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The map label for this gene is hbdA [H]

Identifier: 150397375

GI number: 150397375

Start: 2244802

End: 2246292

Strand: Direct

Name: hbdA [H]

Synonym: Smed_2174

Alternate gene names: 150397375

Gene position: 2244802-2246292 (Clockwise)

Preceding gene: 150397374

Following gene: 150397376

Centisome position: 59.36

GC content: 62.98

Gene sequence:

>1491_bases
ATGACCACCATTACCAAGGCCGCCTGTGTCGGCGGCGGCGTCATCGGCGGGGCCTGGGCTGCGCGTTTTGCGCTTGCAGG
GATAGACGTCAACATCTTCGACCCGCATCCGGAGGCCGAGCGCATTATCGGCGAGGTCATGGCCAATGCTGAACGCGCTT
ATGGCATGCTGACCATGGCGCCGCTGCCGCCGCTCGGAAAATTAACTTTCTGCAAGAGCATTCAGGAAGCAGTCGAAGAC
GTTGACTGGATTCAGGAAAGCGTGCCCGAACGGCTGCCGCTGAAGCGCGGCGTCATCACCGAAATCGACGCGGCCGCCCG
GCCCGACGCACTGATCGGCTCCTCCACTTCGGGACTGCTCCCGTCCGACCTGCAGGCCGAGATGAAGCACCCCGAACGCA
TGTTCGTGGCCCATCCCTACAACCCGGTCTATCTGCTGCCCCTGGTGGAGCTCGTCGGCGGCAAGAAGACTTCGCCGCAA
ACGATCAGGCGCGCCGAAGAAGCCGTCGCCGAGATCGGCATGAAAGGCGTTGTGATCGCCAAGGAGATAGAGGCTTTCGT
CGGCGACCGGCTGCTCGAGGCGTTATGGCGCGAGGCGCTGTGGCTGATCCAGGATGACATCTGCGATACCGAGACGCTCG
ACGACGTCATGCGCTATTCCTTCGGCATGCGCTGGGCGCAGATGGGTCTCTTCGAAACTTATCGAATCGCCGGCGGCGAA
GCCGGCATGCGCCACTTCCTCGCCCAGTTCGGCCCCTGCCTCAAATGGCCATGGACGAAATTCACCGACGTGGTCGATCT
GGACGAGGCGCTTGTCGAGAAGATCGGCGCGCAATCCGACGCGCAGGCCGCCGGTCGCTCGATCCGCGAGCTCGAGCGCA
TCCGCGATGAGAATCTCGTCGGCATCATGCACGCCCTGAAAGCGAGCGACGGCGGCAAGGGCTGGGGTGCGGGCAAGCTG
CTGGCCGATTTCGAGAAGCGGCTTTGGGCGAAGGGCGGCACCCCCTCGACAGCCCACGATGTTTCCGGGCCGCTGCGTCT
GGTCGAGACCAGGGTCAATGCCGCCTGGGTCGACTACAACGGCCACATGACCGAGCATCGCTATCTGCAGCTTTTCGGAG
ATACCTCGGATGCTCTGCTCAAGCTGATCGGCGTCGACTTCGCCTATGTCGAGGCCGGTCACAGCTACTATACGGTCGAG
ACCCACATCCGCCATCTCGGCGAAGCCAAGCTGGGACAGGCACTCTATACGACGCTGCAACTTCTTTCGTCCGACGAGAA
GCGGATTCACTTCTTCACCCGAATTCACGATGCAGCTTCGGGAGACGTGATCGCCACCGCCGAACAGATGATGCTGCATG
TCGACGCCAAAGCCGGCAAGTCCGTGCCGGCGCCGGCCGAGGTGATGGCGAAGCTGAAGCCGATCGCCGAAGGCCATGCG
AAGCTCGATGCGCCTGACGGCGCGGGGCGTCATGTGGGGCAGAAGCGGTAA

Upstream 100 bases:

>100_bases
GCCTGGGCCGGAGGGGCCAGTCCTCGGGTCGAACCCGAGGAGAGGAGCAGACTGCGATTTCAGGGGCAGACCGGGATTAC
AAGGAATCGAGGAGAGCGGA

Downstream 100 bases:

