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The map label for this gene is tdh [H]

Identifier: 150397424

GI number: 150397424

Start: 2302218

End: 2303252

Strand: Reverse

Name: tdh [H]

Synonym: Smed_2224

Alternate gene names: 150397424

Gene position: 2303252-2302218 (Counterclockwise)

Preceding gene: 150397425

Following gene: 150397423

Centisome position: 60.9

GC content: 60.1

Gene sequence:

>1035_bases
ATGACCAATATGATGAGGGCACTCGTAAAGACCAGGCCCGAGGTGGGGCTCTGGATGGAGCGGGTGCCGGTCCCGGAAGT
CGGGCCGAATGATGTTCTGATCCGCGTCAGGAAATCGGCGATCTGCGGCACCGATGTCCATATCTGGAACTGGGATCAAT
GGGCGCAGAAAACGATTCCCGTGCCGATGGTCGTCGGGCACGAATTCATGGGCGAAATCGTCGAGGTCGGGCCGGCCGTG
ACGAAGCATCATGTCGGCGAGCGGGTTTCCGGAGAGGGCCACATCGTTTGCGGCAAGTGCCGCAATTGCCGCGCCGGCAG
GGGGCATCTCTGCCGCAACACCCTCGGCGTCGGCGTCAACCGTCCCGGCTCCTTCGCCGAATTCGTGTGTCTGCCGGAAT
ATAATGTCGTGTCGATCCCGGACGACGTTCCCGACGAGATCGCCGCGATCTTCGATCCCTTCGGCAACGCTGTGCACACA
GCGCTCTCCTTCGATCTCGTCGGCGAAGACGTGCTTGTCACCGGCGCTGGGCCGATCGGCATCATGGGGGCTTTGGTTGC
CAAGCGGTGCGGTGCCCGCAAGGTCGTGATCACCGACATCAATCCGGTCCGCCTCGATCTCGCGCGCAAGGTCGGTATCG
ACTATGTCGTCGACGCATCGAAGGAAAATCTCGCCGATGTGATGCGGGTGATCGGCATGACCGAGGGCTTCGATGTCGGC
CTGGAAATGTCGGGTGCCGCACCCGCCTTTCGCGACATGATCGACAAGATGAACAATGGCGGCAAGATCGCAATCCTCGG
CATTGCGCCGGCGGGCTTCGAAATCGACTGGAACAAGGTGATCTTCAAGATGCTCAATCTGAAGGGCATCTATGGTCGAG
AGATGTTCGAGACCTGGTACAAGATGATCGCCTTCGTCCAGGGCGGGCTTGACCTTTCACAGATAATCACGCACCGCATC
GGCATCGACGAGTTTGGTGACGGCTTCGAAGCGATGCGCTCTGGCAATTCCGGCAAGGTCGTGATGGACTGGTAG

Upstream 100 bases:

>100_bases
GATATCCGCCGCGCCATAGCCGTCTTCGAGGAGGTGGGCCGAGAGTTGAACGTGATTTAAGGGGCGAACGGGGGTCCCGC
GCAACGCGGAGGAGCGAGCA

Downstream 100 bases:

>100_bases
GCAGCGCGCCCGGGCACCATCTGGGCCGATTTCCTTGATGTAGTGTGCTCGGATGGAGGAGCGGCCCTTGTCTTTCTGTG
GGGCGCTCCTACATGTTGAG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTNMMRALVKTRPEVGLWMERVPVPEVGPNDVLIRVRKSAICGTDVHIWNWDQWAQKTIPVPMVVGHEFMGEIVEVGPAV
TKHHVGERVSGEGHIVCGKCRNCRAGRGHLCRNTLGVGVNRPGSFAEFVCLPEYNVVSIPDDVPDEIAAIFDPFGNAVHT
ALSFDLVGEDVLVTGAGPIGIMGALVAKRCGARKVVITDINPVRLDLARKVGIDYVVDASKENLADVMRVIGMTEGFDVG
LEMSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNKVIFKMLNLKGIYGREMFETWYKMIAFVQGGLDLSQIITHRI
GIDEFGDGFEAMRSGNSGKVVMDW

Sequences:

>Translated_344_residues
MTNMMRALVKTRPEVGLWMERVPVPEVGPNDVLIRVRKSAICGTDVHIWNWDQWAQKTIPVPMVVGHEFMGEIVEVGPAV
TKHHVGERVSGEGHIVCGKCRNCRAGRGHLCRNTLGVGVNRPGSFAEFVCLPEYNVVSIPDDVPDEIAAIFDPFGNAVHT
ALSFDLVGEDVLVTGAGPIGIMGALVAKRCGARKVVITDINPVRLDLARKVGIDYVVDASKENLADVMRVIGMTEGFDVG
LEMSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNKVIFKMLNLKGIYGREMFETWYKMIAFVQGGLDLSQIITHRI
GIDEFGDGFEAMRSGNSGKVVMDW
>Mature_343_residues
TNMMRALVKTRPEVGLWMERVPVPEVGPNDVLIRVRKSAICGTDVHIWNWDQWAQKTIPVPMVVGHEFMGEIVEVGPAVT
KHHVGERVSGEGHIVCGKCRNCRAGRGHLCRNTLGVGVNRPGSFAEFVCLPEYNVVSIPDDVPDEIAAIFDPFGNAVHTA
LSFDLVGEDVLVTGAGPIGIMGALVAKRCGARKVVITDINPVRLDLARKVGIDYVVDASKENLADVMRVIGMTEGFDVGL
EMSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNKVIFKMLNLKGIYGREMFETWYKMIAFVQGGLDLSQIITHRIG
IDEFGDGFEAMRSGNSGKVVMDW

