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The map label for this gene is yybE [H]

Identifier: 150397387

GI number: 150397387

Start: 2261833

End: 2262741

Strand: Direct

Name: yybE [H]

Synonym: Smed_2186

Alternate gene names: 150397387

Gene position: 2261833-2262741 (Clockwise)

Preceding gene: 150397385

Following gene: 150397388

Centisome position: 59.81

GC content: 64.58

Gene sequence:

>909_bases
ATGGCGTTCACACTCCGGCAGTTGCAATATTTCGTCGCCGTCGCCGAGCAGGGCTCGGTCACCCGCGCGGCGCAGAACCT
CTCCATTTCGCAGTCGTCGATCACCGAGGCAGTCAAGGAGCTCGAATCCGATCTCGGCGTCGAACTCTTCGACCGGCATC
CGCGCGGGCTTTCGATCACCCATAACGGGCATCAGTTCCTGCGCCACGCGACCAAGATCCTCGCCGATGTTTCCGATGCG
CGGCGCAGCTTCTCCGACAGCCGCGAAGAACGCAGCGGCAGGCTCAATCTCGGCGTCACTTCCCTCGTCGCCGGATACGT
GCTCTCCGACCTGCTTGCGCGCTACCGCCGCGCCTGCCCCGGCGTCGAGGTGAGCGCCATCGAGGACAATGGTTCCTATC
TCGAGCACCTCCTGATCGGCGGCGAACTCGACGTCGCCGTGATGGTCATCTCGAACCTGCGCGACCGCATGGCGCTGCAG
GCGGAAATATTGGAAACTTCACCTTACCGGCTCTGGTTGCCGATCGGCCATCCGCTTGTCAGCGCCGACATCATATCGGT
CGAGGATATCGCCAGGGAGCCGCTCATCATGCTGACGGTGGACGAAATCGAGGAGAACACCGGCAAACTTCTGACGGCGC
TTGGCGCGCGCCCACACGTCGCGTTCCGAACCCGTTCCGTGGAAGCGGTCAGAAGTCTGGTCGCAACCGGCGCGGGCATC
GCCCTTCTGCCTGATCTCGTCTACCGTCCCTGGTCGCTGGAAGGCGACCGGATTGAAAGCCGCGACGTTTCCGGCGCGCT
GCCGGTCGTGCAGGTCGGCATGGTCTGGCGGAAGGGGTCGAGCCTGCCCCAGTCCGCGCGCGATTTCGTCGGCATAGCCG
AAGCGCTGCGCAGCGCGAGGCCGAGGTGA

Upstream 100 bases:

>100_bases
ATGATCAAGCCGATTTAAGGGCAAATGTACAAGGTTTCAAAGTGCTGCCGGCGACCTTTGTCTGCTTGATTTCGCCTCGG
CAAGCAGTGTTAATTTGACA

Downstream 100 bases:

>100_bases
TCCATCGGAAAAACCGATACCGTCATTCTGATTAATGAATTTGCGAATGCGAGGAAATCAAGGCACGCTTCATTCCGGGA
ACAAAGCCGCAAACGGCGTT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MAFTLRQLQYFVAVAEQGSVTRAAQNLSISQSSITEAVKELESDLGVELFDRHPRGLSITHNGHQFLRHATKILADVSDA
RRSFSDSREERSGRLNLGVTSLVAGYVLSDLLARYRRACPGVEVSAIEDNGSYLEHLLIGGELDVAVMVISNLRDRMALQ
AEILETSPYRLWLPIGHPLVSADIISVEDIAREPLIMLTVDEIEENTGKLLTALGARPHVAFRTRSVEAVRSLVATGAGI
ALLPDLVYRPWSLEGDRIESRDVSGALPVVQVGMVWRKGSSLPQSARDFVGIAEALRSARPR

Sequences:

