Click here to switch to the map view.

The map label for this gene is clpA [C]

Identifier: 150396336

GI number: 150396336

Start: 1185891

End: 1188407

Strand: Direct

Name: clpA [C]

Synonym: Smed_1117

Alternate gene names: 150396336

Gene position: 1185891-1188407 (Clockwise)

Preceding gene: 150396335

Following gene: 150396337

Centisome position: 31.36

GC content: 60.43

Gene sequence:

>2517_bases
GTGCCAACATTTTCGCCCAGCCTCGAAAAGGCGCTGCATCAGGCACTGACTTTTGCCAACGAGCGCCATCATGAATATGC
GACGCTCGAGCACCTGCTGCTGGCATTGATCGACGATGCCGATGCGGCGGCTGTGATGGGCGCGTGCAATGTCAATCTGG
ATACGCTTCGTAAGACCGTGACCGATTATGTCGACAATGAATTGTCGAACCTGGTCACCGGTTATGATGAAGATTCCAAG
CCGACGGCCGGTTTTCAGCGCGTAATCCAGCGCGCCGTCATCCATGTGCAGTCGTCCGGCCGCGAGGAGGTGACGGGCGC
CAACGTGCTCGTGGCGATCTTCGCCGAGCGCGAGAGTCATGCTGCCTATTTCCTGCAGGAGCAGGAAATGACGCGTTACG
ACGCCGTCAATTTCATTTCGCACGGTATCGGCAAGCGGCCGGGCAGTTCCGAGGCGCGGCCGGTGCGCGGGGCTGAAGAC
CAGGACTCCGAGCAGAAGGCATCGCGCGAGAGCGAGGAAACCGGTCCGAAGAAACAGCAGGATGCGCTCACCGCCTATTG
CGTGAACCTCAACGAAAAGGCGAAGTCCGGCAAGATCGATCCGTTGATCGGGCGTCATGCGGAGGTCAACCGGACGATTC
AGGTCCTTTGCCGCAGGTCCAAGAACAACCCGCTCTATGTGGGCGATCCGGGCGTGGGCAAGACGGCGATCGCCGAAGGT
CTCGCCAAGCGCATCATAGAAAAGAAAGTGCCAGAGGCGCTGCAGGACGCCACGATTTTCGCGCTCGACATGGGGACGCT
GCTCGCCGGCACGCGCTACCGCGGCGACTTCGAGGAACGGTTGAAGCAGGTAGTCAAGGAGCTCGAAGACTATCCCGGCG
CGGTGCTTTTCATCGATGAGATCCATACGGTTATCGGAGCCGGCGCCACATCCGGCGGCGCCATGGATGCGTCGAACCTC
CTGAAGCCCGCGCTTTCTTCCGGCGCGATCCGCTGCATCGGCTCGACGACCTACAAGGAGTACCGCCAGTTCTTCGAAAA
AGACCGGGCGCTTGTTCGCCGTTTCCAGAAGATCGACGTTAACGAGCCGACAATTGCAGACGCAATCGAGATCATGAAGG
GTTTGAAGCCCTATTTCGAGGACTACCACCGGCTGAAATACACCAACGATGCCATAAAGGCGGCGGTGGAGCTTTCCGCA
CGCTACATCAACGACCGGAAACTCCCGGATAAGGCGATCGATGTCATCGACGAGTCCGGTGCCGCGCAGATGCTTCTGCC
CGTCAGCAAGCGCCGCAAGCTGATCACGGAGAGGGAGATCGAGGCGACGATCGCGACAATGGCGCGCATCCCGCCCAAGA
CGGTCTCCAAGGACGACGAGGCGGTGCTCGCCAATCTGGAGCAAGAACTGCGGTCCGTCGTATATGGCCAGGATCTGGCG
ATCGAGGCGCTGGCCTCGTCGATCAAGCTGGCACGGGCGGGTCTCAGAGAGCCGAACAAGCCTATCGGCTGCTACGTCTT
CTCCGGCCCGACAGGTGTCGGCAAGACGGAAGTGGCAAAGCAACTCGCCACCTCGCTCGGCGTCGAGCTGCTGCGCTTCG
ACATGTCGGAGTACATGGAACGCCACACGGTTTCCCGACTGATCGGCGCACCTCCGGGCTATGTCGGCTTCGATCAGGGC
GGGCTCCTGACCGATGGCGTCGACCAGCATCCGCACTGCGTGCTGCTTCTGGACGAGATCGAAAAGGCGCATCCGGACTT
ATTCAACATCCTCCTGCAGGTGATGGACCACGGTTCATTGACCGACCACAACGGCAAGAAGATCGATTTCCGGAACGTCA
TCCTTATCATGACGACCAATGCGGGCGCGTCCGATATGGCTCGGGCGGCAATCGGCTTCGGTTCTTCCAAGCGGACCGGC
GAGGACGTGGAGGCACTGAATCGTCTCTTCACGCCGGAATTCCGCAACCGCCTGGACGCGGTCATTCCGTTCAATTCCCT
GCCGACTCCGGTCATCCACAAGGTGGTTCAGAAGTTCGTCATGCAGCTCGAGACGCAGCTTGCCGAGCGCAACGTCACCT
TCGATCTCGCGCCCGATGCGATCGCCTGGCTTGCCGAGAGGGGTTATGATGAGAAGATGGGTGCGCGGCCGCTGTCGCGC
GTCATCCAGGAAAACATCAAGAAGCCTCTCGCGGACGAAATTCTGTTCGGCAAGCTCAAGAAGGGCGGCGTCGTCAAAGT
GACGATCGGTACGAAGGAAGACGGTGCGAAAGGGCTCATGCTCGAAGCTGTGCCGGAAACCGCTCCGATCAAGCCCAAAG
CCGAGGTCTCGCGGCCGGCCGGCAAGGGCGCGAAACCCAAGAAGGCAAGCGAAAAGGAGAGCGTGGCCGCGGCCGGAGAG
GGTGCCAAAGCCAAGTCGAAGAAGACGACGGCCAAATCCGCGAACAAGAGCGGTGGCGGTTCCGATACCGCTCCTCTCAG
GGGACGTACGGTTCCGAAGGTGCCGCGAAAGAAATAG

Upstream 100 bases:

>100_bases
CTACGAGGTCGCCGAAACCAAGGTGACGCAGGTGATGGATTTCGCCAGGCAGCATCAACACCCGTTGCAATGCGTCATGG
AAAAGAAATGAGGAACTAAC

Downstream 100 bases:

>100_bases
CGCGATCGAGATTGCGTGTGACTGTGCCGGGCGAGTTGCCCGGCACTTTCTTGTGAGCGGGGAGCGTCGTTCTCGTGAAT
TCCGTAGACCCAATCGAAGA

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 838; Mature: 837

Protein sequence:

>838_residues
MPTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMGACNVNLDTLRKTVTDYVDNELSNLVTGYDEDSK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQEMTRYDAVNFISHGIGKRPGSSEARPVRGAED
QDSEQKASRESEETGPKKQQDALTAYCVNLNEKAKSGKIDPLIGRHAEVNRTIQVLCRRSKNNPLYVGDPGVGKTAIAEG
LAKRIIEKKVPEALQDATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDYPGAVLFIDEIHTVIGAGATSGGAMDASNL
LKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVNEPTIADAIEIMKGLKPYFEDYHRLKYTNDAIKAAVELSA
RYINDRKLPDKAIDVIDESGAAQMLLPVSKRRKLITEREIEATIATMARIPPKTVSKDDEAVLANLEQELRSVVYGQDLA
IEALASSIKLARAGLREPNKPIGCYVFSGPTGVGKTEVAKQLATSLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQG
GLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGSLTDHNGKKIDFRNVILIMTTNAGASDMARAAIGFGSSKRTG
EDVEALNRLFTPEFRNRLDAVIPFNSLPTPVIHKVVQKFVMQLETQLAERNVTFDLAPDAIAWLAERGYDEKMGARPLSR
VIQENIKKPLADEILFGKLKKGGVVKVTIGTKEDGAKGLMLEAVPETAPIKPKAEVSRPAGKGAKPKKASEKESVAAAGE
GAKAKSKKTTAKSANKSGGGSDTAPLRGRTVPKVPRKK

Sequences:

>Translated_838_residues
MPTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMGACNVNLDTLRKTVTDYVDNELSNLVTGYDEDSK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQEMTRYDAVNFISHGIGKRPGSSEARPVRGAED
QDSEQKASRESEETGPKKQQDALTAYCVNLNEKAKSGKIDPLIGRHAEVNRTIQVLCRRSKNNPLYVGDPGVGKTAIAEG
LAKRIIEKKVPEALQDATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDYPGAVLFIDEIHTVIGAGATSGGAMDASNL
LKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVNEPTIADAIEIMKGLKPYFEDYHRLKYTNDAIKAAVELSA
RYINDRKLPDKAIDVIDESGAAQMLLPVSKRRKLITEREIEATIATMARIPPKTVSKDDEAVLANLEQELRSVVYGQDLA
IEALASSIKLARAGLREPNKPIGCYVFSGPTGVGKTEVAKQLATSLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQG
GLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGSLTDHNGKKIDFRNVILIMTTNAGASDMARAAIGFGSSKRTG
EDVEALNRLFTPEFRNRLDAVIPFNSLPTPVIHKVVQKFVMQLETQLAERNVTFDLAPDAIAWLAERGYDEKMGARPLSR
VIQENIKKPLADEILFGKLKKGGVVKVTIGTKEDGAKGLMLEAVPETAPIKPKAEVSRPAGKGAKPKKASEKESVAAAGE
GAKAKSKKTTAKSANKSGGGSDTAPLRGRTVPKVPRKK
>Mature_837_residues
PTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMGACNVNLDTLRKTVTDYVDNELSNLVTGYDEDSKP
TAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQEMTRYDAVNFISHGIGKRPGSSEARPVRGAEDQ
DSEQKASRESEETGPKKQQDALTAYCVNLNEKAKSGKIDPLIGRHAEVNRTIQVLCRRSKNNPLYVGDPGVGKTAIAEGL
AKRIIEKKVPEALQDATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDYPGAVLFIDEIHTVIGAGATSGGAMDASNLL
KPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVNEPTIADAIEIMKGLKPYFEDYHRLKYTNDAIKAAVELSAR
YINDRKLPDKAIDVIDESGAAQMLLPVSKRRKLITEREIEATIATMARIPPKTVSKDDEAVLANLEQELRSVVYGQDLAI
EALASSIKLARAGLREPNKPIGCYVFSGPTGVGKTEVAKQLATSLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGG
LLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGSLTDHNGKKIDFRNVILIMTTNAGASDMARAAIGFGSSKRTGE
DVEALNRLFTPEFRNRLDAVIPFNSLPTPVIHKVVQKFVMQLETQLAERNVTFDLAPDAIAWLAERGYDEKMGARPLSRV
IQENIKKPLADEILFGKLKKGGVVKVTIGTKEDGAKGLMLEAVPETAPIKPKAEVSRPAGKGAKPKKASEKESVAAAGEG
AKAKSKKTTAKSANKSGGGSDTAPLRGRTVPKVPRKK

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=351, Percent_Identity=31.6239316239316, Blast_Score=156, Evalue=7e-38,
Organism=Escherichia coli, GI1787109, Length=747, Percent_Identity=57.5635876840696, Blast_Score=894, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=422, Percent_Identity=40.2843601895735, Blast_Score=296, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6320464, Length=322, Percent_Identity=42.5465838509317, Blast_Score=269, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323002, Length=281, Percent_Identity=44.8398576512456, Blast_Score=247, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 91566; Mature: 91434

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMGACNVNLDTLRKTV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHH
TDYVDNELSNLVTGYDEDSKPTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQEMTRYDAVNFISHGIGKRPGSSEARPVRGAEDQDSEQKASRESEETGPKKQQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
DALTAYCVNLNEKAKSGKIDPLIGRHAEVNRTIQVLCRRSKNNPLYVGDPGVGKTAIAEG
HHHHHHHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
LAKRIIEKKVPEALQDATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDYPGAVLFIDE
HHHHHHHHHHHHHHHCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHH
IHTVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDV
HHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
NEPTIADAIEIMKGLKPYFEDYHRLKYTNDAIKAAVELSARYINDRKLPDKAIDVIDESG
CCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
AAQMLLPVSKRRKLITEREIEATIATMARIPPKTVSKDDEAVLANLEQELRSVVYGQDLA
CCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHCCCHHH
IEALASSIKLARAGLREPNKPIGCYVFSGPTGVGKTEVAKQLATSLGVELLRFDMSEYME
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RHTVSRLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGSL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCC
TDHNGKKIDFRNVILIMTTNAGASDMARAAIGFGSSKRTGEDVEALNRLFTPEFRNRLDA
CCCCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHCCCCE
VIPFNSLPTPVIHKVVQKFVMQLETQLAERNVTFDLAPDAIAWLAERGYDEKMGARPLSR
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCHHHCCHHHHH
VIQENIKKPLADEILFGKLKKGGVVKVTIGTKEDGAKGLMLEAVPETAPIKPKAEVSRPA
HHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCHHCCCCC
GKGAKPKKASEKESVAAAGEGAKAKSKKTTAKSANKSGGGSDTAPLRGRTVPKVPRKK
CCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMGACNVNLDTLRKTV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHH
TDYVDNELSNLVTGYDEDSKPTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQEMTRYDAVNFISHGIGKRPGSSEARPVRGAEDQDSEQKASRESEETGPKKQQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
DALTAYCVNLNEKAKSGKIDPLIGRHAEVNRTIQVLCRRSKNNPLYVGDPGVGKTAIAEG
HHHHHHHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
LAKRIIEKKVPEALQDATIFALDMGTLLAGTRYRGDFEERLKQVVKELEDYPGAVLFIDE
HHHHHHHHHHHHHHHCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHH
IHTVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDV
HHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
NEPTIADAIEIMKGLKPYFEDYHRLKYTNDAIKAAVELSARYINDRKLPDKAIDVIDESG
CCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
AAQMLLPVSKRRKLITEREIEATIATMARIPPKTVSKDDEAVLANLEQELRSVVYGQDLA
CCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHCCCHHH
IEALASSIKLARAGLREPNKPIGCYVFSGPTGVGKTEVAKQLATSLGVELLRFDMSEYME
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RHTVSRLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGSL
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCC
TDHNGKKIDFRNVILIMTTNAGASDMARAAIGFGSSKRTGEDVEALNRLFTPEFRNRLDA
CCCCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHCCCCE
VIPFNSLPTPVIHKVVQKFVMQLETQLAERNVTFDLAPDAIAWLAERGYDEKMGARPLSR
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCHHHCCHHHHH
VIQENIKKPLADEILFGKLKKGGVVKVTIGTKEDGAKGLMLEAVPETAPIKPKAEVSRPA
HHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCHHCCCCC
GKGAKPKKASEKESVAAAGEGAKAKSKKTTAKSANKSGGGSDTAPLRGRTVPKVPRKK
CCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]