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The map label for this gene is yjmC [H]

Identifier: 150397657

GI number: 150397657

Start: 2539447

End: 2540517

Strand: Reverse

Name: yjmC [H]

Synonym: Smed_2457

Alternate gene names: 150397657

Gene position: 2540517-2539447 (Counterclockwise)

Preceding gene: 150397673

Following gene: 150397656

Centisome position: 67.18

GC content: 67.13

Gene sequence:

>1071_bases
ATGTCCCTTCAGACACTAGTTGCCCCTGATTTGCTCGAAGCGCGAGTCGAAAACGCATTGCGCAATGCCGGTGCGGCGCA
GGGTTCCGCCGCCGCGGCGGTCCGGGCGATGATGCATGCCTCACTCATCGGGGTAGATAGTCACGGCGTTCGGCTGGTGG
TGCATTATGACCGGGTGCTGCGGGGCGGCCGGGTCAACGGCACGCCGAATCTGTCGGTCCGGCGGACGGCGGCAGCCACT
GCGGTCGTGGACGGGGATAATGCGCTCGGCCATCATGCGGCATATGTCGCAATGGACAAGGCGATCGAACTGGCACGCGA
AAGCGGCATAGGTGCGGTCGGCGTCATCCGGTCCTCGCATTTCGGCGCAGCCGGCGCTTACGCGCGGGTCGCGGCCGAGG
CGGGCATGATCGGCTTCGCCACCACGAATTCCGACAAGGTCGTGGCACCGTTTCAGGGCCGCGAGCCCTTTCACGGCACC
AACCCGCTGGCCTTCGCCGCGCCGAGCGGCGGTGCGCGGCCCTGGCTGCTCGATATGGCGACCTCGTCCATACCGTTGAA
CCGGTTGCTTCTCTGCAAATCGCTCGGGATGTCTTTGCCGGCGGGAGTGGCGGTGGACGAGGCGGGGCAGCCCACGACCG
AGCCTTTCGAGGGCAGGACGCTCCTGCCGCTCGGCGGCGTGGATTTTTCCTTCAAGGGCGCGGCACTTGCCGGCGTGGCG
ACGCTGCTGTCGGCCATTCTGCAGGGCATGACCCTCGATCATGCGCTCATGCCCATGGTCGGCACCGACGATTATTCGAC
GCCGCGCGAAATGGGTCATTTCCTGCTTGCCATCGATCCCGACCGCTTTGGCGGACGCGGCGTCTTCGACGAGGGCATGT
CTGCCTATCTGGAGGCCCTGCGGAGCGCGCCGGCGCAGGAGGGTTGCGAAGTGCTGGCGCCCGGCGACCGCGAGTGGCGT
GTCGAAGCCGCGCGCAGACAGAACGGCATTCCGATCGATCCCGATACCGCGGCCTTCCTCGGCCTGTCGCGGAGCCCGGC
CGCACCGGCCGGAAATGCCGGGGAGAACTAG

Upstream 100 bases:

>100_bases
CGCAAAGCAGCAGGCATGCCGAAATCGCCTGCTCTTTACACTGAGATATCAGATTTGATACGCCAATTTACGTCGCCCGC
AATCTCCTGGTAGGCTTGAT

Downstream 100 bases:

>100_bases
TCTCATAGCCGTGCCGGGGCAGGGAGTCTCCGGCCAACAACAGGGAGGGAACAATATGAAATCAATGCTGAAAAAGGGCT
TGCTCGCCGCGGCGCTGATG

Product: malate/L-lactate dehydrogenase

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSLQTLVAPDLLEARVENALRNAGAAQGSAAAAVRAMMHASLIGVDSHGVRLVVHYDRVLRGGRVNGTPNLSVRRTAAAT
AVVDGDNALGHHAAYVAMDKAIELARESGIGAVGVIRSSHFGAAGAYARVAAEAGMIGFATTNSDKVVAPFQGREPFHGT
NPLAFAAPSGGARPWLLDMATSSIPLNRLLLCKSLGMSLPAGVAVDEAGQPTTEPFEGRTLLPLGGVDFSFKGAALAGVA
TLLSAILQGMTLDHALMPMVGTDDYSTPREMGHFLLAIDPDRFGGRGVFDEGMSAYLEALRSAPAQEGCEVLAPGDREWR
VEAARRQNGIPIDPDTAAFLGLSRSPAAPAGNAGEN

Sequences:

