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The map label for this gene is corA [H]

Identifier: 150395668

GI number: 150395668

Start: 480223

End: 481200

Strand: Direct

Name: corA [H]

Synonym: Smed_0443

Alternate gene names: 150395668

Gene position: 480223-481200 (Clockwise)

Preceding gene: 150395667

Following gene: 150395669

Centisome position: 12.7

GC content: 59.51

Gene sequence:

>978_bases
ATGATCACAGGCTATTGCGTCAACGGCGAAGCTGTTGCGCTCTCGACGGCGGAGCCGCCGTCGGCCCTGCGTCCCGATCT
CGTCTGGATCGACCTTGTCGAGCCGACCAAGGCGGAAGACCTGATGATCGAAAGCCTGCTCGGCATACCCATTCCGACGC
GGGACGAGTTGAGGGACATCGAGCCATCGAGCAGGCTTTATACAGATGATGGTGCCGTCTTCATGACGGCGTCGCTCGTC
TATAGAAGCGACACGGAAATGCCGGGCCTCACGGATGTTGGCTTTATCCTGGCAGGCAAACGTCTTGTCACCGTACGCTA
TGCCGAGCCAAGGGCTTTCGGGCTTTTCAAGGCCAGCGTTCATCGCATTTCCGGCGGCTGCCGCAACGGCGCGGTGATTC
TGACGCGCCTGCTCGAGACGATCGTCGACCGTACGGCGGAAATCCTTGAACAGGCAGTGGACAAGATCGACGATCTGGCG
CTGCAGGTTTTTGGCGACAAGGCCTCGACCAGGCGCAGGCCGCCGCACTTCCTCGAAGCACGGCTACGCGATGTCGCTGG
ACATCACCGGCTTGTTGCCAAGACGCGCGACAGCCTCGCTTCGCTTTCGAGGCTGTTGAGCTTCGTCTATACGGTCTCCG
ACGTGCAGGCGGACAAGGAAAGCCGCGAACTCTGCCGCACTGTTTCGCGCGACATACAGTCGCTTTCGGAGCATACGGCC
TTCATCTCGGGAAACATCACCTTCCTGCTTGATGCTTCGCTCGGCCTTATCAATGTCGAGCAGAACGCCATCATCAAGAT
CTTCTCGATCGCGTCCGTCGTTCTGCTGCCGCCGACGCTGGTGGCGTCGGTTTACGGGATGAACTTCCGCATGATGCCCG
AACTCGAATGGCAGTTCGGCTATCCGTGGGCGCTTGCGGTCATGGTCCTTTCGGCCGTGATTCCGTTTTTCTTCTTCCGC
TGGAAAGGCTGGCTCTAG

Upstream 100 bases:

>100_bases
CTTCTCATCGGATGAATGTCCATTGTGGAAATGGTGCGGCGGCTGATCCTGCGGGTTCTCCCCGGTTTATTAGCGCCGGT
TGCATGAAAAAGGCGGCCAC

Downstream 100 bases:

>100_bases
GAGCTTGTTGGGCCCATGTCTCAATTGTCTGCTCCCGGGGCGGAGAACACCCGCCGCCTGCTTGCCATGGCTCTCGGATC
CGTAGGCGTCGTCTATGGCG

Product: magnesium and cobalt transport protein CorA

Products: Ni2; [Cytoplasm]; Co; 2 [Cytoplasm]; Mg (II) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MITGYCVNGEAVALSTAEPPSALRPDLVWIDLVEPTKAEDLMIESLLGIPIPTRDELRDIEPSSRLYTDDGAVFMTASLV
YRSDTEMPGLTDVGFILAGKRLVTVRYAEPRAFGLFKASVHRISGGCRNGAVILTRLLETIVDRTAEILEQAVDKIDDLA
LQVFGDKASTRRRPPHFLEARLRDVAGHHRLVAKTRDSLASLSRLLSFVYTVSDVQADKESRELCRTVSRDIQSLSEHTA
FISGNITFLLDASLGLINVEQNAIIKIFSIASVVLLPPTLVASVYGMNFRMMPELEWQFGYPWALAVMVLSAVIPFFFFR
WKGWL

Sequences:

>Translated_325_residues
MITGYCVNGEAVALSTAEPPSALRPDLVWIDLVEPTKAEDLMIESLLGIPIPTRDELRDIEPSSRLYTDDGAVFMTASLV
YRSDTEMPGLTDVGFILAGKRLVTVRYAEPRAFGLFKASVHRISGGCRNGAVILTRLLETIVDRTAEILEQAVDKIDDLA
LQVFGDKASTRRRPPHFLEARLRDVAGHHRLVAKTRDSLASLSRLLSFVYTVSDVQADKESRELCRTVSRDIQSLSEHTA
FISGNITFLLDASLGLINVEQNAIIKIFSIASVVLLPPTLVASVYGMNFRMMPELEWQFGYPWALAVMVLSAVIPFFFFR
WKGWL
>Mature_325_residues
MITGYCVNGEAVALSTAEPPSALRPDLVWIDLVEPTKAEDLMIESLLGIPIPTRDELRDIEPSSRLYTDDGAVFMTASLV
YRSDTEMPGLTDVGFILAGKRLVTVRYAEPRAFGLFKASVHRISGGCRNGAVILTRLLETIVDRTAEILEQAVDKIDDLA
LQVFGDKASTRRRPPHFLEARLRDVAGHHRLVAKTRDSLASLSRLLSFVYTVSDVQADKESRELCRTVSRDIQSLSEHTA
FISGNITFLLDASLGLINVEQNAIIKIFSIASVVLLPPTLVASVYGMNFRMMPELEWQFGYPWALAVMVLSAVIPFFFFR
WKGWL

Specific function: Mediates influx of magnesium ions [H]

COG id: COG0598

COG function: function code P; Mg2+ and Co2+ transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family [H]

Homologues:

Organism=Escherichia coli, GI2367297, Length=298, Percent_Identity=36.9127516778523, Blast_Score=188, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004488
- InterPro:   IPR002523 [H]

Pfam domain/function: PF01544 CorA [H]

EC number: NA

Molecular weight: Translated: 36176; Mature: 36176

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITGYCVNGEAVALSTAEPPSALRPDLVWIDLVEPTKAEDLMIESLLGIPIPTRDELRDI
CEEEEEECCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHCC
EPSSRLYTDDGAVFMTASLVYRSDTEMPGLTDVGFILAGKRLVTVRYAEPRAFGLFKASV
CCCCCEEECCCCEEEEEEEEEECCCCCCCCCHHHHHHCCCEEEEEEECCCCHHHHHHHHH
HRISGGCRNGAVILTRLLETIVDRTAEILEQAVDKIDDLALQVFGDKASTRRRPPHFLEA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHH
RLRDVAGHHRLVAKTRDSLASLSRLLSFVYTVSDVQADKESRELCRTVSRDIQSLSEHTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCE
FISGNITFLLDASLGLINVEQNAIIKIFSIASVVLLPPTLVASVYGMNFRMMPELEWQFG
EEECCEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHCCCEEECCCCCCCCC
YPWALAVMVLSAVIPFFFFRWKGWL
CHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MITGYCVNGEAVALSTAEPPSALRPDLVWIDLVEPTKAEDLMIESLLGIPIPTRDELRDI
CEEEEEECCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHCC
EPSSRLYTDDGAVFMTASLVYRSDTEMPGLTDVGFILAGKRLVTVRYAEPRAFGLFKASV
CCCCCEEECCCCEEEEEEEEEECCCCCCCCCHHHHHHCCCEEEEEEECCCCHHHHHHHHH
HRISGGCRNGAVILTRLLETIVDRTAEILEQAVDKIDDLALQVFGDKASTRRRPPHFLEA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHH
RLRDVAGHHRLVAKTRDSLASLSRLLSFVYTVSDVQADKESRELCRTVSRDIQSLSEHTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCE
FISGNITFLLDASLGLINVEQNAIIKIFSIASVVLLPPTLVASVYGMNFRMMPELEWQFG
EEECCEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHCCCEEECCCCCCCCC
YPWALAVMVLSAVIPFFFFRWKGWL
CHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; Co; 2 [Periplasm]; Mg (II) [Periplasm] [C]

Specific reaction: Ni2+ [Periplasm] = Ni2+ [Cytoplasm] Co+2 [Periplasm] = Co+2 [Cytoplasm] Mg (II) [Periplasm] = Mg (II) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]