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The map label for this gene is cysQ [H]

Identifier: 150397598

GI number: 150397598

Start: 2474157

End: 2474933

Strand: Direct

Name: cysQ [H]

Synonym: Smed_2398

Alternate gene names: 150397598

Gene position: 2474157-2474933 (Clockwise)

Preceding gene: 150397591

Following gene: 150397601

Centisome position: 65.42

GC content: 62.81

Gene sequence:

>777_bases
ATGCTCGAAATACTGGAAGCCTCGGCGCTCGCCGCCGGACAAGCAATTATGGAGATCTATCTTGCCGGCCCCTCGGTCAC
CTACAAGCGGGACGCCTCGCCGGTAACCGATGCGGACCATCGTGCCGAGCGGATCATTCTTGCCGACCTGGCGGCCGCCT
TTCCAGATATCCCCGTCGTAGCGGAAGAGGAGGTCGCAGCAGGCCGCGTTCCCGATATCGCCGGCAAGCGGTTCTTCCTC
GTCGATCCGCTGGACGGCACGAAGGAATTCGTCAAGCGCAACAGCCATTTTACCGTCAATATCGGGCTCATCGAAAATGG
CGAGCCGGTGACTGGCGTCGTCTATGCGCCGGCGCTCGGCCTGATCTATTCGGCAGCCGCTGGCAGGGCGAAGAAGGCGC
TGGTGGAGAATGGCAAGCCTGCCGGTCAATGGACGACGATCGGCTGCCGCCGATGCGGCGACCGCCCCATGGCGTTGACC
AGCCGCTGGCACAACAGCCCCGAAACCGTATCCTTCCTTACCGATCAGGGCATAGAGGACAGCGAGGCAGTCGGGTCGTC
GCTGAAATTTTGCCTCCTGGCGGAAGGCACGGCCGATATCTATCCGCGATTCAGCCGGACGATGGAGTGGGACACCGCGG
CCGGCGACGCGATTCTGAGGGCAGCGGGCGGAGAGACGTTGACGACGGCGGGCATTTCACTTGCCTACGGCAAGCGCAAT
CAACCGGACGACAGCGACTTCGCCAATCCATGGTTCATCTCACGCGGGCGAGCGTGA

Upstream 100 bases:

>100_bases
ACTAAGAAGCGCAGGTTCAAAGTGCTACAGTGACCTTTCCACGTCTGATAAGACGCGAGCGCCCGATGCGAATCGCTGCG
ACGCCAAAGAACAGGAAACA

Downstream 100 bases:

>100_bases
CCCGAAGGCAACTGCTCGCCTTCGCGCGTATCATCGGCGCTGCAGACGTTCACACGTCCCGTGGATTGGCAGCAGTGGCA
ATGAGACTGCTCAGCGTTCC

Product: 3'(2'),5'-bisphosphate nucleotidase

Products: NA

Alternate protein names: 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; 3'-phosphoadenosine 5'-phosphate phosphatase; PAP phosphatase; DPNPase [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MLEILEASALAAGQAIMEIYLAGPSVTYKRDASPVTDADHRAERIILADLAAAFPDIPVVAEEEVAAGRVPDIAGKRFFL
VDPLDGTKEFVKRNSHFTVNIGLIENGEPVTGVVYAPALGLIYSAAAGRAKKALVENGKPAGQWTTIGCRRCGDRPMALT
SRWHNSPETVSFLTDQGIEDSEAVGSSLKFCLLAEGTADIYPRFSRTMEWDTAAGDAILRAAGGETLTTAGISLAYGKRN
QPDDSDFANPWFISRGRA

Sequences:

>Translated_258_residues
MLEILEASALAAGQAIMEIYLAGPSVTYKRDASPVTDADHRAERIILADLAAAFPDIPVVAEEEVAAGRVPDIAGKRFFL
VDPLDGTKEFVKRNSHFTVNIGLIENGEPVTGVVYAPALGLIYSAAAGRAKKALVENGKPAGQWTTIGCRRCGDRPMALT
SRWHNSPETVSFLTDQGIEDSEAVGSSLKFCLLAEGTADIYPRFSRTMEWDTAAGDAILRAAGGETLTTAGISLAYGKRN
QPDDSDFANPWFISRGRA
>Mature_258_residues
MLEILEASALAAGQAIMEIYLAGPSVTYKRDASPVTDADHRAERIILADLAAAFPDIPVVAEEEVAAGRVPDIAGKRFFL
VDPLDGTKEFVKRNSHFTVNIGLIENGEPVTGVVYAPALGLIYSAAAGRAKKALVENGKPAGQWTTIGCRRCGDRPMALT
SRWHNSPETVSFLTDQGIEDSEAVGSSLKFCLLAEGTADIYPRFSRTMEWDTAAGDAILRAAGGETLTTAGISLAYGKRN
QPDDSDFANPWFISRGRA

Specific function: Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) [H]

COG id: COG1218

COG function: function code P; 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=233, Percent_Identity=31.7596566523605, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI5031789, Length=235, Percent_Identity=26.8085106382979, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI221625487, Length=235, Percent_Identity=26.8085106382979, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1790659, Length=254, Percent_Identity=43.3070866141732, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1788882, Length=226, Percent_Identity=25.2212389380531, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193202570, Length=209, Percent_Identity=26.7942583732057, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193202572, Length=206, Percent_Identity=26.6990291262136, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324508, Length=272, Percent_Identity=26.8382352941176, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320493, Length=199, Percent_Identity=29.1457286432161, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321836, Length=209, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357957, Length=237, Percent_Identity=27.0042194092827, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24664926, Length=204, Percent_Identity=27.4509803921569, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664922, Length=216, Percent_Identity=30.0925925925926, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24664918, Length=232, Percent_Identity=27.5862068965517, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641722, Length=244, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006240
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.7 [H]

Molecular weight: Translated: 27588; Mature: 27588

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEILEASALAAGQAIMEIYLAGPSVTYKRDASPVTDADHRAERIILADLAAAFPDIPVV
CCCCHHHHHHHHHHEEEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCE
AEEEVAAGRVPDIAGKRFFLVDPLDGTKEFVKRNSHFTVNIGLIENGEPVTGVVYAPALG
ECCCHHCCCCCCCCCCEEEEECCCCCHHHHHHCCCCEEEEEEEEECCCCCEEEEHHHHHH
LIYSAAAGRAKKALVENGKPAGQWTTIGCRRCGDRPMALTSRWHNSPETVSFLTDQGIED
HHHHHHCCHHHHHHHHCCCCCCCEEEEHHHHCCCCCCCHHHHHCCCCCEEEEECCCCCCH
SEAVGSSLKFCLLAEGTADIYPRFSRTMEWDTAAGDAILRAAGGETLTTAGISLAYGKRN
HHHHCCCCEEEEEECCCHHHCHHHHCCCCCCCCCCCCEEEECCCCEEEECCEEEEECCCC
QPDDSDFANPWFISRGRA
CCCCCCCCCCEEEECCCC
>Mature Secondary Structure
MLEILEASALAAGQAIMEIYLAGPSVTYKRDASPVTDADHRAERIILADLAAAFPDIPVV
CCCCHHHHHHHHHHEEEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCE
AEEEVAAGRVPDIAGKRFFLVDPLDGTKEFVKRNSHFTVNIGLIENGEPVTGVVYAPALG
ECCCHHCCCCCCCCCCEEEEECCCCCHHHHHHCCCCEEEEEEEEECCCCCEEEEHHHHHH
LIYSAAAGRAKKALVENGKPAGQWTTIGCRRCGDRPMALTSRWHNSPETVSFLTDQGIED
HHHHHHCCHHHHHHHHCCCCCCCEEEEHHHHCCCCCCCHHHHHCCCCCEEEEECCCCCCH
SEAVGSSLKFCLLAEGTADIYPRFSRTMEWDTAAGDAILRAAGGETLTTAGISLAYGKRN
HHHHCCCCEEEEEECCCHHHCHHHHCCCCCCCCCCCCEEEECCCCEEEECCEEEEECCCC
QPDDSDFANPWFISRGRA
CCCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]