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The map label for this gene is aapM [H]

Identifier: 150397301

GI number: 150397301

Start: 2161142

End: 2162272

Strand: Direct

Name: aapM [H]

Synonym: Smed_2100

Alternate gene names: 150397301

Gene position: 2161142-2162272 (Clockwise)

Preceding gene: 150397300

Following gene: 150397302

Centisome position: 57.14

GC content: 61.27

Gene sequence:

>1131_bases
ATGATCGCCAGATTCCTGAAATGGTCGCGGCACAATCTGTTCGGCAAGCCGTTCGACATTCTGCTGTCTCTCACCGTCAT
ACCCGGCTTTCTCTGGCTGGCCTACCAGGTCGCGGCCTGGACGGTTACGACGGCGCGATGGGAGATCATCCCCGAGAGCC
TGCGGATCCTGATGATCGGCATTTTCCCGGCCGAGCAGGCATGGCGCGCCTGGGTCGCGATCATGATCATCGCCGCCCTC
CTCGGCGCGGCGCTGGGATGCGTGTTCGCCTTCAGGAAGCGCCACGCGGCTGGCTTGCTCTTGGTGCTGGCTGCCGTCAT
CGCGCTTACGGGTTCAAAAGACCTGACGAATGCGCTCCTTACCGCCTCGACCATTGCGATCTTTGCGAGCGGCTGCGCGG
CAATCTCGCTTATCCCCTTGCTTCGCAGAGCATTGTTGCCGGCTGGCTTCATTGCGCTGATCGCAATCTTCGCCGTCATG
TCGCCGCCCGGCGCCGGCCTTTGGGGTGGCCTGCTCCTGAGCATTCTGCTGACGCTCGTGACATCGATTGTCTCGCTTCC
GGTCGGAATCCTGCTCGCCTTTGGCCGCCGCAGCCGTTTCTCGAGCATGCGGTGGATCTGTATGGGCTATATCGAGGTGA
TGCGGTCCGTGCCATTGATCATGGTCGTCTACTGGATCTGGATTCTGATGCCAGTCCTGGCGCCGCAATTCGGCCTCGCG
GACGTCGTGCGCGGCATGATCGGCTTCACCCTGTTCTATTCCGCCTATGTGGCCGAATATGTCCGGAGCGGCCTGCAAGC
CGTTCCCCGCGAACAGACCGAGGCGGCCCGCTCGCTCGGCATGAGCGAGTTCGACATCAACCGCTCGATCGTACTGCCGC
AGGCCCTTCGCGTGGCGGTGCCGCCGCTTGTCGGCAATGTGCTCGATATTTTCAATACGGCGCCGCTGGTCTTCATCATC
GGCCTGACGGATTTTCTGCGCGCCGGTCAGATGATCCTGGCCAATCCCCAATATGGCGACCGGACCTATGAGGTCTACGC
CTTCCTGTTTCTCACCTATTTCCTTGTCGGATCCCTGATAACCTTCGTCGCGCGCAGGCTCGAAACGCATCTTGCACGAG
GCAATCGGTGA

Upstream 100 bases:

>100_bases
GCATCCTCATCGTCATGGCGTCCTATCTGATCCTTAGCTGGGCTATCAGCGCGACCGTCGCCTGGGCCGACCGCCGCCTG
AGCAAACGCGGAGCGATGTG

Downstream 100 bases:

>100_bases
CCGAAATGAGCCATGCTGGAGACAGTTCCATGAACGCCATCATCGAAATGAAGAACCTCAACAAGTTCTATGGAAGCCAT
CATGTTCTGAAGGATATCGA

Product: polar amino acid ABC transporter inner membrane subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MIARFLKWSRHNLFGKPFDILLSLTVIPGFLWLAYQVAAWTVTTARWEIIPESLRILMIGIFPAEQAWRAWVAIMIIAAL
LGAALGCVFAFRKRHAAGLLLVLAAVIALTGSKDLTNALLTASTIAIFASGCAAISLIPLLRRALLPAGFIALIAIFAVM
SPPGAGLWGGLLLSILLTLVTSIVSLPVGILLAFGRRSRFSSMRWICMGYIEVMRSVPLIMVVYWIWILMPVLAPQFGLA
DVVRGMIGFTLFYSAYVAEYVRSGLQAVPREQTEAARSLGMSEFDINRSIVLPQALRVAVPPLVGNVLDIFNTAPLVFII
GLTDFLRAGQMILANPQYGDRTYEVYAFLFLTYFLVGSLITFVARRLETHLARGNR

Sequences:

>Translated_376_residues
MIARFLKWSRHNLFGKPFDILLSLTVIPGFLWLAYQVAAWTVTTARWEIIPESLRILMIGIFPAEQAWRAWVAIMIIAAL
LGAALGCVFAFRKRHAAGLLLVLAAVIALTGSKDLTNALLTASTIAIFASGCAAISLIPLLRRALLPAGFIALIAIFAVM
SPPGAGLWGGLLLSILLTLVTSIVSLPVGILLAFGRRSRFSSMRWICMGYIEVMRSVPLIMVVYWIWILMPVLAPQFGLA
DVVRGMIGFTLFYSAYVAEYVRSGLQAVPREQTEAARSLGMSEFDINRSIVLPQALRVAVPPLVGNVLDIFNTAPLVFII
GLTDFLRAGQMILANPQYGDRTYEVYAFLFLTYFLVGSLITFVARRLETHLARGNR
>Mature_376_residues
MIARFLKWSRHNLFGKPFDILLSLTVIPGFLWLAYQVAAWTVTTARWEIIPESLRILMIGIFPAEQAWRAWVAIMIIAAL
LGAALGCVFAFRKRHAAGLLLVLAAVIALTGSKDLTNALLTASTIAIFASGCAAISLIPLLRRALLPAGFIALIAIFAVM
SPPGAGLWGGLLLSILLTLVTSIVSLPVGILLAFGRRSRFSSMRWICMGYIEVMRSVPLIMVVYWIWILMPVLAPQFGLA
DVVRGMIGFTLFYSAYVAEYVRSGLQAVPREQTEAARSLGMSEFDINRSIVLPQALRVAVPPLVGNVLDIFNTAPLVFII
GLTDFLRAGQMILANPQYGDRTYEVYAFLFLTYFLVGSLITFVARRLETHLARGNR

Specific function: Part of a binding-protein-dependent transport system for L-amino acids, affects the uptake as well as efflux of these amino acids. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI87082239, Length=389, Percent_Identity=29.305912596401, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786873, Length=213, Percent_Identity=31.4553990610329, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788226, Length=194, Percent_Identity=31.4432989690722, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1786874, Length=214, Percent_Identity=26.1682242990654, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787030, Length=189, Percent_Identity=27.5132275132275, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788646, Length=222, Percent_Identity=25.2252252252252, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI48994930, Length=78, Percent_Identity=43.5897435897436, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787087, Length=229, Percent_Identity=23.1441048034935, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 41349; Mature: 41349

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARFLKWSRHNLFGKPFDILLSLTVIPGFLWLAYQVAAWTVTTARWEIIPESLRILMIG
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
IFPAEQAWRAWVAIMIIAALLGAALGCVFAFRKRHAAGLLLVLAAVIALTGSKDLTNALL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
TASTIAIFASGCAAISLIPLLRRALLPAGFIALIAIFAVMSPPGAGLWGGLLLSILLTLV
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TSIVSLPVGILLAFGRRSRFSSMRWICMGYIEVMRSVPLIMVVYWIWILMPVLAPQFGLA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DVVRGMIGFTLFYSAYVAEYVRSGLQAVPREQTEAARSLGMSEFDINRSIVLPQALRVAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCCCEECHHHHHHHC
PPLVGNVLDIFNTAPLVFIIGLTDFLRAGQMILANPQYGDRTYEVYAFLFLTYFLVGSLI
CHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
TFVARRLETHLARGNR
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIARFLKWSRHNLFGKPFDILLSLTVIPGFLWLAYQVAAWTVTTARWEIIPESLRILMIG
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
IFPAEQAWRAWVAIMIIAALLGAALGCVFAFRKRHAAGLLLVLAAVIALTGSKDLTNALL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
TASTIAIFASGCAAISLIPLLRRALLPAGFIALIAIFAVMSPPGAGLWGGLLLSILLTLV
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TSIVSLPVGILLAFGRRSRFSSMRWICMGYIEVMRSVPLIMVVYWIWILMPVLAPQFGLA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DVVRGMIGFTLFYSAYVAEYVRSGLQAVPREQTEAARSLGMSEFDINRSIVLPQALRVAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCCCEECHHHHHHHC
PPLVGNVLDIFNTAPLVFIIGLTDFLRAGQMILANPQYGDRTYEVYAFLFLTYFLVGSLI
CHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
TFVARRLETHLARGNR
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]