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The map label for this gene is hisD1 [H]

Identifier: 150396916

GI number: 150396916

Start: 1792392

End: 1793690

Strand: Reverse

Name: hisD1 [H]

Synonym: Smed_1713

Alternate gene names: 150396916

Gene position: 1793690-1792392 (Counterclockwise)

Preceding gene: 150396922

Following gene: 150396913

Centisome position: 47.43

GC content: 61.74

Gene sequence:

>1299_bases
ATGGCATCGCGTCTCAGTGCTTTGGACGGCAAGTTCACTCAGATCAAGAAACCTGGCCGCGATGCGGTCTCCGACACGGC
TCCGGTTGAGAAGACGGTCAAGGAGATCATCGCGAACGTGCGCGAGCGGGGCGACGCCGCTGTTCGCGAATATTCGGCAG
CCTTCGACAAAGTGGAGCTGGAAAAATTCGAAGTAAGCCAGGAGGAGAGGCTGAAGGCTGTCGCGGAACTCGACCCGCAG
ACCCGCGAAGACACCGAATTCGCTATTGCGAATGTCCGCGCCTTTGCAGAGGCTCAGCTCAAGACCATCCTCCCGCTGGA
GATCGAGACGCTTCCCGGCCTGCACCTCGGCCACCGTGTCATTCCGATCGAAATCGTGGGCTGCTACGTACCCGGCGGTC
GCTATCCCCTCCTGTCCGCTCCGGTCATGACCATCGTGCCGGCCAAAGTCGCCGGTTGCGATCAGGTCATCGCCTGCCTC
CCGCCGAATGCACATCCTGCAATGATTGCCGGCTGCCATCTGTCCGGCGCTGATCGAATCTTCCGCGTGGGTGGAGCCCA
GGCGATCGCAGCAATGGCATCCGGAACCGAAACCATCCCTGCAGTCGACAAGATCGTAGGGCCCGGCAACGCATTCGTAA
ACGAAGCCAAGCGCCAGGTGTTCGGTCAGGTCGGTATCGACCAGCTTGCCGGTCCGAGCGAAATCTTCATCGTCGCTGAC
GAGACCGGCAAGGCGGCGATGATTGCCACCGACCTCCTCGCTCAGGCGGAACATGACGTTCGCACCCGCGTCGGCCTGAT
CACGACCGATCGCAAACTCGCCGAAGAGACCCTGGTCGAAGTCGAAAAGCAGCTCCAGGATCTCTCCACTGCCAACGTGG
CCTCGGTCGCCTGGAAAGACTATGGCGAGATTACCGTCTGCGAAGACGAAACAACCATGATTGCTTACTCGGACTACATC
GCAGCCGAGCACCTTCAGGTCCACACCCGCGACCCGCAGGCGACAGCCAGGAAGCTCCGCAACTATGGTTCGCTGTTCAT
TGGCGAACTGGCGAGCGTGGTTTACTCGGATAAGTGCTGCGGCACCAACCACACTCTCCCGACCATGGCGGCGGGTCGCT
ACACGGGCGGCCTCTGGGTCGGTTCCTACCTCAAGACCTGCACGCACCAATGGTTGGATGAACGCGGCGTTGCCGCCGTG
GCCCCAGCCGCCGTGCGGCAAAGCGCTACGGAGCGGCTCGAAGGCCATCGTCGCGCAGCTGCCCTGAGGCTCAGCCCCCA
GCAGTTCGCTGCAGAGTAA

Upstream 100 bases:

>100_bases
GTCAAAGTGGTGAGAATACTGAACAGGTGGTTTGTGGGCAATTGCCCGTCCGCAGCGGTTCAACGATGCTGAGTGCACAT
CACCCACAAAGGAGCTTCAA

Downstream 100 bases:

>100_bases
TCGCCTCCCAGGCGTATAGAGCGGGATGATGAAAACTCTGCGCCGCTTTCCGCATCCCGCTCTAATTTTTTGGAATCTAT
CAGGCTCATGATTGCAGTGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MASRLSALDGKFTQIKKPGRDAVSDTAPVEKTVKEIIANVRERGDAAVREYSAAFDKVELEKFEVSQEERLKAVAELDPQ
TREDTEFAIANVRAFAEAQLKTILPLEIETLPGLHLGHRVIPIEIVGCYVPGGRYPLLSAPVMTIVPAKVAGCDQVIACL
PPNAHPAMIAGCHLSGADRIFRVGGAQAIAAMASGTETIPAVDKIVGPGNAFVNEAKRQVFGQVGIDQLAGPSEIFIVAD
ETGKAAMIATDLLAQAEHDVRTRVGLITTDRKLAEETLVEVEKQLQDLSTANVASVAWKDYGEITVCEDETTMIAYSDYI
AAEHLQVHTRDPQATARKLRNYGSLFIGELASVVYSDKCCGTNHTLPTMAAGRYTGGLWVGSYLKTCTHQWLDERGVAAV
APAAVRQSATERLEGHRRAAALRLSPQQFAAE

Sequences:

