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The map label for this gene is gyaR [H]

Identifier: 150397590

GI number: 150397590

Start: 2465841

End: 2466815

Strand: Reverse

Name: gyaR [H]

Synonym: Smed_2390

Alternate gene names: 150397590

Gene position: 2466815-2465841 (Counterclockwise)

Preceding gene: 150397592

Following gene: 150397589

Centisome position: 65.23

GC content: 64.41

Gene sequence:

>975_bases
GTGACTGCGAGATTCCGTATTCTTGTCACTCGCCGCTGGCCGCGAGCCGTCGAACAGGTCTTGGCCGAAAGGTTCGAGAC
AGTTCTCAACGAGGAGGACAGGCCGCTCGACAGAAGTGCCCTCGCGGATGCGCTGCGCAATTTCGATGCGGTGCTGCCGA
CCGTCTCCGACCGCCTGCCGGAGGATGTTTTCGCGGGCGAGGGGCTTCGCGCCCGGATTCTCGGCAATTTCGGGGTGGGC
TACAATCATATCGACATCGAGGCTGCCAAGGCTGCAGGTATCGTGGTGACGAACACGCCAGGCGTTCTGACCGACTGCAC
CGCAGACCTCGCGGTATCGCTGCTGCTTGCGGTCGCGCGGCGCGCGGGCGAGGGCGAGCGGCAGGTGAGGACCGGCACTT
GGACTGGCTGGCGGCCGACCCATATGATCGGGACGAAGGTAACCGGAAAGACACTCGGCATCATCGGATTCGGGCGCATC
GGCAAGGCCATGGCGAAGCGCTGCCATTTCGGCTTCGACATGGATGTCGTCTTCTACAATCGATCGAGAATCGCACCGGA
GGAAGCGGCTCGATTCGGGGCACGACAGTTCCGCACGGTCGAGAACGTACTCAAGGCAGCAGATTTCGTGTCGCTGCATT
GCCCGGGCGGCGGCGAGAACCGGAATCTGATCGACGCGGAGCGTCTGGCGGCGATGAAGCCCGGCGCCTACCTCATCAAC
ACGGCGCGCGGCGATGTCGTCGATGAAGCCGCGTTGATCGAGGCCCTCGAGAAGGGCGTGATCCGCGGCGCCGGTCTCGA
CGTCTATGCGGCAGAGCCGGACGTACCGGCCCGTCTGAGCGCGCTTGAAAACGTCGTGCTGCTACCGCATCTCGGAAGCG
CCACGGAGGAGACGCGCACGGCAATGGGAATGAAGGTGGTCGACAACGTCACGGCTTTCTTCGCCGGCCTGGCGCCGCCG
GACCGAGTGGCGTGA

Upstream 100 bases:

>100_bases
TGACATTTTGCAATTTCTTGGTAGAACTTGCGTTCAGGTAATAGACAAACTTATTACTTATGTAAACCTTAGCGCTGGTG
TTTTTTATGGAGGTAGCATT

Downstream 100 bases:

>100_bases
CTTTCGGGTGCGTTGGCCGACCTCATGAAAGCTACGATTTGACTTTGCCCTTGTGGTTTCGGACGATAGTCGTATCGGCA
GGAACACTTCGGCGAAGATC

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTARFRILVTRRWPRAVEQVLAERFETVLNEEDRPLDRSALADALRNFDAVLPTVSDRLPEDVFAGEGLRARILGNFGVG
YNHIDIEAAKAAGIVVTNTPGVLTDCTADLAVSLLLAVARRAGEGERQVRTGTWTGWRPTHMIGTKVTGKTLGIIGFGRI
GKAMAKRCHFGFDMDVVFYNRSRIAPEEAARFGARQFRTVENVLKAADFVSLHCPGGGENRNLIDAERLAAMKPGAYLIN
TARGDVVDEAALIEALEKGVIRGAGLDVYAAEPDVPARLSALENVVLLPHLGSATEETRTAMGMKVVDNVTAFFAGLAPP
DRVA

Sequences:

