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The map label for this gene is groEL

Identifier: 150010353

GI number: 150010353

Start: 4616561

End: 4618201

Strand: Direct

Name: groEL

Synonym: BDI_3787

Alternate gene names: 150010353

Gene position: 4616561-4618201 (Clockwise)

Preceding gene: 150010352

Following gene: 150010354

Centisome position: 95.95

GC content: 49.18

Gene sequence:

>1641_bases
ATGGCAAAAGAGATTAAATACGATATGGATGCCCGCGACCTTTTGAAGAAAGGTGTGGATGAGTTGGCTAATGCCGTTAA
GGTAACATTAGGCCCGAAAGGTCGTAACGTAATTATCGAGAAGAAATTCGGAGCTCCTCACATCACGAAAGATGGTGTAA
CGGTTGCTAAAGAAGTAGAGTTGACTTGCCCGTTCGAGAACATGGGTGCTCAATTGGTTAAGGAAGTGGCTTCCAAGACA
AACGATAACGCCGGTGACGGTACGACTACAGCTACGGTTTTGGCTCAGTCTATCATTGGTGTCGGTTTAAAGAACGTTAC
TGCCGGAGCGAACCCGATGGATTTGAAACGTGGTATCGACAAGGCTGTCGCTAAGGTTGTAGAGAGCATCGCTAACCAAG
CTGAGGCTGTAGGTGATAAGTTCGAGAAGATCGAGCATGTAGCGAAGATCTCCGCAAATGGTGACGAGGCTATCGGTAAG
TTGATCGCGGAGGCTATGCAACGTGTGAAGACTGAAGGTGTTATCACGGTTGAGGAAGCTAAAGGTACTGAAACTACAGT
TGACGTAGTTGAGGGTATGCAGTTCGACCGCGGTTATATCTCTCCGTACTTCGTAACGGATACAGAGAAGATGGAGTGCC
AGATGGAGAATCCGTATATCTTGATTTATGACAAGAAGATCTCCGTATTAAAAGACCTTCTTCCTATCCTTGAGCCGACC
GTACAGAGCGGACGTCCTCTTTTGATCATCGCTGAGGATATCGACAGCGAGGCTTTGGCTACATTGGTAGTGAACCGTCT
GCGTGGTTCCTTGAAGATCTGCGCTGTTAAGGCTCCGGGCTTCGGCGACCGTCGTAAGGCTATGTTGGAAGATATCGCTG
TATTGACAGGCGGTACGGTTATCTCTGAGGAGAAAGGTTTGAAATTGGAAGGTGCTACAATGGATATGCTAGGTACCGCT
GAGAAGATCACGGTAGACAAAGATACCACTACCATTGTAAATGGTGCTGGTGACAAGGAGGCTATCCAAGCTCGTATCGG
CCAGATCAAGATCCAGATGGAGAACACGACATCTGATTACGATAAAGAGAAATTGCAAGAGCGTTTGGCTAAGATGGCCG
GCGGTGTAGCTGTTCTTTACGTAGGTGCTCCTTCTGAGGTTGAGATGAAAGAGAAGAAAGACCGTGTGGATGACGCATTG
CACGCAACTCGTGCCGCTATCGAAGAAGGTACGGTGCCCGGTGGTGGTGTTGCCTATATCCGTGCTATCGATGCATTGGA
AGGCATGAAGGGCGACAACGAGGACGAGACTACAGGTATCGAGATCGTTAAGCGCGCTATCGAGGAGCCGCTTCGCCAGA
TCGTAGCTAACGCTGGTAAGGAAGGTGCCGTTATCGTTCAGAAAGTGAAGGAAGGCAAGGGCGACTTCGGTTACAACGCT
CGTAAGGACTGTTTCGAGAATTTGTGCGAGGCTGGTGTAATCGACCCGGCTAAGGTAACTCGCGTAGCATTGGAGAACGC
AGCTTCTATCGCTGGTATGTTCTTGACTACAGAGTGTGTGATCGCAGAGAAGAAAGAAGAGACTCCGGCTATGCCTCCGA
TGAACCCGGGTATGGGTGGCGGAATGGGCGGTATGATGTAA

Upstream 100 bases:

>100_bases
GAACTAGATGGTGAGAAATACTTGATCATGCGCCAAGCAGACGTTTTAGCTATTATCTAATTCATTTTTATAAACAACAA
TATTAAAAAGAAATACAATC

Downstream 100 bases:

>100_bases
TCGACTCCCGTGATTAATGATATGGGCGGCCGTTCCGGAAGGGACGGTCGCTTTTTTTATTTTCATTTGCTTGCTAATTG
GAAAAAACGATTACCTTTGT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAKEIKYDMDARDLLKKGVDELANAVKVTLGPKGRNVIIEKKFGAPHITKDGVTVAKEVELTCPFENMGAQLVKEVASKT
NDNAGDGTTTATVLAQSIIGVGLKNVTAGANPMDLKRGIDKAVAKVVESIANQAEAVGDKFEKIEHVAKISANGDEAIGK
LIAEAMQRVKTEGVITVEEAKGTETTVDVVEGMQFDRGYISPYFVTDTEKMECQMENPYILIYDKKISVLKDLLPILEPT
VQSGRPLLIIAEDIDSEALATLVVNRLRGSLKICAVKAPGFGDRRKAMLEDIAVLTGGTVISEEKGLKLEGATMDMLGTA
EKITVDKDTTTIVNGAGDKEAIQARIGQIKIQMENTTSDYDKEKLQERLAKMAGGVAVLYVGAPSEVEMKEKKDRVDDAL
HATRAAIEEGTVPGGGVAYIRAIDALEGMKGDNEDETTGIEIVKRAIEEPLRQIVANAGKEGAVIVQKVKEGKGDFGYNA
RKDCFENLCEAGVIDPAKVTRVALENAASIAGMFLTTECVIAEKKEETPAMPPMNPGMGGGMGGMM

Sequences:

>Translated_546_residues
MAKEIKYDMDARDLLKKGVDELANAVKVTLGPKGRNVIIEKKFGAPHITKDGVTVAKEVELTCPFENMGAQLVKEVASKT
NDNAGDGTTTATVLAQSIIGVGLKNVTAGANPMDLKRGIDKAVAKVVESIANQAEAVGDKFEKIEHVAKISANGDEAIGK
LIAEAMQRVKTEGVITVEEAKGTETTVDVVEGMQFDRGYISPYFVTDTEKMECQMENPYILIYDKKISVLKDLLPILEPT
VQSGRPLLIIAEDIDSEALATLVVNRLRGSLKICAVKAPGFGDRRKAMLEDIAVLTGGTVISEEKGLKLEGATMDMLGTA
EKITVDKDTTTIVNGAGDKEAIQARIGQIKIQMENTTSDYDKEKLQERLAKMAGGVAVLYVGAPSEVEMKEKKDRVDDAL
HATRAAIEEGTVPGGGVAYIRAIDALEGMKGDNEDETTGIEIVKRAIEEPLRQIVANAGKEGAVIVQKVKEGKGDFGYNA
RKDCFENLCEAGVIDPAKVTRVALENAASIAGMFLTTECVIAEKKEETPAMPPMNPGMGGGMGGMM
>Mature_545_residues
AKEIKYDMDARDLLKKGVDELANAVKVTLGPKGRNVIIEKKFGAPHITKDGVTVAKEVELTCPFENMGAQLVKEVASKTN
DNAGDGTTTATVLAQSIIGVGLKNVTAGANPMDLKRGIDKAVAKVVESIANQAEAVGDKFEKIEHVAKISANGDEAIGKL
IAEAMQRVKTEGVITVEEAKGTETTVDVVEGMQFDRGYISPYFVTDTEKMECQMENPYILIYDKKISVLKDLLPILEPTV
QSGRPLLIIAEDIDSEALATLVVNRLRGSLKICAVKAPGFGDRRKAMLEDIAVLTGGTVISEEKGLKLEGATMDMLGTAE
KITVDKDTTTIVNGAGDKEAIQARIGQIKIQMENTTSDYDKEKLQERLAKMAGGVAVLYVGAPSEVEMKEKKDRVDDALH
ATRAAIEEGTVPGGGVAYIRAIDALEGMKGDNEDETTGIEIVKRAIEEPLRQIVANAGKEGAVIVQKVKEGKGDFGYNAR
KDCFENLCEAGVIDPAKVTRVALENAASIAGMFLTTECVIAEKKEETPAMPPMNPGMGGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=49.9058380414313, Blast_Score=504, Evalue=1e-142,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=49.9058380414313, Blast_Score=504, Evalue=1e-142,
Organism=Escherichia coli, GI1790586, Length=522, Percent_Identity=61.1111111111111, Blast_Score=639, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=48.7712665406427, Blast_Score=493, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI193210679, Length=239, Percent_Identity=46.4435146443515, Blast_Score=203, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=55.1330798479088, Blast_Score=548, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=50.6641366223909, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=50.6641366223909, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45550936, Length=523, Percent_Identity=47.9923518164436, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550132, Length=523, Percent_Identity=47.9923518164436, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550935, Length=523, Percent_Identity=47.9923518164436, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17864606, Length=543, Percent_Identity=42.5414364640884, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24584129, Length=535, Percent_Identity=37.5700934579439, Blast_Score=335, Evalue=7e-92,
Organism=Drosophila melanogaster, GI19921262, Length=535, Percent_Identity=37.5700934579439, Blast_Score=335, Evalue=7e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_PARD8 (A6LIG0)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001305096.1
- ProteinModelPortal:   A6LIG0
- SMR:   A6LIG0
- STRING:   A6LIG0
- GeneID:   5308936
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_3787
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   EIDTKEQ
- ProtClustDB:   PRK00013
- BioCyc:   PDIS435591:BDI_3787-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58362; Mature: 58231