>100_bases
GGATCGCATGCGGCAGCCCTCATCCGGCTGCCGCAGCCGCTTGCACCCATTTACCCCGGGGAGAGGGGCAACTGACGAGG
GAGAACCATGAATTTCGCAC

Product: bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MTTITKAACVGGGVIGGAWAARFALAGIDVNIFDPHPEAERIIGEVMANAERAYGMLTMAPLPPLGKLTFCKSIQEAVED
VDWIQESVPERLPLKRGVITEIDAAARPDALIGSSTSGLLPSDLQAEMKHPERMFVAHPYNPVYLLPLVELVGGKKTSPQ
TIRRAEEAVAEIGMKGVVIAKEIEAFVGDRLLEALWREALWLIQDDICDTETLDDVMRYSFGMRWAQMGLFETYRIAGGE
AGMRHFLAQFGPCLKWPWTKFTDVVDLDEALVEKIGAQSDAQAAGRSIRELERIRDENLVGIMHALKASDGGKGWGAGKL
LADFEKRLWAKGGTPSTAHDVSGPLRLVETRVNAAWVDYNGHMTEHRYLQLFGDTSDALLKLIGVDFAYVEAGHSYYTVE
THIRHLGEAKLGQALYTTLQLLSSDEKRIHFFTRIHDAASGDVIATAEQMMLHVDAKAGKSVPAPAEVMAKLKPIAEGHA
KLDAPDGAGRHVGQKR

Sequences:

>Translated_496_residues
MTTITKAACVGGGVIGGAWAARFALAGIDVNIFDPHPEAERIIGEVMANAERAYGMLTMAPLPPLGKLTFCKSIQEAVED
VDWIQESVPERLPLKRGVITEIDAAARPDALIGSSTSGLLPSDLQAEMKHPERMFVAHPYNPVYLLPLVELVGGKKTSPQ
TIRRAEEAVAEIGMKGVVIAKEIEAFVGDRLLEALWREALWLIQDDICDTETLDDVMRYSFGMRWAQMGLFETYRIAGGE
AGMRHFLAQFGPCLKWPWTKFTDVVDLDEALVEKIGAQSDAQAAGRSIRELERIRDENLVGIMHALKASDGGKGWGAGKL
LADFEKRLWAKGGTPSTAHDVSGPLRLVETRVNAAWVDYNGHMTEHRYLQLFGDTSDALLKLIGVDFAYVEAGHSYYTVE
THIRHLGEAKLGQALYTTLQLLSSDEKRIHFFTRIHDAASGDVIATAEQMMLHVDAKAGKSVPAPAEVMAKLKPIAEGHA
KLDAPDGAGRHVGQKR
>Mature_495_residues
TTITKAACVGGGVIGGAWAARFALAGIDVNIFDPHPEAERIIGEVMANAERAYGMLTMAPLPPLGKLTFCKSIQEAVEDV
DWIQESVPERLPLKRGVITEIDAAARPDALIGSSTSGLLPSDLQAEMKHPERMFVAHPYNPVYLLPLVELVGGKKTSPQT
IRRAEEAVAEIGMKGVVIAKEIEAFVGDRLLEALWREALWLIQDDICDTETLDDVMRYSFGMRWAQMGLFETYRIAGGEA
GMRHFLAQFGPCLKWPWTKFTDVVDLDEALVEKIGAQSDAQAAGRSIRELERIRDENLVGIMHALKASDGGKGWGAGKLL
ADFEKRLWAKGGTPSTAHDVSGPLRLVETRVNAAWVDYNGHMTEHRYLQLFGDTSDALLKLIGVDFAYVEAGHSYYTVET
HIRHLGEAKLGQALYTTLQLLSSDEKRIHFFTRIHDAASGDVIATAEQMMLHVDAKAGKSVPAPAEVMAKLKPIAEGHAK
LDAPDGAGRHVGQKR

