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The map label for this gene is strE [H]

Identifier: 150010392

GI number: 150010392

Start: 4664418

End: 4665437

Strand: Direct

Name: strE [H]

Synonym: BDI_3829

Alternate gene names: 150010392

Gene position: 4664418-4665437 (Clockwise)

Preceding gene: 150010391

Following gene: 150010393

Centisome position: 96.95

GC content: 35.49

Gene sequence:

>1020_bases
ATGAGTCAACTTATTAAACAAGATATAGAGGAGTTTGTGAGATCTTTTGAGCTTTCCGCACAACTTGGTCATACAATTTT
TCTTATTACAGGAGGAACAGGACTGATAGGTTCTACTTTAATACATTGTTTATTAGCGTTAAACAGGAATATTCGTATTG
TCGCACCTGTACGCTGTAAAGCTAAGGCGCAAGATATGTATGAAAGTGAGGAGCATACTCATATACATTTTATAGAGTGC
GATTTGTCTTCATTTGATTATAGTGAAATTGGTGAAGTGGATTTCATCGTGCATTGTGCAGCCCCTACTTCAAGTAAATT
TTTTGTCGAAAAGCCAGTAGAAACATTTAATACGATTGTTAATTGTACGCAAGTTTTATTGGAGTATGTAAGGCGTTTTC
CGGTAAAAGGCTTTGTCTATTTATCATCATTGGAAGTGTATGGTACTATTTTAGATGATTCCAATCTTGTAACAGAAGAG
GTTCAAGGCTATTTGGATCCAATGGCGACACGTAGTAGTTATCCGATGGCAAAACGTGCTGCTGAAAATTTATGTGCGTT
GTATGCGGCTGAGTATAATTTGAATATAATGGTGGCTCGTTTGACACAAACGACAGGAGCTAATGTAAGTAGTACGGATA
ATCGTTATGTTGCCCATTTTTGCCGTTTAACATCCAAGGGGGATAATATTATTTTATATTCTAAAGGTGAGTCTGCTAAA
CCTATTTGCTATACAATAGATTGTGTTTCAGCGATACTTTATATATTACTCAAAGGTGAAAAAGGCAATGCGTATAATGT
AGCAAATGCAGATACTTATATTTCTGCAAGGGGATTGGCTGAACTTCTAAGAGACAACTTTAATCCAAATATAAGTGTGG
AGTTTAGATTAAATGATAATATGGGGTATGCCCCAGAAACAAAATTAAGATTAAGTACCGCTAAGTTGCAGGAATTAGGG
TGGTCGCCCCAAAATGACTTGAAAGCTATCTTATCAAAACTTATTTCAACTTATAAATAA

Upstream 100 bases:

>100_bases
ACCTATGGAGAATATTAAAATTACGACTCCTACCGACTATTTTATATTTAGGGCTATGGTAGAGGTGCATGAGAATCAAC
AAATTTTTGGGTTTTAATTT

Downstream 100 bases:

>100_bases
TTATAGATAGGTATCACATGAAATTTCTTAATGTTATTTTTAAAGGACATAGTATTTCCGAACTTATTCAAGAGGTAATT
TATGTATTTATAGGGTACTT

Product: putative dTDP-glucose 4-6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSQLIKQDIEEFVRSFELSAQLGHTIFLITGGTGLIGSTLIHCLLALNRNIRIVAPVRCKAKAQDMYESEEHTHIHFIEC
DLSSFDYSEIGEVDFIVHCAAPTSSKFFVEKPVETFNTIVNCTQVLLEYVRRFPVKGFVYLSSLEVYGTILDDSNLVTEE
VQGYLDPMATRSSYPMAKRAAENLCALYAAEYNLNIMVARLTQTTGANVSSTDNRYVAHFCRLTSKGDNIILYSKGESAK
PICYTIDCVSAILYILLKGEKGNAYNVANADTYISARGLAELLRDNFNPNISVEFRLNDNMGYAPETKLRLSTAKLQELG
WSPQNDLKAILSKLISTYK

Sequences:

