Click here to switch to the map view.

The map label for this gene is atpB [H]

Identifier: 150395672

GI number: 150395672

Start: 485209

End: 485961

Strand: Direct

Name: atpB [H]

Synonym: Smed_0447

Alternate gene names: 150395672

Gene position: 485209-485961 (Clockwise)

Preceding gene: 150395671

Following gene: 150395673

Centisome position: 12.83

GC content: 58.43

Gene sequence:

>753_bases
GTGTCAAACGATCCGACCCATCAGTTCCTGGTCAACAAGATTGTCTCGATCGACATTGGCGGAATCGACTTTTCCTTCAC
CAATGCGTCGCTGTTCATGGTGGCCACGGTCGGTGCGGCCGCTGGATTCCTCTATCTGACGACATCGCAGCGCGGTCTGA
TCCCGACGCGCATGCAGTCGGTGTCGGAGATGTCCTACGAGTTCATTGCCTCCATGCTTCGCGAGGGGGCCGGCAGTCAG
GGAATGAAATTCTTCCCCATGGTCTTTTCGCTGTTCATGTTCATCCTGACGGCGAACCTGCTCGGCATGGTGCCCTATTT
CTTCACCGTCACCAGCCAGATCATCGTGACCTTCGCGCTTGCGGTCTTCGTGATCGGCACGGTCATTCTCTACGGCTTCT
ATAAGCACGGTTTCGGCTTCCTCAAGCTTTTCGTGCCGCATGGCGTGCCGGGCGCGCTCCTGCCGCTGGTCGTGGCGATC
GAAATCATCTCGTTCCTTTCCCGTCCCATCAGCCTCTCGGTCCGTCTATTCGCCAACATGCTGGCTGGCCATATCACGCT
GAAGGTATTCGCAGGCTTCGTCGCCTCGCTCAGCGCATTCGGTGCGCTCGGCATCGGCGGCGCGATCCTGCCGCTCATCA
TGACCGTCGCCCTTACCGGTCTTGAGTTCCTCGTCGCCTTCCTCCAGGCCTATGTCTTTGCGGTGCTGACCTGCATGTAC
CTCAATGACGCTGTCCATCCGGGAAGCCACTAA

Upstream 100 bases:

>100_bases
CGGGCCCGGCACGGATAAGAAGGACGGCGACGGCGCCTGAGGCGTCGTCCGGAAGAATAGTATTTCCGCTTGCGGGCGGG
CAGAAGGAAAGAGAAGCGCG

Downstream 100 bases:

>100_bases
GGAATACAGTCGCTGGTTTCCGGTCGGCTTGCCGCCGGAAGCGCAATCCTAAGCCGCAACACCATTTCGAAGGAGTCAAT
CATGGAAGCGGAAGCAGCAA

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MSNDPTHQFLVNKIVSIDIGGIDFSFTNASLFMVATVGAAAGFLYLTTSQRGLIPTRMQSVSEMSYEFIASMLREGAGSQ
GMKFFPMVFSLFMFILTANLLGMVPYFFTVTSQIIVTFALAVFVIGTVILYGFYKHGFGFLKLFVPHGVPGALLPLVVAI
EIISFLSRPISLSVRLFANMLAGHITLKVFAGFVASLSAFGALGIGGAILPLIMTVALTGLEFLVAFLQAYVFAVLTCMY
LNDAVHPGSH

Sequences:

>Translated_250_residues
MSNDPTHQFLVNKIVSIDIGGIDFSFTNASLFMVATVGAAAGFLYLTTSQRGLIPTRMQSVSEMSYEFIASMLREGAGSQ
GMKFFPMVFSLFMFILTANLLGMVPYFFTVTSQIIVTFALAVFVIGTVILYGFYKHGFGFLKLFVPHGVPGALLPLVVAI
EIISFLSRPISLSVRLFANMLAGHITLKVFAGFVASLSAFGALGIGGAILPLIMTVALTGLEFLVAFLQAYVFAVLTCMY
LNDAVHPGSH
>Mature_249_residues
SNDPTHQFLVNKIVSIDIGGIDFSFTNASLFMVATVGAAAGFLYLTTSQRGLIPTRMQSVSEMSYEFIASMLREGAGSQG
MKFFPMVFSLFMFILTANLLGMVPYFFTVTSQIIVTFALAVFVIGTVILYGFYKHGFGFLKLFVPHGVPGALLPLVVAIE
IISFLSRPISLSVRLFANMLAGHITLKVFAGFVASLSAFGALGIGGAILPLIMTVALTGLEFLVAFLQAYVFAVLTCMYL
NDAVHPGSH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Homo sapiens, GI251831112, Length=198, Percent_Identity=32.8282828282828, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6226527, Length=248, Percent_Identity=35.4838709677419, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 26927; Mature: 26795

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDPTHQFLVNKIVSIDIGGIDFSFTNASLFMVATVGAAAGFLYLTTSQRGLIPTRMQS
CCCCHHHHHHHHHHHHHEECCEEEEECCCHHHHHHHHHHHHCEEEEECCCCCCCHHHHHH
VSEMSYEFIASMLREGAGSQGMKFFPMVFSLFMFILTANLLGMVPYFFTVTSQIIVTFAL
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVFVIGTVILYGFYKHGFGFLKLFVPHGVPGALLPLVVAIEIISFLSRPISLSVRLFANM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LAGHITLKVFAGFVASLSAFGALGIGGAILPLIMTVALTGLEFLVAFLQAYVFAVLTCMY
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNDAVHPGSH
HHHCCCCCCC
>Mature Secondary Structure 
SNDPTHQFLVNKIVSIDIGGIDFSFTNASLFMVATVGAAAGFLYLTTSQRGLIPTRMQS
CCCHHHHHHHHHHHHHEECCEEEEECCCHHHHHHHHHHHHCEEEEECCCCCCCHHHHHH
VSEMSYEFIASMLREGAGSQGMKFFPMVFSLFMFILTANLLGMVPYFFTVTSQIIVTFAL
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVFVIGTVILYGFYKHGFGFLKLFVPHGVPGALLPLVVAIEIISFLSRPISLSVRLFANM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LAGHITLKVFAGFVASLSAFGALGIGGAILPLIMTVALTGLEFLVAFLQAYVFAVLTCMY
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNDAVHPGSH
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]