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The map label for this gene is yqjI [H]

Identifier: 150396935

GI number: 150396935

Start: 1812163

End: 1813593

Strand: Reverse

Name: yqjI [H]

Synonym: Smed_1732

Alternate gene names: 150396935

Gene position: 1813593-1812163 (Counterclockwise)

Preceding gene: 150396939

Following gene: 150396934

Centisome position: 47.95

GC content: 62.61

Gene sequence:

>1431_bases
GTGTCACAGGCGGAAATCGGCCTAATCGGTCTCGGAGTCATGGGCTCGAACCTGGCGCTCAACATTGCTGAAAAAGGCAA
CAAGATCGCCGTTTTCAACCGCACGGTTGATGCGACGCGCAGATTTTACGCGGAGGCCGGCGCTCTGAAGGATCAGATCG
TCCCCTGCGAAACGATTCAGGAATTCGTCGCCGCGATCCGCCCGCCGCGTCCGATCATCATCATGATCAAAGCCGGCGAC
CCGGTCGATCAGCAGATGGAGGCGCTGAAACCCCATCTCGCTAAGGGCGACATCATGATCGATGCGGGCAACGCCAATTT
CCGCGACACGATGCGCCGTTTCGATGCGCTGAAGGACTCCGGCCTGACCTTTATCGGGATGGGTGTTTCCGGTGGCGAGG
AGGGCGCGCGGCATGGGCCCTCCATCATGGTCGGAGGCACGGAGGAATCCTACCGGCGCGTGGAGAAGGTTCTGACTTCG
ATCGCTGCGAAATATGACAGCGACCCCTGCGTCGCCTGGCTCGGAGAGAACGGCGCCGGACACTTTGTCAAGACGATCCA
CAACGGTATCGAATATGCCGACATGCAGATGATCGCCGAGATTTACGGCATTCTGCGTGACGGGCTGAAGATGTCGGCAC
AGGAGATCGGCGAGGTCTTCGGCGCCTGGAACAAGGGGCGACTCAATTCGTATCTGATCGAGATAACCGAGAAGGTGCTG
AAGGCCGCCGATCCGCTGACGGGCAATCCCATTGTCGACATGATCCTCGACAAGGCCGGCCAGAAGGGCACCGGCAAATG
GTCGGTGATCGAGGCGCAGAACATGGGCGTGCCTGCGACCGCCATCGAAGCTGCGGTCGCAGCCCGCAGCATTTCCTCGG
CGAAGGGGGAGCGCGAGGCGGCCGAGAAGATCCTCGGCCTGCCTCCGGTCGGCGAGATCCGGGTCACCGACAGGGACGCC
TTCATCAAAGATCTGGAAAACGCGCTGCTCGCCGCCAAGGTCGGCGCCTATGCGCAGGGATTCGCCGTCATGTCAGCTGC
GTCCAACGAGTTCGGCTGGAACCTGCCGATGCCGACGATCGCAAAGATCTGGCGCGCCGGCTGCATTATCCGCTCTCAGT
TCCTAGATGAGATCACCACGGCTTTCACCAAGGCGCCCGATGCGGCGAATCTGATCGTCACGCCCGCCTTCGCGGCCATG
GTCAAGGAGACCGACGGGGCCTTGCGCCGGGTGGTTTCGACGGCTGTCCTCGGAGGTCTTCCGGTACCGGCGCTTGCCTC
GGCGCTCGGCTACTTCGACAGCTACCGCCGCGGCCGCGGCACTGCAAACGTCATCCAGGCGCAGCGCGACTTCTTCGGCG
CCCATGGCTTCGACCGCATCGACGGCGCCGACAGCCATCATGGGCCGTGGGGCAGCGGCTTGAGCGCTTGA

Upstream 100 bases:

>100_bases
TTTTCACGGGGTCGGCAGACATGCGCAGATCAATTCGAGGGGCCGGCACGCGCGCAATCGCGCCCTGTGGCCGCCTCTCC
TGTCCAATGGAGGCAACCAC

Downstream 100 bases:

>100_bases
GTTCGCATGCGTCAGGAGGGGCGGCTGGGCCGTCCCTCTTACGACACGTCCAGGCAAGCCACGGCGTTTAAGATCTCAAC
AAGGGAGCCCTTCGAGAAGG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSQAEIGLIGLGVMGSNLALNIAEKGNKIAVFNRTVDATRRFYAEAGALKDQIVPCETIQEFVAAIRPPRPIIIMIKAGD
PVDQQMEALKPHLAKGDIMIDAGNANFRDTMRRFDALKDSGLTFIGMGVSGGEEGARHGPSIMVGGTEESYRRVEKVLTS
IAAKYDSDPCVAWLGENGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLKMSAQEIGEVFGAWNKGRLNSYLIEITEKVL
KAADPLTGNPIVDMILDKAGQKGTGKWSVIEAQNMGVPATAIEAAVAARSISSAKGEREAAEKILGLPPVGEIRVTDRDA
FIKDLENALLAAKVGAYAQGFAVMSAASNEFGWNLPMPTIAKIWRAGCIIRSQFLDEITTAFTKAPDAANLIVTPAFAAM
VKETDGALRRVVSTAVLGGLPVPALASALGYFDSYRRGRGTANVIQAQRDFFGAHGFDRIDGADSHHGPWGSGLSA

Sequences:

>Translated_476_residues
MSQAEIGLIGLGVMGSNLALNIAEKGNKIAVFNRTVDATRRFYAEAGALKDQIVPCETIQEFVAAIRPPRPIIIMIKAGD
PVDQQMEALKPHLAKGDIMIDAGNANFRDTMRRFDALKDSGLTFIGMGVSGGEEGARHGPSIMVGGTEESYRRVEKVLTS
IAAKYDSDPCVAWLGENGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLKMSAQEIGEVFGAWNKGRLNSYLIEITEKVL
KAADPLTGNPIVDMILDKAGQKGTGKWSVIEAQNMGVPATAIEAAVAARSISSAKGEREAAEKILGLPPVGEIRVTDRDA
FIKDLENALLAAKVGAYAQGFAVMSAASNEFGWNLPMPTIAKIWRAGCIIRSQFLDEITTAFTKAPDAANLIVTPAFAAM
VKETDGALRRVVSTAVLGGLPVPALASALGYFDSYRRGRGTANVIQAQRDFFGAHGFDRIDGADSHHGPWGSGLSA
>Mature_475_residues
SQAEIGLIGLGVMGSNLALNIAEKGNKIAVFNRTVDATRRFYAEAGALKDQIVPCETIQEFVAAIRPPRPIIIMIKAGDP
VDQQMEALKPHLAKGDIMIDAGNANFRDTMRRFDALKDSGLTFIGMGVSGGEEGARHGPSIMVGGTEESYRRVEKVLTSI
AAKYDSDPCVAWLGENGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLKMSAQEIGEVFGAWNKGRLNSYLIEITEKVLK
AADPLTGNPIVDMILDKAGQKGTGKWSVIEAQNMGVPATAIEAAVAARSISSAKGEREAAEKILGLPPVGEIRVTDRDAF
IKDLENALLAAKVGAYAQGFAVMSAASNEFGWNLPMPTIAKIWRAGCIIRSQFLDEITTAFTKAPDAANLIVTPAFAAMV
KETDGALRRVVSTAVLGGLPVPALASALGYFDSYRRGRGTANVIQAQRDFFGAHGFDRIDGADSHHGPWGSGLSA

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=461, Percent_Identity=46.4208242950108, Blast_Score=399, Evalue=1e-111,
Organism=Escherichia coli, GI1788341, Length=474, Percent_Identity=48.3122362869198, Blast_Score=453, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17542558, Length=461, Percent_Identity=45.7700650759219, Blast_Score=420, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321695, Length=471, Percent_Identity=47.3460721868365, Blast_Score=451, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6321977, Length=454, Percent_Identity=46.9162995594714, Blast_Score=419, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24639279, Length=473, Percent_Identity=44.1860465116279, Blast_Score=392, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 50779; Mature: 50648

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAEIGLIGLGVMGSNLALNIAEKGNKIAVFNRTVDATRRFYAEAGALKDQIVPCETIQ
CCCCCEEEEEEEEECCCEEEEEECCCCEEEEEECCHHHHHHHHHHHCCHHHCCCCHHHHH
EFVAAIRPPRPIIIMIKAGDPVDQQMEALKPHLAKGDIMIDAGNANFRDTMRRFDALKDS
HHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHC
GLTFIGMGVSGGEEGARHGPSIMVGGTEESYRRVEKVLTSIAAKYDSDPCVAWLGENGAG
CCEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
HFVKTIHNGIEYADMQMIAEIYGILRDGLKMSAQEIGEVFGAWNKGRLNSYLIEITEKVL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KAADPLTGNPIVDMILDKAGQKGTGKWSVIEAQNMGVPATAIEAAVAARSISSAKGEREA
HHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHH
AEKILGLPPVGEIRVTDRDAFIKDLENALLAAKVGAYAQGFAVMSAASNEFGWNLPMPTI
HHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
AKIWRAGCIIRSQFLDEITTAFTKAPDAANLIVTPAFAAMVKETDGALRRVVSTAVLGGL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVPALASALGYFDSYRRGRGTANVIQAQRDFFGAHGFDRIDGADSHHGPWGSGLSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQAEIGLIGLGVMGSNLALNIAEKGNKIAVFNRTVDATRRFYAEAGALKDQIVPCETIQ
CCCCEEEEEEEEECCCEEEEEECCCCEEEEEECCHHHHHHHHHHHCCHHHCCCCHHHHH
EFVAAIRPPRPIIIMIKAGDPVDQQMEALKPHLAKGDIMIDAGNANFRDTMRRFDALKDS
HHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHC
GLTFIGMGVSGGEEGARHGPSIMVGGTEESYRRVEKVLTSIAAKYDSDPCVAWLGENGAG
CCEEEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
HFVKTIHNGIEYADMQMIAEIYGILRDGLKMSAQEIGEVFGAWNKGRLNSYLIEITEKVL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KAADPLTGNPIVDMILDKAGQKGTGKWSVIEAQNMGVPATAIEAAVAARSISSAKGEREA
HHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHH
AEKILGLPPVGEIRVTDRDAFIKDLENALLAAKVGAYAQGFAVMSAASNEFGWNLPMPTI
HHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
AKIWRAGCIIRSQFLDEITTAFTKAPDAANLIVTPAFAAMVKETDGALRRVVSTAVLGGL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVPALASALGYFDSYRRGRGTANVIQAQRDFFGAHGFDRIDGADSHHGPWGSGLSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]