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The map label for this gene is lspA [H]

Identifier: 150395254

GI number: 150395254

Start: 21889

End: 22386

Strand: Direct

Name: lspA [H]

Synonym: Smed_0026

Alternate gene names: 150395254

Gene position: 21889-22386 (Clockwise)

Preceding gene: 150395253

Following gene: 150395255

Centisome position: 0.58

GC content: 59.04

Gene sequence:

>498_bases
ATGCAGGAACGAACGCTGTTCTCGCGGCCGCTCCCGATCGCGCTCTTCATCCTGACCGCGCTCGCCGCCGATCAGTTCAT
AAAATATCTGGTCGAGGCGTTTCTGCCATTCCAGCAGGGCGTGCCGGTCGTGCCGATGCTCGCCCTCTACCGCACCTATA
ATTACGGTGTCGCCTTCTCGATGCTGTCAGGCATGGAGGGCTGGTTCATCGTCGGCATTCGCCTGGGTGTCGTCACCTTC
GTGCTCTGGCTCTGGCGCCGCACGCCGAAAGACCGTTTCTTCGCCCATCTGGGTTACGCCATGATCATTGCCGGCGCGCT
CGGCAACCTCGTCGACCGGCTGCTTTTCGGCTATGTCATCGATTATATCCTGTTCTACACGGCGACCTGGTCCTTCGCCG
TCTTCAACCTTGCGGACAGCTTCATCACCGTCGGCGCCGGCGCGATCATTCTCGATGAGCTGCTACAAGCGAAAAAGGAA
CGGTCGCTAAAACTTTAG

Upstream 100 bases:

>100_bases
CGCAGTCGGGACGTGCCGACTCGCTCAATCTCGCCATTGCGACCGGTATCATGCTGTTCGAGGCACGGCGCCATCTTCTC
TCGCTGGATGAGGGCCGATA

Downstream 100 bases:

>100_bases
ACGTCGGCTGAAGGCATTCGGAAGGCTCGCCATGGTAGTCCGCGGGCATGAGCGAACGGATGTTTCGAGGGCGTATGAGG
GCTGGCGCGGAAACGGCACG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MQERTLFSRPLPIALFILTALAADQFIKYLVEAFLPFQQGVPVVPMLALYRTYNYGVAFSMLSGMEGWFIVGIRLGVVTF
VLWLWRRTPKDRFFAHLGYAMIIAGALGNLVDRLLFGYVIDYILFYTATWSFAVFNLADSFITVGAGAIILDELLQAKKE
RSLKL

Sequences:

>Translated_165_residues
MQERTLFSRPLPIALFILTALAADQFIKYLVEAFLPFQQGVPVVPMLALYRTYNYGVAFSMLSGMEGWFIVGIRLGVVTF
VLWLWRRTPKDRFFAHLGYAMIIAGALGNLVDRLLFGYVIDYILFYTATWSFAVFNLADSFITVGAGAIILDELLQAKKE
RSLKL
>Mature_165_residues
MQERTLFSRPLPIALFILTALAADQFIKYLVEAFLPFQQGVPVVPMLALYRTYNYGVAFSMLSGMEGWFIVGIRLGVVTF
VLWLWRRTPKDRFFAHLGYAMIIAGALGNLVDRLLFGYVIDYILFYTATWSFAVFNLADSFITVGAGAIILDELLQAKKE
RSLKL

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=163, Percent_Identity=36.8098159509202, Blast_Score=105, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 18718; Mature: 18718

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQERTLFSRPLPIALFILTALAADQFIKYLVEAFLPFQQGVPVVPMLALYRTYNYGVAFS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHH
MLSGMEGWFIVGIRLGVVTFVLWLWRRTPKDRFFAHLGYAMIIAGALGNLVDRLLFGYVI
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYILFYTATWSFAVFNLADSFITVGAGAIILDELLQAKKERSLKL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQERTLFSRPLPIALFILTALAADQFIKYLVEAFLPFQQGVPVVPMLALYRTYNYGVAFS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHH
MLSGMEGWFIVGIRLGVVTFVLWLWRRTPKDRFFAHLGYAMIIAGALGNLVDRLLFGYVI
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYILFYTATWSFAVFNLADSFITVGAGAIILDELLQAKKERSLKL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]