATCATGGGGCTGATGGACCAGCCATTCACCGGCGAGCGCTATTTCGCCGACGGCGAGAAG
GCGCTTTATCGCGGCCCGGACGGAGAAAGGGTGCTCGCCACGCGGCCCTGTCACGCGCTTTCGGATGCTGTCCTGTTCAC
GACTTCTCCGCATCTTTATCAGGGAGCGCTCAAAGAGCGCTTCGAGACATTGCAGGCGAAGGTGCGGCTCTTCCGCTACG
GCTGCGATTGTTACGCCTTCGCCTTGCTTGCCGCCGGCCATGTCGATCTCGTCATAGAGTGCGGCCTGAAGCCCTACGAC
GTCGGCGGGCTCATCCCTCTGATTGAGCAGGCGGGCGGCATCATCACCAATTGGCAGGGCGGACCCGCCGAGATGGGCGG
CGAAATCATCGCCGCCGGCAGCCGTGAAGTGCATGCGCGGGCGCTGGAGGTGCTCAAGGGGGATTAG

Upstream 100 bases:

>100_bases
GCCACGAGTGACTGCATGCGGAGGATATTGCTGCAGTGCACAATTGTCAAGATTCGAAGATGCAGACTTTGGTATCGGCC
GATCTGCCTGTCGTTTCCGA

Downstream 100 bases:

>100_bases
GGCTTTTCCAGTCGGCACGAAAGGCACTAAGCCTCTTCCAGCTGCCGAGGCAGGGAGCCGGGGTCCTCGGCGTCCGCACC
GGGCAGGAAAGCGAAGATTG

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MIGNCGREPGRCLSLNFGYSGRNSSLSENDMLPDRSFFDRLADAAKAETMPRFRVGTSVLNKLEGGFDPVTEADRSAEAS
IRALIESSFPDHGILGEEHGNIGLDRELVWVIDPIDGTRAFISGLPVWGTLIGLYRNGKAIMGLMDQPFTGERYFADGEK
ALYRGPDGERVLATRPCHALSDAVLFTTSPHLYQGALKERFETLQAKVRLFRYGCDCYAFALLAAGHVDLVIECGLKPYD
VGGLIPLIEQAGGIITNWQGGPAEMGGEIIAAGSREVHARALEVLKGD

Sequences:

>Translated_288_residues
MIGNCGREPGRCLSLNFGYSGRNSSLSENDMLPDRSFFDRLADAAKAETMPRFRVGTSVLNKLEGGFDPVTEADRSAEAS
IRALIESSFPDHGILGEEHGNIGLDRELVWVIDPIDGTRAFISGLPVWGTLIGLYRNGKAIMGLMDQPFTGERYFADGEK
ALYRGPDGERVLATRPCHALSDAVLFTTSPHLYQGALKERFETLQAKVRLFRYGCDCYAFALLAAGHVDLVIECGLKPYD
VGGLIPLIEQAGGIITNWQGGPAEMGGEIIAAGSREVHARALEVLKGD
>Mature_288_residues
MIGNCGREPGRCLSLNFGYSGRNSSLSENDMLPDRSFFDRLADAAKAETMPRFRVGTSVLNKLEGGFDPVTEADRSAEAS
IRALIESSFPDHGILGEEHGNIGLDRELVWVIDPIDGTRAFISGLPVWGTLIGLYRNGKAIMGLMDQPFTGERYFADGEK
ALYRGPDGERVLATRPCHALSDAVLFTTSPHLYQGALKERFETLQAKVRLFRYGCDCYAFALLAAGHVDLVIECGLKPYD
VGGLIPLIEQAGGIITNWQGGPAEMGGEIIAAGSREVHARALEVLKGD

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI221625487, Length=232, Percent_Identity=27.1551724137931, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI5031789, Length=232, Percent_Identity=27.1551724137931, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI7657236, Length=241, Percent_Identity=28.2157676348548, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788882, Length=228, Percent_Identity=32.4561403508772, Blast_Score=95, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI193202572, Length=247, Percent_Identity=25.9109311740891, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193202570, Length=249, Percent_Identity=26.9076305220884, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24664918, Length=233, Percent_Identity=28.3261802575107, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21357957, Length=277, Percent_Identity=27.0758122743682, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357329, Length=231, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664926, Length=233, Percent_Identity=24.8927038626609, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 31237; Mature: 31237

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00094 C5_MTASE_1 ; PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGNCGREPGRCLSLNFGYSGRNSSLSENDMLPDRSFFDRLADAAKAETMPRFRVGTSVL
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
NKLEGGFDPVTEADRSAEASIRALIESSFPDHGILGEEHGNIGLDRELVWVIDPIDGTRA
HHHCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHH
FISGLPVWGTLIGLYRNGKAIMGLMDQPFTGERYFADGEKALYRGPDGERVLATRPCHAL
HHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCHHEEECCCCCEEEEECCCHHH
SDAVLFTTSPHLYQGALKERFETLQAKVRLFRYGCDCYAFALLAAGHVDLVIECGLKPYD
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCEEC
VGGLIPLIEQAGGIITNWQGGPAEMGGEIIAAGSREVHARALEVLKGD
CCCHHHHHHHCCCEEECCCCCHHHHCCEEEECCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MIGNCGREPGRCLSLNFGYSGRNSSLSENDMLPDRSFFDRLADAAKAETMPRFRVGTSVL
CCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
NKLEGGFDPVTEADRSAEASIRALIESSFPDHGILGEEHGNIGLDRELVWVIDPIDGTRA
HHHCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHH
FISGLPVWGTLIGLYRNGKAIMGLMDQPFTGERYFADGEKALYRGPDGERVLATRPCHAL
HHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCHHEEECCCCCEEEEECCCHHH
SDAVLFTTSPHLYQGALKERFETLQAKVRLFRYGCDCYAFALLAAGHVDLVIECGLKPYD
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCEEC
VGGLIPLIEQAGGIITNWQGGPAEMGGEIIAAGSREVHARALEVLKGD
CCCHHHHHHHCCCEEECCCCCHHHHCCEEEECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]