>Translated_356_residues
MSLQTLVAPDLLEARVENALRNAGAAQGSAAAAVRAMMHASLIGVDSHGVRLVVHYDRVLRGGRVNGTPNLSVRRTAAAT
AVVDGDNALGHHAAYVAMDKAIELARESGIGAVGVIRSSHFGAAGAYARVAAEAGMIGFATTNSDKVVAPFQGREPFHGT
NPLAFAAPSGGARPWLLDMATSSIPLNRLLLCKSLGMSLPAGVAVDEAGQPTTEPFEGRTLLPLGGVDFSFKGAALAGVA
TLLSAILQGMTLDHALMPMVGTDDYSTPREMGHFLLAIDPDRFGGRGVFDEGMSAYLEALRSAPAQEGCEVLAPGDREWR
VEAARRQNGIPIDPDTAAFLGLSRSPAAPAGNAGEN
>Mature_355_residues
SLQTLVAPDLLEARVENALRNAGAAQGSAAAAVRAMMHASLIGVDSHGVRLVVHYDRVLRGGRVNGTPNLSVRRTAAATA
VVDGDNALGHHAAYVAMDKAIELARESGIGAVGVIRSSHFGAAGAYARVAAEAGMIGFATTNSDKVVAPFQGREPFHGTN
PLAFAAPSGGARPWLLDMATSSIPLNRLLLCKSLGMSLPAGVAVDEAGQPTTEPFEGRTLLPLGGVDFSFKGAALAGVAT
LLSAILQGMTLDHALMPMVGTDDYSTPREMGHFLLAIDPDRFGGRGVFDEGMSAYLEALRSAPAQEGCEVLAPGDREWRV
EAARRQNGIPIDPDTAAFLGLSRSPAAPAGNAGEN

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=336, Percent_Identity=33.6309523809524, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1787020, Length=327, Percent_Identity=30.5810397553517, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1790000, Length=338, Percent_Identity=28.9940828402367, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17507179, Length=288, Percent_Identity=31.25, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17536633, Length=344, Percent_Identity=30.2325581395349, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI45553211, Length=300, Percent_Identity=31.3333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24667912, Length=300, Percent_Identity=31.3333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24667908, Length=300, Percent_Identity=31.3333333333333, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24667904, Length=300, Percent_Identity=31.3333333333333, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24648360, Length=337, Percent_Identity=29.3768545994065, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24658010, Length=318, Percent_Identity=26.4150943396226, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 36811; Mature: 36680

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQTLVAPDLLEARVENALRNAGAAQGSAAAAVRAMMHASLIGVDSHGVRLVVHYDRVL
CCCHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEEEHHHH
RGGRVNGTPNLSVRRTAAATAVVDGDNALGHHAAYVAMDKAIELARESGIGAVGVIRSSH
CCCCCCCCCCCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
FGAAGAYARVAAEAGMIGFATTNSDKVVAPFQGREPFHGTNPLAFAAPSGGARPWLLDMA
CCCCHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEECC
TSSIPLNRLLLCKSLGMSLPAGVAVDEAGQPTTEPFEGRTLLPLGGVDFSFKGAALAGVA
CCCCCHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHH
TLLSAILQGMTLDHALMPMVGTDDYSTPREMGHFLLAIDPDRFGGRGVFDEGMSAYLEAL
HHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHH
RSAPAQEGCEVLAPGDREWRVEAARRQNGIPIDPDTAAFLGLSRSPAAPAGNAGEN
HCCCHHCCCEEECCCCCHHHHHHHHHCCCCCCCCCCHHHEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLQTLVAPDLLEARVENALRNAGAAQGSAAAAVRAMMHASLIGVDSHGVRLVVHYDRVL
CCHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEEEHHHH
RGGRVNGTPNLSVRRTAAATAVVDGDNALGHHAAYVAMDKAIELARESGIGAVGVIRSSH
CCCCCCCCCCCEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
FGAAGAYARVAAEAGMIGFATTNSDKVVAPFQGREPFHGTNPLAFAAPSGGARPWLLDMA
CCCCHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEECC
TSSIPLNRLLLCKSLGMSLPAGVAVDEAGQPTTEPFEGRTLLPLGGVDFSFKGAALAGVA
CCCCCHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHH
TLLSAILQGMTLDHALMPMVGTDDYSTPREMGHFLLAIDPDRFGGRGVFDEGMSAYLEAL
HHHHHHHCCCCCCHHHCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHH
RSAPAQEGCEVLAPGDREWRVEAARRQNGIPIDPDTAAFLGLSRSPAAPAGNAGEN
HCCCHHCCCEEECCCCCHHHHHHHHHCCCCCCCCCCHHHEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]