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The map label for this gene is map [H]

Identifier: 150396671

GI number: 150396671

Start: 1540394

End: 1541233

Strand: Direct

Name: map [H]

Synonym: Smed_1458

Alternate gene names: 150396671

Gene position: 1540394-1541233 (Clockwise)

Preceding gene: 150396670

Following gene: 150396672

Centisome position: 40.73

GC content: 60.71

Gene sequence:

>840_bases
ATGGTAACCTACATCGATGCCGGCGCGGCCCCCTACAAAAACACCGGCGTCATTCGTCTTTACGGAGCGGAGGGATTTGA
AGGCATGCGCAAGGCCTGTCAGGTGACCGCACTTTGCCTGGACGAACTCGTGACGCGCGTGAGCCCGGGCGTGACGACGG
AGGAGATCGACCGCTTCGTCTTCGAGTTCGGCATGGACCACGGTGCGCTGCCTGCAACGCTTAATTATCGCGGCTATACC
AAGTCGTCCTGCACCTCGATAAACCATGTGGTCTGTCACGGCATCCCGAACGATAAGCCGTTACGCGAAGGGGACATCGT
CAACATCGACGTGACCTATGTCGTCGATGGCTGGCACGGCGATTCCAGCCGTATGTATCCTGTCGGTGAGATAAAGCGCG
CCGCCGAGCGCCTGCTGGACGTTACGCATGAATGTCTGATGCGCGGCATAGCCGCGGTTCGCCCAGGCGCGCGCACCGGG
GCGATCGGCGAGGCGATCCAGCACTACGCCGAATCCGAGCGTTGTTCTGTCGTGCGAGACTTCTGCGGCCATGGCGTCGG
CCGGCTTTTTCACGACGCACCCAATATCCTTCATTACGGCAGCGCCAATGAGGGACCGGAGCTCAAGGAGGGCATGATTT
TCACGATCGAGCCGATGATCAATCTTGGCCGCCCGCATGTGAAGGTCCTTTCCGACGGCTGGACGGCGGTCACGCGAGAT
CGTTCGCTGTCGGCACAATACGAGCACACGGTCGGCGTCACTGCCGAGGGCTGCGAAATATTCACGCTTTCACCGGCCGG
CCTTTTCAAGCCCGGTATTCAGGTTCCGGGCGACGCGTGA

Upstream 100 bases:

>100_bases
AGGTGTCGCCCCTGCAAATCGTGGCGACGGGACCGATGATGGTGGACGAAGCGGTCCCTGCTGTTTTATGAAAACCGCCT
GAAACAACGGAAGTTCTGGA

Downstream 100 bases:

>100_bases
CGAAGACACCGCCCGCCCCCGAACCCGACGTCCTTTTCGGCGCCACGGACGAACGTCAGTTTATCCCGCAGCAGCAAACG
CCCGCCGCCGCGCCGGCGCC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MVTYIDAGAAPYKNTGVIRLYGAEGFEGMRKACQVTALCLDELVTRVSPGVTTEEIDRFVFEFGMDHGALPATLNYRGYT
KSSCTSINHVVCHGIPNDKPLREGDIVNIDVTYVVDGWHGDSSRMYPVGEIKRAAERLLDVTHECLMRGIAAVRPGARTG
AIGEAIQHYAESERCSVVRDFCGHGVGRLFHDAPNILHYGSANEGPELKEGMIFTIEPMINLGRPHVKVLSDGWTAVTRD
RSLSAQYEHTVGVTAEGCEIFTLSPAGLFKPGIQVPGDA

Sequences:

>Translated_279_residues
MVTYIDAGAAPYKNTGVIRLYGAEGFEGMRKACQVTALCLDELVTRVSPGVTTEEIDRFVFEFGMDHGALPATLNYRGYT
KSSCTSINHVVCHGIPNDKPLREGDIVNIDVTYVVDGWHGDSSRMYPVGEIKRAAERLLDVTHECLMRGIAAVRPGARTG
AIGEAIQHYAESERCSVVRDFCGHGVGRLFHDAPNILHYGSANEGPELKEGMIFTIEPMINLGRPHVKVLSDGWTAVTRD
RSLSAQYEHTVGVTAEGCEIFTLSPAGLFKPGIQVPGDA
>Mature_279_residues
MVTYIDAGAAPYKNTGVIRLYGAEGFEGMRKACQVTALCLDELVTRVSPGVTTEEIDRFVFEFGMDHGALPATLNYRGYT
KSSCTSINHVVCHGIPNDKPLREGDIVNIDVTYVVDGWHGDSSRMYPVGEIKRAAERLLDVTHECLMRGIAAVRPGARTG
AIGEAIQHYAESERCSVVRDFCGHGVGRLFHDAPNILHYGSANEGPELKEGMIFTIEPMINLGRPHVKVLSDGWTAVTRD
RSLSAQYEHTVGVTAEGCEIFTLSPAGLFKPGIQVPGDA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=250, Percent_Identity=48, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI40385867, Length=261, Percent_Identity=40.9961685823755, Blast_Score=207, Evalue=6e-54,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=50.4032258064516, Blast_Score=245, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI71996291, Length=251, Percent_Identity=46.2151394422311, Blast_Score=226, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6323273, Length=246, Percent_Identity=43.9024390243902, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21355531, Length=245, Percent_Identity=44.8979591836735, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24583427, Length=237, Percent_Identity=42.1940928270042, Blast_Score=197, Evalue=8e-51,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 30324; Mature: 30324

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTYIDAGAAPYKNTGVIRLYGAEGFEGMRKACQVTALCLDELVTRVSPGVTTEEIDRFV
CEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
FEFGMDHGALPATLNYRGYTKSSCTSINHVVCHGIPNDKPLREGDIVNIDVTYVVDGWHG
HHHCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEEECEEC
DSSRMYPVGEIKRAAERLLDVTHECLMRGIAAVRPGARTGAIGEAIQHYAESERCSVVRD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHH
FCGHGVGRLFHDAPNILHYGSANEGPELKEGMIFTIEPMINLGRPHVKVLSDGWTAVTRD
HHCCCHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEECHHCCCCCCEEEEECCCEEEECC
RSLSAQYEHTVGVTAEGCEIFTLSPAGLFKPGIQVPGDA
CCCCCCHHHEECCEECCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVTYIDAGAAPYKNTGVIRLYGAEGFEGMRKACQVTALCLDELVTRVSPGVTTEEIDRFV
CEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
FEFGMDHGALPATLNYRGYTKSSCTSINHVVCHGIPNDKPLREGDIVNIDVTYVVDGWHG
HHHCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEEECEEC
DSSRMYPVGEIKRAAERLLDVTHECLMRGIAAVRPGARTGAIGEAIQHYAESERCSVVRD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHH
FCGHGVGRLFHDAPNILHYGSANEGPELKEGMIFTIEPMINLGRPHVKVLSDGWTAVTRD
HHCCCHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEECHHCCCCCCEEEEECCCEEEECC
RSLSAQYEHTVGVTAEGCEIFTLSPAGLFKPGIQVPGDA
CCCCCCHHHEECCEECCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]