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The map label for this gene is hisD [H]

Identifier: 150395435

GI number: 150395435

Start: 235116

End: 236420

Strand: Direct

Name: hisD [H]

Synonym: Smed_0208

Alternate gene names: 150395435

Gene position: 235116-236420 (Clockwise)

Preceding gene: 150395434

Following gene: 150395436

Centisome position: 6.22

GC content: 64.6

Gene sequence:

>1305_bases
TTGGCAATCAGGCTGAACTATCTCGATACCGGCTTTGAGCGCGATTTCGCCGCATTCCTGACGACCAAGCGGGAAGTTTC
CGAAGACGTAAACGCCGTCGTGCGCGACATTATCGACGATGTCCGCGCGCGCGGCGATGCGGCGCTTGCAGATTATTCGG
CGCGTTTTGACGGAATAGACTTCAATGTCACGGGCATGGCGGTGACGGCGGCGGAGATAGATGCGGCGATCCACGCCGTT
GCTCCGGAGGTTCTCGGCGCCCTGAAGGTCGCCGCGACCCGCATCGAGGCGCATCACCGGCGGCAATTGCCGAAGGACGA
CATCTATGAAGACCAGATGGGCGTCGGCCTCGGCTCCCGCTGGACGCCGATCGATGCGGTGGGCCTCTATGTTCCGGGTG
GCACGGCGAGCTATCCGAGCTCGGTTCTGATGAACGCTCTGCCGGCAAAGGTCGCCGGCGTCCCCCGCATCGTCATGGTC
GTGCCGGCAATGGGCGGTGCGGTCAATCCTGCGGTGCTTGCGGCGGCGCGGCTCGCCGGCGTGGAAGAAATCTATCGCAT
CGGTGGTGCCCAGGCCGTCGCGGCCCTTGCCTACGGGACCGGGACGATCGCGCCGGTGGCCAAAATCATGGGCCCCGGAA
ACGCCTATGTCGCGGCCGCCAAGCGACAGGTTTTCGGCACCGTCGGCATCGACATGATCGCCGGACCTTCGGAAGTGCTG
GTGATTGCGGATCGCGACAACGATCCGGATTGGATCGCCGCGGACATGCTTGCTCAGGCAGAGCACGATGCCGGCGCTCA
GGCGATCCTGATCACCGACGATGCCGCTTTCGGCGATGCAGTCGAAGAGGCTGTGGAGCGTCAGTTGAAGACGCTGCCGC
GTGCCGACACGGCGGCAGCGAGCTGGCGCGATTTCGGTGCCATCATTCTGGTTCCGGATTTCGACAAGGCCATCCCGCTC
GCCAACCGCATCGCTCCCGAACATCTCGAACTGGCGACGGCCGATCCGGACGCGATGGTCCCCGCCATCCGCAATGCCGG
CGCGATCTTCATCGGCAGGCACACGCCCGAAGTCATCGGCGATTATGTGGGCGGTTCCAACCACGTGCTGCCGACGGCGC
GTTCGGCGCGCTTCTCGTCCGGCCTCGGCGTGCTCGACTATATGAAGCGAACGTCTATCCTGCGGCTCGATCCGGAACAG
TTGCGCATACTCGGCCCCGCCGCGATCGCGCTGGCGAGATCGGAAGGGCTCGAGGCTCACGCCCGATCGGTCGCAATCCG
CCTCAACCTCGGGGAAAAGGGATGA

Upstream 100 bases:

>100_bases
CGGCGCCTGGGAGACGGCGTTCAAGCCGCGTCACCCCGAAGGCGCCTGAGCCTCTCCGCTTGAGCACCTCCGCCGGCCAA
CATCCAAAAGGATCATCGCA

Downstream 100 bases:

>100_bases
GGGCCGATCGCAATCTGCGCCTCTGCGATGTCGTGCTGGACGAGACGATCGGCCGCTCGACGCCGGATGTGGAGCACGAG
CGCGCAGTTGCGATCTTCGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MAIRLNYLDTGFERDFAAFLTTKREVSEDVNAVVRDIIDDVRARGDAALADYSARFDGIDFNVTGMAVTAAEIDAAIHAV
APEVLGALKVAATRIEAHHRRQLPKDDIYEDQMGVGLGSRWTPIDAVGLYVPGGTASYPSSVLMNALPAKVAGVPRIVMV
VPAMGGAVNPAVLAAARLAGVEEIYRIGGAQAVAALAYGTGTIAPVAKIMGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
VIADRDNDPDWIAADMLAQAEHDAGAQAILITDDAAFGDAVEEAVERQLKTLPRADTAAASWRDFGAIILVPDFDKAIPL
ANRIAPEHLELATADPDAMVPAIRNAGAIFIGRHTPEVIGDYVGGSNHVLPTARSARFSSGLGVLDYMKRTSILRLDPEQ
LRILGPAAIALARSEGLEAHARSVAIRLNLGEKG

