Click here to switch to the map view.

The map label for this gene is dht [H]

Identifier: 150397567

GI number: 150397567

Start: 2445501

End: 2446955

Strand: Direct

Name: dht [H]

Synonym: Smed_2367

Alternate gene names: 150397567

Gene position: 2445501-2446955 (Clockwise)

Preceding gene: 150397566

Following gene: 150397569

Centisome position: 64.66

GC content: 62.82

Gene sequence:

>1455_bases
ATGAGCACTGTCATAAAGGGTGGAACCATCGTTACGGCCGACCTGACCTACAGGGCCGACGTGAAGATCGAGGGCGGCAG
GATCGTCGGGATCGGGCCGAACCTATCGGCTGCCGAGACACTGGACGCTACCGGCTGCTACGTCATGCCGGGCGGCATCG
ATCCGCACACCCATCTCGAAATGCCCTTCATGGGCACCTATTCCTCGGACGATTTCGAAAGCGGGACGCGGGCAGCGCTT
GCCGGCGGCACGACGATGGTCGTCGACTTCGCCCTCCCCTCGCCCGGTCAGTCGCTGCTCGAAGCGCTCACGATGTGGGA
CAACAAGTCGACGCGCGCCAATTGCGACTATTCCTTCCACATGGCGATCACCTGGTGGAGCGAGCAGGTCTTCAACGAGA
TGGAGTCCGTCGTCAAAGAGAAGGGCATCAACACCTTCAAGCACTTCATGGCTTATAAAGGCGCTCTGATGGTGGACGAT
GACGAGATGTTTTCCTCATTCCAGCGCTGCGCGGCACTTGGCGCCCTGCCGCTGGTTCACGCCGAGAACGGCGACGTGGT
TGCGCAGTTGCAGGCGAAGCTGCTGGCGGAAGGAAATTCCGGTCCCGAGGCGCATGCCTATTCGCGGCCGGCAGAAGTCG
AGGGCGAGGCCACCAACCGGGCGATCATGATCGCCGACATGGCCGGCTGTCCCGTCTACATCGTGCACACCTCCTGCGAA
CAGTCGCATGAGGCCATCCGGCGCGCCCGCGCCAAGGGCATGCGCGTCTTCGGCGAGCCCTTGATCCAGCACCTGACCCT
CGACGAGACGGAGTATTTCGACAAGGACTGGGACCACGCCGCACGTCGGGTGATGTCACCGCCCTTCCGCAACAAGCTGC
ATCAGGACAGCCTCTGGGCGGGCCTCGCCTCCGGTTCGCTGCAGGTGGTCGCGACCGATCATTGCGCCTTCACGACCGAG
CAGAAACGCTTCGGCGTCGGCGATTTCACCAGGATCCCGAACGGCACCGGCGGCCTGGAGGATCGCATGCCGATGCTCTG
GACCCATGGCGTCGCGACTGGCCGCATCACCATGAACGAATTCGTGGCGGTCACCTCGACCAACATCGCCAAGATCCTCA
ACATCTATCCGAAGAAGGGTGCAATCCTCGTCGGCGCCGATGCCGACATCGTCGTGTGGGACCCGAAGCGGTCGAAGACG
ATCTCTGCGAAGACGCAGCAATCGGCGATCGACTACAACGTCTTCGAAGGCAAGACCGTTACCGGTCTTCCGCGCTTCAC
GCTGTCGCGTGGCGTGGTTTCTATCGAGGAGGGTTCGGTCAAGACACAGGAAGGCCACGGCGAATTCGTGCGGCGCGACC
CCTTCCCCGCTGTCAGCACCGCGCTTTCGACCTGGAAGGAAGTGACGGCACCTCGCGCAGTACAGCGCAGCGGCATCCCC
GCAAGCGGCGTCTGA

Upstream 100 bases:

>100_bases
CATGCAGCAATTCAAAGGATGCAGCGCCTTTGCACGTCTGAGACATGCGGCGCTGCAGGCGGCTCAGCCGCCGAAAGCAT
CATCCAGAGGAACATAATCC

Downstream 100 bases:

>100_bases
ACCGAGATGCCGCACCCCTATGCCATCAGACAAAAATACGTCGGCGACCCGTCAGGCGGGCACCAGCTCGTCAAGTTCCG
GCAACAGCACGACGCTCTCG

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSTVIKGGTIVTADLTYRADVKIEGGRIVGIGPNLSAAETLDATGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAAL
AGGTTMVVDFALPSPGQSLLEALTMWDNKSTRANCDYSFHMAITWWSEQVFNEMESVVKEKGINTFKHFMAYKGALMVDD
DEMFSSFQRCAALGALPLVHAENGDVVAQLQAKLLAEGNSGPEAHAYSRPAEVEGEATNRAIMIADMAGCPVYIVHTSCE
QSHEAIRRARAKGMRVFGEPLIQHLTLDETEYFDKDWDHAARRVMSPPFRNKLHQDSLWAGLASGSLQVVATDHCAFTTE
QKRFGVGDFTRIPNGTGGLEDRMPMLWTHGVATGRITMNEFVAVTSTNIAKILNIYPKKGAILVGADADIVVWDPKRSKT
ISAKTQQSAIDYNVFEGKTVTGLPRFTLSRGVVSIEEGSVKTQEGHGEFVRRDPFPAVSTALSTWKEVTAPRAVQRSGIP
ASGV

Sequences:

>Translated_484_residues
MSTVIKGGTIVTADLTYRADVKIEGGRIVGIGPNLSAAETLDATGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAAL
AGGTTMVVDFALPSPGQSLLEALTMWDNKSTRANCDYSFHMAITWWSEQVFNEMESVVKEKGINTFKHFMAYKGALMVDD
DEMFSSFQRCAALGALPLVHAENGDVVAQLQAKLLAEGNSGPEAHAYSRPAEVEGEATNRAIMIADMAGCPVYIVHTSCE
QSHEAIRRARAKGMRVFGEPLIQHLTLDETEYFDKDWDHAARRVMSPPFRNKLHQDSLWAGLASGSLQVVATDHCAFTTE
QKRFGVGDFTRIPNGTGGLEDRMPMLWTHGVATGRITMNEFVAVTSTNIAKILNIYPKKGAILVGADADIVVWDPKRSKT
ISAKTQQSAIDYNVFEGKTVTGLPRFTLSRGVVSIEEGSVKTQEGHGEFVRRDPFPAVSTALSTWKEVTAPRAVQRSGIP
ASGV
>Mature_483_residues
STVIKGGTIVTADLTYRADVKIEGGRIVGIGPNLSAAETLDATGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAALA
GGTTMVVDFALPSPGQSLLEALTMWDNKSTRANCDYSFHMAITWWSEQVFNEMESVVKEKGINTFKHFMAYKGALMVDDD
EMFSSFQRCAALGALPLVHAENGDVVAQLQAKLLAEGNSGPEAHAYSRPAEVEGEATNRAIMIADMAGCPVYIVHTSCEQ
SHEAIRRARAKGMRVFGEPLIQHLTLDETEYFDKDWDHAARRVMSPPFRNKLHQDSLWAGLASGSLQVVATDHCAFTTEQ
KRFGVGDFTRIPNGTGGLEDRMPMLWTHGVATGRITMNEFVAVTSTNIAKILNIYPKKGAILVGADADIVVWDPKRSKTI
SAKTQQSAIDYNVFEGKTVTGLPRFTLSRGVVSIEEGSVKTQEGHGEFVRRDPFPAVSTALSTWKEVTAPRAVQRSGIPA
SGV

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=461, Percent_Identity=49.2407809110629, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI4503051, Length=458, Percent_Identity=46.5065502183406, Blast_Score=427, Evalue=1e-120,
Organism=Homo sapiens, GI190194363, Length=458, Percent_Identity=47.3799126637555, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI62422571, Length=458, Percent_Identity=46.5065502183406, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI4503377, Length=483, Percent_Identity=44.3064182194617, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI4503379, Length=460, Percent_Identity=45.6521739130435, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI19923821, Length=480, Percent_Identity=43.75, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI18105007, Length=439, Percent_Identity=25.5125284738041, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI87082175, Length=462, Percent_Identity=40.2597402597403, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1786722, Length=447, Percent_Identity=28.1879194630872, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17539558, Length=483, Percent_Identity=47.4120082815735, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71989490, Length=484, Percent_Identity=45.0413223140496, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI86575075, Length=456, Percent_Identity=33.7719298245614, Blast_Score=247, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI193204318, Length=438, Percent_Identity=23.5159817351598, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=406, Percent_Identity=26.1083743842365, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221377917, Length=463, Percent_Identity=46.0043196544276, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI17137462, Length=461, Percent_Identity=45.119305856833, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24644287, Length=294, Percent_Identity=44.2176870748299, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24644289, Length=258, Percent_Identity=44.5736434108527, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI24642586, Length=419, Percent_Identity=28.4009546539379, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18859883, Length=424, Percent_Identity=21.4622641509434, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 52602; Mature: 52471

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVIKGGTIVTADLTYRADVKIEGGRIVGIGPNLSAAETLDATGCYVMPGGIDPHTHLE
CCCEECCCEEEEEEEEEEEEEEECCCEEEEECCCCCHHHHCCCCCCEEECCCCCCCCEEC
MPFMGTYSSDDFESGTRAALAGGTTMVVDFALPSPGQSLLEALTMWDNKSTRANCDYSFH
CCEECCCCCCCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEE
MAITWWSEQVFNEMESVVKEKGINTFKHFMAYKGALMVDDDEMFSSFQRCAALGALPLVH
EEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHCCCEEEE
AENGDVVAQLQAKLLAEGNSGPEAHAYSRPAEVEGEATNRAIMIADMAGCPVYIVHTSCE
CCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCH
QSHEAIRRARAKGMRVFGEPLIQHLTLDETEYFDKDWDHAARRVMSPPFRNKLHQDSLWA
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHCCCHHHHHCCHHHHHH
GLASGSLQVVATDHCAFTTEQKRFGVGDFTRIPNGTGGLEDRMPMLWTHGVATGRITMNE
HHCCCCEEEEEECCEEEECCHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEECEEEHHH
FVAVTSTNIAKILNIYPKKGAILVGADADIVVWDPKRSKTISAKTQQSAIDYNVFEGKTV
EEEEECCCHHHHHHCCCCCCEEEEECCCCEEEECCCCCCEEECHHHHHCCCEEEECCCEE
TGLPRFTLSRGVVSIEEGSVKTQEGHGEFVRRDPFPAVSTALSTWKEVTAPRAVQRSGIP
CCCCCHHHHCCEEEEECCCEEECCCCCCCEECCCCHHHHHHHHHHHHHHCCHHHHHCCCC
ASGV
CCCC
>Mature Secondary Structure 
STVIKGGTIVTADLTYRADVKIEGGRIVGIGPNLSAAETLDATGCYVMPGGIDPHTHLE
CCEECCCEEEEEEEEEEEEEEECCCEEEEECCCCCHHHHCCCCCCEEECCCCCCCCEEC
MPFMGTYSSDDFESGTRAALAGGTTMVVDFALPSPGQSLLEALTMWDNKSTRANCDYSFH
CCEECCCCCCCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEE
MAITWWSEQVFNEMESVVKEKGINTFKHFMAYKGALMVDDDEMFSSFQRCAALGALPLVH
EEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHCCCEEEE
AENGDVVAQLQAKLLAEGNSGPEAHAYSRPAEVEGEATNRAIMIADMAGCPVYIVHTSCE
CCCCCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCH
QSHEAIRRARAKGMRVFGEPLIQHLTLDETEYFDKDWDHAARRVMSPPFRNKLHQDSLWA
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHCCCHHHHHCCHHHHHH
GLASGSLQVVATDHCAFTTEQKRFGVGDFTRIPNGTGGLEDRMPMLWTHGVATGRITMNE
HHCCCCEEEEEECCEEEECCHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEECEEEHHH
FVAVTSTNIAKILNIYPKKGAILVGADADIVVWDPKRSKTISAKTQQSAIDYNVFEGKTV
EEEEECCCHHHHHHCCCCCCEEEEECCCCEEEECCCCCCEEECHHHHHCCCEEEECCCEE
TGLPRFTLSRGVVSIEEGSVKTQEGHGEFVRRDPFPAVSTALSTWKEVTAPRAVQRSGIP
CCCCCHHHHCCEEEEECCCEEECCCCCCCEECCCCHHHHHHHHHHHHHHCCHHHHHCCCC
ASGV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]