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The map label for this gene is purL [H]

Identifier: 150396717

GI number: 150396717

Start: 1586239

End: 1588470

Strand: Direct

Name: purL [H]

Synonym: Smed_1505

Alternate gene names: 150396717

Gene position: 1586239-1588470 (Clockwise)

Preceding gene: 150396716

Following gene: 150396718

Centisome position: 41.94

GC content: 62.77

Gene sequence:

>2232_bases
ATGACGATTTCCAACACCCGCCCCATCACCCCGGACCTGATCGCTTCGCACGGGCTCAAGCCTGACGAATACGAACGCAT
TCTGAACCTGATCGGGCGCGAGCCGACCTTTACGGAGCTCGGCATCTTCTCGGCAATGTGGAACGAGCATTGCTCATACA
AATCCTCGAAGAAATGGCTGCGCACGCTTCCGACCAAGGGGCCGCGCGTCATCCAGGGACCCGGTGAGAACGCCGGCGTG
GTCGACATCGACGACGGGGATTGCGTCGTATTCAAGATGGAAAGCCACAACCACCCCTCCTACATCGAACCCTACCAGGG
CGCAGCTACGGGCGTCGGCGGCATACTGCGTGACGTCTTCACCATGGGTGCGCGTCCCATTGCGGCGATGAACGCGCTGC
GTTTCGGTTCTCCGGATCACCCGAAGACCCGGCACCTCGTCTCCGGGGTCGTAGCTGGCGTCGGCGGTTACGGCAATTCC
TTCGGCGTGCCGACCGTCGGCGGCGAAGTCGAGTTCGACGCGCGCTATAACGGCAACATTCTCGTCAATGCCTTCGCGGC
AGGCCTCGCCAAAACAGATGCGATCTTCTATTCCAAGGCGGAAGGCGTCGGCCTCCCCGTCGTCTATCTCGGTGCAAAGA
CCGGCCGCGACGGCGTCGGCGGTGCGACCATGGCATCTGCCGAGTTCGATGAATCGATCGAAGAAAAGCGCCCGACCGTT
CAAGTCGGCGATCCCTTTACAGAGAAGTGCCTGCTCGAGGCCTGCCTGGAGTTGATGCAGACCGGCGCGGTCATCGCGAT
CCAGGACATGGGCGCGGCCGGCCTCACCTGCTCGGCCGTCGAAATGGGCGCCAAGGGCGATCTCGGCATCGAGCTCGATC
TCGACAAGGTGCCGGTGCGCGAAGAGCGCATGACCGCTTACGAGATGATGCTTTCCGAAAGCCAGGAGCGCATGCTCATG
GTGCTGCGCCCGGAGAAGGAAGAGGAAGCCAAGGCGATCTTCGTCAAATGGGGCCTCGATTTCGCAATCGTCGGCAAGAC
CACCGACGACCTGCGTTTCCGTATCCTGCATCAGGGCGAAGAAGTGGCGAACCTGCCGATCAAGGAACTCGGCGACGAGG
CACCGGAATATGATCGGCCCTGGACGCCGGCCAAGGTGCCCTCGCCGCTCGCCACCAATGACATCCCGCAGGCTGATGTC
GCCGATACACTCTTGCAACTCGTCGGCTCCGCCAACAATTCCTCGCGCCGCTGGGTTTATGAGCAGTATGACACGCTGAT
CCAGGGCAATTCGCTGCAGCTTCCGGGGGGCGACGCCGGCGTGGTTCGCGTCGAGGGCCATGAGGCCAAGGCGCTTGCAT
TCTCTTCGGACGTGACGCCGCGCTATGTCGAAGCCGATCCGTTCGAGGGTGGCAAGCAGGCAGTCGCCGAATGCTGGCGC
AACCTGACCGCGACCGGCGCGCTGCCGCTCGCCGCAACCGACAATCTCAACTTCGGCAACCCCGAGCGTCCCGAGATCAT
GAGCCAGCTCGTCCATGCGATCAAAGGCATAGGTGAAGCCTGCCAGGCGCTCGACTTTCCGATCGTCTCCGGAAACGTGT
CGCTTTATAACGAGACCAACGGACAGGCTATCCTGCCGACCCCCACGATCGGCGGCGTCGGCCTCGTCCGCGACTGGTCG
AAAATGGCGCGGATACGCTTTGCTGTTGCGGACGAAACCATCCTTCTTGCCGGCGCTCCAAAAAGCTGGGGAACACACAT
TGGCCAGTCCGTCTACATGCGCGACATTCACGGCCGCACGGATGGTCCGGCGCCGCATGTCGACCTCGCCCATGAACGCA
AGGTCGGCGATTTCGTTCGCGGGCTGATCGGCGACGGTCTGGTCACGGCCGTCCACGACTGCTCGTCGGGCGGACTTGCA
CTGGCCGTGGCCGAGATGGCCATGGCTTCCGGCATCGGCGCGACGATCGCGGCACCGGCGGAGCACGACGCGATTCCGGT
CTTCTACGGCGAGGATCAAGGTCGCTATGTCGTAACCGTCGCAAATGGCGCGGTCGAGACGGTGGCTGCTCGGGCAAAAG
CCGCCGGAGTTGCGCTGCCGGTAATTGGCAGGACCGGCGGAGATGCGGTGAAGCTCGGGGATGCAAGACCCGTTTCGGTA
AACGCCTTGCGTTCCGCGCATGAAGCGTGGTTCCCCAATTATATGGGCGGCGATCTTGCGCCGGACAATTGA

Upstream 100 bases:

>100_bases
CTGTTGATCGCCCGTATTTTTCTGTCGCACCATGCCGCGGCATAGGCTAAAGAAGCCGCAAAGTGCCCTATAGCGCCGCG
CGAAGGATTGACGGTCGACG

Downstream 100 bases:

>100_bases
TCCGCCGACCGGGCGGACGGCGGAAACAGCATTTGCGTTCGGCCCCTGAATCGTGTTTCCCTTGGGACCATAGCGAGCGG
CAGCAATGTTGCCGCCCCAA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MTISNTRPITPDLIASHGLKPDEYERILNLIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGV
VDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGSPDHPKTRHLVSGVVAGVGGYGNS
FGVPTVGGEVEFDARYNGNILVNAFAAGLAKTDAIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
QVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMTAYEMMLSESQERMLM
VLRPEKEEEAKAIFVKWGLDFAIVGKTTDDLRFRILHQGEEVANLPIKELGDEAPEYDRPWTPAKVPSPLATNDIPQADV
ADTLLQLVGSANNSSRRWVYEQYDTLIQGNSLQLPGGDAGVVRVEGHEAKALAFSSDVTPRYVEADPFEGGKQAVAECWR
NLTATGALPLAATDNLNFGNPERPEIMSQLVHAIKGIGEACQALDFPIVSGNVSLYNETNGQAILPTPTIGGVGLVRDWS
KMARIRFAVADETILLAGAPKSWGTHIGQSVYMRDIHGRTDGPAPHVDLAHERKVGDFVRGLIGDGLVTAVHDCSSGGLA
LAVAEMAMASGIGATIAAPAEHDAIPVFYGEDQGRYVVTVANGAVETVAARAKAAGVALPVIGRTGGDAVKLGDARPVSV
NALRSAHEAWFPNYMGGDLAPDN

Sequences:

>Translated_743_residues
MTISNTRPITPDLIASHGLKPDEYERILNLIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGV
VDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGSPDHPKTRHLVSGVVAGVGGYGNS
FGVPTVGGEVEFDARYNGNILVNAFAAGLAKTDAIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
QVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMTAYEMMLSESQERMLM
VLRPEKEEEAKAIFVKWGLDFAIVGKTTDDLRFRILHQGEEVANLPIKELGDEAPEYDRPWTPAKVPSPLATNDIPQADV
ADTLLQLVGSANNSSRRWVYEQYDTLIQGNSLQLPGGDAGVVRVEGHEAKALAFSSDVTPRYVEADPFEGGKQAVAECWR
NLTATGALPLAATDNLNFGNPERPEIMSQLVHAIKGIGEACQALDFPIVSGNVSLYNETNGQAILPTPTIGGVGLVRDWS
KMARIRFAVADETILLAGAPKSWGTHIGQSVYMRDIHGRTDGPAPHVDLAHERKVGDFVRGLIGDGLVTAVHDCSSGGLA
LAVAEMAMASGIGATIAAPAEHDAIPVFYGEDQGRYVVTVANGAVETVAARAKAAGVALPVIGRTGGDAVKLGDARPVSV
NALRSAHEAWFPNYMGGDLAPDN
>Mature_742_residues
TISNTRPITPDLIASHGLKPDEYERILNLIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGVV
DIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGSPDHPKTRHLVSGVVAGVGGYGNSF
GVPTVGGEVEFDARYNGNILVNAFAAGLAKTDAIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTVQ
VGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMTAYEMMLSESQERMLMV
LRPEKEEEAKAIFVKWGLDFAIVGKTTDDLRFRILHQGEEVANLPIKELGDEAPEYDRPWTPAKVPSPLATNDIPQADVA
DTLLQLVGSANNSSRRWVYEQYDTLIQGNSLQLPGGDAGVVRVEGHEAKALAFSSDVTPRYVEADPFEGGKQAVAECWRN
LTATGALPLAATDNLNFGNPERPEIMSQLVHAIKGIGEACQALDFPIVSGNVSLYNETNGQAILPTPTIGGVGLVRDWSK
MARIRFAVADETILLAGAPKSWGTHIGQSVYMRDIHGRTDGPAPHVDLAHERKVGDFVRGLIGDGLVTAVHDCSSGGLAL
AVAEMAMASGIGATIAAPAEHDAIPVFYGEDQGRYVVTVANGAVETVAARAKAAGVALPVIGRTGGDAVKLGDARPVSVN
ALRSAHEAWFPNYMGGDLAPDN

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=702, Percent_Identity=24.2165242165242, Blast_Score=93, Evalue=9e-19,
Organism=Escherichia coli, GI48994899, Length=768, Percent_Identity=24.8697916666667, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6321498, Length=731, Percent_Identity=22.7086183310534, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24582111, Length=749, Percent_Identity=24.2990654205607, Blast_Score=104, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24582109, Length=749, Percent_Identity=24.2990654205607, Blast_Score=104, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17137292, Length=749, Percent_Identity=24.2990654205607, Blast_Score=104, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 79085; Mature: 78954

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISNTRPITPDLIASHGLKPDEYERILNLIGREPTFTELGIFSAMWNEHCSYKSSKKWL
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
RTLPTKGPRVIQGPGENAGVVDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVF
HHCCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPIAAMNALRFGSPDHPKTRHLVSGVVAGVGGYGNSFGVPTVGGEVEFDARYNGNI
HHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCEECCCE
LVNAFAAGLAKTDAIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
EEEEHHHHHHHHCEEEEECCCCCCCCEEEEECCCCCCCCCCCEEECHHHHHHHHHCCCEE
QVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHEECCCCCCCEEEEECCCCCCH
EERMTAYEMMLSESQERMLMVLRPEKEEEAKAIFVKWGLDFAIVGKTTDDLRFRILHQGE
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCEEEECCCCCCCEEEEECCCC
EVANLPIKELGDEAPEYDRPWTPAKVPSPLATNDIPQADVADTLLQLVGSANNSSRRWVY
HHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEH
EQYDTLIQGNSLQLPGGDAGVVRVEGHEAKALAFSSDVTPRYVEADPFEGGKQAVAECWR
HHHHHHCCCCEEECCCCCCCEEEECCCCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHH
NLTATGALPLAATDNLNFGNPERPEIMSQLVHAIKGIGEACQALDFPIVSGNVSLYNETN
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCC
GQAILPTPTIGGVGLVRDWSKMARIRFAVADETILLAGAPKSWGTHIGQSVYMRDIHGRT
CCEEECCCCCCCCHHHHHHHHHHHEEEEEECCEEEEEECCCHHHHHHCCHHEEEECCCCC
DGPAPHVDLAHERKVGDFVRGLIGDGLVTAVHDCSSGGLALAVAEMAMASGIGATIAAPA
CCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHCCCCCHHHHHHHHHHHCCCCCEEECCC
EHDAIPVFYGEDQGRYVVTVANGAVETVAARAKAAGVALPVIGRTGGDAVKLGDARPVSV
CCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHHCCEEEEEEECCCCCEEEECCCCCCCH
NALRSAHEAWFPNYMGGDLAPDN
HHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TISNTRPITPDLIASHGLKPDEYERILNLIGREPTFTELGIFSAMWNEHCSYKSSKKWL
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHH
RTLPTKGPRVIQGPGENAGVVDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVF
HHCCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPIAAMNALRFGSPDHPKTRHLVSGVVAGVGGYGNSFGVPTVGGEVEFDARYNGNI
HHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCEECCCE
LVNAFAAGLAKTDAIFYSKAEGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTV
EEEEHHHHHHHHCEEEEECCCCCCCCEEEEECCCCCCCCCCCEEECHHHHHHHHHCCCEE
QVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHEECCCCCCCEEEEECCCCCCH
EERMTAYEMMLSESQERMLMVLRPEKEEEAKAIFVKWGLDFAIVGKTTDDLRFRILHQGE
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCEEEECCCCCCCEEEEECCCC
EVANLPIKELGDEAPEYDRPWTPAKVPSPLATNDIPQADVADTLLQLVGSANNSSRRWVY
HHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEH
EQYDTLIQGNSLQLPGGDAGVVRVEGHEAKALAFSSDVTPRYVEADPFEGGKQAVAECWR
HHHHHHCCCCEEECCCCCCCEEEECCCCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHH
NLTATGALPLAATDNLNFGNPERPEIMSQLVHAIKGIGEACQALDFPIVSGNVSLYNETN
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCC
GQAILPTPTIGGVGLVRDWSKMARIRFAVADETILLAGAPKSWGTHIGQSVYMRDIHGRT
CCEEECCCCCCCCHHHHHHHHHHHEEEEEECCEEEEEECCCHHHHHHCCHHEEEECCCCC
DGPAPHVDLAHERKVGDFVRGLIGDGLVTAVHDCSSGGLALAVAEMAMASGIGATIAAPA
CCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHCCCCCHHHHHHHHHHHCCCCCEEECCC
EHDAIPVFYGEDQGRYVVTVANGAVETVAARAKAAGVALPVIGRTGGDAVKLGDARPVSV
CCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHHCCEEEEEEECCCCCEEEECCCCCCCH
NALRSAHEAWFPNYMGGDLAPDN
HHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA