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The map label for this gene is glxR [H]

Identifier: 150397687

GI number: 150397687

Start: 2571560

End: 2572426

Strand: Direct

Name: glxR [H]

Synonym: Smed_2487

Alternate gene names: 150397687

Gene position: 2571560-2572426 (Clockwise)

Preceding gene: 150397686

Following gene: 150397688

Centisome position: 68.0

GC content: 65.4

Gene sequence:

>867_bases
ATGATTGCGTTTCTCGGCACCGGCTTGATGGGCGCGCCGATGGCTCGGCGCCTGAGCCGTGCCGGTTTTCCGGTTACGGT
ATGGAACCGCGACGCCGCCAAGGCCACACCGCTGGCCGCCGACGGCGCTAAGATTGCTGCCTCGCCGGCCGATGCCGTTG
CCGGAGCCAGGGTCGTCTTCACCATGCTGACCAATGGCGATGCCGTATCGGACGTCCTGTTCGAACGCGGCGTCGCCGAT
GCCTTGCCCGAAGGCGCGGTCGTGGTGGATTGCAGCTCGATCGCCCCGCCGATCGCCCGCGAGCATGCGCTGAAACTGGC
GGAACGTGGCATCCGTCACCTCGACGCACCGGTTTCAGGTGGCGTCGTGGGCGCCACAGCCGGAACGCTCGCCATCATGG
CCGGCGGCGATGGCGCCGTAGTGGAAAGTCTGAAGGATGTCTTTGCGGCGCTTGGCCGCGTGACCCATGTGGGCCCGAGC
GGTGCCGGCCAGATCTGCAAGCTTGCCAACCAGCAGATCGTCGCCGTCACCATCGGCGCCGTAGCCGAAGCGATGATCCT
GGTGGAAGCAGGCGGTGCTTCGCGGGCGGCTTTCCGGGACGCGATCCGCGGCGGCTTCGCCGAAAGCCGGATCCTGGAAT
TGCACGGCGACCGCATGGTGAAGCGCGACTTCGAGCCCGGCGGAGCTTCGAGCAACCAGCTCAAGGATCTGGACGCCGTC
ATGGCGATGATGGAAGAACTTTCCCTCGACCTTCCCCTGACGAAACAGGTACGGAAGGAGTTTGCCGCTTTCGTCGAGTC
CGGCGGTGCCGGACGCGACCACAGCGGATTGCTTCTGCATCTCGAAAAGCTCAACCGGAGAAACTAG

Upstream 100 bases:

>100_bases
GCGCCATCGAACTCGGCTTCACCGCCGAAAAGAGCTTCGACGAGATCATTCGCGTACACGTCGAGGATGAACTGGGAGGA
ACGCTGTGAGCGGAAAGCCG

Downstream 100 bases:

>100_bases
GTTCCGCCATGGCTGACAAACTCCAGCGCCGCTTGCGCTCGCAGGACTGGTTCGACAATCCGGACCATATCGATCTTACG
GCACTCTATCTCGAGCGCTT

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MIAFLGTGLMGAPMARRLSRAGFPVTVWNRDAAKATPLAADGAKIAASPADAVAGARVVFTMLTNGDAVSDVLFERGVAD
ALPEGAVVVDCSSIAPPIAREHALKLAERGIRHLDAPVSGGVVGATAGTLAIMAGGDGAVVESLKDVFAALGRVTHVGPS
GAGQICKLANQQIVAVTIGAVAEAMILVEAGGASRAAFRDAIRGGFAESRILELHGDRMVKRDFEPGGASSNQLKDLDAV
MAMMEELSLDLPLTKQVRKEFAAFVESGGAGRDHSGLLLHLEKLNRRN

Sequences:

>Translated_288_residues
MIAFLGTGLMGAPMARRLSRAGFPVTVWNRDAAKATPLAADGAKIAASPADAVAGARVVFTMLTNGDAVSDVLFERGVAD
ALPEGAVVVDCSSIAPPIAREHALKLAERGIRHLDAPVSGGVVGATAGTLAIMAGGDGAVVESLKDVFAALGRVTHVGPS
GAGQICKLANQQIVAVTIGAVAEAMILVEAGGASRAAFRDAIRGGFAESRILELHGDRMVKRDFEPGGASSNQLKDLDAV
MAMMEELSLDLPLTKQVRKEFAAFVESGGAGRDHSGLLLHLEKLNRRN
>Mature_288_residues
MIAFLGTGLMGAPMARRLSRAGFPVTVWNRDAAKATPLAADGAKIAASPADAVAGARVVFTMLTNGDAVSDVLFERGVAD
ALPEGAVVVDCSSIAPPIAREHALKLAERGIRHLDAPVSGGVVGATAGTLAIMAGGDGAVVESLKDVFAALGRVTHVGPS
GAGQICKLANQQIVAVTIGAVAEAMILVEAGGASRAAFRDAIRGGFAESRILELHGDRMVKRDFEPGGASSNQLKDLDAV
MAMMEELSLDLPLTKQVRKEFAAFVESGGAGRDHSGLLLHLEKLNRRN

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=254, Percent_Identity=29.1338582677165, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI23308751, Length=188, Percent_Identity=31.3829787234043, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786719, Length=283, Percent_Identity=42.0494699646643, Blast_Score=197, Evalue=5e-52,
Organism=Escherichia coli, GI145693186, Length=287, Percent_Identity=37.6306620209059, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1790315, Length=280, Percent_Identity=30.3571428571429, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789092, Length=283, Percent_Identity=31.095406360424, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17557316, Length=190, Percent_Identity=32.1052631578947, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=30.2721088435374, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=30.2721088435374, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=28.9285714285714, Blast_Score=107, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29667; Mature: 29667

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAFLGTGLMGAPMARRLSRAGFPVTVWNRDAAKATPLAADGAKIAASPADAVAGARVVF
CEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHCCEEEE
TMLTNGDAVSDVLFERGVADALPEGAVVVDCSSIAPPIAREHALKLAERGIRHLDAPVSG
EEECCCCHHHHHHHHCCHHHHCCCCCEEEECHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
GVVGATAGTLAIMAGGDGAVVESLKDVFAALGRVTHVGPSGAGQICKLANQQIVAVTIGA
CEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEHHH
VAEAMILVEAGGASRAAFRDAIRGGFAESRILELHGDRMVKRDFEPGGASSNQLKDLDAV
HHHEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHH
MAMMEELSLDLPLTKQVRKEFAAFVESGGAGRDHSGLLLHLEKLNRRN
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHCCCC
>Mature Secondary Structure
MIAFLGTGLMGAPMARRLSRAGFPVTVWNRDAAKATPLAADGAKIAASPADAVAGARVVF
CEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHCCEEEE
TMLTNGDAVSDVLFERGVADALPEGAVVVDCSSIAPPIAREHALKLAERGIRHLDAPVSG
EEECCCCHHHHHHHHCCHHHHCCCCCEEEECHHCCCCHHHHHHHHHHHHHHHHCCCCCCC
GVVGATAGTLAIMAGGDGAVVESLKDVFAALGRVTHVGPSGAGQICKLANQQIVAVTIGA
CEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEHHH
VAEAMILVEAGGASRAAFRDAIRGGFAESRILELHGDRMVKRDFEPGGASSNQLKDLDAV
HHHEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHH
MAMMEELSLDLPLTKQVRKEFAAFVESGGAGRDHSGLLLHLEKLNRRN
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]