>Translated_432_residues
MASRLSALDGKFTQIKKPGRDAVSDTAPVEKTVKEIIANVRERGDAAVREYSAAFDKVELEKFEVSQEERLKAVAELDPQ
TREDTEFAIANVRAFAEAQLKTILPLEIETLPGLHLGHRVIPIEIVGCYVPGGRYPLLSAPVMTIVPAKVAGCDQVIACL
PPNAHPAMIAGCHLSGADRIFRVGGAQAIAAMASGTETIPAVDKIVGPGNAFVNEAKRQVFGQVGIDQLAGPSEIFIVAD
ETGKAAMIATDLLAQAEHDVRTRVGLITTDRKLAEETLVEVEKQLQDLSTANVASVAWKDYGEITVCEDETTMIAYSDYI
AAEHLQVHTRDPQATARKLRNYGSLFIGELASVVYSDKCCGTNHTLPTMAAGRYTGGLWVGSYLKTCTHQWLDERGVAAV
APAAVRQSATERLEGHRRAAALRLSPQQFAAE
>Mature_431_residues
ASRLSALDGKFTQIKKPGRDAVSDTAPVEKTVKEIIANVRERGDAAVREYSAAFDKVELEKFEVSQEERLKAVAELDPQT
REDTEFAIANVRAFAEAQLKTILPLEIETLPGLHLGHRVIPIEIVGCYVPGGRYPLLSAPVMTIVPAKVAGCDQVIACLP
PNAHPAMIAGCHLSGADRIFRVGGAQAIAAMASGTETIPAVDKIVGPGNAFVNEAKRQVFGQVGIDQLAGPSEIFIVADE
TGKAAMIATDLLAQAEHDVRTRVGLITTDRKLAEETLVEVEKQLQDLSTANVASVAWKDYGEITVCEDETTMIAYSDYIA
AEHLQVHTRDPQATARKLRNYGSLFIGELASVVYSDKCCGTNHTLPTMAAGRYTGGLWVGSYLKTCTHQWLDERGVAAVA
PAAVRQSATERLEGHRRAAALRLSPQQFAAE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=409, Percent_Identity=37.8973105134474, Blast_Score=272, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6319819, Length=426, Percent_Identity=35.4460093896714, Blast_Score=228, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46541; Mature: 46410

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASRLSALDGKFTQIKKPGRDAVSDTAPVEKTVKEIIANVRERGDAAVREYSAAFDKVEL
CCCCHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EKFEVSQEERLKAVAELDPQTREDTEFAIANVRAFAEAQLKTILPLEIETLPGLHLGHRV
HHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEE
IPIEIVGCYVPGGRYPLLSAPVMTIVPAKVAGCDQVIACLPPNAHPAMIAGCHLSGADRI
EEEEEEEEEECCCCCCCCCCCHHHHHCCHHCCCCCEEEECCCCCCCCEEEEEECCCCCCE
FRVGGAQAIAAMASGTETIPAVDKIVGPGNAFVNEAKRQVFGQVGIDQLAGPSEIFIVAD
EECCCHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCHHHCCCCCEEEEEEC
ETGKAAMIATDLLAQAEHDVRTRVGLITTDRKLAEETLVEVEKQLQDLSTANVASVAWKD
CCCCCHHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
YGEITVCEDETTMIAYSDYIAAEHLQVHTRDPQATARKLRNYGSLFIGELASVVYSDKCC
CCCEEEECCCCEEEEEHHHHHHHHEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
GTNHTLPTMAAGRYTGGLWVGSYLKTCTHQWLDERGVAAVAPAAVRQSATERLEGHRRAA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ALRLSPQQFAAE
EEEECHHHHCCC
>Mature Secondary Structure 
ASRLSALDGKFTQIKKPGRDAVSDTAPVEKTVKEIIANVRERGDAAVREYSAAFDKVEL
CCCHHHCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EKFEVSQEERLKAVAELDPQTREDTEFAIANVRAFAEAQLKTILPLEIETLPGLHLGHRV
HHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEE
IPIEIVGCYVPGGRYPLLSAPVMTIVPAKVAGCDQVIACLPPNAHPAMIAGCHLSGADRI
EEEEEEEEEECCCCCCCCCCCHHHHHCCHHCCCCCEEEECCCCCCCCEEEEEECCCCCCE
FRVGGAQAIAAMASGTETIPAVDKIVGPGNAFVNEAKRQVFGQVGIDQLAGPSEIFIVAD
EECCCHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCHHHCCCCCEEEEEEC
ETGKAAMIATDLLAQAEHDVRTRVGLITTDRKLAEETLVEVEKQLQDLSTANVASVAWKD
CCCCCHHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
YGEITVCEDETTMIAYSDYIAAEHLQVHTRDPQATARKLRNYGSLFIGELASVVYSDKCC
CCCEEEECCCCEEEEEHHHHHHHHEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
GTNHTLPTMAAGRYTGGLWVGSYLKTCTHQWLDERGVAAVAPAAVRQSATERLEGHRRAA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ALRLSPQQFAAE
EEEECHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA