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The map label for this gene is adk [H]

Identifier: 150396228

GI number: 150396228

Start: 1079219

End: 1079797

Strand: Direct

Name: adk [H]

Synonym: Smed_1007

Alternate gene names: 150396228

Gene position: 1079219-1079797 (Clockwise)

Preceding gene: 150396227

Following gene: 150396229

Centisome position: 28.54

GC content: 59.59

Gene sequence:

>579_bases
ATGAGACTGATATTTTTGGGACCGCCGGGCGCTGGCAAGGGAACTCAGGCCAAGCATCTGACGGAGAGATATGGTATTCC
GCAGCTTTCCACGGGGGATATGTTGCGGGCGGCCGTAGCTCAGGCGACCGAAGTCGGTAAGCGGGCGAAAGCCGTCATGG
ATGCCGGCCAGCTCGTTTCCGACGAAATCGTCAATGAGATCGTCTCGGATCGCATCGATGCACCAGACTGCGCCAAGGGC
TTCATTCTGGACGGCTATCCTCGGACGGTCCCGCAGGCCGTCGCGCTCGATCGGATGCTTGAAGAAAAGAACCTCAAACT
TGATGCTGTCATCGAGTTGAAAGTGGATGAGGCGGCCCTTGTGCGGCGTATGGAGAATCGCGTAGCCGAGACAGTGGCTG
CCGGCGGCACGGTGCGTTCCGACGACAACCCGGAAGCATTCCGGCGCCGTCTCCAGGAATACCGGGAAAAGACCGCGCCG
CTTTCGGAGCATTACGCCCGAACTGGTCGGTTGAAGACCGTGGACGGCATGGCGGATGTGAAGACGGTCACCGCCGAGAT
CGAGAAGATTCTGGCATAG

Upstream 100 bases:

>100_bases
TGACCCTCGATACGGTAGCACAGATCCAGGGTCACCTCATCGCTCAGCAATATGAGGGGCTGATCAAGAAGTCGAAGCTG
CGCGGAGGAAAGAGGGGACG

Downstream 100 bases:

>100_bases
GCTTGGCCATTGCCAAAATGGAAGCGTCTGGGGAGTTGACTTTTCCGGCCGATTCCTCCAAAGACTGCGTCAACTCGCGA
CATGAGAAGCGATCGGCGCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MRLIFLGPPGAGKGTQAKHLTERYGIPQLSTGDMLRAAVAQATEVGKRAKAVMDAGQLVSDEIVNEIVSDRIDAPDCAKG
FILDGYPRTVPQAVALDRMLEEKNLKLDAVIELKVDEAALVRRMENRVAETVAAGGTVRSDDNPEAFRRRLQEYREKTAP
LSEHYARTGRLKTVDGMADVKTVTAEIEKILA

Sequences:

>Translated_192_residues
MRLIFLGPPGAGKGTQAKHLTERYGIPQLSTGDMLRAAVAQATEVGKRAKAVMDAGQLVSDEIVNEIVSDRIDAPDCAKG
FILDGYPRTVPQAVALDRMLEEKNLKLDAVIELKVDEAALVRRMENRVAETVAAGGTVRSDDNPEAFRRRLQEYREKTAP
LSEHYARTGRLKTVDGMADVKTVTAEIEKILA
>Mature_192_residues
MRLIFLGPPGAGKGTQAKHLTERYGIPQLSTGDMLRAAVAQATEVGKRAKAVMDAGQLVSDEIVNEIVSDRIDAPDCAKG
FILDGYPRTVPQAVALDRMLEEKNLKLDAVIELKVDEAALVRRMENRVAETVAAGGTVRSDDNPEAFRRRLQEYREKTAP
LSEHYARTGRLKTVDGMADVKTVTAEIEKILA

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=208, Percent_Identity=41.8269230769231, Blast_Score=165, Evalue=2e-41,
Organism=Homo sapiens, GI7524346, Length=208, Percent_Identity=41.8269230769231, Blast_Score=165, Evalue=3e-41,
Organism=Homo sapiens, GI19923437, Length=199, Percent_Identity=32.1608040201005, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI4502011, Length=188, Percent_Identity=32.9787234042553, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=29.4416243654822, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=29.4416243654822, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=29.4416243654822, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=29.4416243654822, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI28144897, Length=188, Percent_Identity=30.3191489361702, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI28144899, Length=188, Percent_Identity=30.3191489361702, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI7706497, Length=194, Percent_Identity=27.319587628866, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI22749187, Length=99, Percent_Identity=35.3535353535354, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786680, Length=220, Percent_Identity=43.6363636363636, Blast_Score=167, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=40.6542056074766, Blast_Score=167, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17567503, Length=187, Percent_Identity=32.620320855615, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17533833, Length=190, Percent_Identity=30.5263157894737, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=192, Percent_Identity=29.6875, Blast_Score=93, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17537943, Length=201, Percent_Identity=28.3582089552239, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25147457, Length=193, Percent_Identity=24.8704663212435, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=41.9047619047619, Blast_Score=164, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=33.8383838383838, Blast_Score=115, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322828, Length=168, Percent_Identity=30.952380952381, Blast_Score=88, Evalue=7e-19,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=40.9523809523809, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17647141, Length=164, Percent_Identity=35.9756097560976, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24663208, Length=164, Percent_Identity=35.9756097560976, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=32.1608040201005, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=32.1608040201005, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221459597, Length=192, Percent_Identity=28.125, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21356893, Length=192, Percent_Identity=28.125, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24582962, Length=193, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 21001; Mature: 21001

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIFLGPPGAGKGTQAKHLTERYGIPQLSTGDMLRAAVAQATEVGKRAKAVMDAGQLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEIVNEIVSDRIDAPDCAKGFILDGYPRTVPQAVALDRMLEEKNLKLDAVIELKVDEAAL
HHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHH
VRRMENRVAETVAAGGTVRSDDNPEAFRRRLQEYREKTAPLSEHYARTGRLKTVDGMADV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHH
KTVTAEIEKILA
HHHHHHHHHHHC
>Mature Secondary Structure
MRLIFLGPPGAGKGTQAKHLTERYGIPQLSTGDMLRAAVAQATEVGKRAKAVMDAGQLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEIVNEIVSDRIDAPDCAKGFILDGYPRTVPQAVALDRMLEEKNLKLDAVIELKVDEAAL
HHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHH
VRRMENRVAETVAAGGTVRSDDNPEAFRRRLQEYREKTAPLSEHYARTGRLKTVDGMADV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHH
KTVTAEIEKILA
HHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]