Click here to switch to the map view.

The map label for this gene is qor [C]

Identifier: 150397647

GI number: 150397647

Start: 2529698

End: 2530693

Strand: Reverse

Name: qor [C]

Synonym: Smed_2447

Alternate gene names: 150397647

Gene position: 2530693-2529698 (Counterclockwise)

Preceding gene: 150397648

Following gene: 150397646

Centisome position: 66.92

GC content: 65.16

Gene sequence:

>996_bases
ATGAAAGCCATTGTTCTCCCCGGACCGCAGGCGCAAATTGACAACGTGACACTGACCGACCTGCCGACCCCGGAGCCCGG
GCCGGGCGAACTGCGAATCAAGGTCATCGCCGTTTCCATCAATCCCGTGGACTGGAAGCTGACCTTCGATCACAAACCGG
AATGGACCTACCCGCATGTGCTGGGGCTCGACGCTGCCGGTGTGATCGATGCGGTCGGCCGGGGCGTCGAGGGCTGGAAA
GCCGGCGACAGGGCGGTCGTTCACAACAATCTCTGGAAGCCCGGCGTCTTCGCCGAATATTGCCTTGCGCCGGCGCACGC
GACATCGCGGCTGCCCGGCAGCGTGAACTTCACCGATGCGGCCGCCATCCCCTGTGCCGGCTATACGGCCTATCAGGCGC
TCTTCCGCAAGGCGAGGCTTGAGGCGGGGCAGACCATACTCATTCAGGGCGCCAATGGCGGTGTCGGCGGATTTGCCACG
CAACTTGCCCATCAGGCCGGGGCCACGGTCATCGCGCTGGCGCGGCCTGAGCATTTCGCCGCCGTACGCGGGTTCGGTGC
CGATATCGTCTTCGATTACCGGGACGCGGATCTGCTGCATAAGGTGCGGGCGGAAACGGAAGGCGGGGACGGCGTCGATG
TCATGCTCGAAGTCGTCAATCCCGGCGACGCCCGCAAGTCGCTCGCCTTCCTTCACTATAACGGGCATCTCGTATCCATC
GACCCGCTGCCGGTCATGACAGAGGTGCCGTCCTACACCTATGCCGCCTCGATCCACGAGGTGGCGCTTGGCGGCGCCTA
TCATGCCGGCCACCTGCCGACCCAGCGCGATTTCGCCCGTATCGGCGATGACATGATGGCGCGCCTTGCGGCAGGCAAGC
TCGATCCGATGGTCGAGGAGATCGTGGCGCTCGGAGACATACCGGACGCCCTGCGGCGGCTGCGGCGCCGGGACGTGACG
GGCAAGATCGTCGCCCGCATTGCTTCGGATGCCTGA

Upstream 100 bases:

>100_bases
TCGCCGGTGGCGTTCTTTATCTGTCCTCGCCGCTTGCAAGCTTCGTTACCGGCAGCGTGCTGGTCATCGATGGCGGCTAT
CTGATCATGTGAGGCACGAT

Downstream 100 bases:

>100_bases
CGAGAACAACCCAACGGGGAGGAAGAGCATGTCCACGAACACGCATTATATTGACGGCCGGTTTGTCGAGGATCGCATCT
CAGGCCGCATCGCGGTCTAC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Acryloyl-CoA reductase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKAIVLPGPQAQIDNVTLTDLPTPEPGPGELRIKVIAVSINPVDWKLTFDHKPEWTYPHVLGLDAAGVIDAVGRGVEGWK
AGDRAVVHNNLWKPGVFAEYCLAPAHATSRLPGSVNFTDAAAIPCAGYTAYQALFRKARLEAGQTILIQGANGGVGGFAT
QLAHQAGATVIALARPEHFAAVRGFGADIVFDYRDADLLHKVRAETEGGDGVDVMLEVVNPGDARKSLAFLHYNGHLVSI
DPLPVMTEVPSYTYAASIHEVALGGAYHAGHLPTQRDFARIGDDMMARLAAGKLDPMVEEIVALGDIPDALRRLRRRDVT
GKIVARIASDA

Sequences:

>Translated_331_residues
MKAIVLPGPQAQIDNVTLTDLPTPEPGPGELRIKVIAVSINPVDWKLTFDHKPEWTYPHVLGLDAAGVIDAVGRGVEGWK
AGDRAVVHNNLWKPGVFAEYCLAPAHATSRLPGSVNFTDAAAIPCAGYTAYQALFRKARLEAGQTILIQGANGGVGGFAT
QLAHQAGATVIALARPEHFAAVRGFGADIVFDYRDADLLHKVRAETEGGDGVDVMLEVVNPGDARKSLAFLHYNGHLVSI
DPLPVMTEVPSYTYAASIHEVALGGAYHAGHLPTQRDFARIGDDMMARLAAGKLDPMVEEIVALGDIPDALRRLRRRDVT
GKIVARIASDA
>Mature_331_residues
MKAIVLPGPQAQIDNVTLTDLPTPEPGPGELRIKVIAVSINPVDWKLTFDHKPEWTYPHVLGLDAAGVIDAVGRGVEGWK
AGDRAVVHNNLWKPGVFAEYCLAPAHATSRLPGSVNFTDAAAIPCAGYTAYQALFRKARLEAGQTILIQGANGGVGGFAT
QLAHQAGATVIALARPEHFAAVRGFGADIVFDYRDADLLHKVRAETEGGDGVDVMLEVVNPGDARKSLAFLHYNGHLVSI
DPLPVMTEVPSYTYAASIHEVALGGAYHAGHLPTQRDFARIGDDMMARLAAGKLDPMVEEIVALGDIPDALRRLRRRDVT
GKIVARIASDA

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA [H]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=313, Percent_Identity=30.0319488817891, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI13236495, Length=313, Percent_Identity=30.0319488817891, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI24308257, Length=348, Percent_Identity=26.4367816091954, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI194239676, Length=189, Percent_Identity=35.978835978836, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI47519420, Length=339, Percent_Identity=26.2536873156342, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI22538446, Length=228, Percent_Identity=30.2631578947368, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI22538444, Length=228, Percent_Identity=30.2631578947368, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI18379349, Length=318, Percent_Identity=26.1006289308176, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI28557745, Length=232, Percent_Identity=30.6034482758621, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790485, Length=313, Percent_Identity=26.8370607028754, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=360, Percent_Identity=25, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=209, Percent_Identity=28.7081339712919, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17507255, Length=199, Percent_Identity=29.6482412060301, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=342, Percent_Identity=26.6081871345029, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=334, Percent_Identity=24.251497005988, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=355, Percent_Identity=25.6338028169014, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=365, Percent_Identity=25.2054794520548, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=336, Percent_Identity=25.5952380952381, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=345, Percent_Identity=24.6376811594203, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319520, Length=321, Percent_Identity=24.9221183800623, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.3.1.84 [H]

Molecular weight: Translated: 35325; Mature: 35325

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIVLPGPQAQIDNVTLTDLPTPEPGPGELRIKVIAVSINPVDWKLTFDHKPEWTYPHV
CCEEECCCCCCCCCCEEEECCCCCCCCCCCEEEEEEEEEECCEEEEEEECCCCCCCCCEE
LGLDAAGVIDAVGRGVEGWKAGDRAVVHNNLWKPGVFAEYCLAPAHATSRLPGSVNFTDA
ECCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHCCCCCCCCCCC
AAIPCAGYTAYQALFRKARLEAGQTILIQGANGGVGGFATQLAHQAGATVIALARPEHFA
CCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCHHH
AVRGFGADIVFDYRDADLLHKVRAETEGGDGVDVMLEVVNPGDARKSLAFLHYNGHLVSI
HHHCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHEEEEEEECCEEEEE
DPLPVMTEVPSYTYAASIHEVALGGAYHAGHLPTQRDFARIGDDMMARLAAGKLDPMVEE
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
IVALGDIPDALRRLRRRDVTGKIVARIASDA
HHHHCCCHHHHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKAIVLPGPQAQIDNVTLTDLPTPEPGPGELRIKVIAVSINPVDWKLTFDHKPEWTYPHV
CCEEECCCCCCCCCCEEEECCCCCCCCCCCEEEEEEEEEECCEEEEEEECCCCCCCCCEE
LGLDAAGVIDAVGRGVEGWKAGDRAVVHNNLWKPGVFAEYCLAPAHATSRLPGSVNFTDA
ECCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHCCCCCCCCCCC
AAIPCAGYTAYQALFRKARLEAGQTILIQGANGGVGGFATQLAHQAGATVIALARPEHFA
CCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCHHH
AVRGFGADIVFDYRDADLLHKVRAETEGGDGVDVMLEVVNPGDARKSLAFLHYNGHLVSI
HHHCCCCEEEEECCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHEEEEEEECCEEEEE
DPLPVMTEVPSYTYAASIHEVALGGAYHAGHLPTQRDFARIGDDMMARLAAGKLDPMVEE
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
IVALGDIPDALRRLRRRDVTGKIVARIASDA
HHHHCCCHHHHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]