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEIKYDMDARDLLKKGVDELANAVKVTLGPKGRNVIIEKKFGAPHITKDGVTVAKEVE
CCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEEE
LTCPFENMGAQLVKEVASKTNDNAGDGTTTATVLAQSIIGVGLKNVTAGANPMDLKRGID
EECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHH
KAVAKVVESIANQAEAVGDKFEKIEHVAKISANGDEAIGKLIAEAMQRVKTEGVITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEECC
KGTETTVDVVEGMQFDRGYISPYFVTDTEKMECQMENPYILIYDKKISVLKDLLPILEPT
CCCCHHHHHHHCCCCCCCCCCCEEEECCHHHEEEECCCEEEEECCHHHHHHHHHHHHHHH
VQSGRPLLIIAEDIDSEALATLVVNRLRGSLKICAVKAPGFGDRRKAMLEDIAVLTGGTV
HHCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEKGLKLEGATMDMLGTAEKITVDKDTTTIVNGAGDKEAIQARIGQIKIQMENTTSDY
EECCCCCEECCCCHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHCEEEEEECCCCCCC
DKEKLQERLAKMAGGVAVLYVGAPSEVEMKEKKDRVDDALHATRAAIEEGTVPGGGVAYI
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RAIDALEGMKGDNEDETTGIEIVKRAIEEPLRQIVANAGKEGAVIVQKVKEGKGDFGYNA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCH
RKDCFENLCEAGVIDPAKVTRVALENAASIAGMFLTTECVIAEKKEETPAMPPMNPGMGG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCC
GMGGMM
CCCCCC
>Mature Secondary Structure 
AKEIKYDMDARDLLKKGVDELANAVKVTLGPKGRNVIIEKKFGAPHITKDGVTVAKEVE
CCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEEE
LTCPFENMGAQLVKEVASKTNDNAGDGTTTATVLAQSIIGVGLKNVTAGANPMDLKRGID
EECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHH
KAVAKVVESIANQAEAVGDKFEKIEHVAKISANGDEAIGKLIAEAMQRVKTEGVITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEECC
KGTETTVDVVEGMQFDRGYISPYFVTDTEKMECQMENPYILIYDKKISVLKDLLPILEPT
CCCCHHHHHHHCCCCCCCCCCCEEEECCHHHEEEECCCEEEEECCHHHHHHHHHHHHHHH
VQSGRPLLIIAEDIDSEALATLVVNRLRGSLKICAVKAPGFGDRRKAMLEDIAVLTGGTV
HHCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEKGLKLEGATMDMLGTAEKITVDKDTTTIVNGAGDKEAIQARIGQIKIQMENTTSDY
EECCCCCEECCCCHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHCEEEEEECCCCCCC
DKEKLQERLAKMAGGVAVLYVGAPSEVEMKEKKDRVDDALHATRAAIEEGTVPGGGVAYI
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RAIDALEGMKGDNEDETTGIEIVKRAIEEPLRQIVANAGKEGAVIVQKVKEGKGDFGYNA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCH
RKDCFENLCEAGVIDPAKVTRVALENAASIAGMFLTTECVIAEKKEETPAMPPMNPGMGG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCC
GMGGMM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA