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The map label for this gene is serA [H]

Identifier: 150397816

GI number: 150397816

Start: 2715154

End: 2716749

Strand: Reverse

Name: serA [H]

Synonym: Smed_2618

Alternate gene names: 150397816

Gene position: 2716749-2715154 (Counterclockwise)

Preceding gene: 150397817

Following gene: 150397814

Centisome position: 71.84

GC content: 61.9

Gene sequence:

>1596_bases
ATGGCACCTCGCGTTCTCGTATCCGATGAACTCTCTGAAACCGCCGTCCAGATCTTCCGCGACCACGGCGTGGAAGTCGA
TTTCCAGCCCAAGCTCGGCAAGGACAAGGAGAAGCTCGCCGAAATCATCGGCAATTACGACGGCCTTGCCATTCGCTCGG
CCACCAAAGTGACCGAAAAGCTGATCGCCGCGGCCACCAATCTCAAGGTCGTCGGCCGCGCCGGTATCGGCGTCGACAAT
GTCGACATTCCCGCGGCTTCTCGCCGCGGCATCATCGTGATGAACACGCCGTTCGGCAATTCAATCACCACTGCCGAGCA
CGCCATCGCGCTGATGTTTGCCGTTGCCCGGCAGCTTCCCGCCGCCGACGGTTCGACCCAGGCCGGCAAGTGGGAGAAGT
CGAAGTTCATGGGTGTCGAGATCACCGGCAAGGTGCTCGGGGTCATCGGCGCCGGCAATATAGGCTCGATCGTCTGTGCC
CGTGCAATCGGGCTCAAGATGCATGTCATTGCTTACGATCCCTTCCTGTCGAAGGAGCGGGCCGAGGAAATGGGCGTGGC
CAAGGTCGAGCTCGACGAGCTCCTCGCCCAGGCTGATTTCATCAGCCTGCACGTGCCGCTGACGGACAAGACCCGCAGCA
TCCTGAATGCGGAGGCGATCGCCAAGGCCAAGCCGGGCGTGCGCATCATCAATTGCGCTCGAGGCGGCCTCGTCGATGAG
AAGGCGCTTGCCGAGGCCATCAAGTCCGGGCATGTCGCCGGCGCCGGTTTCGACGTATTCGAAGTGGAGCCCGCCACAGA
TAGTCCGCTCTTCGGTCTGCCAAATGTCGTCTGCACGCCGCATCTCGGCGCCTCGACGACCGAGGCGCAGGAAAACGTCG
CTCTGCAAGTTGCCGAGCAGATGTCGGAATACCTCGTCAAGGGCGCGGTCACCAACGCCATCAACATGCCGTCGATCACG
GCCGAGGAGGCGCCGATGCTCAAGCCCTTCATCCGGCTTGCGGATGTTCTCGGCGCCTTTGTCGGGCAGGTCACCGAAAG
CGCCATCAAGGAGATCGAGATACTCTATGACGGCTCGACCGCGGCGATGAACACGAAAGCGCTGACGAGCGCGGCTCTCG
CAGGTCTGATCCGGCCGCAGGTCGCCGACGTCAACATGGTTTCGGCTCCGGTGATGATCAAGGAAAAGGGTGTCATTCTT
TCCGAGGTCAAGCGCGACAAGACGGGCGTTTTCGACGGCTACATCAAACTTACGGTGAAGACGGCGAACCAGACCCGCTC
GGTCGCCGGTACGGTCTTCTCCGACGGCAAGCCGCGCTTCATCCAGATCAAGGGCATCAATCTCGACGCGGATGTCGGCG
CCCACATGGTCTACCTGACCAATACCGACGTTCCCGGCATGATCGGCTTCATCGGCTCCACACTCGGCGACGCCGGCGTC
AACATCGCGAACTTCCAGCTCGGCCGCGAGAAGCAGGGCGGCGATGCGATCGCGCTGCTTTACGTCGACGGTCCGGTTTC
GGAGACCGTGCTCGACAGGCTGCGCGCAAACGAAGCGATCCGCCAGGCGAAGCCGCTGGTGTTCAATATCGACTGA

Upstream 100 bases:

>100_bases
CTGTCGCAGGTCGCCGCCTGATCCTATGCGACTGCATCGCTCCCTGAGGGGCGGAGCACGATCCCCAATCGCTCAGACCT
GTTTCTTCAAGGAGGCCTCC

Downstream 100 bases:

>100_bases
GCGGCACCCGGGCTTCAATTGACTCCACCCTCCCACTTGTGGGGAGGGGTGGAGTCATATCATTGCGGAGGCTTCGGCCG
CCCTCGCTCGGCGACGGCGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MAPRVLVSDELSETAVQIFRDHGVEVDFQPKLGKDKEKLAEIIGNYDGLAIRSATKVTEKLIAAATNLKVVGRAGIGVDN
VDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLPAADGSTQAGKWEKSKFMGVEITGKVLGVIGAGNIGSIVCA
RAIGLKMHVIAYDPFLSKERAEEMGVAKVELDELLAQADFISLHVPLTDKTRSILNAEAIAKAKPGVRIINCARGGLVDE
KALAEAIKSGHVAGAGFDVFEVEPATDSPLFGLPNVVCTPHLGASTTEAQENVALQVAEQMSEYLVKGAVTNAINMPSIT
AEEAPMLKPFIRLADVLGAFVGQVTESAIKEIEILYDGSTAAMNTKALTSAALAGLIRPQVADVNMVSAPVMIKEKGVIL
SEVKRDKTGVFDGYIKLTVKTANQTRSVAGTVFSDGKPRFIQIKGINLDADVGAHMVYLTNTDVPGMIGFIGSTLGDAGV
NIANFQLGREKQGGDAIALLYVDGPVSETVLDRLRANEAIRQAKPLVFNID

Sequences:

>Translated_531_residues
MAPRVLVSDELSETAVQIFRDHGVEVDFQPKLGKDKEKLAEIIGNYDGLAIRSATKVTEKLIAAATNLKVVGRAGIGVDN
VDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLPAADGSTQAGKWEKSKFMGVEITGKVLGVIGAGNIGSIVCA
RAIGLKMHVIAYDPFLSKERAEEMGVAKVELDELLAQADFISLHVPLTDKTRSILNAEAIAKAKPGVRIINCARGGLVDE
KALAEAIKSGHVAGAGFDVFEVEPATDSPLFGLPNVVCTPHLGASTTEAQENVALQVAEQMSEYLVKGAVTNAINMPSIT
AEEAPMLKPFIRLADVLGAFVGQVTESAIKEIEILYDGSTAAMNTKALTSAALAGLIRPQVADVNMVSAPVMIKEKGVIL
SEVKRDKTGVFDGYIKLTVKTANQTRSVAGTVFSDGKPRFIQIKGINLDADVGAHMVYLTNTDVPGMIGFIGSTLGDAGV
NIANFQLGREKQGGDAIALLYVDGPVSETVLDRLRANEAIRQAKPLVFNID
>Mature_530_residues
APRVLVSDELSETAVQIFRDHGVEVDFQPKLGKDKEKLAEIIGNYDGLAIRSATKVTEKLIAAATNLKVVGRAGIGVDNV
DIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLPAADGSTQAGKWEKSKFMGVEITGKVLGVIGAGNIGSIVCAR
AIGLKMHVIAYDPFLSKERAEEMGVAKVELDELLAQADFISLHVPLTDKTRSILNAEAIAKAKPGVRIINCARGGLVDEK
ALAEAIKSGHVAGAGFDVFEVEPATDSPLFGLPNVVCTPHLGASTTEAQENVALQVAEQMSEYLVKGAVTNAINMPSITA
EEAPMLKPFIRLADVLGAFVGQVTESAIKEIEILYDGSTAAMNTKALTSAALAGLIRPQVADVNMVSAPVMIKEKGVILS
EVKRDKTGVFDGYIKLTVKTANQTRSVAGTVFSDGKPRFIQIKGINLDADVGAHMVYLTNTDVPGMIGFIGSTLGDAGVN
IANFQLGREKQGGDAIALLYVDGPVSETVLDRLRANEAIRQAKPLVFNID

