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The map label for this gene is atsA [H]

Identifier: 150396349

GI number: 150396349

Start: 1197841

End: 1199454

Strand: Direct

Name: atsA [H]

Synonym: Smed_1130

Alternate gene names: 150396349

Gene position: 1197841-1199454 (Clockwise)

Preceding gene: 150396348

Following gene: 150396350

Centisome position: 31.67

GC content: 58.3

Gene sequence:

>1614_bases
ATGACCAAGCAGCCAAATATTCTGTTCATAATGTCGGACGACCATGCCGCCCGGGCGATATCGGCTTACGGCTCGGGCCT
GAACAGCACGCCCAACATCGACCGCATCGCCAATGAGGGGATGCGGCTCGATCGGTGTTATGTCACCAATTCGATCTGCA
CGCCCAGCCGCGCCGCTATTTTGACCGGTACCTATAACCATGTGAACATGGTCACCACGCTCGACACCCATATCGATAAT
CGGCTCCCAAACGTCGCCAAGCACTTGCGCGCCGGTGGTTATCAGACGGCGATCTTCGGCAAGTGGCATCTGGGCGAGGG
AAAGGCGCACGAGCCTTCGGGTTTCGATGAATGGTCCGTGGTTCCCGGCCAGGGTGAGTATTTCGATCCGGTGATGATCG
ACCCGAGCGGCTCCCGCATGGAGAAGGGCTACGCCACCGACATCATCACCGACAAATGCCTCGATTTTCTCAGCAGGCGC
GATATCGGAAGACCCTTCTTCCTGATGTGCCATCACAAGGCCCCACATCGGAGCTTCGAGCCGCATCCACGCTACAAACA
ACTTTATGCAGACGGGAATCTGCCGGTTCCGGAAACATTTTCCGACGACTATTCCAACCGCGCCGCCGCTGCCGCCGCCG
CGAAAATGCGCGTCCGCTCCGACATGACGTATAAGGACCTCGGTCTCGTCCAGCCCGAAGGCGGCGAGGAGACTGGCGAA
CTGCTCCTGCCGGGCTGGACGCAGCGCAAGGTCCCCGATATCGCGGAAGGTGGATCGTTGCGTCTAATCGACGGGGCGAC
AGGTGAGAACTACCTCTTCACCGATCCGCAGAAGCTGGCTCTTTTCAAATATCAGCGCTACATGATGCGTTATCTGCAGA
CCATCGCCGCCGTGGACGACAATGTCGGCCGATTGCTCGACTATCTCGACGCGGAAGGACTGCGCGGCGACACCATCGTC
ATCTACACGTCCGACCAGGGCTTCTTTCTCGGCGAACACGGCTGGTTCGACAAGCGCTTCATGTACGAAGAATCAATGCA
GATGCCTTTCCTGATCCGCTATCCGCAAGGCATCGAGGCCGGCGTGCAGGCCAGCCACATCGCGACCAATGTCGACTTTG
CGCCGACCTTTCTCGATTATGCCGGCTTGCAGATCCCCAGTTACATGCAGGGACGGAGCATGCGCCCGATTTTCGACCGA
ACGGCAGATGACGGCGACACGGGCCTCGCCTATCACAGATATTGGATGCACAAGGACGAGTTCCACAACGCGTTCGCGCA
TTACGGCGTTCGTGACGCGCGCTATAAGCTCATCTATTGGTATAACGATCCGCTCGGGCAACTCGGCGCCTTTTCCGGTG
TTGAACCTCCGGAGTGGGAGCTGTTCGATTGTGAGAAGGACCCATTCGAACTTCATAACCGCGCGAACGACCCGGCCTAT
TCGGAAATTTTCGAAGAATTGCTTGCCAAGCTCGATGCGCGCATGGCCGAGATCGGCGATACTCCGGAGCATAGGAGCGC
TGAGGTGCTGGCTGGTCTGCGAAGCAGGGGTCTGAGCCTCGACATGCAATCGGATCAAGCGAACGACAGGCGGTGGGCAA
TAGCTGCCCCTTAA

Upstream 100 bases:

>100_bases
ACCCGGAGGATTATTATCTCGCCGACCTTTACGCGGGCAATTAGTCAAAGGCCAACACGCCGGCGGGTAACCTCGCCGGC
ATTTTCCATCGAGACTGAAA

Downstream 100 bases:

>100_bases
AGTGTGTTGACGAGTATGTGGCTCTGAAAAAGCGACATGATGGCTTGATTTCTCGGGCGGTTGCCGGTATGGGGCAGCCA
TTCCACACGTGAGGCATGGG

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTKQPNILFIMSDDHAARAISAYGSGLNSTPNIDRIANEGMRLDRCYVTNSICTPSRAAILTGTYNHVNMVTTLDTHIDN
RLPNVAKHLRAGGYQTAIFGKWHLGEGKAHEPSGFDEWSVVPGQGEYFDPVMIDPSGSRMEKGYATDIITDKCLDFLSRR
DIGRPFFLMCHHKAPHRSFEPHPRYKQLYADGNLPVPETFSDDYSNRAAAAAAAKMRVRSDMTYKDLGLVQPEGGEETGE
LLLPGWTQRKVPDIAEGGSLRLIDGATGENYLFTDPQKLALFKYQRYMMRYLQTIAAVDDNVGRLLDYLDAEGLRGDTIV
IYTSDQGFFLGEHGWFDKRFMYEESMQMPFLIRYPQGIEAGVQASHIATNVDFAPTFLDYAGLQIPSYMQGRSMRPIFDR
TADDGDTGLAYHRYWMHKDEFHNAFAHYGVRDARYKLIYWYNDPLGQLGAFSGVEPPEWELFDCEKDPFELHNRANDPAY
SEIFEELLAKLDARMAEIGDTPEHRSAEVLAGLRSRGLSLDMQSDQANDRRWAIAAP

Sequences:

>Translated_537_residues
MTKQPNILFIMSDDHAARAISAYGSGLNSTPNIDRIANEGMRLDRCYVTNSICTPSRAAILTGTYNHVNMVTTLDTHIDN
RLPNVAKHLRAGGYQTAIFGKWHLGEGKAHEPSGFDEWSVVPGQGEYFDPVMIDPSGSRMEKGYATDIITDKCLDFLSRR
DIGRPFFLMCHHKAPHRSFEPHPRYKQLYADGNLPVPETFSDDYSNRAAAAAAAKMRVRSDMTYKDLGLVQPEGGEETGE
LLLPGWTQRKVPDIAEGGSLRLIDGATGENYLFTDPQKLALFKYQRYMMRYLQTIAAVDDNVGRLLDYLDAEGLRGDTIV
IYTSDQGFFLGEHGWFDKRFMYEESMQMPFLIRYPQGIEAGVQASHIATNVDFAPTFLDYAGLQIPSYMQGRSMRPIFDR
TADDGDTGLAYHRYWMHKDEFHNAFAHYGVRDARYKLIYWYNDPLGQLGAFSGVEPPEWELFDCEKDPFELHNRANDPAY
SEIFEELLAKLDARMAEIGDTPEHRSAEVLAGLRSRGLSLDMQSDQANDRRWAIAAP
>Mature_536_residues
TKQPNILFIMSDDHAARAISAYGSGLNSTPNIDRIANEGMRLDRCYVTNSICTPSRAAILTGTYNHVNMVTTLDTHIDNR
LPNVAKHLRAGGYQTAIFGKWHLGEGKAHEPSGFDEWSVVPGQGEYFDPVMIDPSGSRMEKGYATDIITDKCLDFLSRRD
IGRPFFLMCHHKAPHRSFEPHPRYKQLYADGNLPVPETFSDDYSNRAAAAAAAKMRVRSDMTYKDLGLVQPEGGEETGEL
LLPGWTQRKVPDIAEGGSLRLIDGATGENYLFTDPQKLALFKYQRYMMRYLQTIAAVDDNVGRLLDYLDAEGLRGDTIVI
YTSDQGFFLGEHGWFDKRFMYEESMQMPFLIRYPQGIEAGVQASHIATNVDFAPTFLDYAGLQIPSYMQGRSMRPIFDRT
ADDGDTGLAYHRYWMHKDEFHNAFAHYGVRDARYKLIYWYNDPLGQLGAFSGVEPPEWELFDCEKDPFELHNRANDPAYS
EIFEELLAKLDARMAEIGDTPEHRSAEVLAGLRSRGLSLDMQSDQANDRRWAIAAP

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4504061, Length=424, Percent_Identity=25.4716981132075, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI39930577, Length=516, Percent_Identity=24.6124031007752, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI157266309, Length=546, Percent_Identity=26.3736263736264, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI4503899, Length=208, Percent_Identity=32.2115384615385, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI240255483, Length=129, Percent_Identity=36.4341085271318, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI29789100, Length=129, Percent_Identity=36.4341085271318, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI240255478, Length=129, Percent_Identity=36.4341085271318, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI109389362, Length=212, Percent_Identity=30.6603773584906, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI58743319, Length=118, Percent_Identity=39.8305084745763, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI189571643, Length=111, Percent_Identity=38.7387387387387, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI189571641, Length=111, Percent_Identity=38.7387387387387, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI189571638, Length=111, Percent_Identity=38.7387387387387, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI189571636, Length=111, Percent_Identity=38.7387387387387, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI146229331, Length=112, Percent_Identity=40.1785714285714, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI146229329, Length=112, Percent_Identity=40.1785714285714, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI6005990, Length=112, Percent_Identity=40.1785714285714, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI146229324, Length=112, Percent_Identity=40.1785714285714, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI45430057, Length=239, Percent_Identity=28.0334728033473, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI53831991, Length=114, Percent_Identity=36.8421052631579, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI31742482, Length=138, Percent_Identity=34.7826086956522, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI71852586, Length=138, Percent_Identity=34.0579710144928, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI71852584, Length=138, Percent_Identity=34.0579710144928, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI59797060, Length=198, Percent_Identity=28.7878787878788, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790112, Length=230, Percent_Identity=26.9565217391304, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790233, Length=125, Percent_Identity=32.8, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17568795, Length=204, Percent_Identity=28.4313725490196, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281363223, Length=245, Percent_Identity=33.469387755102, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647401, Length=112, Percent_Identity=42.8571428571429, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666175, Length=207, Percent_Identity=31.8840579710145, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281366397, Length=213, Percent_Identity=31.4553990610329, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI281366395, Length=213, Percent_Identity=31.4553990610329, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24666163, Length=213, Percent_Identity=31.4553990610329, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21356831, Length=234, Percent_Identity=29.0598290598291, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24666109, Length=219, Percent_Identity=31.5068493150685, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24653364, Length=113, Percent_Identity=37.1681415929204, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922168, Length=113, Percent_Identity=37.1681415929204, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 60730; Mature: 60599

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00523 SULFATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQPNILFIMSDDHAARAISAYGSGLNSTPNIDRIANEGMRLDRCYVTNSICTPSRAAI
CCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCCCEE
LTGTYNHVNMVTTLDTHIDNRLPNVAKHLRAGGYQTAIFGKWHLGEGKAHEPSGFDEWSV
EEECCCCEEEEEEEHHHHHHCCHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCE
VPGQGEYFDPVMIDPSGSRMEKGYATDIITDKCLDFLSRRDIGRPFFLMCHHKAPHRSFE
ECCCCCCCCCEEECCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
PHPRYKQLYADGNLPVPETFSDDYSNRAAAAAAAKMRVRSDMTYKDLGLVQPEGGEETGE
CCCCHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCC
LLLPGWTQRKVPDIAEGGSLRLIDGATGENYLFTDPQKLALFKYQRYMMRYLQTIAAVDD
EECCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
NVGRLLDYLDAEGLRGDTIVIYTSDQGFFLGEHGWFDKRFMYEESMQMPFLIRYPQGIEA
CHHHHHHHHCCCCCCCCEEEEEECCCCEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCC
GVQASHIATNVDFAPTFLDYAGLQIPSYMQGRSMRPIFDRTADDGDTGLAYHRYWMHKDE
CCCHHHHEECCCCCHHHHHHCCCCCCHHHCCCCCCCHHHCCCCCCCCCCEEHHHHCCHHH
FHNAFAHYGVRDARYKLIYWYNDPLGQLGAFSGVEPPEWELFDCEKDPFELHNRANDPAY
HHHHHHHCCCCCCEEEEEEEECCCHHHHCCCCCCCCCCCEEEECCCCHHHHHCCCCCCHH
SEIFEELLAKLDARMAEIGDTPEHRSAEVLAGLRSRGLSLDMQSDQANDRRWAIAAP
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECC
>Mature Secondary Structure 
TKQPNILFIMSDDHAARAISAYGSGLNSTPNIDRIANEGMRLDRCYVTNSICTPSRAAI
CCCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCCCEE
LTGTYNHVNMVTTLDTHIDNRLPNVAKHLRAGGYQTAIFGKWHLGEGKAHEPSGFDEWSV
EEECCCCEEEEEEEHHHHHHCCHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCE
VPGQGEYFDPVMIDPSGSRMEKGYATDIITDKCLDFLSRRDIGRPFFLMCHHKAPHRSFE
ECCCCCCCCCEEECCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
PHPRYKQLYADGNLPVPETFSDDYSNRAAAAAAAKMRVRSDMTYKDLGLVQPEGGEETGE
CCCCHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCC
LLLPGWTQRKVPDIAEGGSLRLIDGATGENYLFTDPQKLALFKYQRYMMRYLQTIAAVDD
EECCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
NVGRLLDYLDAEGLRGDTIVIYTSDQGFFLGEHGWFDKRFMYEESMQMPFLIRYPQGIEA
CHHHHHHHHCCCCCCCCEEEEEECCCCEEECCCCCCCHHHHHHHHCCCCEEEECCCCCCC
GVQASHIATNVDFAPTFLDYAGLQIPSYMQGRSMRPIFDRTADDGDTGLAYHRYWMHKDE
CCCHHHHEECCCCCHHHHHHCCCCCCHHHCCCCCCCHHHCCCCCCCCCCEEHHHHCCHHH
FHNAFAHYGVRDARYKLIYWYNDPLGQLGAFSGVEPPEWELFDCEKDPFELHNRANDPAY
HHHHHHHCCCCCCEEEEEEEECCCHHHHCCCCCCCCCCCEEEECCCCHHHHHCCCCCCHH
SEIFEELLAKLDARMAEIGDTPEHRSAEVLAGLRSRGLSLDMQSDQANDRRWAIAAP
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]