>Translated_324_residues
MTARFRILVTRRWPRAVEQVLAERFETVLNEEDRPLDRSALADALRNFDAVLPTVSDRLPEDVFAGEGLRARILGNFGVG
YNHIDIEAAKAAGIVVTNTPGVLTDCTADLAVSLLLAVARRAGEGERQVRTGTWTGWRPTHMIGTKVTGKTLGIIGFGRI
GKAMAKRCHFGFDMDVVFYNRSRIAPEEAARFGARQFRTVENVLKAADFVSLHCPGGGENRNLIDAERLAAMKPGAYLIN
TARGDVVDEAALIEALEKGVIRGAGLDVYAAEPDVPARLSALENVVLLPHLGSATEETRTAMGMKVVDNVTAFFAGLAPP
DRVA
>Mature_323_residues
TARFRILVTRRWPRAVEQVLAERFETVLNEEDRPLDRSALADALRNFDAVLPTVSDRLPEDVFAGEGLRARILGNFGVGY
NHIDIEAAKAAGIVVTNTPGVLTDCTADLAVSLLLAVARRAGEGERQVRTGTWTGWRPTHMIGTKVTGKTLGIIGFGRIG
KAMAKRCHFGFDMDVVFYNRSRIAPEEAARFGARQFRTVENVLKAADFVSLHCPGGGENRNLIDAERLAAMKPGAYLINT
ARGDVVDEAALIEALEKGVIRGAGLDVYAAEPDVPARLSALENVVLLPHLGSATEETRTAMGMKVVDNVTAFFAGLAPPD
RVA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=323, Percent_Identity=35.2941176470588, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI23308577, Length=276, Percent_Identity=33.3333333333333, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI145580578, Length=238, Percent_Identity=36.5546218487395, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI4557499, Length=238, Percent_Identity=36.5546218487395, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI61743967, Length=238, Percent_Identity=36.9747899159664, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI4557497, Length=238, Percent_Identity=36.9747899159664, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI145580575, Length=238, Percent_Identity=36.5546218487395, Blast_Score=130, Evalue=1e-30,
Organism=Escherichia coli, GI87082289, Length=248, Percent_Identity=44.3548387096774, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1789279, Length=313, Percent_Identity=31.3099041533546, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787645, Length=258, Percent_Identity=29.4573643410853, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788660, Length=279, Percent_Identity=27.2401433691756, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=272, Percent_Identity=30.8823529411765, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=257, Percent_Identity=28.7937743190661, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=235, Percent_Identity=39.1489361702128, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320925, Length=310, Percent_Identity=31.2903225806452, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322116, Length=308, Percent_Identity=30.8441558441558, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6325144, Length=169, Percent_Identity=30.1775147928994, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=260, Percent_Identity=27.3076923076923, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=172, Percent_Identity=29.0697674418605, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI28571528, Length=322, Percent_Identity=37.2670807453416, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI45551003, Length=315, Percent_Identity=34.2857142857143, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI45552429, Length=315, Percent_Identity=34.2857142857143, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24585514, Length=315, Percent_Identity=34.2857142857143, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI28574282, Length=315, Percent_Identity=34.2857142857143, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI28574284, Length=315, Percent_Identity=34.2857142857143, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28574286, Length=320, Percent_Identity=33.75, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI19921140, Length=311, Percent_Identity=31.1897106109325, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=27.8846153846154, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24646446, Length=239, Percent_Identity=35.9832635983264, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=239, Percent_Identity=35.9832635983264, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=239, Percent_Identity=35.9832635983264, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=239, Percent_Identity=35.9832635983264, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472511, Length=239, Percent_Identity=35.9832635983264, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35035; Mature: 34903

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARFRILVTRRWPRAVEQVLAERFETVLNEEDRPLDRSALADALRNFDAVLPTVSDRLP
CCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHCC
EDVFAGEGLRARILGNFGVGYNHIDIEAAKAAGIVVTNTPGVLTDCTADLAVSLLLAVAR
HHHHCCCCCEEEEEECCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
RAGEGERQVRTGTWTGWRPTHMIGTKVTGKTLGIIGFGRIGKAMAKRCHFGFDMDVVFYN
HCCCCCCEEECCCCCCCCCCCEECCEECCCEEEEEECHHHHHHHHHHHCCCCCEEEEEEC
RSRIAPEEAARFGARQFRTVENVLKAADFVSLHCPGGGENRNLIDAERLAAMKPGAYLIN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHCCCCCEEEE
TARGDVVDEAALIEALEKGVIRGAGLDVYAAEPDVPARLSALENVVLLPHLGSATEETRT
CCCCCHHHHHHHHHHHHHCCEECCCCEEEECCCCCCHHHHHHCCEEEECCCCCCHHHHHH
AMGMKVVDNVTAFFAGLAPPDRVA
HHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TARFRILVTRRWPRAVEQVLAERFETVLNEEDRPLDRSALADALRNFDAVLPTVSDRLP
CCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHCC
EDVFAGEGLRARILGNFGVGYNHIDIEAAKAAGIVVTNTPGVLTDCTADLAVSLLLAVAR
HHHHCCCCCEEEEEECCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
RAGEGERQVRTGTWTGWRPTHMIGTKVTGKTLGIIGFGRIGKAMAKRCHFGFDMDVVFYN
HCCCCCCEEECCCCCCCCCCCEECCEECCCEEEEEECHHHHHHHHHHHCCCCCEEEEEEC
RSRIAPEEAARFGARQFRTVENVLKAADFVSLHCPGGGENRNLIDAERLAAMKPGAYLIN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHCCCCCEEEE
TARGDVVDEAALIEALEKGVIRGAGLDVYAAEPDVPARLSALENVVLLPHLGSATEETRT
CCCCCHHHHHHHHHHHHHCCEECCCCEEEECCCCCCHHHHHHCCEEEECCCCCCHHHHHH
AMGMKVVDNVTAFFAGLAPPDRVA
HHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA