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The map label for this gene is aacC4 [H]

Identifier: 150397414

GI number: 150397414

Start: 2293869

End: 2294660

Strand: Direct

Name: aacC4 [H]

Synonym: Smed_2214

Alternate gene names: 150397414

Gene position: 2293869-2294660 (Clockwise)

Preceding gene: 150397409

Following gene: 150397416

Centisome position: 60.65

GC content: 61.87

Gene sequence:

>792_bases
ATGACGCAACGTGAATGGCGCATTTCGGAACTCGTCAATCAACTCCTCACCCTCGGGGTGAAGCCCGGAGGCGTTCTTGT
CGTTCACTCTTCGTTTCGCAGCGTCCGGCCGGTCGAAGGCGGTCCGGCCGGCATGATCGCCGCTCTGCGCACCGCCATCG
GCCCGGAAGGCACGCTCGTCATGCCCTCCTGGTCGGGCCTTGACGACGAGCCATTCGAGCCGGCGACGACCTCAGCAACA
TCGGATCTGGGAATACTCGCCGATACTTTCTGGCGTCTTGAGGGTGTGGTGCGCAGCGACCATCCGTTCGCCTTTGCAGC
GGCGGGACCGCTTGCCGCACGCATCACATCGGACCCCCTGCCCCTGCCCCCGCATTGTCCCCCCAGTCCGATAGGGCGTA
TCCATGAACTCGACGGACAGGTGATACTCCTCGGCGTCGGACACGATTCGAACACCACCTTGCATCTCGCCGAGCTGATG
TCCAAGGTTCCTTATGGAGTGCCGAGACACTGCACGATCGTCGAAAATGGCAGCCGGGTCCGCATTGCCTATCTGGAGAA
TGATCACTGTTGCCAGAACTTCAGCCTGGCCGACGTCTGGTTGAGGCGAAACGGCCTCCAGAAGGAGGGGCAGATCGGCA
ACGCCCATGCCCGCCTGGTCCGCTCACGCGACATCGTGAAAATCGCAATGGAACAATTGGCCCACGACCCGCTCGTCTTC
CTGCATCCGGCAGAAGTGGCGTGCGAAGAATGCGATGCAGCACGCCAGTCGATCGGCTATGGGCGTTCGTGA

Upstream 100 bases:

>100_bases
TTCCACGCCCGCCTCAACGCTATTTTCAACGCGTTCGAAGCCGATACCGTGAGCAAGCGCTGTCAGAACACCAATTAAAG
TGGACTCATCCGGTACAACC

Downstream 100 bases:

>100_bases
GAGCCTTTCGGCGCCGGATCACGCTCGCTCTCAGTTTTCTTTATCGTCCCCGGCACGAAACCCACCCCAAAGCCGAATAG
ACGGCCATTTTTTCCAATGT

Product: aminoglycoside N(3')-acetyltransferase

Products: NA

Alternate protein names: ACC(3)-IV; Aminocyclitol 3-N-acetyltransferase type IV [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTQREWRISELVNQLLTLGVKPGGVLVVHSSFRSVRPVEGGPAGMIAALRTAIGPEGTLVMPSWSGLDDEPFEPATTSAT
SDLGILADTFWRLEGVVRSDHPFAFAAAGPLAARITSDPLPLPPHCPPSPIGRIHELDGQVILLGVGHDSNTTLHLAELM
SKVPYGVPRHCTIVENGSRVRIAYLENDHCCQNFSLADVWLRRNGLQKEGQIGNAHARLVRSRDIVKIAMEQLAHDPLVF
LHPAEVACEECDAARQSIGYGRS

Sequences:

>Translated_263_residues
MTQREWRISELVNQLLTLGVKPGGVLVVHSSFRSVRPVEGGPAGMIAALRTAIGPEGTLVMPSWSGLDDEPFEPATTSAT
SDLGILADTFWRLEGVVRSDHPFAFAAAGPLAARITSDPLPLPPHCPPSPIGRIHELDGQVILLGVGHDSNTTLHLAELM
SKVPYGVPRHCTIVENGSRVRIAYLENDHCCQNFSLADVWLRRNGLQKEGQIGNAHARLVRSRDIVKIAMEQLAHDPLVF
LHPAEVACEECDAARQSIGYGRS
>Mature_262_residues
TQREWRISELVNQLLTLGVKPGGVLVVHSSFRSVRPVEGGPAGMIAALRTAIGPEGTLVMPSWSGLDDEPFEPATTSATS
DLGILADTFWRLEGVVRSDHPFAFAAAGPLAARITSDPLPLPPHCPPSPIGRIHELDGQVILLGVGHDSNTTLHLAELMS
KVPYGVPRHCTIVENGSRVRIAYLENDHCCQNFSLADVWLRRNGLQKEGQIGNAHARLVRSRDIVKIAMEQLAHDPLVFL
HPAEVACEECDAARQSIGYGRS

Specific function: Resistance to antibiotics containing the 2-deoxy- streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin [H]

COG id: COG2746

COG function: function code V; Aminoglycoside N3'-acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the antibiotic N-acetyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003679 [H]

Pfam domain/function: PF02522 Antibiotic_NAT [H]

EC number: =2.3.1.81 [H]

Molecular weight: Translated: 28508; Mature: 28377

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQREWRISELVNQLLTLGVKPGGVLVVHSSFRSVRPVEGGPAGMIAALRTAIGPEGTLV
CCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEE
MPSWSGLDDEPFEPATTSATSDLGILADTFWRLEGVVRSDHPFAFAAAGPLAARITSDPL
ECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCEEEEECCCEEEEECCCCC
PLPPHCPPSPIGRIHELDGQVILLGVGHDSNTTLHLAELMSKVPYGVPRHCTIVENGSRV
CCCCCCCCCCCCHHEECCCCEEEEEECCCCCCEEHHHHHHHHCCCCCCCEEEEEECCCEE
RIAYLENDHCCQNFSLADVWLRRNGLQKEGQIGNAHARLVRSRDIVKIAMEQLAHDPLVF
EEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
LHPAEVACEECDAARQSIGYGRS
EECHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TQREWRISELVNQLLTLGVKPGGVLVVHSSFRSVRPVEGGPAGMIAALRTAIGPEGTLV
CCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEE
MPSWSGLDDEPFEPATTSATSDLGILADTFWRLEGVVRSDHPFAFAAAGPLAARITSDPL
ECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEECCCCEEEEECCCEEEEECCCCC
PLPPHCPPSPIGRIHELDGQVILLGVGHDSNTTLHLAELMSKVPYGVPRHCTIVENGSRV
CCCCCCCCCCCCHHEECCCCEEEEEECCCCCCEEHHHHHHHHCCCCCCCEEEEEECCCEE
RIAYLENDHCCQNFSLADVWLRRNGLQKEGQIGNAHARLVRSRDIVKIAMEQLAHDPLVF
EEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
LHPAEVACEECDAARQSIGYGRS
EECHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6318050 [H]