>Translated_302_residues
MAFTLRQLQYFVAVAEQGSVTRAAQNLSISQSSITEAVKELESDLGVELFDRHPRGLSITHNGHQFLRHATKILADVSDA
RRSFSDSREERSGRLNLGVTSLVAGYVLSDLLARYRRACPGVEVSAIEDNGSYLEHLLIGGELDVAVMVISNLRDRMALQ
AEILETSPYRLWLPIGHPLVSADIISVEDIAREPLIMLTVDEIEENTGKLLTALGARPHVAFRTRSVEAVRSLVATGAGI
ALLPDLVYRPWSLEGDRIESRDVSGALPVVQVGMVWRKGSSLPQSARDFVGIAEALRSARPR
>Mature_301_residues
AFTLRQLQYFVAVAEQGSVTRAAQNLSISQSSITEAVKELESDLGVELFDRHPRGLSITHNGHQFLRHATKILADVSDAR
RSFSDSREERSGRLNLGVTSLVAGYVLSDLLARYRRACPGVEVSAIEDNGSYLEHLLIGGELDVAVMVISNLRDRMALQA
EILETSPYRLWLPIGHPLVSADIISVEDIAREPLIMLTVDEIEENTGKLLTALGARPHVAFRTRSVEAVRSLVATGAGIA
LLPDLVYRPWSLEGDRIESRDVSGALPVVQVGMVWRKGSSLPQSARDFVGIAEALRSARPR

Specific function: Hydrogen Peroxide Sensor. Activates The Expression Of A Regulon Of Hydrogen Peroxide-Inducible Genes Such As Katg, Gor, Ahpc, Ahpf, Oxys (A Regulatory RNA), Dps, Fur And Grxa. Oxyr Expression Is Negatively Autoregulated By Binding To A 43 Bp Region Upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=304, Percent_Identity=28.9473684210526, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI157672245, Length=291, Percent_Identity=27.4914089347079, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1787879, Length=303, Percent_Identity=27.3927392739274, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788887, Length=300, Percent_Identity=27.3333333333333, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1787601, Length=284, Percent_Identity=25.7042253521127, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787806, Length=280, Percent_Identity=28.2142857142857, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI2367136, Length=262, Percent_Identity=26.7175572519084, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87081904, Length=180, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788296, Length=252, Percent_Identity=26.5873015873016, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786401, Length=272, Percent_Identity=27.5735294117647, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788748, Length=293, Percent_Identity=23.8907849829352, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788297, Length=256, Percent_Identity=27.734375, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788481, Length=124, Percent_Identity=33.0645161290323, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI145693105, Length=303, Percent_Identity=22.4422442244224, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787530, Length=320, Percent_Identity=23.75, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1789506, Length=307, Percent_Identity=23.4527687296417, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790262, Length=252, Percent_Identity=25.7936507936508, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082132, Length=144, Percent_Identity=29.1666666666667, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790208, Length=248, Percent_Identity=26.6129032258064, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787589, Length=150, Percent_Identity=28.6666666666667, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789204, Length=285, Percent_Identity=22.8070175438596, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788626, Length=240, Percent_Identity=27.5, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33101; Mature: 32970

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFTLRQLQYFVAVAEQGSVTRAAQNLSISQSSITEAVKELESDLGVELFDRHPRGLSIT
CCHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCEEEE
HNGHQFLRHATKILADVSDARRSFSDSREERSGRLNLGVTSLVAGYVLSDLLARYRRACP
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GVEVSAIEDNGSYLEHLLIGGELDVAVMVISNLRDRMALQAEILETSPYRLWLPIGHPLV
CCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
SADIISVEDIAREPLIMLTVDEIEENTGKLLTALGARPHVAFRTRSVEAVRSLVATGAGI
HHHHCCHHHHCCCCEEEEEHHHHHCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCH
ALLPDLVYRPWSLEGDRIESRDVSGALPVVQVGMVWRKGSSLPQSARDFVGIAEALRSAR
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
PR
CC
>Mature Secondary Structure 
AFTLRQLQYFVAVAEQGSVTRAAQNLSISQSSITEAVKELESDLGVELFDRHPRGLSIT
CHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCEEEE
HNGHQFLRHATKILADVSDARRSFSDSREERSGRLNLGVTSLVAGYVLSDLLARYRRACP
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
GVEVSAIEDNGSYLEHLLIGGELDVAVMVISNLRDRMALQAEILETSPYRLWLPIGHPLV
CCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCH
SADIISVEDIAREPLIMLTVDEIEENTGKLLTALGARPHVAFRTRSVEAVRSLVATGAGI
HHHHCCHHHHCCCCEEEEEHHHHHCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCH
ALLPDLVYRPWSLEGDRIESRDVSGALPVVQVGMVWRKGSSLPQSARDFVGIAEALRSAR
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
PR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]