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The map label for this gene is cbf2 [H]

Identifier: 150397715

GI number: 150397715

Start: 2612691

End: 2613545

Strand: Reverse

Name: cbf2 [H]

Synonym: Smed_2517

Alternate gene names: 150397715

Gene position: 2613545-2612691 (Counterclockwise)

Preceding gene: 150397720

Following gene: 150397714

Centisome position: 69.11

GC content: 59.42

Gene sequence:

>855_bases
ATGCTCAGATACAAGACCCTTGCGGCCGCGGCCCTGGTCGCGATGATTGCAGCGGGCGTCGCCCGCGCCGAAGGGACCGA
CCCGGTCATTGCGAAAGTCGGGGACCAGGAAATCCGCCAGTCGGAACTTGATCTCGCAGTCACGAGCCTCGATCCGCAAC
TTCAGCGGATGCCCGACGAGCAGAAGCGCGCCGCAGCGCTTTCGGCCGTTATCGACGTCAAGCTGCTTTTGAAGGACGCC
GAAAAGGAAGGCCTTCAGAACGACGAGACGTTCAAGCAGCGCATTGCCTTCCTGACGGAACGGGAATTGCACAACGCCTA
TTTCAAAAAGCATGTGATCGATGCCGTGACGCCTGAAGAAGTGAAGGCGCGCTATGACAAGGAAATTGCAGCCATTCCTC
CGCAGGAAGAGGTGAAGGCCCGGCATATCCTCGTCAAGACAGAGGACGAGGCGAAGGCAGTGATCAAGGAACTGGACGCC
GGCAAGAACTTTGCGGAGCTTGCCAAGGCGAAGTCCACCGATCCGAACAAGGACGAGGGCGGCGACCTCGGATATTTCAC
CAAGGGCCGCATGGTGCCGGAATTCGAAACGGCAGCTTTCGCTCTGGAAAAGGGCGCCTACACGAAGACACCGGTCAAGA
CGCAGTTCGGCTTCCACGTCATCCTCGTCGAGGACAAGCGTCCCCAGGCGCCGCCGACGCTGGAGCAGGTCGAGCCCCAG
GTTCGCCAGCTCGTCATGCGCGACAGGTATCTCGAGCTTCTGAATTCAGCGAAGGAGAGCACTGCAGTCGAAATCTCCGA
CCCGGCTCTCAAGAAGGCCTATGACGAGGCCGGCAAACCGCAGAAAAGCAAGTAA

Upstream 100 bases:

>100_bases
ACGGCCGGACGGCTGCAGAACCGCCACATTCTGGTTGTTGTGCAGCACTCGCAGGGCCGGCGCCAATCGCGCTGGCGGCC
AATGGTGAAAGGTTAGGAAA

Downstream 100 bases:

>100_bases
GCACCGAAGGCCGGGCGGGGCTGTCCCTTCGGGGCGCGTACGGCCCGAGCGGGGTTGAAGGTCTGCTCGCATTTGCTCCG
CTCGCCTTTAAAAGACCAGG

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: peptidylproline (omega=0) [C]

Alternate protein names: Major antigen peb4A [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MLRYKTLAAAALVAMIAAGVARAEGTDPVIAKVGDQEIRQSELDLAVTSLDPQLQRMPDEQKRAAALSAVIDVKLLLKDA
EKEGLQNDETFKQRIAFLTERELHNAYFKKHVIDAVTPEEVKARYDKEIAAIPPQEEVKARHILVKTEDEAKAVIKELDA
GKNFAELAKAKSTDPNKDEGGDLGYFTKGRMVPEFETAAFALEKGAYTKTPVKTQFGFHVILVEDKRPQAPPTLEQVEPQ
VRQLVMRDRYLELLNSAKESTAVEISDPALKKAYDEAGKPQKSK

Sequences:

>Translated_284_residues
MLRYKTLAAAALVAMIAAGVARAEGTDPVIAKVGDQEIRQSELDLAVTSLDPQLQRMPDEQKRAAALSAVIDVKLLLKDA
EKEGLQNDETFKQRIAFLTERELHNAYFKKHVIDAVTPEEVKARYDKEIAAIPPQEEVKARHILVKTEDEAKAVIKELDA
GKNFAELAKAKSTDPNKDEGGDLGYFTKGRMVPEFETAAFALEKGAYTKTPVKTQFGFHVILVEDKRPQAPPTLEQVEPQ
VRQLVMRDRYLELLNSAKESTAVEISDPALKKAYDEAGKPQKSK
>Mature_284_residues
MLRYKTLAAAALVAMIAAGVARAEGTDPVIAKVGDQEIRQSELDLAVTSLDPQLQRMPDEQKRAAALSAVIDVKLLLKDA
EKEGLQNDETFKQRIAFLTERELHNAYFKKHVIDAVTPEEVKARYDKEIAAIPPQEEVKARHILVKTEDEAKAVIKELDA
GKNFAELAKAKSTDPNKDEGGDLGYFTKGRMVPEFETAAFALEKGAYTKTPVKTQFGFHVILVEDKRPQAPPTLEQVEPQ
VRQLVMRDRYLELLNSAKESTAVEISDPALKKAYDEAGKPQKSK

Specific function: Ppiases Accelerate The Folding Of Proteins. It Prefers Amino Acid Residues With Hydrophobic Side Chains Like Leucine And Phenylalanine In The P1 Position Of The Peptides Substrates. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=95, Percent_Identity=42.1052631578947, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790211, Length=84, Percent_Identity=42.8571428571429, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1786645, Length=163, Percent_Identity=29.4478527607362, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537235, Length=95, Percent_Identity=47.3684210526316, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356303, Length=95, Percent_Identity=43.1578947368421, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 31525; Mature: 31525

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRYKTLAAAALVAMIAAGVARAEGTDPVIAKVGDQEIRQSELDLAVTSLDPQLQRMPDE
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHEEHCCCCHHHHHCCCH
QKRAAALSAVIDVKLLLKDAEKEGLQNDETFKQRIAFLTERELHNAYFKKHVIDAVTPEE
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VKARYDKEIAAIPPQEEVKARHILVKTEDEAKAVIKELDAGKNFAELAKAKSTDPNKDEG
HHHHHCCCCCCCCCHHHHHHHEEEEECCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
GDLGYFTKGRMVPEFETAAFALEKGAYTKTPVKTQFGFHVILVEDKRPQAPPTLEQVEPQ
CCCCEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHCHH
VRQLVMRDRYLELLNSAKESTAVEISDPALKKAYDEAGKPQKSK
HHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLRYKTLAAAALVAMIAAGVARAEGTDPVIAKVGDQEIRQSELDLAVTSLDPQLQRMPDE
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHEEHCCCCHHHHHCCCH
QKRAAALSAVIDVKLLLKDAEKEGLQNDETFKQRIAFLTERELHNAYFKKHVIDAVTPEE
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VKARYDKEIAAIPPQEEVKARHILVKTEDEAKAVIKELDAGKNFAELAKAKSTDPNKDEG
HHHHHCCCCCCCCCHHHHHHHEEEEECCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
GDLGYFTKGRMVPEFETAAFALEKGAYTKTPVKTQFGFHVILVEDKRPQAPPTLEQVEPQ
CCCCEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHCHH
VRQLVMRDRYLELLNSAKESTAVEISDPALKKAYDEAGKPQKSK
HHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]