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=492, Percent_Identity=37.8048780487805, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI145580578, Length=282, Percent_Identity=34.3971631205674, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4557499, Length=282, Percent_Identity=34.3971631205674, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=32.8413284132841, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4557497, Length=271, Percent_Identity=32.8413284132841, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI145580575, Length=252, Percent_Identity=36.5079365079365, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI6912396, Length=246, Percent_Identity=33.739837398374, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI1789279, Length=325, Percent_Identity=37.8461538461538, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=31.875, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=36.2244897959184, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=28.4644194756554, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87081824, Length=264, Percent_Identity=27.6515151515151, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=313, Percent_Identity=45.3674121405751, Blast_Score=278, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI25147481, Length=273, Percent_Identity=31.5018315018315, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322116, Length=331, Percent_Identity=36.2537764350453, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6320925, Length=331, Percent_Identity=36.2537764350453, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324055, Length=283, Percent_Identity=29.6819787985866, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=277, Percent_Identity=29.2418772563177, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324980, Length=198, Percent_Identity=28.7878787878788, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=188, Percent_Identity=31.3829787234043, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=198, Percent_Identity=26.2626262626263, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=43.3774834437086, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24646446, Length=248, Percent_Identity=35.4838709677419, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646448, Length=248, Percent_Identity=35.4838709677419, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646452, Length=248, Percent_Identity=35.4838709677419, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646450, Length=248, Percent_Identity=35.4838709677419, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI62472511, Length=248, Percent_Identity=35.4838709677419, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24585516, Length=332, Percent_Identity=28.3132530120482, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574286, Length=242, Percent_Identity=32.6446280991736, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24585514, Length=242, Percent_Identity=32.6446280991736, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574282, Length=242, Percent_Identity=32.6446280991736, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45552429, Length=242, Percent_Identity=32.6446280991736, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574284, Length=242, Percent_Identity=32.6446280991736, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45551003, Length=242, Percent_Identity=32.6446280991736, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=34.7169811320755, Blast_Score=129, Evalue=6e-30,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56123; Mature: 55992

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRVLVSDELSETAVQIFRDHGVEVDFQPKLGKDKEKLAEIIGNYDGLAIRSATKVTEK
CCCCEEECCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCCEEEEHHHHHHHH
LIAAATNLKVVGRAGIGVDNVDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLP
HHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
AADGSTQAGKWEKSKFMGVEITGKVLGVIGAGNIGSIVCARAIGLKMHVIAYDPFLSKER
CCCCCCCCCCCCHHEEEEEEEECEEEEEEECCCHHHHHHHHHHCCEEEEEEECCCCCHHH
AEEMGVAKVELDELLAQADFISLHVPLTDKTRSILNAEAIAKAKPGVRIINCARGGLVDE
HHHCCCCEEEHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCH
KALAEAIKSGHVAGAGFDVFEVEPATDSPLFGLPNVVCTPHLGASTTEAQENVALQVAEQ
HHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHH
MSEYLVKGAVTNAINMPSITAEEAPMLKPFIRLADVLGAFVGQVTESAIKEIEILYDGST
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
AAMNTKALTSAALAGLIRPQVADVNMVSAPVMIKEKGVILSEVKRDKTGVFDGYIKLTVK
CCCCHHHHHHHHHHHHHCCCCCCCEEECCCEEEECCCCHHHHHHCCCCCCEEEEEEEEEE
TANQTRSVAGTVFSDGKPRFIQIKGINLDADVGAHMVYLTNTDVPGMIGFIGSTLGDAGV
ECCCCCHHEEEEECCCCCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC
NIANFQLGREKQGGDAIALLYVDGPVSETVLDRLRANEAIRQAKPLVFNID
EEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure 
APRVLVSDELSETAVQIFRDHGVEVDFQPKLGKDKEKLAEIIGNYDGLAIRSATKVTEK
CCCEEECCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCCEEEEHHHHHHHH
LIAAATNLKVVGRAGIGVDNVDIPAASRRGIIVMNTPFGNSITTAEHAIALMFAVARQLP
HHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
AADGSTQAGKWEKSKFMGVEITGKVLGVIGAGNIGSIVCARAIGLKMHVIAYDPFLSKER
CCCCCCCCCCCCHHEEEEEEEECEEEEEEECCCHHHHHHHHHHCCEEEEEEECCCCCHHH
AEEMGVAKVELDELLAQADFISLHVPLTDKTRSILNAEAIAKAKPGVRIINCARGGLVDE
HHHCCCCEEEHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCH
KALAEAIKSGHVAGAGFDVFEVEPATDSPLFGLPNVVCTPHLGASTTEAQENVALQVAEQ
HHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHH
MSEYLVKGAVTNAINMPSITAEEAPMLKPFIRLADVLGAFVGQVTESAIKEIEILYDGST
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
AAMNTKALTSAALAGLIRPQVADVNMVSAPVMIKEKGVILSEVKRDKTGVFDGYIKLTVK
CCCCHHHHHHHHHHHHHCCCCCCCEEECCCEEEECCCCHHHHHHCCCCCCEEEEEEEEEE
TANQTRSVAGTVFSDGKPRFIQIKGINLDADVGAHMVYLTNTDVPGMIGFIGSTLGDAGV
ECCCCCHHEEEEECCCCCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCC
NIANFQLGREKQGGDAIALLYVDGPVSETVLDRLRANEAIRQAKPLVFNID
EEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]