Sequences:

>Translated_434_residues
MAIRLNYLDTGFERDFAAFLTTKREVSEDVNAVVRDIIDDVRARGDAALADYSARFDGIDFNVTGMAVTAAEIDAAIHAV
APEVLGALKVAATRIEAHHRRQLPKDDIYEDQMGVGLGSRWTPIDAVGLYVPGGTASYPSSVLMNALPAKVAGVPRIVMV
VPAMGGAVNPAVLAAARLAGVEEIYRIGGAQAVAALAYGTGTIAPVAKIMGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
VIADRDNDPDWIAADMLAQAEHDAGAQAILITDDAAFGDAVEEAVERQLKTLPRADTAAASWRDFGAIILVPDFDKAIPL
ANRIAPEHLELATADPDAMVPAIRNAGAIFIGRHTPEVIGDYVGGSNHVLPTARSARFSSGLGVLDYMKRTSILRLDPEQ
LRILGPAAIALARSEGLEAHARSVAIRLNLGEKG
>Mature_433_residues
AIRLNYLDTGFERDFAAFLTTKREVSEDVNAVVRDIIDDVRARGDAALADYSARFDGIDFNVTGMAVTAAEIDAAIHAVA
PEVLGALKVAATRIEAHHRRQLPKDDIYEDQMGVGLGSRWTPIDAVGLYVPGGTASYPSSVLMNALPAKVAGVPRIVMVV
PAMGGAVNPAVLAAARLAGVEEIYRIGGAQAVAALAYGTGTIAPVAKIMGPGNAYVAAAKRQVFGTVGIDMIAGPSEVLV
IADRDNDPDWIAADMLAQAEHDAGAQAILITDDAAFGDAVEEAVERQLKTLPRADTAAASWRDFGAIILVPDFDKAIPLA
NRIAPEHLELATADPDAMVPAIRNAGAIFIGRHTPEVIGDYVGGSNHVLPTARSARFSSGLGVLDYMKRTSILRLDPEQL
RILGPAAIALARSEGLEAHARSVAIRLNLGEKG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=407, Percent_Identity=43.7346437346437, Blast_Score=310, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6319819, Length=413, Percent_Identity=39.4673123486683, Blast_Score=273, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45619; Mature: 45487

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRLNYLDTGFERDFAAFLTTKREVSEDVNAVVRDIIDDVRARGDAALADYSARFDGID
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCE
FNVTGMAVTAAEIDAAIHAVAPEVLGALKVAATRIEAHHRRQLPKDDIYEDQMGVGLGSR
EEECEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
WTPIDAVGLYVPGGTASYPSSVLMNALPAKVAGVPRIVMVVPAMGGAVNPAVLAAARLAG
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHH
VEEIYRIGGAQAVAALAYGTGTIAPVAKIMGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHCCEEEECCCCEEE
VIADRDNDPDWIAADMLAQAEHDAGAQAILITDDAAFGDAVEEAVERQLKTLPRADTAAA
EEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHH
SWRDFGAIILVPDFDKAIPLANRIAPEHLELATADPDAMVPAIRNAGAIFIGRHTPEVIG
HHHHCCEEEEEECCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCEEEEECCCHHHHH
DYVGGSNHVLPTARSARFSSGLGVLDYMKRTSILRLDPEQLRILGPAAIALARSEGLEAH
HHCCCCCCCCCCCCCCHHCCCCCHHHHHHHCCEEEECHHHHEEECHHHHHHHHHCCCCCC
ARSVAIRLNLGEKG
CEEEEEEEECCCCC
>Mature Secondary Structure 
AIRLNYLDTGFERDFAAFLTTKREVSEDVNAVVRDIIDDVRARGDAALADYSARFDGID
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCE
FNVTGMAVTAAEIDAAIHAVAPEVLGALKVAATRIEAHHRRQLPKDDIYEDQMGVGLGSR
EEECEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
WTPIDAVGLYVPGGTASYPSSVLMNALPAKVAGVPRIVMVVPAMGGAVNPAVLAAARLAG
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHH
VEEIYRIGGAQAVAALAYGTGTIAPVAKIMGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
HHHHHHHCCHHHHHHHHCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHCCEEEECCCCEEE
VIADRDNDPDWIAADMLAQAEHDAGAQAILITDDAAFGDAVEEAVERQLKTLPRADTAAA
EEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHH
SWRDFGAIILVPDFDKAIPLANRIAPEHLELATADPDAMVPAIRNAGAIFIGRHTPEVIG
HHHHCCEEEEEECCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCEEEEECCCHHHHH
DYVGGSNHVLPTARSARFSSGLGVLDYMKRTSILRLDPEQLRILGPAAIALARSEGLEAH
HHCCCCCCCCCCCCCCHHCCCCCHHHHHHHCCEEEECHHHHEEECHHHHHHHHHCCCCCC
ARSVAIRLNLGEKG
CEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]