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The map label for this gene is argD [H]

Identifier: 150395355

GI number: 150395355

Start: 140812

End: 142011

Strand: Direct

Name: argD [H]

Synonym: Smed_0127

Alternate gene names: 150395355

Gene position: 140812-142011 (Clockwise)

Preceding gene: 150395352

Following gene: 150395356

Centisome position: 3.72

GC content: 63.42

Gene sequence:

>1200_bases
ATGGCCGCAACCACGCCGCTTTACGACACCTATATGCGCGCGCCGTTGCGTTTCGAGCGAGGTGAAGGCGTTTGGCTGAT
TGCCGAAGACGGCACGCGTTATCTCGACTTCGCCGCCGGCGTTGCCGTGAATTCGCTCGGTCATGCCCACCCGCATCTCG
TCGAGGCATTGAAGGCGCAGGCCGACAAAGTCTGGCATCTGTCCAATCTCTACGAGATCCCGGGCCAGGAAAGCCTTGCA
CGCCGGCTGACCCAGGTCACGTTCGCCGACCGGGTGTTCTTCACCAATTCGGGTGCGGAAGCACTCGAATGCGCGATCAA
GACGGCCCGGCGCTACCACTACGCCAAGGGGCATGTCGAGAAGTTTCACGTCATCACCTTCGAAGGTGCTTTTCATGGCC
GCACGATCGCGACGATCGCCGCCGGCGGTCAGCAGAAGTATATCGAAGGCTTCGGCCCGAAGGCGCCGGGTTTCTATCAG
GTCCCCTTTGGAGATATCGCTGCGGTCAAGGACGCGATCAATGACGAAACGGCGGCGATCCTGGTCGAACCGATCCAGGG
CGAGGGGGGCATTCGGCTGGCGCCGAAAGAGTTCATGCAAGGGCTGCGCGAACTCTGTGACGAGTTCGGTCTGCTTCTCA
TCCTAGACGAGGTCCAGTCAGGGGTCGGCCGCACCGGCAAGCTCTTCGCCCATGAATGGGCGGGGATAAAGCCGGATATC
ATGGCCGTCGCCAAAGGCATTGGCGGCGGCTTCCCGCTCGGCGCCTGCCTTGCGACGGAAGCGGCTGCCGCCGGTATGGC
TGCAGGCACGCACGGTTCGACCTATGGTGGCAATCCGCTTGCGATGGCGGTCGGAAATGCAGTGCTGGACGTCGTTCTCG
CGGAAGGCTTCCTCGAGCACGTGCGCGAGGTGGCGCTAGTCTTCCGTCAGGGGCTCGCTTCCCTGAAGGATCGTTTTCCC
GACGTTATCGAGGAAATCCGAGGCGACGGGCTTATGCTAGGCATCAAAGCGAAGGTCCCTACGGCGGATCTCCTGAAGGC
AATCCGCGATGAGAAGCTGCTCGCCGTTCCGGCCGGCGAAAACGTGCTGCGCCTGTTGCCGCCGCTGATCACCACCCCGG
CCGAGGCGCGCGAGGGGCTGGCGCGGCTCGAGCGCGCCGCGGAAACGATGGCCGGCAAGAGCGGGCACGCCGCGGCTTAA

Upstream 100 bases:

>100_bases
GTGCGAAATGGGAATAGTGCCTCTCGCCGCCGCAAGGCGGCATTTTTAATTTTATCGGACCGAATGTCCGATGCGCCGCC
GGGATGAAGGAGAGTTCAAC

Downstream 100 bases:

>100_bases
GCTCCACGACAAACGGATTTACGACAGGAACCAAGGCAGAATGACCAGACACTTCCTCGATCTCTCGGCCATGGCGGCTA
CCGACCTCAGGACAATCATC

Product: acetylornithine transaminase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAATTPLYDTYMRAPLRFERGEGVWLIAEDGTRYLDFAAGVAVNSLGHAHPHLVEALKAQADKVWHLSNLYEIPGQESLA
RRLTQVTFADRVFFTNSGAEALECAIKTARRYHYAKGHVEKFHVITFEGAFHGRTIATIAAGGQQKYIEGFGPKAPGFYQ
VPFGDIAAVKDAINDETAAILVEPIQGEGGIRLAPKEFMQGLRELCDEFGLLLILDEVQSGVGRTGKLFAHEWAGIKPDI
MAVAKGIGGGFPLGACLATEAAAAGMAAGTHGSTYGGNPLAMAVGNAVLDVVLAEGFLEHVREVALVFRQGLASLKDRFP
DVIEEIRGDGLMLGIKAKVPTADLLKAIRDEKLLAVPAGENVLRLLPPLITTPAEAREGLARLERAAETMAGKSGHAAA

Sequences:

>Translated_399_residues
MAATTPLYDTYMRAPLRFERGEGVWLIAEDGTRYLDFAAGVAVNSLGHAHPHLVEALKAQADKVWHLSNLYEIPGQESLA
RRLTQVTFADRVFFTNSGAEALECAIKTARRYHYAKGHVEKFHVITFEGAFHGRTIATIAAGGQQKYIEGFGPKAPGFYQ
VPFGDIAAVKDAINDETAAILVEPIQGEGGIRLAPKEFMQGLRELCDEFGLLLILDEVQSGVGRTGKLFAHEWAGIKPDI
MAVAKGIGGGFPLGACLATEAAAAGMAAGTHGSTYGGNPLAMAVGNAVLDVVLAEGFLEHVREVALVFRQGLASLKDRFP
DVIEEIRGDGLMLGIKAKVPTADLLKAIRDEKLLAVPAGENVLRLLPPLITTPAEAREGLARLERAAETMAGKSGHAAA
>Mature_398_residues
AATTPLYDTYMRAPLRFERGEGVWLIAEDGTRYLDFAAGVAVNSLGHAHPHLVEALKAQADKVWHLSNLYEIPGQESLAR
RLTQVTFADRVFFTNSGAEALECAIKTARRYHYAKGHVEKFHVITFEGAFHGRTIATIAAGGQQKYIEGFGPKAPGFYQV
PFGDIAAVKDAINDETAAILVEPIQGEGGIRLAPKEFMQGLRELCDEFGLLLILDEVQSGVGRTGKLFAHEWAGIKPDIM
AVAKGIGGGFPLGACLATEAAAAGMAAGTHGSTYGGNPLAMAVGNAVLDVVLAEGFLEHVREVALVFRQGLASLKDRFPD
VIEEIRGDGLMLGIKAKVPTADLLKAIRDEKLLAVPAGENVLRLLPPLITTPAEAREGLARLERAAETMAGKSGHAAA

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=385, Percent_Identity=34.025974025974, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI284507298, Length=299, Percent_Identity=35.4515050167224, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI13994255, Length=377, Percent_Identity=31.8302387267904, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI37574042, Length=418, Percent_Identity=29.6650717703349, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI24119277, Length=425, Percent_Identity=27.0588235294118, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI226442705, Length=418, Percent_Identity=28.7081339712919, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=29.7157622739018, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI188536080, Length=411, Percent_Identity=23.8442822384428, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI38679950, Length=411, Percent_Identity=23.8442822384428, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI38679946, Length=411, Percent_Identity=23.8442822384428, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1789759, Length=393, Percent_Identity=43.765903307888, Blast_Score=321, Evalue=4e-89,
Organism=Escherichia coli, GI1788044, Length=387, Percent_Identity=44.702842377261, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI145693181, Length=323, Percent_Identity=38.0804953560372, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1789016, Length=402, Percent_Identity=36.318407960199, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1787560, Length=401, Percent_Identity=36.4089775561097, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1786991, Length=410, Percent_Identity=31.7073170731707, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1786349, Length=338, Percent_Identity=32.2485207100592, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25144271, Length=375, Percent_Identity=34.9333333333333, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI32564660, Length=421, Percent_Identity=31.8289786223278, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=259, Percent_Identity=36.6795366795367, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=28.4064665127021, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=429, Percent_Identity=25.8741258741259, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71981843, Length=159, Percent_Identity=32.7044025157233, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=396, Percent_Identity=36.6161616161616, Blast_Score=256, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6323470, Length=403, Percent_Identity=32.0099255583127, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6321456, Length=382, Percent_Identity=26.9633507853403, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324386, Length=332, Percent_Identity=25.6024096385542, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357415, Length=387, Percent_Identity=32.0413436692506, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=32.7146171693735, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=32.1428571428571, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI21356575, Length=417, Percent_Identity=29.9760191846523, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI281366494, Length=431, Percent_Identity=24.5939675174014, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24667139, Length=431, Percent_Identity=24.5939675174014, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24667143, Length=431, Percent_Identity=24.5939675174014, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 42558; Mature: 42427

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATTPLYDTYMRAPLRFERGEGVWLIAEDGTRYLDFAAGVAVNSLGHAHPHLVEALKAQ
CCCCCCHHHHHHCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
ADKVWHLSNLYEIPGQESLARRLTQVTFADRVFFTNSGAEALECAIKTARRYHYAKGHVE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCE
KFHVITFEGAFHGRTIATIAAGGQQKYIEGFGPKAPGFYQVPFGDIAAVKDAINDETAAI
EEEEEEEECCCCCCEEEEEECCCCHHHHHCCCCCCCCEEECCCCHHHHHHHHCCCCCEEE
LVEPIQGEGGIRLAPKEFMQGLRELCDEFGLLLILDEVQSGVGRTGKLFAHEWAGIKPDI
EEEEECCCCCEEECHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCHHHHHCCCCCHHH
MAVAKGIGGGFPLGACLATEAAAAGMAAGTHGSTYGGNPLAMAVGNAVLDVVLAEGFLEH
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VREVALVFRQGLASLKDRFPDVIEEIRGDGLMLGIKAKVPTADLLKAIRDEKLLAVPAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEECCCC
NVLRLLPPLITTPAEAREGLARLERAAETMAGKSGHAAA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AATTPLYDTYMRAPLRFERGEGVWLIAEDGTRYLDFAAGVAVNSLGHAHPHLVEALKAQ
CCCCCHHHHHHCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
ADKVWHLSNLYEIPGQESLARRLTQVTFADRVFFTNSGAEALECAIKTARRYHYAKGHVE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCE
KFHVITFEGAFHGRTIATIAAGGQQKYIEGFGPKAPGFYQVPFGDIAAVKDAINDETAAI
EEEEEEEECCCCCCEEEEEECCCCHHHHHCCCCCCCCEEECCCCHHHHHHHHCCCCCEEE
LVEPIQGEGGIRLAPKEFMQGLRELCDEFGLLLILDEVQSGVGRTGKLFAHEWAGIKPDI
EEEEECCCCCEEECHHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCHHHHHCCCCCHHH
MAVAKGIGGGFPLGACLATEAAAAGMAAGTHGSTYGGNPLAMAVGNAVLDVVLAEGFLEH
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VREVALVFRQGLASLKDRFPDVIEEIRGDGLMLGIKAKVPTADLLKAIRDEKLLAVPAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCEEEECCCC
NVLRLLPPLITTPAEAREGLARLERAAETMAGKSGHAAA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]