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The map label for this gene is recQ [H]

Identifier: 150397426

GI number: 150397426

Start: 2304702

End: 2306645

Strand: Reverse

Name: recQ [H]

Synonym: Smed_2226

Alternate gene names: 150397426

Gene position: 2306645-2304702 (Counterclockwise)

Preceding gene: 150397427

Following gene: 150397425

Centisome position: 60.99

GC content: 64.09

Gene sequence:

>1944_bases
GTGCGGCGAGTCAGCAGGCTAGCGGAATGCTGCCTGTGGTTTACACGCGAGCACCCGCGACGCCATATTGTACGCACCGA
CGAAAGCGATTCCATGCCCGAAAGCCACAGCACCGCCTGCCTGTTCGAAACGGAAGGCGTCCGCAATCCGCTCGATCTCT
TGAAACGCATTTACGGCTATTCCACCTTCCGCGGTCAGCAGCAGGAGGTCATCGAGCATGTGGTTGCCGGCGGCGATGCC
GTCGTGCTTTTTCCGACCGGGGCGGGCAAATCGCTCTGCTTCCAGATTCCGGCGCTCTGCCGTGGCGGCGTCGGCGTCGT
CGTTTCGCCGCTGATCGCTTTGATGCGCGATCAGGTGGAGGCGCTCAAGCAGCTCGGCGTCCGGGCGGCCGCCCTCAATT
CCTCCCTGACGCGGGAGGAGGCGATTGCCGTTCGCCGTTCGCTTTCGACCGGCACTCTGGACCTCATCTATGTGACGCCG
GAACGCGCCGTCACCGATGGTTTCGCCGAAATGATCGCCGGTGCCGAAATTGCTCTTTTCGCGATCGACGAGGCCCATTG
CGTTTCGCAATGGGGACATGACTTTCGCCCGGAATATCGCGGCCTCGGCTGCCTCGCCGAACGCTTCCCGAACGTACCGC
GCATCGCGCTCACGGCCACCGCGGATCCGCACACACGCGCCGACCTGATCGAGCGCCTGGCACTTGGCGCGGCGCGGGTT
TTCACCTCCAGTTTCGACCGCCCGAACATCGCCTATGAGATCGTGGAGCGCGATCAGCCGCGCCAGCAATTGCTGCGCTT
CCTGTCGCGCTTCAAGGATGCAAGCGGCATCGTTTATTGCCTCTCTCGCGCGAAGGTCGAGGACACGGCGGAATGGCTGA
ATACGCAGGGGATTCGTGCGCTCCCCTATCACGCCGGCATGGACAGGGCGTTGCGTGACGCGCATCAGGACGCTTTCCTC
AAGGAGGAGAATTTGTGCCTCGTCGCAACCGTCGCCTTCGGTATGGGAATCGACAAACCGGATGTGCGCTACGTTGCCCA
TCTGGATCTGCCAGGTTCGGTGGAGGCTTATTACCAGGAGACGGGGAGGGCCGGGCGCGACGGGCTGCCTTCGGAAGTGT
GGATGGCCTATGGCATGGCCGACGTCATCCAGCGCCGGCGAATGATCGACGAGGGCGGTGCGCCCGAGGAGGTCAAGAGA
ATTGAGCGGGCGAAACTCAATTCGCTGCTTGCAATTTGCGAGACGGCAGGCTGCCGGCGCCAGGCGGTCCTCGCGCATTT
CGGCGAAGCGCATCCGGGCGGGTGCGGCCATTGCGACACCTGCCTGAAACCGGTCGAGACCTGGGACGGTACGGAAGCGG
CGATCAAGGCGCTCGCGGCCGTTTACAGGACCGGCGAGCGTTTCGGAACCGGCCATCTGATCGATGTACTTATGGGCAGC
GTGAACGAAAAGACCGAGCGCTTCGGGCATGTCGACATGCCGGTGTTCGGGGCCGGCAAGGACCTGCCGGCGCGCACCTG
GCAATCCATCTTCCGCCAACTGCTCGCCGCGGGGCTCATCTCCGTGGATCACGGCGCCTTCGGGGCATTGAAACTCGAGC
CTGAGGCACGCAGCGTCTTCCGCCGCGAGCGGCAGGTGCTCTTCCGCAAGGACCGCCCGAGTTCCGGTAAGGCGGCGCGC
GGCCAGAAGGCGACGCGAGAGCGGTCCGACCTCGCGGGCTCCGATCTCGAGTTGTTTGAGCGGCTTCGCTCCGAGCGTCT
TACTATCGCCCGCGAGATGGACGTGCCGCCCTATGTCGTCTTCCCGGACGCTACCTTGATTGCGCTTGCCAAGCGCCGAC
CGCGCGATTTCGACGATCTCCTGGGCGTCCCCGGTATCGGAGAGACCAAGCGGGAGAGGTACGGACAGGCTTTCCTCGCG
GTGATCGAGGCTTTCGAGGGCTGA

Upstream 100 bases:

>100_bases
GCTGGAGCTTCACCGGATGGACAAGCTCGAAGCAATCATCGAAGGCTTCGGCGTGCTTTCGGGGAGGGTGAAGGGGCCTG
CGGCGCGGTAATCATCTGTC

Downstream 100 bases:

>100_bases
CGTCGAGTGATCATCCGCCCTCCATCCGCCTGCCGGCACCTTCTCCCGCAAGCGGGGCGAAGGAGACCAGCGCCAGCGTC
GTGCTCGTCCCCGCTCCCTG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 647; Mature: 647

Protein sequence:

>647_residues
MRRVSRLAECCLWFTREHPRRHIVRTDESDSMPESHSTACLFETEGVRNPLDLLKRIYGYSTFRGQQQEVIEHVVAGGDA
VVLFPTGAGKSLCFQIPALCRGGVGVVVSPLIALMRDQVEALKQLGVRAAALNSSLTREEAIAVRRSLSTGTLDLIYVTP
ERAVTDGFAEMIAGAEIALFAIDEAHCVSQWGHDFRPEYRGLGCLAERFPNVPRIALTATADPHTRADLIERLALGAARV
FTSSFDRPNIAYEIVERDQPRQQLLRFLSRFKDASGIVYCLSRAKVEDTAEWLNTQGIRALPYHAGMDRALRDAHQDAFL
KEENLCLVATVAFGMGIDKPDVRYVAHLDLPGSVEAYYQETGRAGRDGLPSEVWMAYGMADVIQRRRMIDEGGAPEEVKR
IERAKLNSLLAICETAGCRRQAVLAHFGEAHPGGCGHCDTCLKPVETWDGTEAAIKALAAVYRTGERFGTGHLIDVLMGS
VNEKTERFGHVDMPVFGAGKDLPARTWQSIFRQLLAAGLISVDHGAFGALKLEPEARSVFRRERQVLFRKDRPSSGKAAR
GQKATRERSDLAGSDLELFERLRSERLTIAREMDVPPYVVFPDATLIALAKRRPRDFDDLLGVPGIGETKRERYGQAFLA
VIEAFEG

Sequences:

>Translated_647_residues
MRRVSRLAECCLWFTREHPRRHIVRTDESDSMPESHSTACLFETEGVRNPLDLLKRIYGYSTFRGQQQEVIEHVVAGGDA
VVLFPTGAGKSLCFQIPALCRGGVGVVVSPLIALMRDQVEALKQLGVRAAALNSSLTREEAIAVRRSLSTGTLDLIYVTP
ERAVTDGFAEMIAGAEIALFAIDEAHCVSQWGHDFRPEYRGLGCLAERFPNVPRIALTATADPHTRADLIERLALGAARV
FTSSFDRPNIAYEIVERDQPRQQLLRFLSRFKDASGIVYCLSRAKVEDTAEWLNTQGIRALPYHAGMDRALRDAHQDAFL
KEENLCLVATVAFGMGIDKPDVRYVAHLDLPGSVEAYYQETGRAGRDGLPSEVWMAYGMADVIQRRRMIDEGGAPEEVKR
IERAKLNSLLAICETAGCRRQAVLAHFGEAHPGGCGHCDTCLKPVETWDGTEAAIKALAAVYRTGERFGTGHLIDVLMGS
VNEKTERFGHVDMPVFGAGKDLPARTWQSIFRQLLAAGLISVDHGAFGALKLEPEARSVFRRERQVLFRKDRPSSGKAAR
GQKATRERSDLAGSDLELFERLRSERLTIAREMDVPPYVVFPDATLIALAKRRPRDFDDLLGVPGIGETKRERYGQAFLA
VIEAFEG
>Mature_647_residues
MRRVSRLAECCLWFTREHPRRHIVRTDESDSMPESHSTACLFETEGVRNPLDLLKRIYGYSTFRGQQQEVIEHVVAGGDA
VVLFPTGAGKSLCFQIPALCRGGVGVVVSPLIALMRDQVEALKQLGVRAAALNSSLTREEAIAVRRSLSTGTLDLIYVTP
ERAVTDGFAEMIAGAEIALFAIDEAHCVSQWGHDFRPEYRGLGCLAERFPNVPRIALTATADPHTRADLIERLALGAARV
FTSSFDRPNIAYEIVERDQPRQQLLRFLSRFKDASGIVYCLSRAKVEDTAEWLNTQGIRALPYHAGMDRALRDAHQDAFL
KEENLCLVATVAFGMGIDKPDVRYVAHLDLPGSVEAYYQETGRAGRDGLPSEVWMAYGMADVIQRRRMIDEGGAPEEVKR
IERAKLNSLLAICETAGCRRQAVLAHFGEAHPGGCGHCDTCLKPVETWDGTEAAIKALAAVYRTGERFGTGHLIDVLMGS
VNEKTERFGHVDMPVFGAGKDLPARTWQSIFRQLLAAGLISVDHGAFGALKLEPEARSVFRRERQVLFRKDRPSSGKAAR
GQKATRERSDLAGSDLELFERLRSERLTIAREMDVPPYVVFPDATLIALAKRRPRDFDDLLGVPGIGETKRERYGQAFLA
VIEAFEG

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=645, Percent_Identity=33.4883720930233, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI14591902, Length=550, Percent_Identity=34.3636363636364, Blast_Score=301, Evalue=2e-81,
Organism=Homo sapiens, GI14591904, Length=550, Percent_Identity=34.3636363636364, Blast_Score=301, Evalue=2e-81,
Organism=Homo sapiens, GI169218196, Length=691, Percent_Identity=31.4037626628075, Blast_Score=288, Evalue=8e-78,
Organism=Homo sapiens, GI110735439, Length=691, Percent_Identity=31.4037626628075, Blast_Score=288, Evalue=1e-77,
Organism=Homo sapiens, GI148612816, Length=438, Percent_Identity=37.8995433789954, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI51242943, Length=410, Percent_Identity=37.8048780487805, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI51242947, Length=410, Percent_Identity=37.8048780487805, Blast_Score=253, Evalue=5e-67,
Organism=Homo sapiens, GI284005309, Length=337, Percent_Identity=37.6854599406528, Blast_Score=186, Evalue=9e-47,
Organism=Homo sapiens, GI21071032, Length=388, Percent_Identity=21.9072164948454, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI48994977, Length=594, Percent_Identity=46.1279461279461, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI25145561, Length=498, Percent_Identity=37.9518072289157, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI71987993, Length=407, Percent_Identity=38.5749385749386, Blast_Score=294, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI71987997, Length=407, Percent_Identity=38.5749385749386, Blast_Score=294, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI32564293, Length=700, Percent_Identity=29.8571428571429, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17552866, Length=435, Percent_Identity=36.3218390804598, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17507945, Length=382, Percent_Identity=22.2513089005236, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555296, Length=361, Percent_Identity=27.7008310249307, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI86570094, Length=344, Percent_Identity=24.4186046511628, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995718, Length=137, Percent_Identity=32.8467153284672, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17537549, Length=332, Percent_Identity=21.6867469879518, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=676, Percent_Identity=31.6568047337278, Blast_Score=309, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6324217, Length=337, Percent_Identity=22.5519287833828, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646066, Length=628, Percent_Identity=34.3949044585987, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24664226, Length=444, Percent_Identity=38.2882882882883, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI62472181, Length=444, Percent_Identity=38.2882882882883, Blast_Score=271, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24664230, Length=444, Percent_Identity=38.2882882882883, Blast_Score=271, Evalue=1e-72,
Organism=Drosophila melanogaster, GI21358123, Length=348, Percent_Identity=36.4942528735632, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 71677; Mature: 71677

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVSRLAECCLWFTREHPRRHIVRTDESDSMPESHSTACLFETEGVRNPLDLLKRIYGY
CCHHHHHHHHHHHHHHCCCHHCCEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCC
STFRGQQQEVIEHVVAGGDAVVLFPTGAGKSLCFQIPALCRGGVGVVVSPLIALMRDQVE
HHCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHCCCHHHHHHHHHHHHHHHHH
ALKQLGVRAAALNSSLTREEAIAVRRSLSTGTLDLIYVTPERAVTDGFAEMIAGAEIALF
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEE
AIDEAHCVSQWGHDFRPEYRGLGCLAERFPNVPRIALTATADPHTRADLIERLALGAARV
EECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
FTSSFDRPNIAYEIVERDQPRQQLLRFLSRFKDASGIVYCLSRAKVEDTAEWLNTQGIRA
HHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHCCCCCEE
LPYHAGMDRALRDAHQDAFLKEENLCLVATVAFGMGIDKPDVRYVAHLDLPGSVEAYYQE
CCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCEEEEEECCCCCHHHHHHH
TGRAGRDGLPSEVWMAYGMADVIQRRRMIDEGGAPEEVKRIERAKLNSLLAICETAGCRR
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
QAVLAHFGEAHPGGCGHCDTCLKPVETWDGTEAAIKALAAVYRTGERFGTGHLIDVLMGS
HHHHHHCCCCCCCCCCCHHHHHCHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
VNEKTERFGHVDMPVFGAGKDLPARTWQSIFRQLLAAGLISVDHGAFGALKLEPEARSVF
CHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCEEEEECHHHHHHH
RRERQVLFRKDRPSSGKAARGQKATRERSDLAGSDLELFERLRSERLTIAREMDVPPYVV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCCEEE
FPDATLIALAKRRPRDFDDLLGVPGIGETKRERYGQAFLAVIEAFEG
CCCHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRVSRLAECCLWFTREHPRRHIVRTDESDSMPESHSTACLFETEGVRNPLDLLKRIYGY
CCHHHHHHHHHHHHHHCCCHHCCEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCC
STFRGQQQEVIEHVVAGGDAVVLFPTGAGKSLCFQIPALCRGGVGVVVSPLIALMRDQVE
HHCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHCCHHHHCCCHHHHHHHHHHHHHHHHH
ALKQLGVRAAALNSSLTREEAIAVRRSLSTGTLDLIYVTPERAVTDGFAEMIAGAEIALF
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEE
AIDEAHCVSQWGHDFRPEYRGLGCLAERFPNVPRIALTATADPHTRADLIERLALGAARV
EECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
FTSSFDRPNIAYEIVERDQPRQQLLRFLSRFKDASGIVYCLSRAKVEDTAEWLNTQGIRA
HHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHCCCCCEE
LPYHAGMDRALRDAHQDAFLKEENLCLVATVAFGMGIDKPDVRYVAHLDLPGSVEAYYQE
CCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCEEEEEECCCCCHHHHHHH
TGRAGRDGLPSEVWMAYGMADVIQRRRMIDEGGAPEEVKRIERAKLNSLLAICETAGCRR
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
QAVLAHFGEAHPGGCGHCDTCLKPVETWDGTEAAIKALAAVYRTGERFGTGHLIDVLMGS
HHHHHHCCCCCCCCCCCHHHHHCHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
VNEKTERFGHVDMPVFGAGKDLPARTWQSIFRQLLAAGLISVDHGAFGALKLEPEARSVF
CHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCEEEEECHHHHHHH
RRERQVLFRKDRPSSGKAARGQKATRERSDLAGSDLELFERLRSERLTIAREMDVPPYVV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEECCCCCEEE
FPDATLIALAKRRPRDFDDLLGVPGIGETKRERYGQAFLAVIEAFEG
CCCHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]