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The map label for this gene is dacC [H]

Identifier: 150397770

GI number: 150397770

Start: 2668810

End: 2669940

Strand: Reverse

Name: dacC [H]

Synonym: Smed_2572

Alternate gene names: 150397770

Gene position: 2669940-2668810 (Counterclockwise)

Preceding gene: 150397773

Following gene: 150397769

Centisome position: 70.6

GC content: 61.98

Gene sequence:

>1131_bases
GTGGCGATAACAGGATTGTCGGTAGGTGACAGGCTAGGCAGGATGGGCACGCTTGCAGGCGCTTGCGCGATCTTTTTGGC
TGCGGTGCTTCCCGCTTCTGCCAATCCGCGGCTCGTGATCGACGTCGATACGCTCAAGGTCTACGAGCATCAGGACATTT
TCCAGAAGTGGTATCCGGCGTCGCTGACCAAGCTGATGACAGCCTATATCACGTTCAGAGCGATCAAGGCGGACCAACTG
ACGCTGGAGAGCCCGGTCGTGATGACGAAGAACGCCGCTTCCGAGCCGCCGAGCAAGATGTTCTACAAGCCTGGCCAGAA
GATGACGCTCGACAGCGCATTGAAGATGATGCTGGTCAAGTCGGCAAACGACGTCGCCGTTGCGATCGCCGAGACGGTCG
GCGGAACCGAGCAGGCCTTCATCGAGAGGATGAACGCCGAGGCCCGCCGCATCGGAATGACGTCGTCGCGGTTCATCAAT
CCCCACGGCCTTCCCGGCGAAGGGCAATATACGACGGCCCGGGACCTTGCGGTCCTCGCTGTCACGCTGAAGCGCGAATT
CCCGCAATATGCCTCCTATTTCGCGCTGGAAGGCTTCACCACCGGGAAGAAGGATTATCCCAACTACAACATGCTGATCG
GCCGTTTCGAGGGTGCCGACGGCATGAAGACGGGGTTCATCTGCGCTTCGGGGTTCAATCAGGTCTCCTCGGCGGTCCGC
TCCGGACGCCGGGTGGTCTCGGTCGTGCTTGGCGAAGACAGTCTTGGAGCGCGCGCCGACGAGTCGGCCCGGCTCCTGCA
GAAGGCATTGACGACGGTGGCCACGGACAAGCCTTCGCTTGCGGAGATTCCGCCTTACGGCGAGAGCCGCGAAGTCGTTG
CCGACGTCAGCAGGGAGATCTGCTCCAAGCAGGCAGCGAAGGTGCGCAGCGAGGGCCGCGACGAAGCGGGCCGGCAGAAA
CTGCTTTCACCCTATATTCACGAGATCGACCGTCCGCTGAAACTTGCCTTCGCCGGGCTCATGCCGGGCAGCAACGACAA
GATCGCAAAGGCCGGCAAGAATGCCACGGCGCAGGGCGACGCCGTCGAGATCGCTGACGTGCCGATTCCGGTCCCGCGCC
CGAGCTTCTGA

Upstream 100 bases:

>100_bases
TGACGCGGCCGCCAAAATGAATGGGCTTTGCCATTTCCTTGCCATATAGGCTAAATAGCGGGACGATACGAGGCAACAGC
GGATTTTCGAGGTTTGGATT

Downstream 100 bases:

>100_bases
ACGGAGTCTTTCATGAATGGTCCAATGCCGGTGGTGCCGGTCTCGATCCTCACCGGCTTTCTCGGCGCGGGCAAGACGAC
CCTTCTGAACCGGGTTCTCA

Product: Serine-type D-Ala-D-Ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MAITGLSVGDRLGRMGTLAGACAIFLAAVLPASANPRLVIDVDTLKVYEHQDIFQKWYPASLTKLMTAYITFRAIKADQL
TLESPVVMTKNAASEPPSKMFYKPGQKMTLDSALKMMLVKSANDVAVAIAETVGGTEQAFIERMNAEARRIGMTSSRFIN
PHGLPGEGQYTTARDLAVLAVTLKREFPQYASYFALEGFTTGKKDYPNYNMLIGRFEGADGMKTGFICASGFNQVSSAVR
SGRRVVSVVLGEDSLGARADESARLLQKALTTVATDKPSLAEIPPYGESREVVADVSREICSKQAAKVRSEGRDEAGRQK
LLSPYIHEIDRPLKLAFAGLMPGSNDKIAKAGKNATAQGDAVEIADVPIPVPRPSF