Specific function: Threonine catabolism; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=331, Percent_Identity=29.0030211480363, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI262073058, Length=367, Percent_Identity=24.7956403269755, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI71743840, Length=367, Percent_Identity=24.7956403269755, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=25.0673854447439, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI4501929, Length=362, Percent_Identity=24.3093922651934, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501933, Length=362, Percent_Identity=24.3093922651934, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI71565154, Length=366, Percent_Identity=23.4972677595628, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=69.7058823529412, Blast_Score=506, Evalue=1e-145,
Organism=Escherichia coli, GI1788075, Length=364, Percent_Identity=30.4945054945055, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1788073, Length=331, Percent_Identity=27.4924471299094, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=26.4264264264264, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082125, Length=362, Percent_Identity=29.5580110497238, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787863, Length=329, Percent_Identity=26.1398176291793, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790718, Length=268, Percent_Identity=25.3731343283582, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788407, Length=335, Percent_Identity=25.0746268656716, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1786825, Length=384, Percent_Identity=27.34375, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1786552, Length=373, Percent_Identity=26.8096514745308, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081918, Length=265, Percent_Identity=26.7924528301887, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=31.3432835820896, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17562878, Length=335, Percent_Identity=30.1492537313433, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71988145, Length=202, Percent_Identity=31.1881188118812, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=293, Percent_Identity=23.8907849829352, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=337, Percent_Identity=24.3323442136499, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=341, Percent_Identity=29.3255131964809, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=326, Percent_Identity=27.3006134969325, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319258, Length=303, Percent_Identity=29.3729372937294, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319955, Length=326, Percent_Identity=26.9938650306748, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320033, Length=365, Percent_Identity=27.6712328767123, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=342, Percent_Identity=26.6081871345029, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=353, Percent_Identity=27.1954674220963, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=338, Percent_Identity=27.810650887574, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=223, Percent_Identity=27.8026905829596, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=25.8823529411765, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=204, Percent_Identity=30.3921568627451, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=288, Percent_Identity=28.125, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737897, Length=331, Percent_Identity=27.4924471299094, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17137530, Length=341, Percent_Identity=26.3929618768328, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI17737895, Length=375, Percent_Identity=24.8, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221457811, Length=217, Percent_Identity=27.1889400921659, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550770, Length=217, Percent_Identity=27.1889400921659, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45551930, Length=217, Percent_Identity=27.1889400921659, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37564; Mature: 37433

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNMMRALVKTRPEVGLWMERVPVPEVGPNDVLIRVRKSAICGTDVHIWNWDQWAQKTIP
CCHHHHHHHHCCCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEECCHHHHHHCCC
VPMVVGHEFMGEIVEVGPAVTKHHVGERVSGEGHIVCGKCRNCRAGRGHLCRNTLGVGVN
CCHHHCHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHCCCCC
RPGSFAEFVCLPEYNVVSIPDDVPDEIAAIFDPFGNAVHTALSFDLVGEDVLVTGAGPIG
CCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHEECCCCEEEECCCHHH
IMGALVAKRCGARKVVITDINPVRLDLARKVGIDYVVDASKENLADVMRVIGMTEGFDVG
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCCCCCCCC
LEMSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNKVIFKMLNLKGIYGREMFETWY
EEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCEECHHHHHHHHHCCCCCCHHHHHHHHH
KMIAFVQGGLDLSQIITHRIGIDEFGDGFEAMRSGNSGKVVMDW
HHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCEEEEEC
>Mature Secondary Structure 
TNMMRALVKTRPEVGLWMERVPVPEVGPNDVLIRVRKSAICGTDVHIWNWDQWAQKTIP
CHHHHHHHHCCCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEECCHHHHHHCCC
VPMVVGHEFMGEIVEVGPAVTKHHVGERVSGEGHIVCGKCRNCRAGRGHLCRNTLGVGVN
CCHHHCHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHCCCCC
RPGSFAEFVCLPEYNVVSIPDDVPDEIAAIFDPFGNAVHTALSFDLVGEDVLVTGAGPIG
CCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHEECCCCEEEECCCHHH
IMGALVAKRCGARKVVITDINPVRLDLARKVGIDYVVDASKENLADVMRVIGMTEGFDVG
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCCCCCCCC
LEMSGAAPAFRDMIDKMNNGGKIAILGIAPAGFEIDWNKVIFKMLNLKGIYGREMFETWY
EEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCEECHHHHHHHHHCCCCCCHHHHHHHHH
KMIAFVQGGLDLSQIITHRIGIDEFGDGFEAMRSGNSGKVVMDW
HHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA