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The map label for this gene is sthA [H]

Identifier: 150396675

GI number: 150396675

Start: 1544468

End: 1545976

Strand: Direct

Name: sthA [H]

Synonym: Smed_1462

Alternate gene names: 150396675

Gene position: 1544468-1545976 (Clockwise)

Preceding gene: 150396674

Following gene: 150396683

Centisome position: 40.84

GC content: 60.04

Gene sequence:

>1509_bases
ATGCCGCATTGCACGTCATCAAACGGTGCGATTGACGATATAGCTGTGCGTGCGCGAAATATGCCGCATCGCACAACGAT
TCTCACAGGATCAGGGGAAGCGTTCATGAACCAGTACGATCTCATCGTCGTCGGCAGTGGTCCGGCCGGGCGCAGGGGTG
CTATCCAGGCTGCGAAGCTCGGCAAGAAGGTGCTCGTCATCGAACAGGGGAAACGGGTCGGTGGCGTTTCCGTCCACACC
GGAACCATCCCGTCGAAAACCCTGCGGGAAACGGCGCTCAACCTGACAGGCTGGCGCGAGCGCGGCTTCTACGGCCGTTC
CTATCGGGTCAAGCAGGAGATCAGTGCCGAAGATCTGCGCCGGCGTCTCATTATCACCCTCAACCATGAGGTGGAGGTGC
TCGAACACCAGTTCGCGCGAAACCGGGTGCAACACATTCGCGGCCGGGCAAGCTTCGTTGGACCGACGACTCTCGAGATC
TCCAAGGACGACGACGAGAGCATGCTCGTCTCCGGCACCAGCATCCTGCTTGCGGTGGGAACGAAGCCTTTTCGGCCGGA
CGACATGCCTTTCGACGGCAGAACGGTCGTCGACAGCGACGAATTGCTGGATATCCAGGAACTGCCGCGCTCGCTCGTGG
TGATCGGCGCCGGCGTCATCGGAATAGAATACGCCACCATCTTCAGTGCTCTGGACATCCAGGTGACGGTCATTGATCCC
AAGACGACCATGCTCGATTTCATCGACCGGGAGATTGTCGAGGACTTCACCTATCAACTGCGCGACCGCGCCATGAAGCT
CAACCTTGGCCAGAAGGCGGAAAAGGTCGAGCGGCTTGAGGACGGCAAGGTACTGCTCACCCTCGACAACGGCCGCAAGA
TCACGACCGAAATGGTATTGTTCGCCGCCGGCCGGATGGGTGCAACCGACGCGCTCAACCTTCCCGCCGCCGGCCTCGAG
GCGGATGCCCGCGGGCGGCTGAAGGTCAATCCCGAGACCTTCCAGACGACGGTTCCGAACATCTACGCCGCAGGCGACGT
CGTGGGCTTTCCGAGTCTTGCTTCGACCTCGATGGAGCAGGGCCGCGTCGCGGCTCGCGTGGCTGTCGGCGCGATCGCCA
AGGAACCGCAGAAGTATTTCCCTTACGGAATTTATGCCGTGCCGGAGATCTCGACCTGCGGCCTCTCGGAAGAAGAGGTC
AAAGAGCGGGGAATTCCGTACGAATGCGGCCTTGCGCGCTTCCGGGAAACCTCACGCGGACATATCATGGGCCTGGATTC
CGGCCTCTTGAAAATGATCTTTTCGCTGAGGACACGGCGGCTGCTGGGCGTACATATCATCGGTGAAGGTGCTACCGAGC
TCGTCCATATCGGACAGGCCGTGTTGAATCTGAAAGGCACCGTCGAATACTTCGTGGAGAATACTTTCAACTATCCCACG
CTCGCCGAAGCCTACAAGATCGCCGGCCTCGACGCATGGAACCGCATGGGAGAGATCAAGTCGGAGTAG

Upstream 100 bases:

>100_bases
GTCGTGTAGATGCAAACGTATCATCGTGGGGCGCGTTCTCCTCGAAAGGACGTCCATCGTTCTGACGAAAACGTGCAGCA
GACGCATCCGGGACAGAGTG

Downstream 100 bases:

>100_bases
CGGAAGGGATTGCCGGCACTCATCCGCCTGCCGGCACGTTCTACGCGTTCTGACGGGAGAAGGAGATTCGCCGCTCCTGC
CTCGCCAACTCCTGGGGGCT

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MPHCTSSNGAIDDIAVRARNMPHRTTILTGSGEAFMNQYDLIVVGSGPAGRRGAIQAAKLGKKVLVIEQGKRVGGVSVHT
GTIPSKTLRETALNLTGWRERGFYGRSYRVKQEISAEDLRRRLIITLNHEVEVLEHQFARNRVQHIRGRASFVGPTTLEI
SKDDDESMLVSGTSILLAVGTKPFRPDDMPFDGRTVVDSDELLDIQELPRSLVVIGAGVIGIEYATIFSALDIQVTVIDP
KTTMLDFIDREIVEDFTYQLRDRAMKLNLGQKAEKVERLEDGKVLLTLDNGRKITTEMVLFAAGRMGATDALNLPAAGLE
ADARGRLKVNPETFQTTVPNIYAAGDVVGFPSLASTSMEQGRVAARVAVGAIAKEPQKYFPYGIYAVPEISTCGLSEEEV
KERGIPYECGLARFRETSRGHIMGLDSGLLKMIFSLRTRRLLGVHIIGEGATELVHIGQAVLNLKGTVEYFVENTFNYPT
LAEAYKIAGLDAWNRMGEIKSE

Sequences:

>Translated_502_residues
MPHCTSSNGAIDDIAVRARNMPHRTTILTGSGEAFMNQYDLIVVGSGPAGRRGAIQAAKLGKKVLVIEQGKRVGGVSVHT
GTIPSKTLRETALNLTGWRERGFYGRSYRVKQEISAEDLRRRLIITLNHEVEVLEHQFARNRVQHIRGRASFVGPTTLEI
SKDDDESMLVSGTSILLAVGTKPFRPDDMPFDGRTVVDSDELLDIQELPRSLVVIGAGVIGIEYATIFSALDIQVTVIDP
KTTMLDFIDREIVEDFTYQLRDRAMKLNLGQKAEKVERLEDGKVLLTLDNGRKITTEMVLFAAGRMGATDALNLPAAGLE
ADARGRLKVNPETFQTTVPNIYAAGDVVGFPSLASTSMEQGRVAARVAVGAIAKEPQKYFPYGIYAVPEISTCGLSEEEV
KERGIPYECGLARFRETSRGHIMGLDSGLLKMIFSLRTRRLLGVHIIGEGATELVHIGQAVLNLKGTVEYFVENTFNYPT
LAEAYKIAGLDAWNRMGEIKSE
>Mature_501_residues
PHCTSSNGAIDDIAVRARNMPHRTTILTGSGEAFMNQYDLIVVGSGPAGRRGAIQAAKLGKKVLVIEQGKRVGGVSVHTG
TIPSKTLRETALNLTGWRERGFYGRSYRVKQEISAEDLRRRLIITLNHEVEVLEHQFARNRVQHIRGRASFVGPTTLEIS
KDDDESMLVSGTSILLAVGTKPFRPDDMPFDGRTVVDSDELLDIQELPRSLVVIGAGVIGIEYATIFSALDIQVTVIDPK
TTMLDFIDREIVEDFTYQLRDRAMKLNLGQKAEKVERLEDGKVLLTLDNGRKITTEMVLFAAGRMGATDALNLPAAGLEA
DARGRLKVNPETFQTTVPNIYAAGDVVGFPSLASTSMEQGRVAARVAVGAIAKEPQKYFPYGIYAVPEISTCGLSEEEVK
ERGIPYECGLARFRETSRGHIMGLDSGLLKMIFSLRTRRLLGVHIIGEGATELVHIGQAVLNLKGTVEYFVENTFNYPTL
AEAYKIAGLDAWNRMGEIKSE

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=460, Percent_Identity=31.7391304347826, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI50301238, Length=469, Percent_Identity=27.2921108742004, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI22035672, Length=385, Percent_Identity=28.5714285714286, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI33519430, Length=483, Percent_Identity=24.8447204968944, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI33519428, Length=483, Percent_Identity=24.8447204968944, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI33519426, Length=483, Percent_Identity=24.8447204968944, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI148277065, Length=483, Percent_Identity=24.8447204968944, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI148277071, Length=483, Percent_Identity=24.8447204968944, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI291045266, Length=496, Percent_Identity=26.2096774193548, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI291045268, Length=361, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87082354, Length=469, Percent_Identity=39.0191897654584, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=30.1762114537445, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87081717, Length=466, Percent_Identity=26.1802575107296, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1789915, Length=441, Percent_Identity=26.0770975056689, Blast_Score=125, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=29.7180043383948, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=24.364406779661, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982272, Length=490, Percent_Identity=25.9183673469388, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71983429, Length=394, Percent_Identity=26.6497461928934, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71983419, Length=382, Percent_Identity=26.7015706806283, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321091, Length=474, Percent_Identity=27.4261603375527, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6325240, Length=476, Percent_Identity=25.4201680672269, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6325166, Length=470, Percent_Identity=24.8936170212766, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI21358499, Length=469, Percent_Identity=31.3432835820896, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24640549, Length=483, Percent_Identity=27.7432712215321, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24640551, Length=483, Percent_Identity=27.7432712215321, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24640553, Length=483, Percent_Identity=27.7432712215321, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=28.0590717299578, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 55108; Mature: 54977

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHCTSSNGAIDDIAVRARNMPHRTTILTGSGEAFMNQYDLIVVGSGPAGRRGAIQAAKL
CCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHCCCCEEEECCCCCCCCCCHHHHHC
GKKVLVIEQGKRVGGVSVHTGTIPSKTLRETALNLTGWRERGFYGRSYRVKQEISAEDLR
CCEEEEEECCCCCCCEEEECCCCCHHHHHHHHCCCCCCHHCCCCCCCEEEHHHCCHHHHC
RRLIITLNHEVEVLEHQFARNRVQHIRGRASFVGPTTLEISKDDDESMLVSGTSILLAVG
CEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEECCEEEEEEC
TKPFRPDDMPFDGRTVVDSDELLDIQELPRSLVVIGAGVIGIEYATIFSALDIQVTVIDP
CCCCCCCCCCCCCCEEECCHHCCCHHHCCCEEEEEECCHHHHHHHHHHHEEEEEEEEECC
KTTMLDFIDREIVEDFTYQLRDRAMKLNLGQKAEKVERLEDGKVLLTLDNGRKITTEMVL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEECCCCEEHHEEEE
FAAGRMGATDALNLPAAGLEADARGRLKVNPETFQTTVPNIYAAGDVVGFPSLASTSMEQ
EECCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCEEECCCCCCCCCHHHCCHHH
GRVAARVAVGAIAKEPQKYFPYGIYAVPEISTCGLSEEEVKERGIPYECGLARFRETSRG
CHHHHHHHHHHHHCCCHHHCCCCEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCC
HIMGLDSGLLKMIFSLRTRRLLGVHIIGEGATELVHIGQAVLNLKGTVEYFVENTFNYPT
EEEECCHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
LAEAYKIAGLDAWNRMGEIKSE
HHHHHHHCCCHHHHHCCCCCCC
>Mature Secondary Structure 
PHCTSSNGAIDDIAVRARNMPHRTTILTGSGEAFMNQYDLIVVGSGPAGRRGAIQAAKL
CCCCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHCCCCEEEECCCCCCCCCCHHHHHC
GKKVLVIEQGKRVGGVSVHTGTIPSKTLRETALNLTGWRERGFYGRSYRVKQEISAEDLR
CCEEEEEECCCCCCCEEEECCCCCHHHHHHHHCCCCCCHHCCCCCCCEEEHHHCCHHHHC
RRLIITLNHEVEVLEHQFARNRVQHIRGRASFVGPTTLEISKDDDESMLVSGTSILLAVG
CEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEECCEEEEEEC
TKPFRPDDMPFDGRTVVDSDELLDIQELPRSLVVIGAGVIGIEYATIFSALDIQVTVIDP
CCCCCCCCCCCCCCEEECCHHCCCHHHCCCEEEEEECCHHHHHHHHHHHEEEEEEEEECC
KTTMLDFIDREIVEDFTYQLRDRAMKLNLGQKAEKVERLEDGKVLLTLDNGRKITTEMVL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEECCCCEEHHEEEE
FAAGRMGATDALNLPAAGLEADARGRLKVNPETFQTTVPNIYAAGDVVGFPSLASTSMEQ
EECCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCEEECCCCCCCCCHHHCCHHH
GRVAARVAVGAIAKEPQKYFPYGIYAVPEISTCGLSEEEVKERGIPYECGLARFRETSRG
CHHHHHHHHHHHHCCCHHHCCCCEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCC
HIMGLDSGLLKMIFSLRTRRLLGVHIIGEGATELVHIGQAVLNLKGTVEYFVENTFNYPT
EEEECCHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
LAEAYKIAGLDAWNRMGEIKSE
HHHHHHHCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]