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The map label for this gene is uppS [H]

Identifier: 150396354

GI number: 150396354

Start: 1203128

End: 1203886

Strand: Direct

Name: uppS [H]

Synonym: Smed_1135

Alternate gene names: 150396354

Gene position: 1203128-1203886 (Clockwise)

Preceding gene: 150396353

Following gene: 150396355

Centisome position: 31.81

GC content: 62.19

Gene sequence:

>759_bases
TTGTCCGGACAGCCCATGCAAGAATTCAATCCCGCAAACGTGCCGGCGCACGTCGCCATCATCATGGACGGCAACGGTCG
CTGGGCGAATGCGCGCGGACTGCCGCGCACCATGGGGCACCGCAAGGGCGTCGAGGCGGTCCGTGGCGCGGTGAAGACGG
CTGCTGAGTTAGGCATCCGATATCTGACGCTGTTCGCTTTCTCGTCGGAGAACTGGAACAGGCCCGAAAACGAAGTCAGC
GATCTCATGGGCCTGCTCAAGGCTTTCATCCGCCGGGACCTCGCCGATCTCCACCGTGAGAATGTCCGCATACGGGTCAT
CGGAGACCGCTCGAATCTGAGCGGAGATATCCTGCCGCTGCTCATCGAAGCGGAGGAGACGACGATCGCCAATAGCGGCA
TCACGGTCATCATTGCATTCAATTACGGCGCCAGGGACGAGCTGGCGAGGGCCATGCGCCATCTGGCGGAACACGTCGCC
GCCGGTCGTCTCCGGCCGGATGAGATCACCCCCGAAAGAATCTCGGCAACGATCGACACGGCGGGGGTTCCGGATCCCGA
TCTCATAATCCGGACGAGCGGCGAGGAGCGCCTCTCCAACTTTCTCCTGTGGCAGGGCGCCTACTCCGAATTGCTGTTCA
TTCCGGAACTCTGGCCGGATTTCACGCGCGAGACGTTTCTCGCGGCGATCGAACAATATGCCTGCCGAGAGCGCCGTTTC
GGTGGTTTGGCGCAACCGACTCTGGCGGTCGGCTCCTGA

Upstream 100 bases:

>100_bases
CCAAAAAATGACCGATGACGTGATTTCCGAAATCGACCGCTTGCTCGCGGACAAGGAAAAGGAAATCATGCAGGTCTGAC
CTGCGGATAGGTGAGTCTTA

Downstream 100 bases:

>100_bases
TGCAGGCGGAACTCAAACTTCGCATCGCTTCAGGCGTAGTTCTCGCTGCGGCGGTTCTTGCTGCGACCTGGGTCGGCGAC
TTCGCATTCCAACTCCTCTC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSGQPMQEFNPANVPAHVAIIMDGNGRWANARGLPRTMGHRKGVEAVRGAVKTAAELGIRYLTLFAFSSENWNRPENEVS
DLMGLLKAFIRRDLADLHRENVRIRVIGDRSNLSGDILPLLIEAEETTIANSGITVIIAFNYGARDELARAMRHLAEHVA
AGRLRPDEITPERISATIDTAGVPDPDLIIRTSGEERLSNFLLWQGAYSELLFIPELWPDFTRETFLAAIEQYACRERRF
GGLAQPTLAVGS

Sequences:

>Translated_252_residues
MSGQPMQEFNPANVPAHVAIIMDGNGRWANARGLPRTMGHRKGVEAVRGAVKTAAELGIRYLTLFAFSSENWNRPENEVS
DLMGLLKAFIRRDLADLHRENVRIRVIGDRSNLSGDILPLLIEAEETTIANSGITVIIAFNYGARDELARAMRHLAEHVA
AGRLRPDEITPERISATIDTAGVPDPDLIIRTSGEERLSNFLLWQGAYSELLFIPELWPDFTRETFLAAIEQYACRERRF
GGLAQPTLAVGS
>Mature_251_residues
SGQPMQEFNPANVPAHVAIIMDGNGRWANARGLPRTMGHRKGVEAVRGAVKTAAELGIRYLTLFAFSSENWNRPENEVSD
LMGLLKAFIRRDLADLHRENVRIRVIGDRSNLSGDILPLLIEAEETTIANSGITVIIAFNYGARDELARAMRHLAEHVAA
GRLRPDEITPERISATIDTAGVPDPDLIIRTSGEERLSNFLLWQGAYSELLFIPELWPDFTRETFLAAIEQYACRERRFG
GLAQPTLAVGS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=37.219730941704, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=37.219730941704, Blast_Score=152, Evalue=2e-37,
Organism=Escherichia coli, GI1786371, Length=239, Percent_Identity=49.3723849372385, Blast_Score=232, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=37.7777777777778, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=218, Percent_Identity=39.9082568807339, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=240, Percent_Identity=32.5, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI18857969, Length=223, Percent_Identity=36.7713004484305, Blast_Score=141, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27961; Mature: 27830

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQPMQEFNPANVPAHVAIIMDGNGRWANARGLPRTMGHRKGVEAVRGAVKTAAELGIR
CCCCCCCCCCCCCCCEEEEEEECCCCCEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHH
YLTLFAFSSENWNRPENEVSDLMGLLKAFIRRDLADLHRENVRIRVIGDRSNLSGDILPL
HHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEE
LIEAEETTIANSGITVIIAFNYGARDELARAMRHLAEHVAAGRLRPDEITPERISATIDT
EEECCHHEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEECC
AGVPDPDLIIRTSGEERLSNFLLWQGAYSELLFIPELWPDFTRETFLAAIEQYACRERRF
CCCCCCCEEEECCCHHHHHHHHHCCCCHHHEEECCHHCCHHHHHHHHHHHHHHHHHHHHC
GGLAQPTLAVGS
CCCCCCCCCCCC
>Mature Secondary Structure 
SGQPMQEFNPANVPAHVAIIMDGNGRWANARGLPRTMGHRKGVEAVRGAVKTAAELGIR
CCCCCCCCCCCCCCEEEEEEECCCCCEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHH
YLTLFAFSSENWNRPENEVSDLMGLLKAFIRRDLADLHRENVRIRVIGDRSNLSGDILPL
HHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEE
LIEAEETTIANSGITVIIAFNYGARDELARAMRHLAEHVAAGRLRPDEITPERISATIDT
EEECCHHEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEECC
AGVPDPDLIIRTSGEERLSNFLLWQGAYSELLFIPELWPDFTRETFLAAIEQYACRERRF
CCCCCCCEEEECCCHHHHHHHHHCCCCHHHEEECCHHCCHHHHHHHHHHHHHHHHHHHHC
GGLAQPTLAVGS
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]