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The map label for this gene is coxN [H]

Identifier: 150397626

GI number: 150397626

Start: 2504004

End: 2505782

Strand: Direct

Name: coxN [H]

Synonym: Smed_2426

Alternate gene names: 150397626

Gene position: 2504004-2505782 (Clockwise)

Preceding gene: 150397625

Following gene: 150397627

Centisome position: 66.21

GC content: 60.15

Gene sequence:

>1779_bases
ATGGTCGACGTCCGGTCCGGTATTGGCGAGGCACTCCCGCCTCCCGAAGTCGAGGATGTTGAGCTTTACCATCCGCATAG
CTGGTGGACGCGCTATGTCTTCAGCCAGGATGCGAAAATCATCGCCATTCAGTACGGAACGACCGCAATCGCCATCGGAA
TGGTTGCGCTTGCACTCTCCTGGCTGATCCGGCTGCAACTCGGTTTTCCCGGCACGTTCGAGCTGATCGATGCCGAGCGC
TATTATCAGTTCATCACCATGCACGGCATGATCATGGTAATCTATCTGCTCACCGCACTCTTCCTCGGCGGCTTCGGCAA
CTATCTGATCCCGCTGATGGTCGGCGCGCGCGACATGGTGTTTCCCTACGCCAACATGCTGAGCTATTGGATTTATCTGC
TCGCCGTGCTCGTCCTGGCCGCCAGTTTCTTCACGCCCGGCGGACCGACGGGCGCCGGCTGGACGCTCTATCCGCCCCAG
GCCGTTCTTTCCGGCACACCCGGCGGCAGGGACTGGGGCATCATCATGATGCTGTCGTCCCTGATCATCTTCATCATCGG
CTTCACCATGGGTGGCCTCAACTATGTCGTAACCGTTCTCCAGGGCCGTGCGCGTGGTATGACTCTGATGCGGCTGCCGC
TGACCGTCTGGGGTATTTTCACCGCGACCGTGATGGCGCTCCTTGCCTTCCCTGCCCTTTTCGTCGCCTGCGTCATGATG
CTCTTCGACCGGCTGCTCGGCACGAGTTTCTTCATGCCGGCCATTGTCGAAATGGGCGAGCAGCTGCAGCATGGCGGCGG
CAGCCCGATCCTCTTCCAGCACCTGTTCTGGTTTTTCGGCCATCCCGAAGTCTACATCGTCGCGCTTCCCGCCTTCGGCA
TCGTTTCCGATCTCATCAGCACCCACGCGCGCAAGAACATCTTCGGCTATCGCATGATGGTCTGGGCAATCGTCGTCATC
GGCGGGCTGTCTTTCATCGTCTGGGCGCACCATATGTATGTCAGCGGCATGAACCCCTATTTCGGCTTCTTCTTCGCCAC
CACGACGCTGATCATTGCGGTGCCGACGGCGATCAAGGTCTATAACTGGGTGCTCACCCTCTGGCGCGGCAACATCCATC
TGACGCTGCCGATGCTCTTTGCGCTCGCCTTCATCGTCACCTTCGTCAATGGCGGACTGACGGGCCTCTTCCTCGGCAAT
GTCGTCGTCGACGTTCCGCTCTCCGACACCATGTTCGTCGTCGCGCATTTCCACATGGTCATGGGCGTTGCCCCGATCAT
GGTCATCTTCGGCGCCATCTATCACTGGTATCCGAAGATCACCGGGCGCATGCTCAACGAAGCGATGGGCCAGATCCATT
TCTGGATCAGCTTCATCGGCGCCTATGCGATCTTCTTCCCGATGCACTATCTCGGCCTCATCGGCGTTCCGCGCCGCTAT
CACGAACTCGGCGAGGCCTCGTTCGTCTCGACATCGATCGCCGAGCTCAACGCCTTCATCAGCGTCATGGCGCTGCTCGT
CGGCGCGGCGCAGATCCTGTTTCTCTTCAATCTCGTCTGGAGCCTTCGCCACGGCAGGGAAGCCGGTGGCAATCCATGGC
GTGCGACCACGCTCGAATGGCAGACACCGGAGACGCCGCCGGCTCACGGCAACTGGGGCAAGGAACTGCCCGTCGTCTAC
CGTTGGGCCTACGATTACAGTGTTCCCGGGGCGCCCGAAGATTTCATTCCGCAGAACCAGCCGACGCCAGGCCGCTTGAG
CCATGAGGCTGCCTCATGA