>Translated_339_residues
MSQLIKQDIEEFVRSFELSAQLGHTIFLITGGTGLIGSTLIHCLLALNRNIRIVAPVRCKAKAQDMYESEEHTHIHFIEC
DLSSFDYSEIGEVDFIVHCAAPTSSKFFVEKPVETFNTIVNCTQVLLEYVRRFPVKGFVYLSSLEVYGTILDDSNLVTEE
VQGYLDPMATRSSYPMAKRAAENLCALYAAEYNLNIMVARLTQTTGANVSSTDNRYVAHFCRLTSKGDNIILYSKGESAK
PICYTIDCVSAILYILLKGEKGNAYNVANADTYISARGLAELLRDNFNPNISVEFRLNDNMGYAPETKLRLSTAKLQELG
WSPQNDLKAILSKLISTYK
>Mature_338_residues
SQLIKQDIEEFVRSFELSAQLGHTIFLITGGTGLIGSTLIHCLLALNRNIRIVAPVRCKAKAQDMYESEEHTHIHFIECD
LSSFDYSEIGEVDFIVHCAAPTSSKFFVEKPVETFNTIVNCTQVLLEYVRRFPVKGFVYLSSLEVYGTILDDSNLVTEEV
QGYLDPMATRSSYPMAKRAAENLCALYAAEYNLNIMVARLTQTTGANVSSTDNRYVAHFCRLTSKGDNIILYSKGESAKP
ICYTIDCVSAILYILLKGEKGNAYNVANADTYISARGLAELLRDNFNPNISVEFRLNDNMGYAPETKLRLSTAKLQELGW
SPQNDLKAILSKLISTYK

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=346, Percent_Identity=24.2774566473988, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7657641, Length=323, Percent_Identity=24.1486068111455, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539532, Length=318, Percent_Identity=24.8427672955975, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17568069, Length=260, Percent_Identity=26.9230769230769, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356223, Length=343, Percent_Identity=24.7813411078717, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 37901; Mature: 37770

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLIKQDIEEFVRSFELSAQLGHTIFLITGGTGLIGSTLIHCLLALNRNIRIVAPVRCK
CHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCC
AKAQDMYESEEHTHIHFIECDLSSFDYSEIGEVDFIVHCAAPTSSKFFVEKPVETFNTIV
HHHHHHHCCCCCCEEEEEEECCCCCCHHHCCCEEEEEEECCCCCCCEEEECCHHHHHHHH
NCTQVLLEYVRRFPVKGFVYLSSLEVYGTILDDSNLVTEEVQGYLDPMATRSSYPMAKRA
HHHHHHHHHHHHCCCCEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHH
AENLCALYAAEYNLNIMVARLTQTTGANVSSTDNRYVAHFCRLTSKGDNIILYSKGESAK
HHHHHHHEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCC
PICYTIDCVSAILYILLKGEKGNAYNVANADTYISARGLAELLRDNFNPNISVEFRLNDN
CEEEEHHHHHHHHHHEEECCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCC
MGYAPETKLRLSTAKLQELGWSPQNDLKAILSKLISTYK
CCCCCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQLIKQDIEEFVRSFELSAQLGHTIFLITGGTGLIGSTLIHCLLALNRNIRIVAPVRCK
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCC
AKAQDMYESEEHTHIHFIECDLSSFDYSEIGEVDFIVHCAAPTSSKFFVEKPVETFNTIV
HHHHHHHCCCCCCEEEEEEECCCCCCHHHCCCEEEEEEECCCCCCCEEEECCHHHHHHHH
NCTQVLLEYVRRFPVKGFVYLSSLEVYGTILDDSNLVTEEVQGYLDPMATRSSYPMAKRA
HHHHHHHHHHHHCCCCEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHH
AENLCALYAAEYNLNIMVARLTQTTGANVSSTDNRYVAHFCRLTSKGDNIILYSKGESAK
HHHHHHHEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCC
PICYTIDCVSAILYILLKGEKGNAYNVANADTYISARGLAELLRDNFNPNISVEFRLNDN
CEEEEHHHHHHHHHHEEECCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCC
MGYAPETKLRLSTAKLQELGWSPQNDLKAILSKLISTYK
CCCCCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1661369 [H]