Sequences:

>Translated_376_residues
MAITGLSVGDRLGRMGTLAGACAIFLAAVLPASANPRLVIDVDTLKVYEHQDIFQKWYPASLTKLMTAYITFRAIKADQL
TLESPVVMTKNAASEPPSKMFYKPGQKMTLDSALKMMLVKSANDVAVAIAETVGGTEQAFIERMNAEARRIGMTSSRFIN
PHGLPGEGQYTTARDLAVLAVTLKREFPQYASYFALEGFTTGKKDYPNYNMLIGRFEGADGMKTGFICASGFNQVSSAVR
SGRRVVSVVLGEDSLGARADESARLLQKALTTVATDKPSLAEIPPYGESREVVADVSREICSKQAAKVRSEGRDEAGRQK
LLSPYIHEIDRPLKLAFAGLMPGSNDKIAKAGKNATAQGDAVEIADVPIPVPRPSF
>Mature_375_residues
AITGLSVGDRLGRMGTLAGACAIFLAAVLPASANPRLVIDVDTLKVYEHQDIFQKWYPASLTKLMTAYITFRAIKADQLT
LESPVVMTKNAASEPPSKMFYKPGQKMTLDSALKMMLVKSANDVAVAIAETVGGTEQAFIERMNAEARRIGMTSSRFINP
HGLPGEGQYTTARDLAVLAVTLKREFPQYASYFALEGFTTGKKDYPNYNMLIGRFEGADGMKTGFICASGFNQVSSAVRS
GRRVVSVVLGEDSLGARADESARLLQKALTTVATDKPSLAEIPPYGESREVVADVSREICSKQAAKVRSEGRDEAGRQKL
LSPYIHEIDRPLKLAFAGLMPGSNDKIAKAGKNATAQGDAVEIADVPIPVPRPSF

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=272, Percent_Identity=33.8235294117647, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI87082022, Length=266, Percent_Identity=32.7067669172932, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786851, Length=252, Percent_Identity=31.7460317460317, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082054, Length=237, Percent_Identity=28.2700421940928, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 40532; Mature: 40401

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITGLSVGDRLGRMGTLAGACAIFLAAVLPASANPRLVIDVDTLKVYEHQDIFQKWYPA
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHEEHHHHHHHHHHHCCH
SLTKLMTAYITFRAIKADQLTLESPVVMTKNAASEPPSKMFYKPGQKMTLDSALKMMLVK
HHHHHHHHHHHHHEECCCCEEECCCEEEECCCCCCCCHHHHCCCCCCEEHHHHHHHHHHH
SANDVAVAIAETVGGTEQAFIERMNAEARRIGMTSSRFINPHGLPGEGQYTTARDLAVLA
CCCCEEEEEHHHCCCHHHHHHHHHCCHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHH
VTLKREFPQYASYFALEGFTTGKKDYPNYNMLIGRFEGADGMKTGFICASGFNQVSSAVR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHH
SGRRVVSVVLGEDSLGARADESARLLQKALTTVATDKPSLAEIPPYGESREVVADVSREI
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
CSKQAAKVRSEGRDEAGRQKLLSPYIHEIDRPLKLAFAGLMPGSNDKIAKAGKNATAQGD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCC
AVEIADVPIPVPRPSF
EEEEECCCCCCCCCCC
>Mature Secondary Structure 
AITGLSVGDRLGRMGTLAGACAIFLAAVLPASANPRLVIDVDTLKVYEHQDIFQKWYPA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHEEHHHHHHHHHHHCCH
SLTKLMTAYITFRAIKADQLTLESPVVMTKNAASEPPSKMFYKPGQKMTLDSALKMMLVK
HHHHHHHHHHHHHEECCCCEEECCCEEEECCCCCCCCHHHHCCCCCCEEHHHHHHHHHHH
SANDVAVAIAETVGGTEQAFIERMNAEARRIGMTSSRFINPHGLPGEGQYTTARDLAVLA
CCCCEEEEEHHHCCCHHHHHHHHHCCHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHH
VTLKREFPQYASYFALEGFTTGKKDYPNYNMLIGRFEGADGMKTGFICASGFNQVSSAVR
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCHHHHHHHHH
SGRRVVSVVLGEDSLGARADESARLLQKALTTVATDKPSLAEIPPYGESREVVADVSREI
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
CSKQAAKVRSEGRDEAGRQKLLSPYIHEIDRPLKLAFAGLMPGSNDKIAKAGKNATAQGD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCC
AVEIADVPIPVPRPSF
EEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]