Click here to switch to the map view.

The map label for this gene is prs [H]

Identifier: 150397457

GI number: 150397457

Start: 2334452

End: 2335384

Strand: Direct

Name: prs [H]

Synonym: Smed_2257

Alternate gene names: 150397457

Gene position: 2334452-2335384 (Clockwise)

Preceding gene: 150397456

Following gene: 150397462

Centisome position: 61.73

GC content: 61.31

Gene sequence:

>933_bases
ATGAAGGTTTTCGCAGGCAATTCGAACCGGCTGCTGGCCGAAGCGATCTGCAACTATCTCAACCTGCCGCTCGGCAAAGC
CACAGTAAGGCGCTTCGCCGATCAGGAAATCTTCGTCGAAATCGGCGAGAACGTGCGCGGCGAGGACGTCTTCATCGTCC
AGTCGACGTCCTTCCCAACGAACGATCATCTGATGGAACTCCTCATCATGATCGACGCGGTCCGCCGTTCCTCCGCCCGC
CGCATCACTGCCGTGCTTCCTTATTTCGGCTATGCCCGGCAGGACCGCAAACCCGGCCCCCGCACACCCATATCCGCCAA
GCTGGTCGCCAATCTCATCACCGAAGCCGGCGCCGACCGCGTTCTGACCCTCGATCTTCACGCTGGGCAGATCCAGGGCT
TCTTCGATATTCCGACCGACAACCTCTACGCCATTCCGATCCTCGCGCGCGACGTGAAGGAGAACTACAATCTCAAGAAT
GTCATGGTCGTTTCGCCCGATGTGGGCGGCGTGGTACGTGCCCGGGCGCTTGCCAAACGACTGGACTGTCTGCTTGCGAT
CGTCGACAAGCGCCGCGACCGGCCCGGTGAATCCGAGGTCATGAACGTCATCGGCGAAGTCAACGGCAAGGACTGCCTCC
TCATCGACGATATCGTCGATTCCGGCGGTACGCTCTGCAACGCCGCCGAGGCCTTGCTGAAGAACGGTGCGACCAGTGTC
ACCGCCTACATCACCCATGGCGTGCTCTCGGGGGGCGCAGTCGCCCGGGTCACGTCCTCGATGCTGAAAGAACTGGTGAT
CACCGACTCGATCCAGCCGACGACGGCGGTCCAGTCGGCGCACAACGTCCGCGTCATCTCGACCGCAGCACTGCTCGGCG
AAGCGATTAGCCGCACGAGCCAGGAAGAATCGGTTTCGAGCCTGTTCGACTGA

Upstream 100 bases:

>100_bases
CAAGTGATTGCCCGCAATCGGAATGGCTCACGGAATCTGCGCGGAGAACCCACCCCCCGGACGACCGGACGTGGCCGCGC
CAGCTCAAGGCGGACCGTCA

Downstream 100 bases:

>100_bases
CGCTTGCGCCGCAGAAGCGGCGCTGCTGATCCCTGTGAACGCGACCGCCATTCATCTCTTGGCGTCGAGCATATAGGATG
CCGCTTCGGCGGCTGGCATG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKVFAGNSNRLLAEAICNYLNLPLGKATVRRFADQEIFVEIGENVRGEDVFIVQSTSFPTNDHLMELLIMIDAVRRSSAR
RITAVLPYFGYARQDRKPGPRTPISAKLVANLITEAGADRVLTLDLHAGQIQGFFDIPTDNLYAIPILARDVKENYNLKN
VMVVSPDVGGVVRARALAKRLDCLLAIVDKRRDRPGESEVMNVIGEVNGKDCLLIDDIVDSGGTLCNAAEALLKNGATSV
TAYITHGVLSGGAVARVTSSMLKELVITDSIQPTTAVQSAHNVRVISTAALLGEAISRTSQEESVSSLFD

Sequences:

>Translated_310_residues
MKVFAGNSNRLLAEAICNYLNLPLGKATVRRFADQEIFVEIGENVRGEDVFIVQSTSFPTNDHLMELLIMIDAVRRSSAR
RITAVLPYFGYARQDRKPGPRTPISAKLVANLITEAGADRVLTLDLHAGQIQGFFDIPTDNLYAIPILARDVKENYNLKN
VMVVSPDVGGVVRARALAKRLDCLLAIVDKRRDRPGESEVMNVIGEVNGKDCLLIDDIVDSGGTLCNAAEALLKNGATSV
TAYITHGVLSGGAVARVTSSMLKELVITDSIQPTTAVQSAHNVRVISTAALLGEAISRTSQEESVSSLFD
>Mature_310_residues
MKVFAGNSNRLLAEAICNYLNLPLGKATVRRFADQEIFVEIGENVRGEDVFIVQSTSFPTNDHLMELLIMIDAVRRSSAR
RITAVLPYFGYARQDRKPGPRTPISAKLVANLITEAGADRVLTLDLHAGQIQGFFDIPTDNLYAIPILARDVKENYNLKN
VMVVSPDVGGVVRARALAKRLDCLLAIVDKRRDRPGESEVMNVIGEVNGKDCLLIDDIVDSGGTLCNAAEALLKNGATSV
TAYITHGVLSGGAVARVTSSMLKELVITDSIQPTTAVQSAHNVRVISTAALLGEAISRTSQEESVSSLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=310, Percent_Identity=47.741935483871, Blast_Score=304, Evalue=6e-83,
Organism=Homo sapiens, GI4506129, Length=308, Percent_Identity=47.0779220779221, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=47.4193548387097, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI84875539, Length=311, Percent_Identity=46.6237942122186, Blast_Score=294, Evalue=7e-80,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=33.6257309941521, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=33.0409356725146, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=34.7222222222222, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=34.7222222222222, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=34.7222222222222, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=34.7222222222222, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=55.4487179487179, Blast_Score=347, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=46.7741935483871, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17554702, Length=310, Percent_Identity=46.7741935483871, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71989924, Length=310, Percent_Identity=46.7741935483871, Blast_Score=293, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=46.7532467532467, Blast_Score=293, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=33.2344213649852, Blast_Score=187, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6321776, Length=310, Percent_Identity=46.1290322580645, Blast_Score=275, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6320946, Length=311, Percent_Identity=45.3376205787781, Blast_Score=265, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=45.5128205128205, Blast_Score=261, Evalue=7e-71,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=44.3877551020408, Blast_Score=168, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6324511, Length=86, Percent_Identity=45.3488372093023, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355239, Length=310, Percent_Identity=47.4193548387097, Blast_Score=293, Evalue=9e-80,
Organism=Drosophila melanogaster, GI45551540, Length=333, Percent_Identity=44.1441441441441, Blast_Score=280, Evalue=7e-76,
Organism=Drosophila melanogaster, GI24651458, Length=351, Percent_Identity=30.7692307692308, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24651456, Length=351, Percent_Identity=30.7692307692308, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI281362873, Length=351, Percent_Identity=30.7692307692308, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24651454, Length=351, Percent_Identity=30.7692307692308, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24651462, Length=370, Percent_Identity=30.2702702702703, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24651464, Length=370, Percent_Identity=30.2702702702703, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI45552010, Length=370, Percent_Identity=30.2702702702703, Blast_Score=171, Evalue=7e-43,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33508; Mature: 33508

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFAGNSNRLLAEAICNYLNLPLGKATVRRFADQEIFVEIGENVRGEDVFIVQSTSFPT
CEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCCCCCCCEEEEEECCCCCC
NDHLMELLIMIDAVRRSSARRITAVLPYFGYARQDRKPGPRTPISAKLVANLITEAGADR
HHHHHHHHHHHHHHHHHCHHHHEEHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCE
VLTLDLHAGQIQGFFDIPTDNLYAIPILARDVKENYNLKNVMVVSPDVGGVVRARALAKR
EEEEEECCCCCCEEEECCCCCEEEEHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
LDCLLAIVDKRRDRPGESEVMNVIGEVNGKDCLLIDDIVDSGGTLCNAAEALLKNGATSV
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEHHHHCCCCCHHHHHHHHHHCCCCHH
TAYITHGVLSGGAVARVTSSMLKELVITDSIQPTTAVQSAHNVRVISTAALLGEAISRTS
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHCC
QEESVSSLFD
HHHHHHHHCC
>Mature Secondary Structure
MKVFAGNSNRLLAEAICNYLNLPLGKATVRRFADQEIFVEIGENVRGEDVFIVQSTSFPT
CEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCCCCCCCEEEEEECCCCCC
NDHLMELLIMIDAVRRSSARRITAVLPYFGYARQDRKPGPRTPISAKLVANLITEAGADR
HHHHHHHHHHHHHHHHHCHHHHEEHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCE
VLTLDLHAGQIQGFFDIPTDNLYAIPILARDVKENYNLKNVMVVSPDVGGVVRARALAKR
EEEEEECCCCCCEEEECCCCCEEEEHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
LDCLLAIVDKRRDRPGESEVMNVIGEVNGKDCLLIDDIVDSGGTLCNAAEALLKNGATSV
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEHHHHCCCCCHHHHHHHHHHCCCCHH
TAYITHGVLSGGAVARVTSSMLKELVITDSIQPTTAVQSAHNVRVISTAALLGEAISRTS
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHCC
QEESVSSLFD
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]