Upstream 100 bases:

>100_bases
TCGAAGAAGAGCGTGAATGCTCCAGCCCCACGGCGACAGCGGTCGCCGCCTCAGCGGCGCAGTAGGAGGCGCCGTGCAGT
AGCCCCTGGGAGGAGATATG

Downstream 100 bases:

>100_bases
GCGTCGTCCTTTTCTTTCTGGCGGCGATCGCTGCCATCGTCGTCTGGTGGCTTGCCGGACAGCGCCTGACGTCGAGGCCA
TGGCTCGAGATCGGGCACCT

Product: cytochrome c oxidase subunit I type

Products: NA

Alternate protein names: Alternative cytochrome c oxidase polypeptide I; Cytochrome BB3 subunit 1; Oxidase BB(3) subunit 1 [H]

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MVDVRSGIGEALPPPEVEDVELYHPHSWWTRYVFSQDAKIIAIQYGTTAIAIGMVALALSWLIRLQLGFPGTFELIDAER
YYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFPYANMLSYWIYLLAVLVLAASFFTPGGPTGAGWTLYPPQ
AVLSGTPGGRDWGIIMMLSSLIIFIIGFTMGGLNYVVTVLQGRARGMTLMRLPLTVWGIFTATVMALLAFPALFVACVMM
LFDRLLGTSFFMPAIVEMGEQLQHGGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLISTHARKNIFGYRMMVWAIVVI
GGLSFIVWAHHMYVSGMNPYFGFFFATTTLIIAVPTAIKVYNWVLTLWRGNIHLTLPMLFALAFIVTFVNGGLTGLFLGN
VVVDVPLSDTMFVVAHFHMVMGVAPIMVIFGAIYHWYPKITGRMLNEAMGQIHFWISFIGAYAIFFPMHYLGLIGVPRRY
HELGEASFVSTSIAELNAFISVMALLVGAAQILFLFNLVWSLRHGREAGGNPWRATTLEWQTPETPPAHGNWGKELPVVY
RWAYDYSVPGAPEDFIPQNQPTPGRLSHEAAS

Sequences:

>Translated_592_residues
MVDVRSGIGEALPPPEVEDVELYHPHSWWTRYVFSQDAKIIAIQYGTTAIAIGMVALALSWLIRLQLGFPGTFELIDAER
YYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFPYANMLSYWIYLLAVLVLAASFFTPGGPTGAGWTLYPPQ
AVLSGTPGGRDWGIIMMLSSLIIFIIGFTMGGLNYVVTVLQGRARGMTLMRLPLTVWGIFTATVMALLAFPALFVACVMM
LFDRLLGTSFFMPAIVEMGEQLQHGGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLISTHARKNIFGYRMMVWAIVVI
GGLSFIVWAHHMYVSGMNPYFGFFFATTTLIIAVPTAIKVYNWVLTLWRGNIHLTLPMLFALAFIVTFVNGGLTGLFLGN
VVVDVPLSDTMFVVAHFHMVMGVAPIMVIFGAIYHWYPKITGRMLNEAMGQIHFWISFIGAYAIFFPMHYLGLIGVPRRY
HELGEASFVSTSIAELNAFISVMALLVGAAQILFLFNLVWSLRHGREAGGNPWRATTLEWQTPETPPAHGNWGKELPVVY
RWAYDYSVPGAPEDFIPQNQPTPGRLSHEAAS
>Mature_592_residues
MVDVRSGIGEALPPPEVEDVELYHPHSWWTRYVFSQDAKIIAIQYGTTAIAIGMVALALSWLIRLQLGFPGTFELIDAER
YYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMVFPYANMLSYWIYLLAVLVLAASFFTPGGPTGAGWTLYPPQ
AVLSGTPGGRDWGIIMMLSSLIIFIIGFTMGGLNYVVTVLQGRARGMTLMRLPLTVWGIFTATVMALLAFPALFVACVMM
LFDRLLGTSFFMPAIVEMGEQLQHGGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLISTHARKNIFGYRMMVWAIVVI
GGLSFIVWAHHMYVSGMNPYFGFFFATTTLIIAVPTAIKVYNWVLTLWRGNIHLTLPMLFALAFIVTFVNGGLTGLFLGN
VVVDVPLSDTMFVVAHFHMVMGVAPIMVIFGAIYHWYPKITGRMLNEAMGQIHFWISFIGAYAIFFPMHYLGLIGVPRRY
HELGEASFVSTSIAELNAFISVMALLVGAAQILFLFNLVWSLRHGREAGGNPWRATTLEWQTPETPPAHGNWGKELPVVY
RWAYDYSVPGAPEDFIPQNQPTPGRLSHEAAS

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=520, Percent_Identity=39.2307692307692, Blast_Score=333, Evalue=2e-91,
Organism=Escherichia coli, GI1786634, Length=522, Percent_Identity=35.4406130268199, Blast_Score=305, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6226519, Length=478, Percent_Identity=41.0041841004184, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6226524, Length=337, Percent_Identity=39.7626112759644, Blast_Score=246, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6226523, Length=259, Percent_Identity=36.6795366795367, Blast_Score=152, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 65895; Mature: 65895

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDVRSGIGEALPPPEVEDVELYHPHSWWTRYVFSQDAKIIAIQYGTTAIAIGMVALALS
CCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
WLIRLQLGFPGTFELIDAERYYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMV
HHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHH
FPYANMLSYWIYLLAVLVLAASFFTPGGPTGAGWTLYPPQAVLSGTPGGRDWGIIMMLSS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHCCCCCCCCHHHHHHHHH
LIIFIIGFTMGGLNYVVTVLQGRARGMTLMRLPLTVWGIFTATVMALLAFPALFVACVMM
HHHHHHHHHHCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFDRLLGTSFFMPAIVEMGEQLQHGGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLIS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHH
THARKNIFGYRMMVWAIVVIGGLSFIVWAHHMYVSGMNPYFGFFFATTTLIIAVPTAIKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YNWVLTLWRGNIHLTLPMLFALAFIVTFVNGGLTGLFLGNVVVDVPLSDTMFVVAHFHMV
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCHHHEECCCEEEECCCCCHHHHHHHHHHH
MGVAPIMVIFGAIYHWYPKITGRMLNEAMGQIHFWISFIGAYAIFFPMHYLGLIGVPRRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
HELGEASFVSTSIAELNAFISVMALLVGAAQILFLFNLVWSLRHGREAGGNPWRATTLEW
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
QTPETPPAHGNWGKELPVVYRWAYDYSVPGAPEDFIPQNQPTPGRLSHEAAS
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVDVRSGIGEALPPPEVEDVELYHPHSWWTRYVFSQDAKIIAIQYGTTAIAIGMVALALS
CCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
WLIRLQLGFPGTFELIDAERYYQFITMHGMIMVIYLLTALFLGGFGNYLIPLMVGARDMV
HHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHH
FPYANMLSYWIYLLAVLVLAASFFTPGGPTGAGWTLYPPQAVLSGTPGGRDWGIIMMLSS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHCCCCCCCCHHHHHHHHH
LIIFIIGFTMGGLNYVVTVLQGRARGMTLMRLPLTVWGIFTATVMALLAFPALFVACVMM
HHHHHHHHHHCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFDRLLGTSFFMPAIVEMGEQLQHGGGSPILFQHLFWFFGHPEVYIVALPAFGIVSDLIS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHH
THARKNIFGYRMMVWAIVVIGGLSFIVWAHHMYVSGMNPYFGFFFATTTLIIAVPTAIKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YNWVLTLWRGNIHLTLPMLFALAFIVTFVNGGLTGLFLGNVVVDVPLSDTMFVVAHFHMV
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCHHHEECCCEEEECCCCCHHHHHHHHHHH
MGVAPIMVIFGAIYHWYPKITGRMLNEAMGQIHFWISFIGAYAIFFPMHYLGLIGVPRRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
HELGEASFVSTSIAELNAFISVMALLVGAAQILFLFNLVWSLRHGREAGGNPWRATTLEW
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
QTPETPPAHGNWGKELPVVYRWAYDYSVPGAPEDFIPQNQPTPGRLSHEAAS
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1444719; 12597275 [H]