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The map label for this gene is uvrD [H]

Identifier: 150397238

GI number: 150397238

Start: 2086986

End: 2089538

Strand: Direct

Name: uvrD [H]

Synonym: Smed_2037

Alternate gene names: 150397238

Gene position: 2086986-2089538 (Clockwise)

Preceding gene: 150397237

Following gene: 150397240

Centisome position: 55.18

GC content: 63.34

Gene sequence:

>2553_bases
ATGAGCAAAGGATTTGACGATATTCCCTTCTTCGACGAGGAGCCCGCTCCCCGGCAAGCGGCGGCTGCTACCGGCGGGAT
CGCCGCACGCGCCATGGCCGCCCGCGACAAGGCCCAGCGGCCGGACTACCTCTCCGGCCTCAATCCGGAGCAGCGTGAGG
CGGTCGAGGCACTGGAGGGTCCGGTGCTCGTCCTCGCCGGAGCCGGTACCGGCAAGACGCGGGTCCTGACGACGCGGATC
GCGCATATCCTCTCGACCGGCCGCGCCTTTCCCTCGCAGATCCTCGCCGTCACCTTCACCAACAAGGCAGCGCGGGAAAT
GAAGGAGCGCATCGGCGTGCTCGTCGGCCACGCCGTCGAAGGCATGCCCTGGCTCGGGACCTTCCACTCGATCGGGGTCA
AACTCCTTCGCCGCCATGCGGAGCTGGTGGGGTTGAGGTCGGACTTCACCATTCTCGACACCGATGACGTCGTCCGTCTC
ATCAAGCAGCTCATCCAGGCCGAAGGGCTCGACGACAAGCGTTGGCCGGCCAAGCAATTCGCCGGTATGATCGACACCTG
GAAGAACAAGGGACTGGACCCCTCGCAGATCCCCGAAGGCGATGCCCGCGCATTCGCGAATGGCAAGGGCCGCGAGCTCT
ATGCCGCCTACCAGAATCGGCTGCTGACGCTCAATGCCTGCGATTTCGGCGATCTGCTGCTTCATCCGATCCGCATGTTC
CGCGCCAATCCGGACGTGCTGAAGGAGTATCACGGCAAGTTCCGCTATATCCTCGTCGACGAATATCAGGACACGAATAC
GGCGCAATATATGTGGCTGCGGCTGCTCGCCCAGCGGCCGCGGCCGTCTGAGCGATCTGCCTCGGCAGGTCCGGGCGACG
CCCGGCAAGGCCAGGTGGCCGCCGCGCCCGATCGCGCGCCCCCGCGCAGCGGCGACAGCGTGAGCGCAAGCAAACAGCAG
CAAATAAATATTTGCTGCGTCGGCGATGACGACCAGTCCATCTACGGCTGGCGTGGCGCCGAGGTGGACAACATCCTCCG
CTTCGAGAAGGATTTCCCCGGCGCCAAGGTCATCAAGCTGGAGCGCAACTACCGCTCCACCGAACATATCCTCGGCGCGG
CAGCGCATCTGATTGCTCATAACGAAGGCCGTCTCGGCAAGACGCTCTTTACGGAACGCACGAATCCTGAGGACGAGAAG
GTGCATGTGCATGCTGCCTGGGACTCCGAAGAAGAGGCCCGCGCGGTCGGCGAGGAGATCGAGCAGCTCCAGCGCAAGAA
TCACAAACTGAACGACATAGCGATCCTGGTGCGCGCCTCCTTTCAGATGCGCGAGTTCGAAGATCGCTTCGTCACTCTCG
GCCTCAACTATCGCGTTATCGGCGGTCCCCGCTTTTACGAGCGGATGGAAATCCGCGATGCCATGGCCTATTTCCGCCTC
GTCTGTCAGCCGGCCGACGACCTCGCCTTCGAGCGCATCGTCAATACGCCGAAACGGGGCCTTGGCGACACGACCGTCCG
CACGCTTCACGACTATGCCCGCGCCCGCGACATCCCCATGCTGGCTGCGGCAAGCGAAATCATCGAGACGGACGAGTTGA
AAGCGAAGGCGCGCAAGTCCCTCTTCGACGTCGTCGCGGATTTCCGCCGCTGGCAGACATTGCTCGAAACGACGCCACAC
ACCGAACTCGCGGAACAGATTCTCGAAGAGAGCGGCTACACCGCAATGTGGCAGGCCGACAAATCGGCGGAGGCACCCGG
GCGCCTCGAAAACCTGAAGGAGCTCATCCGTTCGATGGAAGCCTTCGAGTCGATGCGTGGTTTCCTCGAGCACGTCGCCC
TCGTCATGGACGCCGAGCAGAACGAGAATATGGACGCAGTTTCAATCATGACGCTGCATTCGGCCAAGGGACTGGAATTC
AGTACCGTCTTCCTGCCCGGCTGGGAGGAAGGACTCTTCCCGCACCAGCGCGCTCTCGACGAGGGCGGCCGCTCCGGGCT
GGAGGAAGAACGCCGCCTCGCCTATGTCGGAATTACCCGCGCCAAGCACCGCTGCCATATCTGGTTCGTGTCGAACCGGC
GCATCCACGGTCTCTGGCAGTCGACGCTTCCATCGCGCTTTCTCGACGAGCTCCCGATCGCCCATGTTGAGGTCGCCGAA
CAGGAGGCCTCCTATGGCGGCTATAGTCGCGGCTACGGGCAGTCACGATTCGACAAGGCCGATCCATTCGAAAACAGCTA
CCAGACGCCCGGCTGGAAGCGCGCGCAGCAGCACCGTTCGGAGGCCACCCGCGACAACTGGGGCACCCGGTCCGGCCACT
CTGTTGAACGCATCGGTTACGGCGAATCGGGCCCTCGCACCCGCACCATCGAAGGCGAGCTCGTCGCCAAGTCGACCACG
GCCGAACCATCCCGCTTCAACGTCGGCGACCGCGTCTTCCACATCAAGTTCGGCAACGGAAACATCGCGGCGATCGAGGG
GAACAAGCTGACGATCGACTTCGATCGCGCCGGGCAGAAACGCGTGCTGGATGGGTTTGTCGAGCGGGCGTGA

Upstream 100 bases:

>100_bases
GCCATTCTTTCCACAGGCATGCCGGCAAGGGTGAAGTATCCGGAATAAAAGAAGAACATCATTTCTGGCCTTTCGGTCCC
GAATCACTACATTGGGCCGC

Downstream 100 bases:

>100_bases
AGCTGGAGCCTTCCTGCCGGAGCGCTGGTGAACGAAGTTTGTGCTTCGGATGGGCTCCGCACCCCCTCGATGGCGTAATC
CCACTAAACGAAACGGATCT

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 850; Mature: 849

Protein sequence:

>850_residues
MSKGFDDIPFFDEEPAPRQAAAATGGIAARAMAARDKAQRPDYLSGLNPEQREAVEALEGPVLVLAGAGTGKTRVLTTRI
AHILSTGRAFPSQILAVTFTNKAAREMKERIGVLVGHAVEGMPWLGTFHSIGVKLLRRHAELVGLRSDFTILDTDDVVRL
IKQLIQAEGLDDKRWPAKQFAGMIDTWKNKGLDPSQIPEGDARAFANGKGRELYAAYQNRLLTLNACDFGDLLLHPIRMF
RANPDVLKEYHGKFRYILVDEYQDTNTAQYMWLRLLAQRPRPSERSASAGPGDARQGQVAAAPDRAPPRSGDSVSASKQQ
QINICCVGDDDQSIYGWRGAEVDNILRFEKDFPGAKVIKLERNYRSTEHILGAAAHLIAHNEGRLGKTLFTERTNPEDEK
VHVHAAWDSEEEARAVGEEIEQLQRKNHKLNDIAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERMEIRDAMAYFRL
VCQPADDLAFERIVNTPKRGLGDTTVRTLHDYARARDIPMLAAASEIIETDELKAKARKSLFDVVADFRRWQTLLETTPH
TELAEQILEESGYTAMWQADKSAEAPGRLENLKELIRSMEAFESMRGFLEHVALVMDAEQNENMDAVSIMTLHSAKGLEF
STVFLPGWEEGLFPHQRALDEGGRSGLEEERRLAYVGITRAKHRCHIWFVSNRRIHGLWQSTLPSRFLDELPIAHVEVAE
QEASYGGYSRGYGQSRFDKADPFENSYQTPGWKRAQQHRSEATRDNWGTRSGHSVERIGYGESGPRTRTIEGELVAKSTT
AEPSRFNVGDRVFHIKFGNGNIAAIEGNKLTIDFDRAGQKRVLDGFVERA

Sequences:

>Translated_850_residues
MSKGFDDIPFFDEEPAPRQAAAATGGIAARAMAARDKAQRPDYLSGLNPEQREAVEALEGPVLVLAGAGTGKTRVLTTRI
AHILSTGRAFPSQILAVTFTNKAAREMKERIGVLVGHAVEGMPWLGTFHSIGVKLLRRHAELVGLRSDFTILDTDDVVRL
IKQLIQAEGLDDKRWPAKQFAGMIDTWKNKGLDPSQIPEGDARAFANGKGRELYAAYQNRLLTLNACDFGDLLLHPIRMF
RANPDVLKEYHGKFRYILVDEYQDTNTAQYMWLRLLAQRPRPSERSASAGPGDARQGQVAAAPDRAPPRSGDSVSASKQQ
QINICCVGDDDQSIYGWRGAEVDNILRFEKDFPGAKVIKLERNYRSTEHILGAAAHLIAHNEGRLGKTLFTERTNPEDEK
VHVHAAWDSEEEARAVGEEIEQLQRKNHKLNDIAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERMEIRDAMAYFRL
VCQPADDLAFERIVNTPKRGLGDTTVRTLHDYARARDIPMLAAASEIIETDELKAKARKSLFDVVADFRRWQTLLETTPH
TELAEQILEESGYTAMWQADKSAEAPGRLENLKELIRSMEAFESMRGFLEHVALVMDAEQNENMDAVSIMTLHSAKGLEF
STVFLPGWEEGLFPHQRALDEGGRSGLEEERRLAYVGITRAKHRCHIWFVSNRRIHGLWQSTLPSRFLDELPIAHVEVAE
QEASYGGYSRGYGQSRFDKADPFENSYQTPGWKRAQQHRSEATRDNWGTRSGHSVERIGYGESGPRTRTIEGELVAKSTT
AEPSRFNVGDRVFHIKFGNGNIAAIEGNKLTIDFDRAGQKRVLDGFVERA
>Mature_849_residues
SKGFDDIPFFDEEPAPRQAAAATGGIAARAMAARDKAQRPDYLSGLNPEQREAVEALEGPVLVLAGAGTGKTRVLTTRIA
HILSTGRAFPSQILAVTFTNKAAREMKERIGVLVGHAVEGMPWLGTFHSIGVKLLRRHAELVGLRSDFTILDTDDVVRLI
KQLIQAEGLDDKRWPAKQFAGMIDTWKNKGLDPSQIPEGDARAFANGKGRELYAAYQNRLLTLNACDFGDLLLHPIRMFR
ANPDVLKEYHGKFRYILVDEYQDTNTAQYMWLRLLAQRPRPSERSASAGPGDARQGQVAAAPDRAPPRSGDSVSASKQQQ
INICCVGDDDQSIYGWRGAEVDNILRFEKDFPGAKVIKLERNYRSTEHILGAAAHLIAHNEGRLGKTLFTERTNPEDEKV
HVHAAWDSEEEARAVGEEIEQLQRKNHKLNDIAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERMEIRDAMAYFRLV
CQPADDLAFERIVNTPKRGLGDTTVRTLHDYARARDIPMLAAASEIIETDELKAKARKSLFDVVADFRRWQTLLETTPHT
ELAEQILEESGYTAMWQADKSAEAPGRLENLKELIRSMEAFESMRGFLEHVALVMDAEQNENMDAVSIMTLHSAKGLEFS
TVFLPGWEEGLFPHQRALDEGGRSGLEEERRLAYVGITRAKHRCHIWFVSNRRIHGLWQSTLPSRFLDELPIAHVEVAEQ
EASYGGYSRGYGQSRFDKADPFENSYQTPGWKRAQQHRSEATRDNWGTRSGHSVERIGYGESGPRTRTIEGELVAKSTTA
EPSRFNVGDRVFHIKFGNGNIAAIEGNKLTIDFDRAGQKRVLDGFVERA

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=693, Percent_Identity=41.4141414141414, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI48994965, Length=696, Percent_Identity=36.9252873563218, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1787196, Length=384, Percent_Identity=26.3020833333333, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322369, Length=795, Percent_Identity=26.5408805031447, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 95511; Mature: 95380

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKGFDDIPFFDEEPAPRQAAAATGGIAARAMAARDKAQRPDYLSGLNPEQREAVEALEG
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHCC
PVLVLAGAGTGKTRVLTTRIAHILSTGRAFPSQILAVTFTNKAAREMKERIGVLVGHAVE
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHC
GMPWLGTFHSIGVKLLRRHAELVGLRSDFTILDTDDVVRLIKQLIQAEGLDDKRWPAKQF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCHHHH
AGMIDTWKNKGLDPSQIPEGDARAFANGKGRELYAAYQNRLLTLNACDFGDLLLHPIRMF
HHHHHHHHCCCCCHHHCCCCCHHHCCCCCCCEEHHHHHCCEEEEECCCHHHHHHHHHHHH
RANPDVLKEYHGKFRYILVDEYQDTNTAQYMWLRLLAQRPRPSERSASAGPGDARQGQVA
CCCHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
AAPDRAPPRSGDSVSASKQQQINICCVGDDDQSIYGWRGAEVDNILRFEKDFPGAKVIKL
ECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEE
ERNYRSTEHILGAAAHLIAHNEGRLGKTLFTERTNPEDEKVHVHAAWDSEEEARAVGEEI
ECCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHH
EQLQRKNHKLNDIAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERMEIRDAMAYFRL
HHHHHHCCCCCCEEEEEEHHHHHHHHCCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHH
VCQPADDLAFERIVNTPKRGLGDTTVRTLHDYARARDIPMLAAASEIIETDELKAKARKS
HHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LFDVVADFRRWQTLLETTPHTELAEQILEESGYTAMWQADKSAEAPGRLENLKELIRSME
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
AFESMRGFLEHVALVMDAEQNENMDAVSIMTLHSAKGLEFSTVFLPGWEEGLFPHQRALD
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHH
EGGRSGLEEERRLAYVGITRAKHRCHIWFVSNRRIHGLWQSTLPSRFLDELPIAHVEVAE
HCCCCCCHHHHHEEEEEEECCCCEEEEEEEECCEEEHHHHHHHHHHHHHHCCCHHHHHHH
QEASYGGYSRGYGQSRFDKADPFENSYQTPGWKRAQQHRSEATRDNWGTRSGHSVERIGY
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GESGPRTRTIEGELVAKSTTAEPSRFNVGDRVFHIKFGNGNIAAIEGNKLTIDFDRAGQK
CCCCCCEEEECCEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEECCEEEEEECCCCCH
RVLDGFVERA
HHHHHHHHCC
>Mature Secondary Structure 
SKGFDDIPFFDEEPAPRQAAAATGGIAARAMAARDKAQRPDYLSGLNPEQREAVEALEG
CCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHCC
PVLVLAGAGTGKTRVLTTRIAHILSTGRAFPSQILAVTFTNKAAREMKERIGVLVGHAVE
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHC
GMPWLGTFHSIGVKLLRRHAELVGLRSDFTILDTDDVVRLIKQLIQAEGLDDKRWPAKQF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCHHHH
AGMIDTWKNKGLDPSQIPEGDARAFANGKGRELYAAYQNRLLTLNACDFGDLLLHPIRMF
HHHHHHHHCCCCCHHHCCCCCHHHCCCCCCCEEHHHHHCCEEEEECCCHHHHHHHHHHHH
RANPDVLKEYHGKFRYILVDEYQDTNTAQYMWLRLLAQRPRPSERSASAGPGDARQGQVA
CCCHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
AAPDRAPPRSGDSVSASKQQQINICCVGDDDQSIYGWRGAEVDNILRFEKDFPGAKVIKL
ECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEE
ERNYRSTEHILGAAAHLIAHNEGRLGKTLFTERTNPEDEKVHVHAAWDSEEEARAVGEEI
ECCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHH
EQLQRKNHKLNDIAILVRASFQMREFEDRFVTLGLNYRVIGGPRFYERMEIRDAMAYFRL
HHHHHHCCCCCCEEEEEEHHHHHHHHCCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHH
VCQPADDLAFERIVNTPKRGLGDTTVRTLHDYARARDIPMLAAASEIIETDELKAKARKS
HHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LFDVVADFRRWQTLLETTPHTELAEQILEESGYTAMWQADKSAEAPGRLENLKELIRSME
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
AFESMRGFLEHVALVMDAEQNENMDAVSIMTLHSAKGLEFSTVFLPGWEEGLFPHQRALD
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHH
EGGRSGLEEERRLAYVGITRAKHRCHIWFVSNRRIHGLWQSTLPSRFLDELPIAHVEVAE
HCCCCCCHHHHHEEEEEEECCCCEEEEEEEECCEEEHHHHHHHHHHHHHHCCCHHHHHHH
QEASYGGYSRGYGQSRFDKADPFENSYQTPGWKRAQQHRSEATRDNWGTRSGHSVERIGY
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GESGPRTRTIEGELVAKSTTAEPSRFNVGDRVFHIKFGNGNIAAIEGNKLTIDFDRAGQK
CCCCCCEEEECCEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEECCEEEEEECCCCCH
RVLDGFVERA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]