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The map label for this gene is ispD2 [H]

Identifier: 150010391

GI number: 150010391

Start: 4663683

End: 4664414

Strand: Direct

Name: ispD2 [H]

Synonym: BDI_3828

Alternate gene names: 150010391

Gene position: 4663683-4664414 (Clockwise)

Preceding gene: 150010390

Following gene: 150010392

Centisome position: 96.93

GC content: 38.52

Gene sequence:

>732_bases
ATGAAAAATATAGCAGTCATTTTTGCGGGGGGATCCGGTGTAAGAATGAATACTAGGTCTAAACCTAAACAATTTCTGGA
GTTAAGGGGTAAACCTATTATTATTTATACGCTTGAACTTTTTGACAATCACCCTTTGATTGATGGTATTGTAGTGGTAT
GCCTTGAATCGTGGATTCCTTTTTTGAAAAAGATGTTGAAGAAGTTTGAGATCAACAAGGTGGTTAAAATTGTATCAGGA
GGTGATTCCGGGCAAGATTCTATCTATAGAGGTCTTTGTGCCGTGGAGGATTATTGCAAGGATAAGGGGGAGGAGAATGC
CGTGGTGCTTATTCATGATGGGGTCCGGCCTTTGATCGTGGATGAGACAATTACACGGAATATTGAAAAAGTACATGAAA
AAGGAAGTGCCATAACTGTCGTACCTGCCATAGAAACTTTTGTCATCCAGAAAGAGGAGGGACAAATGGTGATTCCCGAT
CGTTCTTCTTGCCTGCTGGCCCGGGCACCTCAAAGCTTTTATTTAAAGGATATCCTAAGTATCCATAGAAAGAATAAAGA
AAATGGTAACATTACTTTTATAGATTCTTGTTCTATGATGAGTTATTTTGGGTATAAGATGGCAACCATAGAGGGACCTA
TGGAGAATATTAAAATTACGACTCCTACCGACTATTTTATATTTAGGGCTATGGTAGAGGTGCATGAGAATCAACAAATT
TTTGGGTTTTAA

Upstream 100 bases:

>100_bases
TTTGAAGAGGTTGAAGCACTCTTTCCGGAAAATACGATGGATAGTCAATTGGCTTTATTGGAAAAATTAATAGAAGCTTA
GCTTTCTTAGTTTGTTAATC

Downstream 100 bases:

>100_bases
TTTATGAGTCAACTTATTAAACAAGATATAGAGGAGTTTGTGAGATCTTTTGAGCTTTCCGCACAACTTGGTCATACAAT
TTTTCTTATTACAGGAGGAA

Product: putative CDP-ribitol pyrophosphorylase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase 2; MEP cytidylyltransferase 2; MCT 2 [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MKNIAVIFAGGSGVRMNTRSKPKQFLELRGKPIIIYTLELFDNHPLIDGIVVVCLESWIPFLKKMLKKFEINKVVKIVSG
GDSGQDSIYRGLCAVEDYCKDKGEENAVVLIHDGVRPLIVDETITRNIEKVHEKGSAITVVPAIETFVIQKEEGQMVIPD
RSSCLLARAPQSFYLKDILSIHRKNKENGNITFIDSCSMMSYFGYKMATIEGPMENIKITTPTDYFIFRAMVEVHENQQI
FGF

Sequences:

>Translated_243_residues
MKNIAVIFAGGSGVRMNTRSKPKQFLELRGKPIIIYTLELFDNHPLIDGIVVVCLESWIPFLKKMLKKFEINKVVKIVSG
GDSGQDSIYRGLCAVEDYCKDKGEENAVVLIHDGVRPLIVDETITRNIEKVHEKGSAITVVPAIETFVIQKEEGQMVIPD
RSSCLLARAPQSFYLKDILSIHRKNKENGNITFIDSCSMMSYFGYKMATIEGPMENIKITTPTDYFIFRAMVEVHENQQI
FGF
>Mature_243_residues
MKNIAVIFAGGSGVRMNTRSKPKQFLELRGKPIIIYTLELFDNHPLIDGIVVVCLESWIPFLKKMLKKFEINKVVKIVSG
GDSGQDSIYRGLCAVEDYCKDKGEENAVVLIHDGVRPLIVDETITRNIEKVHEKGSAITVVPAIETFVIQKEEGQMVIPD
RSSCLLARAPQSFYLKDILSIHRKNKENGNITFIDSCSMMSYFGYKMATIEGPMENIKITTPTDYFIFRAMVEVHENQQI
FGF

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=240, Percent_Identity=27.5, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI157671913, Length=134, Percent_Identity=32.8358208955224, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1789104, Length=226, Percent_Identity=26.1061946902655, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 27456; Mature: 27456

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIAVIFAGGSGVRMNTRSKPKQFLELRGKPIIIYTLELFDNHPLIDGIVVVCLESWIP
CCCEEEEEECCCCEEECCCCCHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
FLKKMLKKFEINKVVKIVSGGDSGQDSIYRGLCAVEDYCKDKGEENAVVLIHDGVRPLIV
HHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
DETITRNIEKVHEKGSAITVVPAIETFVIQKEEGQMVIPDRSSCLLARAPQSFYLKDILS
CHHHHHHHHHHHHCCCEEEEEEEEEEEEEEECCCCEECCCCCCEEEEECCHHHHHHHHHH
IHRKNKENGNITFIDSCSMMSYFGYKMATIEGPMENIKITTPTDYFIFRAMVEVHENQQI
HHHCCCCCCCEEEEECCCHHHHCCEEEEEECCCHHCCEEECCCHHHHHHHHHHHHCCCEE
FGF
CCC
>Mature Secondary Structure
MKNIAVIFAGGSGVRMNTRSKPKQFLELRGKPIIIYTLELFDNHPLIDGIVVVCLESWIP
CCCEEEEEECCCCEEECCCCCHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
FLKKMLKKFEINKVVKIVSGGDSGQDSIYRGLCAVEDYCKDKGEENAVVLIHDGVRPLIV
HHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
DETITRNIEKVHEKGSAITVVPAIETFVIQKEEGQMVIPDRSSCLLARAPQSFYLKDILS
CHHHHHHHHHHHHCCCEEEEEEEEEEEEEEECCCCEECCCCCCEEEEECCHHHHHHHHHH
IHRKNKENGNITFIDSCSMMSYFGYKMATIEGPMENIKITTPTDYFIFRAMVEVHENQQI
HHHCCCCCCCEEEEECCCHHHHCCEEEEEECCCHHCCEEECCCHHHHHHHHHHHHCCCEE
FGF
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]