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The map label for this gene is atsA [H]

Identifier: 150397266

GI number: 150397266

Start: 2116263

End: 2117891

Strand: Direct

Name: atsA [H]

Synonym: Smed_2065

Alternate gene names: 150397266

Gene position: 2116263-2117891 (Clockwise)

Preceding gene: 150397265

Following gene: 150397267

Centisome position: 55.96

GC content: 60.47

Gene sequence:

>1629_bases
ATGCAACCAACCGAGAGAGCCTTGATGAGCAAGCGCCCCAATATCGTCCTCGTACTGGCTGATGACATGGGTTTTTCCGA
CCTCGGCTGCTATGGCGGAGAAATCTCGACGCCCAATCTGGACAGCCTCGCGCGTCGCGGCGCGCGCTTCACGCAGTTCT
ATAACACGGCGCGATGCAGCCCATCGCGTGCGTCGCTTCTGACCGGGCTTCATCCTCACCAGACCGGCATCGGTATTCTG
ACCAACAACGACTTGCCGCGAGGCTATCCGGGTAACCTGAACCTGCGATGCGCCACGCTGGCGGAAATGCTGAAAGCTGC
CGGATATGCGACATGCCTCTCGGGGAAATGGCACCTGGCGAGCGAAATGCACGAACCGAACGATACCTGGCCGACGAGAC
GCGGTTTCGACCGGTTCTTCGGCACGCTCACCGGCTGCGGCAGCTTCTATACGCCCGGAACGCTGACCCGCGGCGAATGC
GACGCCTCGGCCGAAGCACTCGACCCGGCATTCTTCTATACCGACGCCATCGCCTCTCATGCCGCGGAATTCGTCACCGA
ACAGTCCGCGGCAGGCAATCCGTTCTTTCTCTACGCCGCCTTCACCGCTCCCCATTGGCCGCTTCATGCACATCCCGGCG
ATATCGACCGTTATCGGGGGCGCTTTGACGAAGGCTGGGACGTTCTGCGCGAAAAGCGGATGAAGCGGCTGGTCGAGGAA
GGAATTCTTACGGCGAGCACCGCAATCAGCGCGCGCGATCCCACGCAGCCCGCCTGGTCTGATACGAAGGAAAAGGCTTG
GCAAGTCAAACGAATGCAGGCCTATGCTGCCCAAATCGAGCGAATGGACCGCGGGATCGGCAAAATCATCGAGGCACTTA
AGACCGGCGGCACCTTCGAAAACACGGCTTTCATCTTCCTGTCCGACAATGGAGCATCGCCGGAGGATCTGCCGCAATTC
GACGCCGAAAAATTCATGCGGCGAACGGACATTCTTCCACGGGCGACGCGCGATGGACTACCGATGCGTGTCGGCAATAC
TCCCGATATCTGCCCTGGTGCCGAAGACACATATTCCAGCTATGGCCGTGCCTGGGCAAACCTGTCCAATACGCCCTTCC
GCTTCTACAAACGGTGGGTGCATGAAGGCGGCATCGCCACGCCATTGATTGTCCATTGGCCCGCAGGAGGACTCGATTGC
GGCGCGATCCTCGATCAACCCGCCCAGCTCGTCGATATCGCCCCAACCATTCTGGAAGTGACCGGTGCAAGCTATCCGCT
TCAGGCTATCGGCCGGGAAATCGCTCCGCTGGAAGGCTGCAGCCTGCTTCCTGCATTGAAGGGCGAAATACTCTTCGAGA
GGCCGCTCTACTGGGAACACACGGGTAATGCCGCAATCCGCCTCGGACGATGGAAGCTTGTTCGCGAAGAGCCAAATGGC
TGGGAACTTTACGACCTTGCAGCCGATCGCACAGAGCTGAACGACGTGGCGCCGGGCAACCCTGAGGTCGTCGCGGACCT
CCGGGCAAAATGGGAAGCCTGGGCAGAGCGCATCGGCGTCATCCCCTGGGAGGTAACGCTCGGCATTTACGAGGAACGCG
GTCTGCATCCGACCTGGGCAGCCGGCTGA

Upstream 100 bases:

>100_bases
GCCTGCCCTGCGGGTTCGGCGATCCCTTACAAGCACATCCGACACAGCTGCCGGCATCGGCCGGCGGAAAGGAGCGGGCG
TGCCAGATAACTGAGAACCG

Downstream 100 bases:

>100_bases
GTGCATCAAGAGCCGGTCCGCCAGGCGAGATCACCCGGCCGGGTCCGGCATCAAAAGGAAAGTCACGACCATGGCTTCGG
TCGAAATTCAGAGTGTCAAA

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MQPTERALMSKRPNIVLVLADDMGFSDLGCYGGEISTPNLDSLARRGARFTQFYNTARCSPSRASLLTGLHPHQTGIGIL
TNNDLPRGYPGNLNLRCATLAEMLKAAGYATCLSGKWHLASEMHEPNDTWPTRRGFDRFFGTLTGCGSFYTPGTLTRGEC
DASAEALDPAFFYTDAIASHAAEFVTEQSAAGNPFFLYAAFTAPHWPLHAHPGDIDRYRGRFDEGWDVLREKRMKRLVEE
GILTASTAISARDPTQPAWSDTKEKAWQVKRMQAYAAQIERMDRGIGKIIEALKTGGTFENTAFIFLSDNGASPEDLPQF
DAEKFMRRTDILPRATRDGLPMRVGNTPDICPGAEDTYSSYGRAWANLSNTPFRFYKRWVHEGGIATPLIVHWPAGGLDC
GAILDQPAQLVDIAPTILEVTGASYPLQAIGREIAPLEGCSLLPALKGEILFERPLYWEHTGNAAIRLGRWKLVREEPNG
WELYDLAADRTELNDVAPGNPEVVADLRAKWEAWAERIGVIPWEVTLGIYEERGLHPTWAAG

Sequences:

>Translated_542_residues
MQPTERALMSKRPNIVLVLADDMGFSDLGCYGGEISTPNLDSLARRGARFTQFYNTARCSPSRASLLTGLHPHQTGIGIL
TNNDLPRGYPGNLNLRCATLAEMLKAAGYATCLSGKWHLASEMHEPNDTWPTRRGFDRFFGTLTGCGSFYTPGTLTRGEC
DASAEALDPAFFYTDAIASHAAEFVTEQSAAGNPFFLYAAFTAPHWPLHAHPGDIDRYRGRFDEGWDVLREKRMKRLVEE
GILTASTAISARDPTQPAWSDTKEKAWQVKRMQAYAAQIERMDRGIGKIIEALKTGGTFENTAFIFLSDNGASPEDLPQF
DAEKFMRRTDILPRATRDGLPMRVGNTPDICPGAEDTYSSYGRAWANLSNTPFRFYKRWVHEGGIATPLIVHWPAGGLDC
GAILDQPAQLVDIAPTILEVTGASYPLQAIGREIAPLEGCSLLPALKGEILFERPLYWEHTGNAAIRLGRWKLVREEPNG
WELYDLAADRTELNDVAPGNPEVVADLRAKWEAWAERIGVIPWEVTLGIYEERGLHPTWAAG
>Mature_542_residues
MQPTERALMSKRPNIVLVLADDMGFSDLGCYGGEISTPNLDSLARRGARFTQFYNTARCSPSRASLLTGLHPHQTGIGIL
TNNDLPRGYPGNLNLRCATLAEMLKAAGYATCLSGKWHLASEMHEPNDTWPTRRGFDRFFGTLTGCGSFYTPGTLTRGEC
DASAEALDPAFFYTDAIASHAAEFVTEQSAAGNPFFLYAAFTAPHWPLHAHPGDIDRYRGRFDEGWDVLREKRMKRLVEE
GILTASTAISARDPTQPAWSDTKEKAWQVKRMQAYAAQIERMDRGIGKIIEALKTGGTFENTAFIFLSDNGASPEDLPQF
DAEKFMRRTDILPRATRDGLPMRVGNTPDICPGAEDTYSSYGRAWANLSNTPFRFYKRWVHEGGIATPLIVHWPAGGLDC
GAILDQPAQLVDIAPTILEVTGASYPLQAIGREIAPLEGCSLLPALKGEILFERPLYWEHTGNAAIRLGRWKLVREEPNG
WELYDLAADRTELNDVAPGNPEVVADLRAKWEAWAERIGVIPWEVTLGIYEERGLHPTWAAG

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI109389362, Length=313, Percent_Identity=31.629392971246, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI59797060, Length=535, Percent_Identity=26.9158878504673, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI38569405, Length=322, Percent_Identity=30.4347826086957, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI38569407, Length=323, Percent_Identity=30.3405572755418, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI53831991, Length=493, Percent_Identity=27.1805273833671, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI71852584, Length=518, Percent_Identity=26.4478764478764, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4503899, Length=476, Percent_Identity=27.3109243697479, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI58743319, Length=330, Percent_Identity=29.3939393939394, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI146229331, Length=270, Percent_Identity=34.8148148148148, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI146229329, Length=270, Percent_Identity=34.8148148148148, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI6005990, Length=270, Percent_Identity=34.8148148148148, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI146229324, Length=270, Percent_Identity=34.8148148148148, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI45430057, Length=232, Percent_Identity=35.7758620689655, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI4506919, Length=448, Percent_Identity=28.125, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI31742482, Length=140, Percent_Identity=42.1428571428571, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI157266309, Length=138, Percent_Identity=42.0289855072464, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71852586, Length=162, Percent_Identity=40.1234567901235, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI87081924, Length=495, Percent_Identity=25.6565656565657, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790112, Length=309, Percent_Identity=29.4498381877023, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI1790233, Length=145, Percent_Identity=35.1724137931034, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533416, Length=534, Percent_Identity=24.5318352059925, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI115533418, Length=525, Percent_Identity=24.5714285714286, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17559078, Length=276, Percent_Identity=30.7971014492754, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24666109, Length=527, Percent_Identity=26.7552182163188, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI281366397, Length=315, Percent_Identity=29.8412698412698, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281366395, Length=315, Percent_Identity=29.8412698412698, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24666163, Length=315, Percent_Identity=29.8412698412698, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281363223, Length=478, Percent_Identity=24.4769874476987, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24666175, Length=453, Percent_Identity=28.0353200883002, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24653364, Length=349, Percent_Identity=26.0744985673352, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922168, Length=349, Percent_Identity=25.7879656160458, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 59991; Mature: 59991

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPTERALMSKRPNIVLVLADDMGFSDLGCYGGEISTPNLDSLARRGARFTQFYNTARCS
CCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCC
PSRASLLTGLHPHQTGIGILTNNDLPRGYPGNLNLRCATLAEMLKAAGYATCLSGKWHLA
CHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHHCCCCEEECCCCHHH
SEMHEPNDTWPTRRGFDRFFGTLTGCGSFYTPGTLTRGECDASAEALDPAFFYTDAIASH
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHH
AAEFVTEQSAAGNPFFLYAAFTAPHWPLHAHPGDIDRYRGRFDEGWDVLREKRMKRLVEE
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHH
GILTASTAISARDPTQPAWSDTKEKAWQVKRMQAYAAQIERMDRGIGKIIEALKTGGTFE
CCHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NTAFIFLSDNGASPEDLPQFDAEKFMRRTDILPRATRDGLPMRVGNTPDICPGAEDTYSS
CEEEEEEECCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCHHHHH
YGRAWANLSNTPFRFYKRWVHEGGIATPLIVHWPAGGLDCGAILDQPAQLVDIAPTILEV
HHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHH
TGASYPLQAIGREIAPLEGCSLLPALKGEILFERPLYWEHTGNAAIRLGRWKLVREEPNG
CCCCCCHHHHCCCCCCCCCCCCCHHHCCCEEEECCEEEEECCCCEEEEEEEEEEEECCCC
WELYDLAADRTELNDVAPGNPEVVADLRAKWEAWAERIGVIPWEVTLGIYEERGLHPTWA
CEEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCC
AG
CC
>Mature Secondary Structure
MQPTERALMSKRPNIVLVLADDMGFSDLGCYGGEISTPNLDSLARRGARFTQFYNTARCS
CCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCC
PSRASLLTGLHPHQTGIGILTNNDLPRGYPGNLNLRCATLAEMLKAAGYATCLSGKWHLA
CHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHHCCCCEEECCCCHHH
SEMHEPNDTWPTRRGFDRFFGTLTGCGSFYTPGTLTRGECDASAEALDPAFFYTDAIASH
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHH
AAEFVTEQSAAGNPFFLYAAFTAPHWPLHAHPGDIDRYRGRFDEGWDVLREKRMKRLVEE
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHH
GILTASTAISARDPTQPAWSDTKEKAWQVKRMQAYAAQIERMDRGIGKIIEALKTGGTFE
CCHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NTAFIFLSDNGASPEDLPQFDAEKFMRRTDILPRATRDGLPMRVGNTPDICPGAEDTYSS
CEEEEEEECCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCHHHHH
YGRAWANLSNTPFRFYKRWVHEGGIATPLIVHWPAGGLDCGAILDQPAQLVDIAPTILEV
HHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHH
TGASYPLQAIGREIAPLEGCSLLPALKGEILFERPLYWEHTGNAAIRLGRWKLVREEPNG
CCCCCCHHHHCCCCCCCCCCCCCHHHCCCEEEECCEEEEECCCCEEEEEEEEEEEECCCC
WELYDLAADRTELNDVAPGNPEVVADLRAKWEAWAERIGVIPWEVTLGIYEERGLHPTWA
CEEEEECCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCC
AG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]