Specific function: FADb And FADa Are The Alpha And Beta Subunits Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=260, Percent_Identity=35, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI68989263, Length=260, Percent_Identity=26.9230769230769, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI261878539, Length=260, Percent_Identity=27.3076923076923, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790281, Length=142, Percent_Identity=30.2816901408451, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1787661, Length=320, Percent_Identity=24.375, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193203623, Length=241, Percent_Identity=29.4605809128631, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI115533614, Length=239, Percent_Identity=28.8702928870293, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71985923, Length=192, Percent_Identity=28.125, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17549919, Length=242, Percent_Identity=26.4462809917355, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71985930, Length=202, Percent_Identity=26.2376237623762, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17553560, Length=246, Percent_Identity=25.2032520325203, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=148, Percent_Identity=29.0540540540541, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144276, Length=238, Percent_Identity=26.0504201680672, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508953, Length=236, Percent_Identity=25.4237288135593, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508951, Length=236, Percent_Identity=25.4237288135593, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45549573, Length=261, Percent_Identity=31.8007662835249, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI20129993, Length=311, Percent_Identity=26.6881028938907, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 54269; Mature: 54138

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTITKAACVGGGVIGGAWAARFALAGIDVNIFDPHPEAERIIGEVMANAERAYGMLTMA
CCCCHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCEEEEC
PLPPLGKLTFCKSIQEAVEDVDWIQESVPERLPLKRGVITEIDAAARPDALIGSSTSGLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHHCCCCCCCCCEECCCCCCCC
PSDLQAEMKHPERMFVAHPYNPVYLLPLVELVGGKKTSPQTIRRAEEAVAEIGMKGVVIA
CCHHHHHHCCCCEEEEECCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEHH
KEIEAFVGDRLLEALWREALWLIQDDICDTETLDDVMRYSFGMRWAQMGLFETYRIAGGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCH
AGMRHFLAQFGPCLKWPWTKFTDVVDLDEALVEKIGAQSDAQAAGRSIRELERIRDENLV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHH
GIMHALKASDGGKGWGAGKLLADFEKRLWAKGGTPSTAHDVSGPLRLVETRVNAAWVDYN
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHCEEEEECC
GHMTEHRYLQLFGDTSDALLKLIGVDFAYVEAGHSYYTVETHIRHLGEAKLGQALYTTLQ
CCCCCCHHEEEECCCHHHHHHHHCCCHHEEECCCCEEEHHHHHHHHCHHHHHHHHHHHHH
LLSSDEKRIHFFTRIHDAASGDVIATAEQMMLHVDAKAGKSVPAPAEVMAKLKPIAEGHA
HHCCCCHHHHHHHHHHHCCCCCEEEEHHHHHEEEEHHCCCCCCCCHHHHHHHHHHHCCCC
KLDAPDGAGRHVGQKR
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTITKAACVGGGVIGGAWAARFALAGIDVNIFDPHPEAERIIGEVMANAERAYGMLTMA
CCCHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHCEEEEC
PLPPLGKLTFCKSIQEAVEDVDWIQESVPERLPLKRGVITEIDAAARPDALIGSSTSGLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHHCCCCCCCCCEECCCCCCCC
PSDLQAEMKHPERMFVAHPYNPVYLLPLVELVGGKKTSPQTIRRAEEAVAEIGMKGVVIA
CCHHHHHHCCCCEEEEECCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEHH
KEIEAFVGDRLLEALWREALWLIQDDICDTETLDDVMRYSFGMRWAQMGLFETYRIAGGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCH
AGMRHFLAQFGPCLKWPWTKFTDVVDLDEALVEKIGAQSDAQAAGRSIRELERIRDENLV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHH
GIMHALKASDGGKGWGAGKLLADFEKRLWAKGGTPSTAHDVSGPLRLVETRVNAAWVDYN
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHCEEEEECC
GHMTEHRYLQLFGDTSDALLKLIGVDFAYVEAGHSYYTVETHIRHLGEAKLGQALYTTLQ
CCCCCCHHEEEECCCHHHHHHHHCCCHHEEECCCCEEEHHHHHHHHCHHHHHHHHHHHHH
LLSSDEKRIHFFTRIHDAASGDVIATAEQMMLHVDAKAGKSVPAPAEVMAKLKPIAEGHA
HHCCCCHHHHHHHHHHHCCCCCEEEEHHHHHEEEEHHCCCCCCCCHHHHHHHHHHHCCCC
KLDAPDGAGRHVGQKR
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]