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The map label for this gene is cbs [H]

Identifier: 150396579

GI number: 150396579

Start: 1444310

End: 1445350

Strand: Direct

Name: cbs [H]

Synonym: Smed_1363

Alternate gene names: 150396579

Gene position: 1444310-1445350 (Clockwise)

Preceding gene: 150396577

Following gene: 150396580

Centisome position: 38.19

GC content: 61.38

Gene sequence:

>1041_bases
ATGCCAGTTCTTCCGTCCGTGCTCGAAGCAATCGGCAATACGCCGCTGATCCGGCTCAAGGCCGTGTCCGAAGCGACCGG
CTGCAACATCCTCGGCAAAGCGGAGTTTCTCAACCCTGGGCAGTCGGTAAAGGATAGGGCGGCGCTCTGGATCATCCGCC
AGGCTGAAAAGGCCGGCCAATTGCGACCGGGCGGTGTGATCGTCGAAGGCACCGCGGGCAATACCGGCATTGGCCTTGCC
GTTGTCGCCAGCGCGCTCGGATACCGCACCGTCATCGTTATCCCCGAGACACAGAGCCAGGAGAAGAAGGACGCACTGCG
CCTGCTTGGCGCCGAGCTGGTCGAAGTTCCGGCGGTACCGTACAGGAATCCGAATAATTACGTGAAGATCTCCGGCCGTC
TGGCCGCCCGACTTGCCGAAACCGAGCCGAATGGCGCGATCTGGGCAAACCAGTTCGACAATGTCGCCAATCGGCAGGCC
CATATCGACACGACCGCGCCCGAGATATGGCGCGACACCGATGGAAAGGTCGACGGGTTCATTTGCGCCGTCGGCTCCGG
CGGCACTCTTGCCGGTGTGGCGGAAGGCTTGCGCGCCCGCAAGGCGGGGATCAAGATCGGCATCGCCGATCCGGAAGGCG
CGGCACTCTACAATTTCTATGCCCATGGCGAGCTCAAGTCGAGTGGAAGCTCGATCACCGAAGGAATCGGTCAGGGGCGA
ATCACCGCCAATCTCGAAGGTTTCACGCCGGACTTCGCCTACCAGATTCCAGACGCCGAGGCGGTTCCCTACGTCTTCGA
GCTCATTGAAAAAGAAGGCATCTGCATCGGCGGATCGACCGGCATCAACGTCGCCGGAGCCGTGCGGCTTGCTCGTGAGC
TCGGTCCGGGACACACGATCGTGACGATCCTCTGTGACTATGGTAACCGCTATCAGTCGAAGCTCTTCAATCCGGACTTC
CTGGCCTCCAAGGGTCTGCCTGTCCCGGCCTGGCTGAAGACGGCTTCGAACATTGCAGTGCCATACGAACCCGCTGGATA
G

Upstream 100 bases:

>100_bases
CGATCCTGCTCAAGAAACCAAATGTTTATCGGCTTGCGATCGACCGAGGTAAATGCTTGGCTAAAGCCGGCATCCGTTCC
GTCAGTGCGAGGGTCTCAAT

Downstream 100 bases:

>100_bases
GATTGCCATGACCAGATCTGTCACCGCCCTCTTCCGAGAAGATTTCTATCTTTCGACCTGCGAAGCAAGCGTGACGGCAA
TCCTGGAAGACGGCGGCATC

Product: cysteine synthase A

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MPVLPSVLEAIGNTPLIRLKAVSEATGCNILGKAEFLNPGQSVKDRAALWIIRQAEKAGQLRPGGVIVEGTAGNTGIGLA
VVASALGYRTVIVIPETQSQEKKDALRLLGAELVEVPAVPYRNPNNYVKISGRLAARLAETEPNGAIWANQFDNVANRQA
HIDTTAPEIWRDTDGKVDGFICAVGSGGTLAGVAEGLRARKAGIKIGIADPEGAALYNFYAHGELKSSGSSITEGIGQGR
ITANLEGFTPDFAYQIPDAEAVPYVFELIEKEGICIGGSTGINVAGAVRLARELGPGHTIVTILCDYGNRYQSKLFNPDF
LASKGLPVPAWLKTASNIAVPYEPAG

Sequences:

>Translated_346_residues
MPVLPSVLEAIGNTPLIRLKAVSEATGCNILGKAEFLNPGQSVKDRAALWIIRQAEKAGQLRPGGVIVEGTAGNTGIGLA
VVASALGYRTVIVIPETQSQEKKDALRLLGAELVEVPAVPYRNPNNYVKISGRLAARLAETEPNGAIWANQFDNVANRQA
HIDTTAPEIWRDTDGKVDGFICAVGSGGTLAGVAEGLRARKAGIKIGIADPEGAALYNFYAHGELKSSGSSITEGIGQGR
ITANLEGFTPDFAYQIPDAEAVPYVFELIEKEGICIGGSTGINVAGAVRLARELGPGHTIVTILCDYGNRYQSKLFNPDF
LASKGLPVPAWLKTASNIAVPYEPAG
>Mature_345_residues
PVLPSVLEAIGNTPLIRLKAVSEATGCNILGKAEFLNPGQSVKDRAALWIIRQAEKAGQLRPGGVIVEGTAGNTGIGLAV
VASALGYRTVIVIPETQSQEKKDALRLLGAELVEVPAVPYRNPNNYVKISGRLAARLAETEPNGAIWANQFDNVANRQAH
IDTTAPEIWRDTDGKVDGFICAVGSGGTLAGVAEGLRARKAGIKIGIADPEGAALYNFYAHGELKSSGSSITEGIGQGRI
TANLEGFTPDFAYQIPDAEAVPYVFELIEKEGICIGGSTGINVAGAVRLARELGPGHTIVTILCDYGNRYQSKLFNPDFL
ASKGLPVPAWLKTASNIAVPYEPAG

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=327, Percent_Identity=40.0611620795107, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI295821200, Length=327, Percent_Identity=40.0611620795107, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI4557415, Length=327, Percent_Identity=40.0611620795107, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI11345492, Length=209, Percent_Identity=28.7081339712919, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI2367138, Length=314, Percent_Identity=35.031847133758, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788754, Length=320, Percent_Identity=38.75, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=37.4592833876222, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17562970, Length=315, Percent_Identity=37.4603174603175, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI32566674, Length=305, Percent_Identity=38.0327868852459, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17534315, Length=342, Percent_Identity=34.7953216374269, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17561720, Length=323, Percent_Identity=35.2941176470588, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI25147552, Length=340, Percent_Identity=32.3529411764706, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI115535073, Length=315, Percent_Identity=35.5555555555556, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=229, Percent_Identity=33.6244541484716, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321449, Length=329, Percent_Identity=40.1215805471125, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321594, Length=337, Percent_Identity=33.5311572700297, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24643623, Length=332, Percent_Identity=34.6385542168675, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI20129101, Length=332, Percent_Identity=34.6385542168675, Blast_Score=171, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 36385; Mature: 36254

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVLPSVLEAIGNTPLIRLKAVSEATGCNILGKAEFLNPGQSVKDRAALWIIRQAEKAGQ
CCCCHHHHHHHCCCCEEEEEEECCCCCCCEEECHHHCCCCCCHHHHHHEEEEEEHHHCCC
LRPGGVIVEGTAGNTGIGLAVVASALGYRTVIVIPETQSQEKKDALRLLGAELVEVPAVP
CCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCC
YRNPNNYVKISGRLAARLAETEPNGAIWANQFDNVANRQAHIDTTAPEIWRDTDGKVDGF
CCCCCCEEEECCCEEEEECCCCCCCCEECCHHHHHHCCCEECCCCCHHHHCCCCCCCCEE
ICAVGSGGTLAGVAEGLRARKAGIKIGIADPEGAALYNFYAHGELKSSGSSITEGIGQGR
EEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCEECCCCCHHHHHCCCCE
ITANLEGFTPDFAYQIPDAEAVPYVFELIEKEGICIGGSTGINVAGAVRLARELGPGHTI
EEEEECCCCCCCEEECCCCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCCCEE
VTILCDYGNRYQSKLFNPDFLASKGLPVPAWLKTASNIAVPYEPAG
EEEEECCCCHHHHHCCCCCHHHCCCCCCHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PVLPSVLEAIGNTPLIRLKAVSEATGCNILGKAEFLNPGQSVKDRAALWIIRQAEKAGQ
CCCHHHHHHHCCCCEEEEEEECCCCCCCEEECHHHCCCCCCHHHHHHEEEEEEHHHCCC
LRPGGVIVEGTAGNTGIGLAVVASALGYRTVIVIPETQSQEKKDALRLLGAELVEVPAVP
CCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCC
YRNPNNYVKISGRLAARLAETEPNGAIWANQFDNVANRQAHIDTTAPEIWRDTDGKVDGF
CCCCCCEEEECCCEEEEECCCCCCCCEECCHHHHHHCCCEECCCCCHHHHCCCCCCCCEE
ICAVGSGGTLAGVAEGLRARKAGIKIGIADPEGAALYNFYAHGELKSSGSSITEGIGQGR
EEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCEECCCCCHHHHHCCCCE
ITANLEGFTPDFAYQIPDAEAVPYVFELIEKEGICIGGSTGINVAGAVRLARELGPGHTI
EEEEECCCCCCCEEECCCCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCCCCCEE
VTILCDYGNRYQSKLFNPDFLASKGLPVPAWLKTASNIAVPYEPAG
EEEEECCCCHHHHHCCCCCHHHCCCCCCHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]